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| 1 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 2 | Screening Helicobacter pylori genes induced during infection of mouse stomachs显示文摘AIM:To investigate the effect of in vivo environment on gene expression in Helicobacter pylori(H.pylori) as it relates to its survival in the host.METHODS:In vivo expression technology(IVET) systems are used to identify microbial virulence genes.We modified the IVET-transcriptional fusion vector,pIVET8,which uses antibiotic resistance as the basis for selection of candidate genes in host tissues to develop two unique IVET-promoter-screening vectors,pIVET11 and pIVET12.Our novel IVET systems were developed by the fusion of random Sau3A DNA fragments of H.pylori and a tandem-reporter system of chloramphenicol acetyltransferase and beta-galactosidase.Additionally,each vector contains a kanamycin resistance gene.We used a mouse macrophage cell line,RAW 264.7 and mice,as selective media to identify specific genes that H.pylori expresses in vivo.Gene expression studies were conducted by infecting RAW 264.7 cells with H.pylori.This was followed by real time polymerase chain reaction(PCR) analysis to determine the relative expression levels of in vivo induced genes.RESULTS:In this study,we have identified 31 in vivo induced(ivi) genes in the initial screens.These 31 genes belong to several functional gene families,including several well-known virulence factors that are expressed by the bacterium in infected mouse stomachs.Virulence factors,vacA and cagA,were found in this screen and are known to play important roles in H.pylori infection,colonization and pathogenesis.Their detection validates the efficacy of these screening systems.Some of the identified ivi genes have already been implicated to play an important role in the pathogenesis of H.pylori and other bacterial pathogens such as Escherichia coli and Vibrio cholerae.Transcription profiles of allivi genes were confirmed by real time PCR analysis of H.pylori RNA isolated from H.pylori infected RAW 264.7 macrophages.We compared the expression profile of H.pylori and RAW 264.7 coculture with that of H.pylori only.Some genes such as cag A,vac A,lpx C,mur I,tlp C,trx B,sod B,tnp B,pgi,rbf A and inf B showed a 2-20 fold upregulation.Statistically significant upregulation was obtained for all the above mentioned genes(P < 0.05).tlp C,cag A,vac A,sod B,rbf A,inf B,tnp B,lpx C and mur I were also significantly upregulated(P < 0.01).These data suggest a strong correlation between results obtained in vitro in the macrophage cell line and in the intact animal.CONCLUSION:The positive identification of these genes demonstrates that our IVET systems are powerful tools for studying H.pylori gene expression in the host environment. | Aparna Singh Nathaniel Hodgson Ming Yan Jungsoo Joo Lei Gu Hong Sang Emmalena Gregory-Bryson William G Wood Yisheng Ni Kimberly Smith Sharon H Jackson William G Coleman | 2012 | World Journal of Gastroenterology2012，18，32： | 5 |
| 3 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 4 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 5 | Comment on profitability analysis of a femtosecond laser system for cataract surgery using a fuzzy logic approach显示文摘Dear Editor,We read with interest the recently published study by Trigueros et al^([1]),highlighting the financial and management conditions of femtosecond laser-assisted cataract surgery(FLACS).The authors derived a simulation to | Harrv William Roberts Melody Zhifang Ni David Phillip S. O'Brart | 2017 | International Journal of Ophthalmology(English edition)2017，10，3： | 2 |
| 6 | A simulation study on the perfor- mance of an entrained-flow coal gasifier 显示文摘 | NI Q WILLIAMS A | 1995 | Fuel1995，74，1： | 1 |
| 7 | Cost-Effectiveness of Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease and Abnormal Fractional Flow Reserve显示文摘 | William F. Fearon David Shilane Nico H.J. Pijls Derek B. Boothroyd Pim A.L. Tonino Emanuele Barbato Peter Jüni Bernard De Bruyne Mark A. Hlatky | 2013 | Circulation2013，，12： | 1 |
| 8 | Voxel-based mor- phometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry 显示文摘 | Sawiak SJ Wood NI Williams GB | 2009 | Neurobiology of disease2009，33，1： | 1 |
| 9 | A comprehensive process of reverse engineering from 3D meshes to CAD models显示文摘 | Roseline Bénière Gérard Subsol Gilles Gesquière Fran?ois Le Breton William Puech | 2013 | Computer-Aided Design2013，，11： | 1 |
| 10 | A simulation study on the performance of an entrained-flow coal gasifier显示文摘 | Qizhi Ni and Alan Williams | 1995 | Fuel1995，111，74： | 1 |
| 11 | Contribu- tion of kinins to endotoxin volunteers 显示文摘 | NIES A S FORSYTH R P WILLIAMS H E | 1993 | Blood1993，81，： | 1 |
| 12 | Effects of exercise combined with caloric restriction on inflammatory cytokines显示文摘 | Reed JL De Souza MJ Williams NI | | 0，，05： | 1 |
| 13 | Targeting autophagy for the treatment of liver diseases显示文摘 | Ni HM Williams JA Yang H | 2012 | Pharmacol Res2012，66，： | 1 |
| 14 | Does rejection hurt? An fMRI study of social exclusion 显示文摘 | Eisenberger NI Lieberman MD Williams KD | 2003 | Science2003，302，5643： | 1 |
| 15 | Effect of activation and inhibition of the rennin-angiotensin system on plasma PAI -1显示文摘 | Brown NI Agirbasli MA Williams GH | 1998 | Hypertension1998，32，6： | 1 |
| 16 | Effects of shortterm strenuous endurance exercise upon corpus luteum function 显示文摘 | Williams NI Bullen BA Mcarthur JW | 1999 | Med Sci Sports Exerc1999，31，： | 1 |
| 17 | Depression risk of'eft-behind children'in rural China显示文摘 | Bingyan He Jingyi Fan Ni Liu Huijuan Li Yanjun Wang Joshua Williams Kaishing Wong | 2012 | Psychiatry Research2012，4，23： | 1 |
| 18 | The role exercise in the prevention and treatment of osteopoporosis and osteoarthritis显示文摘 | Sharkey NA Williams NI Guerin JB | 2000 | Reumato12000，35，1： | 1 |
| 19 | Evidence for a causal role of low energy availability in the induction of menstrual cycle disturbances during strenuous exercise training显示文摘 | Williams NI H elmreicb DL Parfitt DB | 2001 | J Clin Endo- crinol Metab2001，86，： | 1 |
| 20 | Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising women显示文摘 | De Souza MJ Williams NI | 2004 | Hum Reprod Update2004，10，： | 1 |
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