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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | Meteorological control on CO_2 flux above broad-leaved Korean pine mixed forest in Changbai Mountains显示文摘The impacts of temperature, photosynthetic active radiation (PAR) and vapor pressure deficit (VPD) on CO2 flux above broad-leaved Korean pine mixed forest in the Changbai Mountains were studied based on eddy covariance and meteorological factors measurements.The results showed that, daytime CO2 flux was mainly controlled by PAR and they fit Michaelis-Menten equation. Meanwhile VPD also had an influence on the daytime flux. Drier air reduced the CO2 assimilation of the ecosystem, the drier the air, the more the reduction of the assimilation. And the forest was more sensitive to VPD in June than that in July and August. The respiration of the ecosystem was mainly controlled by soil temperature and they fit exponential equation. It was found that this relationship was also correlated with seasons; respiration from April to July was higher than that from August to November under the same temperature. Daily net carbon exchange of the ecosystem and the daily mean air temperature fit exponential equation. It was also found that seasonal trend of net carbon exchange was the result of comprehensive impacts of temperature and PAR and so on. These resulted in the biggest CO2 uptake in June and those in July and August were next. Annual carbon uptake of the forest ecosystem in 2003 was -184 gC. m-2. | GUAN Dexin, WU Jiabing, YU Guirui, SUN Xiaomin, ZHAO Xiaosong, HAN Shijie & JIN Changjie Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China | 2005 | Science China Earth Sciences2005，48，z1： | 15 |
| 3 | Tiny YOLO Optimization Oriented Bus Passenger Object Detection显示文摘The real-time collection of bus passenger object detection is an essential part of developing a smart bus system.The difficulty of object detection mainly lies in the objective factors,such as:clothing,hair style and accessories,light,etc.Traditional object detection met hods with the arti ficial feature ext rac tion suffers from insufficien t st reng th in expression,generalization,and recogni tion rate.The objec t detection met hod based on deep learning mainly uses the convol utio nal neural net work in deep learning to learn features from a large set of data.The learned features can describe the rich infbrmation inherent in the data,and improve the expression ability of the features as well as the recognition accuracy.Due to too many parameters of the Convolutional neural network(CNN)model,the amount of calculation is too large to be opera ted on the vehicle terminal.To reduce calculation burden and improve the operation speed,we employs the depthwise separable convolution method to optimize the convolutional layer of tiny YOLO net work model.It decomposes a complete convolution operation into depthwise convolution and pointwise convolution,thus reducing the parameter amount of the CNN and improving the operation speed.The experiment results reveal that the speed of bus passenger object detection detected by our improved model is 4 times faster than the previous one but with the nearly same detection accuracy. | ZHANG Shuo WU Yanxia MEN Chaoguang LI Xiaosong | 2020 | Chinese Journal of Electronics2020，29，1： | 15 |
| 4 | Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo显示文摘Fucoidan 是从棕色的海草孤立的主要 sulfated 多糖之一。在这研究,我们在弥漫的大 B 房间淋巴瘤(DLBCL ) 上决定了 fucoidan 的反癌症活动在 vitro 并且在 vivo 的房间。Fucoidan 在一个剂量依赖者和时间依赖者举止禁止了 DLBCL 细胞的生长,并且 fucoidan 治疗挑起了 G 0/G1 细胞周期拘捕,它被 p21 伴随起来规定和 cyclin D1, Cdk4,和 Cdk6 下面规定。Fucoidan 也在 DLBCL 房间线和主要 DLBCL 房间导致了 caspase 依赖的房间 apoptosis。另外, fucoidan 治疗从线粒体引起了 mitochondrial 膜潜力的损失和细胞色素 c 和导致 apoptosis 因素的版本进 cytosol。Fucoidan 也加强了在杀死 DLBCL 房间的 carfilzomib 的活动。fucoidan 的口头的管理有效地在异种皮移植老鼠模型禁止了肿瘤生长。我们的调查结果作为一个 anti-DLBCL 代理人揭示 fucoidan 的新奇功能,它能在 DLBCL 的临床的治疗被使用。 | Guang Yang Qianqiao Zhang Yuanyuan Kong Bingqian Xie Minjie Gao Yi Tao Hongwei Xu Fenghuang Zhan Bojie Dai Jumei Shi Xiaosong Wu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，11： | 9 |
| 5 | Eddy flux corrections for CO_2 exchange in broad-leaved Korean pine mixed forest of Changbai Mountains显示文摘Based on analysis of mechanisms causing energy no-closure and nocturnal low fluxes issues for CO2 exchange studies by eddy covariance method, corrections were done with the raw data sets obtained from Changbai Mountains forest flux site, to evaluate the impacts of sonic anemometer tilt, frequency response limitations and advection on estimation of CO2 exchange, respectively. The results show that the planar fit coordinate transforming method is superior to the streamline coordinate transforming method in tilt correction. The latter could cause a systematical underestimation of eddy fluxes relating with the angle of sensor and terrain tilt. The underestimation of CO2 and energy fluxes for frequency response limitations average 3.0% and 2.0% during daytime, respectively, which increase by 9.0% and 5.5% during nighttime, respectively. The corrections of frequency response limitations are closely related to atmospheric stability. The advection loss of CO2 fluxes is dominated by nocturnal vertical advection, which is at least 18% when the horizontal advection is neglected. It is suggested that more work be done to understand the characteristics of horizontal advection and turbulent eddies under a complexcircumstance. | WU Jiabing, GUAN Dexin, SUN Xiaomin, YU Guirui, ZHAO Xiaosong, HAN Shijie & JIN Changjie Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China Graduate school of the Chinese Academy of Sciences, Beijing 100093, China Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China | 2005 | Science China Earth Sciences2005，48，z1： | 8 |
| 6 | Development process of muzzle flows including a gun-launched missile显示文摘Numerical investigations on the launch process of a gun-launched missile from the muzzle of a cannon to the free-flight stage have been performed in this paper. The dynamic overlapped grids approach are applied to dealing with the problems of a moving gun-launched missile. The high-resolution upwind scheme(AUSMPW+) and the detailed reaction kinetics model are adopted to solve the chemical non-equilibrium Euler equations for dynamic grids. The development process and flow field structure of muzzle flows including a gun-launched missile are discussed in detail.This present numerical study confirms that complicated transient phenomena exist in the shortly launching stages when the gun-launched missile moves from the muzzle of a cannon to the freeflight stage. The propellant gas flows, the initial environmental ambient air flows and the moving missile mutually couple and interact. A complete structure of flow field is formed at the launching stages, including the blast wave, base shock, reflected shock, incident shock, shear layer, primary vortex ring and triple point. | Zhuo Changfei Feng Feng Wu Xiaosong | 2015 | Chinese Journal of Aeronautics2015，28，2： | 8 |
| 7 | Remote sensing based monitoring of interannual variations in vegetation activity in China from 1982 to 2009显示文摘Terrestrial vegetation is one of the most important components of the Earth's land surface. Variations in terrestrial vegetation directly impact the Earth system's balance of material and energy. This paper describes detected variations in vegetation activity at a national scale for China based on nearly 30 years of remote sensing data derived from NOAA/AVHRR(1982–2006) and MODIS(2001–2009). Vegetation activity is analyzed for four regions covering agriculture, forests, grasslands, and China's Northwest region with sparse vegetation cover(including regions without vegetation). Relationships between variations in vegetation activity and climate change as well as agricultural production are also explored. The results show that vegetation activity has generally increased across large areas, especially during the most recent decade. The variations in vegetation activity have been driven primarily by human factors, especially in the southern forest region and the Northwest region with sparse vegetation cover. The results further show that the variations in vegetation activity have influenced agricultural production, but with a certain time lag. | LI Fei ZENG Yuan LI XiaoSong ZHAO QianJun WU BingFang | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 8 | Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells显示文摘Resveratrol,a natural compound extracted from the skins of grapes,berries,or other fruits,has been shown to have anti-tumor effects against multiple myeloma(MM)via promoting apoptosis and inhibiting cell viability.In addition to apoptosis,autophagy also plays a significant role in anti-tumor effects.However,whether autophagy is involved in anti-MM activity of resveratrol remains unclear.In this study,human MM cell lines U266,RPMI-8226,and NCI-H929 were treated with resveratrol.Cell Counting Kit-8 assay and colony formation assay were used to measure cell viability.Western blot analysis was used to detect apoptosis-and autophagy-associated proteins.3-Methyladenine(3-MA)was applied to inhibit autophagy.Results showed that resveratrol inhibited cell viability and colony formation via promoting apoptosis and autophagy in MM cell lines U266,RPMI-8226,and NCI-H929.Resveratrol promoted apoptosis-related proteins,Caspase-3 activating poly-ADP-ribose polymerase and Caspase-3 cleavage,and decreased the protein level of Survivin in a dose-dependent manner.Additionally,resveratrol upregulated the levels of LC3 and Beclin1 in a dose-dependent way,indicating that autophagy might be implicated in anti-MM effect of resveratrol.Furthermore,3-MA relieved the cytotoxicity of resveratrol by blocking the autophagic flux.Resveratrol increased the phosphorylation of adenosine monophosphate(AMP)-activated protein kinase and decreased the phosphorylation of mammalian target of rapamycin(mTOR)and its downstream substrates p70S6K and 4EBP1 in a dose-dependent manner,leading to autophagy.Therefore,our results suggest that resveratrol exerts anti-MM effects through apoptosis and autophagy,which can be used as a new therapeutic strategy for MM in clinic. | Ruye Ma Dandan Yu Yu Peng Hongfei Yi Yingcong Wang Taofang Cheng Bingqing Shi Guang Yang Weiming Lai Xiaosong Wu Ye Lu Jumei Shi | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 7 |
| 9 | Shift-characteristics and bounds of thermal performance of organic Rankine cycle based on trapezoidal model显示文摘In consideration of the constraints of actual working fluids on theoretical study of organic Rankine cycle(ORC), a trapezoidal cycle(TPC) with theoretical model to simulate ORC was proposed in previous works. In this study, mathematical models of working fluids including model of simulated saturation curve(MSSC) and model of linear saturation lines(MLSL) are proposed and built. Combining mathematical models of working fluids and TPC, the thermodynamic characteristics and principles of TPC(or ORC) can be studied or predicted theoretically. There exists a shift-curve of net power output with corresponding shifttemperature of heating fluid for working fluids, which indicates the shift of net power output from having optimum condition of maximum power to monotonic increase with evaporation temperature. This shift-characteristic is significant to working fluid selection and evaluation of cycle performance, for it indicates that cycle without optimum condition can yield higher net power output than the cycle with optimum condition. Equations to calculate the shift-temperature in ORC(or TPC) are derived; and equations to calculate the highest optimal evaporation temperature and highest maximum power as the highest optimum condition at this shift-temperature are obtained. Based on TPC and its theoretical model, the lower and upper bounds of thermal performance(maximum power and corresponding thermal efficiency) of TPC(or ORC) can be demonstrated and acquired. TPC can develop to Carnot cycle or trilateral cycle that it is significant to use TPC as a generalized cycle to study the general principles and characteristics of the cycles. | LI XinGuo WANG JingYi WU XiaoSong | 2018 | Science China(Technological Sciences)2018，61，12： | 6 |
| 10 | Biocompatibility studies of silk fibroin-based artificial nerve grafts in vitro and in vivo显示文摘Silk fibroin(SF)has been used extensively in the biomedical field including tissue engineering for the generation of artificial bones,skins or ligaments.We have previously reported on good in vitro biocompatibility of SF fibers with peripheral nerve tissues and cells.In the present study,we developed a novel design of the SF-based artificial nerve graft(SF graft)which was composed of a SF-nerve guidance conduit(NGC)inserted with SF fibers.MTT assay was performed to determine the cytotoxicity of the SF-NGC extract fluid on the cultured L929 cells derived from an immortalized mouse fibroblast cell line.In addition,this SF graft was implanted into adult rats for bridging a 10-mm long sciatic nerve defect.The following-up experiments at initial stage(1-4 week)of nerve regeneration including routine blood tests and histochemical investigation were conducted to evaluate the in vivo biocompatibility of the SF graft with peripheral nerves.The results demonstrated that the SF-NGC graft was biocompatible with the surrounding tissues and cells due to its low inflammatory potential with a grade 0 under the U.S.Pharmacopeia guidelines and it was generally suitable to a certain degree for bridging peripheral nerve defects in virtue of supporting Schwann cell adherence,expansion and migration.Therefore the SF graft is a promising alternative to classical autografts for peripheral nerve repair. | Chen Xuemei Yang Yumin Wu Jian Zhao Yahong Ding Fei Gu Xiaosong | 2007 | Progress in Natural Science:Materials International2007，17，9： | 5 |
| 11 | Tweezing and manipulating micro- and nanoparticles by optical nonlinear endoscopy显示文摘The precise control and manipulation of micro-and nanoparticles using an optical endoscope are potentially important in biomedical studies,bedside diagnosis and treatment in an aquatic internal organ environment,but they have not yet been achieved.Here,for the first time,we demonstrate optical nonlinear endoscopic tweezers(ONETs)for directly controlling and manipulating aquatic micro-and nanobeads as well as gold nanorods.It is found that two-photon absorption can enhance the trapping force on fluorescent nanobeads by up to four orders of magnitude compared with dielectric nanobeads of the same size.More importantly,two-photon excitation leads to a plasmon-mediated optothermal attracting force on nanorods,which can extend far beyond the focal spot.This new phenomenon facilitates a snowball effect that allows the fast uploading of nanorods to a targeted cell followed by thermal treatment within 1 min.As two-photon absorption allows an operation wavelength at the center of the transmission window of human tissue,our work demonstrates that ONET is potentially an unprecedented tool for precisely specifying the location and dosage of drug particles and for rapidly uploading metallic nanoparticles to individual cancer cells for treatment. | Min Gu Hongchun Bao Xiaosong Gan Nicholas Stokes Jingzhi Wu | 2014 | Light(Science & Applications)2014，3，1： | 5 |
| 12 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 13 | Evaluation of Chinese tea by the electronic nose and gas chromatography–mass spectrometry: Correlation with sensory properties and classification according to grade level显示文摘 | Zihan Qin Xueli Pang Dong Chen Huan Cheng Xiaosong Hu Jihong Wu | 2013 | Food Research International2013，，： | 5 |
| 14 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 15 | Qualitative and quantitative detection using eDNA technology: A case study of Fenneropenaeus chinensis in the Bohai Sea显示文摘Accurate knowledge of species distributions and population dynamics is the basis for conservation biology.However, for certain species with unique life histories and very small populations, monitoring species distributions and population dynamics is extremely difficult. Recently, newly developed eDNA technology has been widely used in species monitoring, biodiversity assessments, and biomass assessments. In this research, we studied Fenneropenaeus chinensis in the Bohai Sea. We used a 0.45 μm glass fiber filter combined with a vacuum to filter 2 L seawater samples for eDNA enrichment from 54 stations in June and 60 stations in August. A DNeasy Blood and Tissue kit was used to extract the eDNA. After DNA extraction, the specific primers and probes of the mitochondrial DNA COI gene of F. chinensis were designed. Real-time quantitative PCR was used to qualitatively and quantitatively analyze the eDNA in the Bohai Sea. The temporal and spatial distribution of F. chinensis was detected by the eDNA technique. The relationship between the eDNA copy number and trawl-netted F. chinensis biomass was explored. The applicability and sensitivity of eDNA technology in marine crustacean research were verified. The results showed that the mtDNA COI gene of F. chinensis was successfully amplified in the 54 water samples collected in June, and the detection rate reached 100%. Detections occurred in only 23 of the 60 stations sampled in August. F. chinensis had a detection rate of only 38%. The copy number of eDNA obtained by realtime PCR was fitted to the density of F. chinensis captured by bottom trawling. There was not a significant positive correlation between copy number and biomass. The results obtained through this research will provide a method and theoretical basis for the application of eDNA technology in marine crustacean research. | Miao Lia Xiujuan Shan Weiji Wang Xiaosong Ding Fangqun Dai Ding Lv Huanhuan Wu | 2020 | Aquaculture and Fisheries2020，5，3： | 4 |
| 16 | Experimental investigations on cavity-actuated under-expanded supersonic oscillating jet显示文摘As one type of potential flow control actuators, cavity-actuated supersonic jet oscillators,which consist of a 2-D convergent nozzle and two face to face cavities, need to be investigated deeply to get the knowledge of their oscillating feature and underlying mechanism. Wind tunnel testing are conducted under different back pressures in a vacuum-type wind tunnel for two supersonic jet oscillators, to obtain their characteristics and the conditions for jet oscillating. The experimental results show that the continuous, nearly symmetric or asymmetric flipping between the two cavities appears over certain nozzle pressure ratio(NPR) range for both oscillators according to schlieren visualizations. Compared to the free jet, the oscillating jet with large exit achieves larger mixing; the oscillating jet with small exit has less mixing, based on the analysis of jet axial peak velocity and the entrainment. The cross-junction mode for estimating the resonance frequency in a pipe with two closed side branches is modified and obtained comparable estimations of the frequency of jet flipping with experimental data, but further investigations are needed to discover the underlying mechanism for the jet flipping. | Sun Bo Luo Xiaochen Feng Feng Wu Xiaosong | 2015 | Chinese Journal of Aeronautics2015，28，5： | 4 |
| 17 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 18 | Myeloma cells resistance to NK cell lysis mainly involves an HLA class I-dependent mechanism显示文摘房间具有升起的生来的杀手(NK ) 的反多重的骨髓瘤(公里) 潜力对最近的年的兴趣。然而,到骨髓瘤房间的 NK 房间 cytotoxicity 的分子的机制仍然保持不清楚。在现在的学习,我们调查了人的白血球的 theexpressions 在耐心的骨髓瘤房间的抗原(HLA ) 一级和 HLA-G,并且决定了他们的关联住院病人肿瘤房间危险性到 NK 房间 cytotoxicity。我们的结果给那个病人看了骨髓瘤房间(n = 12 ) 对 NK-92 房间细胞溶解相对抵抗,与骨髓瘤房间线相比(n = 7, P < 0.01 ) 。基因表示介绍和流动 cytometry 分析证明 HLA 一级的 mRNA 和蛋白质是在 12 个耐心的骨髓瘤房间的 highlyexpressed。有趣地,没有或低 HLA-G 表面表示被检测,尽管多重 HLA-Gtranscripts 在这些骨髓瘤房间被检测。NK 房间功能试金证明由酸治疗的下面调整的 HLA 一级 expressionon 病人房间显著地增加了公里房间的危险性到调停 NK 的细胞溶解。而且,我们发现在骨髓瘤上用抗体堵住膜界限 HLA 一级而非 HLA-G 显著地取样 increasedtheir 危险性到调停 NK 的杀死。这些结果证明到 NK 的耐心的公里房间的抵抗 lysismainly 包含一个 HLA 班我依赖的机制,建议那 HLA 一级可以涉及保护公里房间调停 fromNK 在 vivo 攻击并且贡献他们的有免疫力的逃跑。 | Minjie Gao Lu Gao Guang Yang Yi Tao Jun Hou Hongwei Xu Xiaojing Hu Ying Han Qianqiao Zhang Xiaosong Wu Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 3 |
| 19 | Proteasome inhibitor carfilzomib interacts synergistically with histone deacetylase inhibitor vorinostat in Jurkat T-leukemia cells显示文摘在现在的学习,我们在 Jurkat T 白血病房间调查了在 proteasome 禁止者 carfilzomib (CFZ ) 和 histone deacetylaseinhibitor vorinostat 之间的相互作用。到 CFZ 与的最低限度地致命的集中的细胞的 Coexposure 很, vorinostat 的 lowconcentration 导致了 synergistic antiproliferative 效果并且在 Jurkat T-leukemiacells 提高了 apoptosis ,与严厉地增加的反应的氧种( ROS )伴随了,在 mitochondrial membranepotential ( MMP )的惹人注目的减少,细胞色素 c 的增加的版本, caspase-9 和-3,和 PARP.The 的劈开的提高的激活联合了 Jurkat 细胞的处理与 ROS 预先对待而且, NAC 也在 apoptotic 房间导致了显著减小,显示为由联合处理的 increasedROS 产生的一个关键角色。另外,联合了逮捕的处理在 G 2-M 的房间周期阶段。这些结果暗示 CFZ 在 Jurkat T 白血病房间与 vorinostat synergistically 交往了,哪个有 vorinostat 的 carfilzomib 的联合可以在对待 T 房间代表新奇策略的 raisedthe 可能性白血病。 | Minjie Gao Lu Gao Yi Tao Jun Hou Guang Yang Xiaosong Wu Hongwei Xu Van S. Tompkins Ying Han Huiqun Wu Fenghuang Zhan Jumei Shi | 2014 | Acta Biochimica et Biophysica Sinica2014，46，6： | 3 |
| 20 | Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care. | Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin | 2021 | Science China(Life Sciences)2021，64，8： | 3 |
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