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| 1 | Karyotype Stability and Unbiased Fractionation in the Paleo-Allotetraploid Cucurbita Genomes显示文摘 | Honghe Sun Shan WU Guoyu Zhang Chen Jiao Shaogui Guo Yi Ren Jie Zhang Haiying Zhang Guoyi Gong Zhangcai Jia Fan Zhang Jiaxing Tian William J. Lucas Jeff J. Doyle Haizhen Li Zhangjun Fei Yong Xu | 2017 | Molecular Plant2017，10，10： | 33 |
| 2 | 南海深水气田测试设计与实践显示文摘南海深水气田测试面临海床温度低致使测试管柱中易产生天然气水合物和深水作业费用昂贵等困难和挑战,使得深水气田测试设计不同于常规气田,测试设计时须考虑天然气水合物的形成条件预测及防治。提出了一开一关的测试流程,并对流程中4个阶段的测试时间进行了优化。以南海深水气田某气井为例进行了应用,结果表明测试非常成功,与设计基本一致。本文的测试流程目前已在南海珠江口盆地多口深水气井测试中成功应用,具有较好的推广价值。 | 戴宗 罗东红 梁卫 Shing-Ming Chen William Gong | 2012 | 中国海上油气2012，24，1： | 25 |
| 3 | 汽车轮胎橡胶摩擦试验研究显示文摘介绍了所开发的轮胎橡胶摩擦试验台,提出了轮胎橡胶摩擦试验方法。在该试验台上进行了干水泥路面、冰面等工况下的轮胎橡胶块摩擦试验,对所得试验结果进行了分析、处理。初步掌握了路面、温度、垂直压力和滑移速度等因素对摩擦因数的影响。在此基础上把动摩擦的概念引入轮胎半经验模型,对现有模型进行了改进。提出了应用轮胎低速试验数据预测高速下轮胎特性的方法。 | 郭孔辉 庄晔 Chen Shih-Ken Lin William | 2004 | 机械工程学报2004，40，10： | 22 |
| 4 | U and Th Contents and Th/U Ratios of Zircon in Felsic and Mafic Magmatic Rocks:Improved Zircon-Melt Distribution Coefficients显示文摘U 和 Th 内容和锆石的 Th/U 比率上的高精确的数据获得了使用第二等的离子团 spectrometry 分析从文学被收集了。在花岗石的岩石中的锆石有 350 ppm U, 140 ppm Th,和 Th/U=0.52 的中部的价值;推荐锆石融化分区系数为杜是 81 并且 8.2 为 DTh。在从 mafic 和中间的岩石的锆石,中部的价值是 270 ppm U , 170 ppm Th ,和 Th/U=0.81 ,并且推荐 zirconmelt 分区系数为杜是 169 并且 59 当锆石与melt 在平衡结晶时,为 DTh , magmatic 锆石的 U 和 Th 内容和 Th/U 比率是低的。增加的岩浆温度应该相对 U 内容支持更高的 Th 内容,导致为在到比在花岗石的岩石中的中间的岩石的 mafic 的锆石的更高的 Th/U 比率。然而,当锆石与 melt 在不平衡结晶时, U 和 Th 更容易能进入锆石格子,并且他们的内容和 Th/U 比率主要取决于不平衡的度。在 magmatic 锆石的 U 和 Th 的行为能被用作 geochemical 指示物决定起源和 magmatic 锆石的结晶化环境。 | WANG Xiang Williams L. GRIFFIN CHEN Jie HUANG Pinyun LI Xiang | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 18 |
| 5 | 中国联苯胺作业工人职业性膀胱癌发病率和死亡率流行病学调查显示文摘本文研究了1972年至1977年在册的累计专业工龄一年以上天津、上海和吉林1972名联苯胺男工的膀胱癌发病率和死亡率。与上海市普通居民相比联苯胺工人膀胱癌的标化死亡比(SMR)为17.5(95%可信限:7.5~34.5)、标化发病比(SIR)为25.0(95%可信限:16.9~35.7)。联苯胺工人膀胱癌发病率增高25倍,与接触水平有关。低接触组SIR=4.8;中接触组SIR=36.2;高接触组SIR=158.4(X^2趋势检验P<0.01)。联苯胺生产工人SIR=45.7(95%可信限:20.9~86.8),联苯胺使用工人SIR=20.9(95%可信限:12.9~32.0)。联苯胺吸烟者危险度增加31倍(95%可信限:20.4~46.4),而非吸烟者仅11倍(95%可信限:3.6~25.8)。 | 毕文芳 Richafd B.Hays 冯佩文 齐瑞蓉 犹学筠 陈志刚 张鸣歧 曲宝庆 富振英 Melode Chen Harvey T.Co Chen William J.Blot | 1992 | 卫生研究1992，21，2： | 13 |
| 6 | Performance characterization of Ni60-WC coating on steel processed with supersonic laser deposition显示文摘Ni60-WC particles are used to improve the wear resistance of hard-facing steel due to their high hardness. An emerging technology that combines laser with cold spraying to deposit the hard-facing coatings is known as supersonic laser deposition. In this study, Ni60-WC is deposited on low-carbon steel using SLD. The microstructure and performance of the coatings are investigated through SEM, optical microscopy, EDS, XRD, microhardness and pin-on-disc wear tests. The experimental results of the coating processed with the optimal parameters are compared to those of the coating deposited using laser cladding. | Fang LUO Andrew COCKBURN Martin SPARKES Rocco LUPOI Zhi-jun CHEN William O'NEILL Jian-hua YAO Rong LIU | 2015 | Defence Technology(防务技术)2015，11，1： | 11 |
| 7 | Changes with Age and the Effect of Recombinant Human BMP-2 on Proteoglycan and Collagen Gene Expression in Rabbit Anulus Fibrosus Cells显示文摘以便比较之间的差别年轻、旧内部脊椎的圆盘房间和他们的应答的海角到 recombinant 人骨头形态基因的 protein-2 (rhBMP-2 ) ,圆盘房间从 anulus fibrosus (AF ) 和腰部的磁盘的转变地区被孤立从八旧并且八只小新西兰白兔子。与从小兔子的房间相比,从年老的兔子的房间关于 sulfated-glycosaminoglycan (sGAG ) 对 rhBMP-2 处理少些作出回应合成和 aggrecan 基因表示。但是在骨胶原我和骨胶原 II 基因表情,在之间没有重要差别旧并且幼仔。当比较 sGAG 内容, aggrecan ,和骨胶原 II 基因时在有没有 rhBMP-2 处理的年轻 AF 房间的 rhBMP-2 处理以后的旧 AF 房间的表示,有 rhBMP-2 处理的旧 AF 房间有一个更大的能力综合,以及表示 aggrecan 和骨胶原 II 基因在房间并且到在媒介的版本 sGAG 的 sGAG 界限。在 rhBMP-2 处理以后的旧 AF 房间有一个更大的能力综合,这能被结束 sGAG 和快速的 aggrecan 和骨胶原 II 作为与没有 rhBMP-2 处理的年轻 AF 房间相比。因此, rhBMP-2 能与变老在圆盘房间的 anabolism 的能力颠倒衰落。那么看起来, rhBMP-2 有用作一个代理人的潜力延迟圆盘退化的一个关键部件和圆盘矩阵的损失。 | Qin-Ming FEI Xiao-Xing JIANG Tong-Yi CHEN Jun LI Hideki MURAKAMI Kai-Jow TSAI William C. HUTTON | 2006 | Acta Biochimica et Biophysica Sinica2006，38，11： | 11 |
| 8 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 9 | CLE25 peptide regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex显示文摘The phloem, located within the vascular system, is critical for delivery of nutrients and signaling molecules throughout the plant body. Although the morphological process and several factors regulating phloem differentiation have been reported, the molecular mechanism underlying its initiation remains largely unknown. Here, we report that the small peptide-coding gene, CLAVATA 3 (CLV3)/EMBEYO SURROUNDING REGION 25 (CLE25), the expression of which begins in provascular initial cells of 64-cell-staged embryos, and continues in sieve element-procambium stem cells and phloem lineage cells, during postembryonic root development, facilitates phloem initiation in Arabidopsis. Knockout of CLE25 led to delayed protophloem formation, and in situ expression of an antagonistic CLE25G6T peptide compromised the fate-determining periclinal division of the sieve element precursor cell and the continuity of the phloem in roots. In stems of CLE25G6T plants the phloem formation was also compromised, and procambial cells were over-accumulated. Genetic and biochemical analyses indicated that a complex, consisting of the CLE-RESISTANT RECEPTOR KINASE (CLERK) leucinerich repeat (LRR) receptor kinase and the CLV2 LRR receptor- like protein, is involved in perceiving the CLE25 peptide. Similar to CLE25, CLERK was also expressed during early embryogenesis. Taken together, our findings suggest that CLE25 regulates phloem initiation in Arabidopsis through a CLERK-CLV2 receptor complex. | Shi-Chao Ren Xiu-Fen Song Wen-Qiang Chen Ran Lu William J. Lucas Chun-Ming Liu | 2019 | Journal of Integrative Plant Biology2019，61，10： | 10 |
| 10 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 11 | Genomic Features and Regulatory Roles of Intermediate-Sized Non-Coding RNAs in Arabidopsis显示文摘在染色体宽的技术的最近的进展与各种各样的尺寸 ineukaryotes 允许几千非编码的 RNA 的鉴定,其中一些进一步被显示了在许多生物进程服务重要函数。然而在 modelplant Arabidopsis,新奇中介大小的 ncRNAs (im-ncRNAs )(50 ~ 300 nt ) 很限制了信息。由与深定序的技术使用修改隔离 strategycombined,我们全球性在 Arabidopsis 识别了 838 im-ncRNAs。多于一半(58%) 是新 ncRNA 种类,主要进化分叉。有趣地,与 5-UTR-derived 小说 im-ncRNAs 注解了 protein-codinggenes 趋于高度被表示。为 intergenic im-ncRNAs,他们比得上在幼苗的 mRNAs 的平均 abundanceswere,而是子集,在开始衰老的展出显著地更低的表示离开。进一步, intergenic im-ncRNAs 被调整由类似基因并且编码蛋白质的基因的到那些的 epigenetic 机制,和 someshowed 发展地调整了表示模式。基因屏蔽显示出的大规模颠倒 down-regulationof 很多 im-ncRNAs 在 vivo 导致了明显的分子的变化或反常发展显型,在植物生长和开发显示 im-ncRNAs 的功能的重要性。一起,我们的结果证明 thatnovel Arabidopsis im-ncRNAs 发展地被调整,功能的部件在 transcriptome.Key 词发现了: | Yuqiu Wang Xuncheng Wang Wei Deng Xiuduo Fan Ting-Ting Liu Guangming He Runsheng Chen William Terzaghi Danmeng Zhu Xing Wang Deng | 2014 | Molecular Plant2014，7，3： | 9 |
| 12 | 轮胎胎面橡胶-冰面摩擦试验方法研究显示文摘基于一种新开发的轮胎胎面橡胶摩擦试验机,建立了轮胎和整车与冰面间的模拟摩擦试验手段,提出了在高滑移速度段的瞬时试验法和低滑移速度段的连续采样试验法;分别在不同滑移速度、压力、温度下针对轮胎胎面胶块与冰面进行了摩擦试验,并对试验结果进行了模型拟合和分析.结果表明:作为轮胎主要组成部分的橡胶表现出很特殊的摩擦特性,其并不符合库仑摩擦定律;橡胶轮胎的机械特性在很大程度上取决于橡胶的摩擦特性,在一些极限工况下尤其如此;相关的橡胶摩擦实验研究对轮胎力学特性的研究具有重要的参考价值. | 郭孔辉 庄晔 CHEN Shih-Ken LIN William | 2005 | 摩擦学学报2005，25，3： | 8 |
| 13 | Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism显示文摘证据的成长身体证明二叠三叠纪的边界(PTB ) 附近的那个火山作用可能在触发 PermianTriassic (PTr ) 是关键的集体扑灭。因此,在华南的 PTB 附近的灰床可以在这个事件上带信息。三暴烈的灰层,改变了到泥土,在在 Zunyi 节的 PTB 床上的 outcropped,贵州省,西南中国。从这三张灰床的锆石谷物的 U-Pb 年龄,踪迹元素,和 Hf 同位素作文用 LA-ICPMS 和 LA-MC-ICPMS 被分析。锆石主要除了二 inherited/xenocrystic 锆石(939 和 2 325 妈) 是在起源(241-279 妈) 的 magmatic。这些 magmatic 锆石的年龄显示发生在中间附近的 magmatism 的三个事件 -- 晚二叠的边界(~ 261.5 妈, MLPB ) , Wuchiapingian-Changhsingian 边界(~ 254.5 妈, WCB ) ,并且 PTB (~ 250.5 妈) 分别地。MLPB 和 WCB 附近的 magmatism 的开始的二个事件可以被归因于 magmatic 继承或重新免职。所有 magmatic 锆石分享类似的踪迹元素和 Hf 同位素作文。他们有 Y, Hf, Th 和 U 内容和 Nb/Ta 比率典型地代表从硅的计算碱的岩浆的锆石。这些锆石也与 -11.4 的 Hf (t) 价值展出充实的 Hf 同位素作文到 +0.2,它建议三个 magmatic 事件涉及大陆人外壳融化。更多的充实的 Hf 同位素作文(床 ZY13 的 Hf (t)=-11.4--4.8)(~ 250.5 妈) 在岩浆暗示古老的外壳的材料的更多的输入。magmatic 锆石的 Hf 同位素和踪迹元素作文的集成建议 magmatism 的这三个事件可以由于 Palaeo-Tethys 海洋的闭合沿着会聚的大陆边缘发生在或在西南的华南附近。 | Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'Reilly | 2015 | Journal of Earth Science2015，26，6： | 8 |
| 14 | Prospective randomized comparison of oral sodium phosphate and polyethylene glycol lavage for colonoscopy preparation显示文摘AIM: To compare the effectiveness, patient acceptability, and physical tolerability of two oral lavage solutions prior to colonoscopy in a Taiwan Residents population. METHODS: Eighty consecutive patients were randomized to receive either standard 4 L of polyethylene glycol (PEG) or 90 mL of sodium phosphate (NaP) in a split regimen of two 45 mL doses separated by 12 h, prior to colonoscopic evaluation. The primary endpoint was the percent of subjects who had completed the preparation. Secondary endpoints included colonic cleansing evaluated with an overall assessment and segmental evaluation, the tolerance and acceptability assessed by a selfadministered structured questionnaire, and a safety profile such as any unexpected adverse events, electrolyte tests, physical exams, vital signs, and body weights. RESULTS: A significantly higher completion rate was found in the NaP group compared to the PEG group(84.2% vs 27.5%, P<0.001). The amount of fluid suctioned was significantly less in patients taking NaP vs PEG (50.13±54.8 cc vs 121.13±115.4 cc, P<0.001),even after controlling for completion of the oral solution(P = 0.031). The two groups showed a comparable overall assessment of bowel preparation with a rate of 'good' or 'excellent' in 78.9% of patients in the NaPgroup and 82.5% in PEG group (P = 0.778). Patients taking NaP tended to have significantly better colonic segmental cleansing relative to stool amount observedin the descending (94.7% vs 70%, P = 0.007) andtransverse (94.6% vs 74.4%, P = 0.025) colon. Slightly more patients graded the taste of NaP as 'good' or 'very good' compared to the PEG patients (32.5% vs 12.5%;P = 0.059). Patients' willingness to take the same preparation in the future was 68.4% in the NaP compared to 75% in the PEG group (P = 0.617). There was a significant increase in serum sodium and a significant decrease in phosphate and chloride levels in NaP group on the day following the colonoscopy without any clinical sequelae. Prolonged (>24 h) hemodynamic changes were also observed in 20-35% subjects of either group.CONCLUSION: Both bowel cleansing agents proved to be similar in safety and effectiveness, while NaP appeared to be more cost-effective. After identifying and excluding patients with potential risk factors, sodium phosphate should become an alternative preparation for patients undergoing elective colonoscopy in the Taiwan Residents population. | Kai-Lin Hwang William Tzu-Liang Chen Koung-Hong Hsiao Hong-Chang Chen Ting-Ming Huang Chien-Ming Chiu Ger-Haur Hsu | 2005 | World Journal of Gastroenterology2005，11，47： | 7 |
| 15 | Anti-mitotic chemotherapeutics promote apoptosis through TL1A-activated death receptor 3 in cancer cells显示文摘 | Chen Qi Xin Wang Zhirong Shen She Chen Hong Yu Noelle Williams Gelin Wang | 2018 | Cell Research2018，28，5： | 7 |
| 16 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 17 | Hyaluronic acid facilitates bone repair effects of calcium phosphate cement by accelerating osteogenic expression显示文摘Calcium phosphate cements(CPC)are widely anticipated to be an optimum bone repair substitute due to its satisfied biocompatibility and degradability,suitable to be used in minimally invasive treatment of bone defects.However the clinical application of CPC is still not satisfied by its poor cohesiveness and mechanical properties,in particular its osteoinductivity.Hyaluronic acid reinforced calcium phosphate cements(HA/CPC)showed extroadinary potential not only enhancing the compressive strength of the cements but also significantly increasing its osteoinductivity.In our study,the compressive strength of HA/CPC increased significantly when the cement was added 1%hyaluronic acid(denoted as 1-HA/CPC).In the meantime,hyaluronic acid obviously promoted ALP activity,osteogenic related protein and mRNA expression of hBMSCs(human bone marrow mesenchymal stem cells)in vitro,cement group of HA/CPC with 4%hyaluronic acid adding(denoted as 4-HA/CPC)showed optimal enhancement in hBMSCs differentiation.After being implanted in rat tibial defects,4-HA/CPC group exhibited better bone repair ability and bone growth promoting factors,comparing to pure CPC and 1-HA/CPC groups.The underlying biological mechanism of this stimulation for HA/CPC may be on account of higher osteogenic promoting factors secretion and osteogenic genes expression with hyaluronic acid incorporation.These results indicate that hyaluronic acid is a highly anticipated additive to improve physicochemical properties and osteoinductivity performance of CPCs for minimally invasive healing of bone defects. | Xu Cui Chengcheng Huang Zhizhen Chen Meng Zhang Chunyu Liu Kun Su Jianyun Wang Li Li Renxian Wang Bing Li Dafu Chen Changshun Ruan Deping Wang William W.Lu Haobo Pan | 2021 | Bioactive Materials2021，6，11： | 6 |
| 18 | Epidemiology of hepatitis B virus infection among young adults in Taiwan,China after public vaccination program显示文摘背景肝炎 B 病毒( HBV )的公共种痘程序在台湾在 1984 期间被运行, China.However ,在比 15 岁老的青少年之中的 HBV 种痘的长持续的保护的功效是很少, recorded.Methods A seroepidemiological 调查在台湾在 4575 个第一年的大学学生之中被进行,中国包括由严峻的 HBV 表面抗原( HBsAg )的 HBV 的血清学的数据,在 2000~2003 期间出现抗体( anti-HBs ), HBV 核心抗体( anti-HBc )并且在东方台湾的男、女的学生让最高的 HBsAg 搬运人与另外的地方相比评价。使用多重逻辑回归分析,与在 1984 年 7 月以后出生的学生,相比调整或 HBsAg,搬运人率为从 1983 年 7 月出生的学生为在 1981 年 6 月前出生的学生从 3.10 减少了到 1.56 到 1984 年 6 月(95%CI 1.96-4.91, P0.001;95%C/1.06-2.28, P=0.024;分别地).Conclusions 公众种痘再提供长持续的保护在在台湾的大学学生之中的 HBV 感染,比 18 岁旧的中国。有在在台湾的年轻成年人之中的 HBV 感染的一个地理变化,中国。 | CHEN Chun-Chieh YEN Chi-Hua WU Wei-Ya HU Suh-Woan CHEN Shiuan-Chih William R. Bell LEE Meng-Chih | 2007 | Chinese Medical Journal2007，，13： | 6 |
| 19 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 20 | Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers显示文摘 | Yi-hua SUN Rong FANG Bin GAO Xiang-kun HAN Jun-hua ZHANG William PAO Hai-quan CHEN Hong-bin JI | 2010 | Acta Pharmacologica Sinica2010，31，5： | 5 |
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