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| 1 | Atorvastatin protects against cerebral ischemia/ reperfusion injury through anti-inflammatory and antioxidant effects显示文摘In addition to its lipid-lowering effect, atorvastatin exerts anti-inflammatory and antioxidant effects as well. In this study, we hypothesized that atorvastatin could protect against cerebral ischemia/reperfusion injury. The middle cerebral artery ischemia/reperfusion model was established, and atorvastatin, 6.5 mg/kg, was administered by gavage. We found that, after cerebral ischemia/ reperfusion injury, levels of the inflammation-related factors E-selectin and myeloperoxidase were upregulated, the oxidative stress-related marker malondialdehyde was increased, and superoxide dismutase activity was decreased in the ischemic cerebral cortex. Atorvastatin pretreatment significantly inhibited these changes. Our findings indicate that atorvastatin protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. | Qiuyun Tu Hui Cao Wei Zhong Binrong Ding Xiangqi Tang | 2014 | Neural Regeneration Research2014，9，3： | 29 |
| 2 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 3 | Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma显示文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis.However,the prognostic value of TLSs in oral squamous cell carcinoma(OSCC)is largely unknown,and the association between tumour infiltrating lymphocytes(TILs)and TLSs has been rarely explored in OSCC.In this study,associated markers of TLS,including peripheral node address(PNAd)in high endothelial venules,CD20 in B cells and CD3 in T cells,were examined in 168 OSCC patients,and survival analysis was performed between TLS-positive and TLS-negative cohorts.We detected the presence of TILs by staining CD8+cytotoxic T cells and CD57+NK cells as well.TLSs appeared as highly organized structures in 45(26.8%)cases.TLSpositive patients had a better 5-year overall survival(OS)rate(88.9%vs.56.1%,P<0.001)and relapse-free survival(RFS)rate(88.9%vs.63.4%,P=0.002).Moreover,the presence of TLS was an independent prognostic factor for both the 5-year OS rate(hazard ratio[HR]=3.784;95%confidence interval[CI],1.498–9.562)and RFS rate(HR=3.296;95%CI,1.279–8.490)in multivariate analysis.Furthermore,a higher density of CD8+T cells and CD57+NK cells was found in TLS-positive sections than in TLS-negative counterparts(P<0.001),and their combination provided a higher predictive accuracy(AUC=0.730;95%CI,0.654–0.805).In conclusion,our results suggest that TLS is an independent positive prognostic factor for OSCC patients.These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment. | Qunxing Li Xiangqi Liu Dikan Wang Yanqiong Wang Huanzi Lu Shuqiong Wen Juan Fang Bin Cheng Zhi Wang | 2020 | International Journal of Oral Science2020，12，3： | 12 |
| 4 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 5 | Transcriptomic and genetic approaches reveal an essential role of the NAC transcription factor SlNAP1 in the growth and defense response of tomato显示文摘With global climate change,plants are frequently being exposed to various stresses,such as pathogen attack,drought,and extreme temperatures.Transcription factors(TFs)play crucial roles in numerous plant biological processes;however,the functions of many tomato(Solanum lycopersicum L.)TFs that regulate plant responses to multiple stresses are largely unknown.Here,using an RNA-seq approach,we identified SlNAP1,a NAC TF-encoding gene,which was strongly induced by various stresses.By generating SlNAP1 transgenic lines and evaluating their responses to biotic and abiotic stresses in tomato,we found that SlNAP1-overexpressing plants showed significantly enhanced defense against two widespread bacterial diseases,leaf speck disease,caused by Pseudomonas syringae pv.tomato(Pst)DC3000,and root-borne bacterial wilt disease,caused by Ralstonia solanacearum.In addition,SlNAP1 overexpression dramatically improved drought tolerance in tomato.Although the SlNAP1-overexpressing plants were shorter than the wild-type plants during the early vegetative stage,eventually,their fruit yield increased by 10.7%.Analysis of different hormone contents revealed a reduced level of physiologically active gibberellins(GAs)and an increased level of salicylic acid(SA)and abscisic acid(ABA)in the SlNAP1-overexpressing plants.Moreover,EMSAs and ChIP-qPCR assays showed that SlNAP1 directly activated the transcription of multiple genes involved in GA deactivation and both SA and ABA biosynthesis.Our findings reveal that SlNAP1 is a positive regulator of the tomato defense response against multiple stresses and thus may be a potential breeding target for improving crop yield and stress resistance. | Jiao Wang Chenfei Zheng Xiangqi Shao Zhangjian Hu Jianxin Li Ping Wang Anran Wang Jingquan Yu Kai Shi | 2020 | Horticulture Research2020，7，1： | 9 |
| 6 | Photodegradation of 17α-ethynylestradiol in dissolved humic substances solution:Kinetics,mechanism and estrogenicity variation显示文摘17α-Ethynylestradiol(EE2) in natural waters may cause adverse effects on organisms due to its high estrogenic potency. Laboratory studies were performed to study the effects of a local humic acid(LHA), fulvic acid(LFA) and Aldrich humic acid(AHA) on the photochemical behavior and estrogenic potency of EE2. Here photolytic experiments demonstrated that pure aqueous EE2 could undergo direct and self-sensitized photodegradation at a global rate of 0.0068 hr^(-1).Photodegradation rate of EE2 in 5.0 mg/L dissolved humic substances(DHS) was determined to be 0.0274, 0.0296 and 0.0254 hr^(-1) for LHA, LFA and AHA, respectively. Reactive oxygen species(ROS) and triplet dissolved humic substances(~3DHS*) scavenging experiments indicated that the promotion effect of DHS on EE2 photodegradation was mainly aroused by the reactions of HOU(35%–50%),~1O_2(<10%) andDHS*(22%–34%). However, the photodegradation of EE2 could also be inhibited when DHS exceeded the threshold of 10 mg/L. Three hydroxylation products of EE2 were identified using GC–MS and their formation pathways were also proposed. In vitro estrogenicity tests showed that EE2 was transformed into chemicals without estrogenic potency. These findings could extend our knowledge on the photochemical behaviors of steroid estrogens in sunlit natural waters. | Dong Ren Bin Huang Dan Xiong Huan He Xiangqi Meng Xuejun Pan | 2017 | Journal of Environmental Sciences2017，29，4： | 9 |
| 7 | Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity显示文摘Background:Lentinan(LNT)may regulate many important physiological functions of human and animals.This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)-challenged weaned pigs.Methods:Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d(n=14).RV infection was executed on d 15.After extracting polysaccharides from LNT product,its major monosaccharides were analyzed.Then,LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.Results:Dietary LNT supplementation supported normal function of piglets even when infected with RV,as reflected by reduced growth performance loss and diarrhea prevalence,and maintained gut immunity(P<0.05).The polysaccharide was isolated from LNT product,which molecular weight was 5303 Da,and major monosaccharides included glucose,arabinose and galactose.In RV-infected IPEC-J2 cells,this polysaccharide significantly increased cell viability(P<0.05),and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides(P<0.05).Conclusion:Those results suggest that LNT administration increases the piglets’resistance to RV-induced stress,likely by supporting intestinal immunity. | Xiangqi Fan Haiyan Hu Daiwen Chen Bing Yu Jun He Jie Yu Junqiu Luo Erik Eckhardt Yuheng Luo Jianping Wang Hui Yan Xiangbing Mao | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 8 |
| 8 | Carbon materials for stable Li metal anodes: Challenges, solutions, and outlook显示文摘Lithium(Li)metal is regarded as the ultimate anode for next-generation Li-ion batteries due to its highest specific capacity and lowest electrochemical potential.However,the Li metal anode has limitations,including virtually infinite volume change,nonuniform Li deposition,and an unstable electrode-electrolyte interface,which lead to rapid capacity degradation and poor cycling stability,significantly hindering its practical application.To address these issues,intensive efforts have been devoted toward accommodating and guiding Li deposition as well as stabilizing the interface using various carbon materials,which have demonstrated excellent effectiveness,benefiting from their vast variety and excellent tunability of the structure-property relationship.This review is intended as a guide through the fundamental challenges of Li metal anodes to the corresponding solutions utilizing carbon materials.The specific functionalities and mechanisms of carbon materials for stabilizing Li metal anodes in these solutions are discussed in detail.Apart from the stabilization of the Li metal anode in liquid electrolytes,attention has also been paid to the review of anode-free Li metal batteries and solid-state batteries enabled by strategies based on carbon materials.Furthermore,we have reviewed the unresolved challenges and presented our outlook on the implementation of carbon materials for stabilizing Li metal anodes in practical applications. | Qiongqiong Lu Yulin Jie Xiangqi Meng Ahmad Omar Daria Mikhailova Ruiguo Cao Shuhong Jiao Yan Lu Yaolin Xu | 2021 | Carbon Energy2021，3，6： | 6 |
| 9 | Internal failure of anode materials for lithium batteriesd——A critical review显示文摘Prevention of mechanical and finally electrochemical failures of lithium batteries is a critical aspect to be considered during their design and performance, especially for those with high specific capacities. Internal failure is observed as one of the most serious factors, including loss of electrode materials, structure deformation and dendrite growth. It usually incubates from atomic/molecular level and progressively aggravates along with lithiation. Understanding the internal failure is of great importance for developing solutions of failure prevention and advanced anode materials. In this research, different internal failure processes of anode materials for lithium batteries are discussed. The progress on observation technologies of the anode failure is further summarized in order to understand their mechanisms of internal failure. On top of them, this review aims to summarize innovative methods to investigate the anode failure mechanisms and to gain new insights to develop advanced and stable anodes for lithium batteries. | Xiangqi Meng Yaolin Xu Hongbin Cao Xiao Lin Pengge Ning Yi Zhang Yaiza Gonzalez Garcia Zhi Sun | 2020 | Green Energy & Environment2020，5，1： | 5 |
| 10 | Emerging roles for PlWl proteins in cancer显示文摘 | Yi Tan Lianyong Liu Mingan Liao Chaobao Zhang Shuanggang Hu Mei Zou Mingjun Gu Xiangqi Li | 2015 | Acta Biochimica et Biophysica Sinica2015，47，5： | 4 |
| 11 | Alteration of Terminal Heterochromatin and Chromosome Rearrangements in Derivatives of Wheat-Rye Hybrids显示文摘小麦黑麦增加和替换线和他们的自我子孙在 telomeric heterochromatin 和着丝点揭示了变化。而且,一个有丝分裂地不稳定的 dicentric 染色体和稳定的 multicentric 染色体在一根中国春天帝国的黑麦 3R 增加线的子孙被观察。一个不稳定的 multicentric 染色体在一根 6R/6D 替换线的子孙被发现。包括终端 heterochromatin 的运动和消失的终端 heterochromatin 的激烈的变化发生在小麦黑麦增加线 3R,和 5RS ditelosomic 增加线的子孙。高度稳定的 minichromosomes 在一根 monosomic 4R 增加线,一根 ditelosomic 5RS 增加线和一根 6R/6D 替换线的子孙被观察。有或没有为 telomeric DNA (TTTAGGG ) n 的 FISH 信号, Minichromosomes 源于一根 monosomic 4R 增加线对下一代稳定、能递送。结果显示着丝点和终端 heterochromatin 能深刻地在小麦黑麦混血儿衍生物被改变。 | Shulan Fu Zhenling Lv Xiang Guo Xiangqi Zhang Fangpu Han | 2013 | Journal of Genetics and Genomics2013，40，8： | 3 |
| 12 | New member of the guanosine triphosphatase activating protein family in the human epididymis显示文摘尽管没有差距在 epididymis 被探索了,在精子发生上激活蛋白质(差距) 的海鸟粪正弦 triphosphatase 的效果多年被学习了,为精子成熟的一个必要机关。在这研究,一个新差距成员,指定了为 MacGAP,在人的 epididymis 被克隆。有 70 kDa 和港口的一种通常认为的尺寸的 618 氨基酸的 Mac 差距 geneencodesaprotein 保存 RhoGAP 领域。MacGAP 的 N 终端和 C 终端肽被表示,他们的相应的反时代被准备。对 N 终端肽的反时代能检测象 0.3 ng 一样低的抗原,并且它的特性也被证实。然而,因为它的低敏感,对 C 终端肽的反时代没能检测它的抗原。Immunohistochemistry 证明 MacGAP 蛋白质依赖于 epididymis 并且有一个区域特定的表示模式,与在上皮的房间在头区域的基础节的高表示。结果在精子成熟为差距的生物效果的进一步的解释创造了一个基础。 | Xiangqi Li Qiang Liu Shigui Liu Jinsong Zhang Yonglian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 3 |
| 13 | The spatiotemporal expression changes of 16 epididymis-specific genes induced by testosterone, heat, and combination treatment in cynomolgus monkey显示文摘包含阴囊的温暖的处理的试验性的不孕模型,睾丸激素植入,并且联合二被开发证实联合处理在 cynomolgus 在细菌房间 apoptosis 上导致的一个 synergistic 行动猴子睾丸。用这个模型, 16 的时间空间的表示变化报导了或在 epididymis 的新奇基因被调查在 epididymal 基因上检验处理的效果。这被表明这些区域特定的基因,其中一些地区性没被修理,随着这些处理极大地变化了。这些 epididymal 基因的表示层次波动,并且大多数基因的表示在处理的结束回到了将近正常的水平。而且,源于联合处理的表示变化不比那些源于单个处理更重要。这建议联合处理在 epididymal 基因的表示上有一个对抗行动并且它的效果不是象二个单个处理的同样在 epididymis 上不利的。 | Xiangqi Li Qiang Liu Shigui Liu Xuesen Zhang Yixun Liu Yonglian Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，8： | 3 |
| 14 | Neck observation versus elective neck dissection in management of clinical T1/2N0 oral squamous cell carcinoma: a retrospective study of 232 patients显示文摘Objective: The management of early-stage(cT1/2N0) oral squamous cell carcinoma(OSCC) remains a controversial issue. The aim of this study was to compare the clinical outcomes of neck observation(OBS) and elective neck dissection(END) in treating patients with cT1/2N0 OSCC.Methods: A total of 232 patients with cT1/2N0 OSCC were included in this retrospective study. Of these patients, 181 were treated with END and 51 with OBS. The survival curves of 5-year overall survival(OS), diseasespecific survival(DSS), and recurrence-free survival(RFS) rates were plotted using the Kaplan-Meier method for each group, and compared using the Log-rank test.Results: There was no significant difference in 5-year OS and DSS rates between END and OBS groups(OS:89.0% vs. 88.2%, P=0.906; DSS: 92.3% vs. 92.2%, P=0.998). However, the END group had a higher 5-year RFS rate than the OBS group(90.1% vs. 76.5%, P=0.009). Patients with occult metastases in OBS group(7/51) had similar 5-year OS rate(57.1% vs. 64.1%, P=0.839) and DSS rate(71.4% vs. 74.4%, P=0.982) to those in END group(39/181). In the regional recurrence patients, the 5-year OS rate(57.1% vs. 11.1%, P=0.011) and DSS rate(71.4% vs. 22.2%, P=0.022) in OBS group(7/51) were higher than those in END group(9/181).Conclusions: The results indicated that OBS policy could obtain the same 5-year OS and DSS as END. Under close follow-up, OBS policy may be an available treatment option for patients with clinical T1/2N0 OSCC. | Xiangqi Liu Xiaomei Lao Lizhong Liang Sien Zhang Kan Li Guiqing Liao Yujie Liang | 2017 | Chinese Journal of Cancer Research2017，29，3： | 2 |
| 15 | Chromosome engineering of pollen wheat显示文摘Chromosome engineering of pollen wheat is the new procedure combining anther culture and chromosome engineering techniques. It could transfer useful alien genes into wheat varieties, enhancing genetic diversity for investigation of genetics and breeding. In the present study, two new procedures, at genome level and single chromosome level, were established.Compared with the classical chromosome engineering, the chromosome engineering of pollen wheat has the following main characters: ( ⅰ ) diversity of products, ( ⅱ ) rapid stability and (ⅲ) high efficiency of selection. Experiments indicated that chromosome engineering of pollen wheat is an efficient way for creating alien translocation line, especially non-Robertsonian translocation line. Meanwhile, using this procedure combined with comprehensive identifying methods, the investigation of useful genes and molecular markers on rye chromosomes 1R and 6R respectively has been done. The roles and relationships between chromosome engineering of pollen | Han Hu Xiangqi Zhang Wenjun Zhang Jiankang Jing Erming Wang Xianping Wang | 1999 | Chinese Science Bulletin1999，44，11： | 2 |
| 16 | Development, identification and utilization of introgression lines using Chinese endemic and synthetic wheat as donors显示文摘Chromosome segmental introgression lines(ILs)are an effective way to utilize germplasm resources in crops.To improve agronomic traits of wheat cultivar(Triticum aestivum) Shi 4185, four sets of ILs were developed. The donors were Chinese endemic subspecies accessions Yunnan wheat(T. aestivum ssp. yunnanense) YN3, Tibetan semiwild wheat(T. aestivum ssp. tibetanum) XZ-ZM19450, and Xinjiang wheat(T. aestivum ssp. petropavlovskyi) XJ5, and synthetic wheat HC-XM1620 derived from a cross between T. durum acc. D67.2/P66.270 with Aegilops tauschii acc. 218.Totals of 356, 366, 445 and 457 simple sequence repeat(SSR)markers were polymorphic between Shi 4185 and YN3, XZZM19450, XJ5 and HC-XM1620, respectively. In total, 991 ILs were identified, including 300 derived from YN3, covering 95%of the genome of Shi 4185, 218 from XZ-ZM19450(79%), 279 from XJ5(97%), and 194 from HC-ZX1620(84%). The sizes and locations of each introgression were determined from a consensus SSR linkage map. Using the ILs, 11 putative Resear quantitative trait loci(QTLs) were identified for plant height(PH), spike length(SL) and grain number per spike(GNS).Comparative analyses of 24 elite ILs with the parents revealed that the four donor parents could be important resources to improve wheat SL and GNS. Our work offers a case for utilizing endemic landraces for QTL mapping and improvement of wheat cultivars using introgression lines. | Liqing Gu Bo Wei Renchun Fan Xu Jia Xianping Wang Xiangqi Zhang | 2015 | Journal of Integrative Plant Biology2015，57，8： | 2 |
| 17 | Short-chain fatty acids in blood pressure, friend or foe显示文摘To the Editor:Gut microbiota,the trillions of microbes living in the human and rodent gut,play a pivotal role in cardiovascular diseases,including hypertension and atherosclerosis.One of the crucial mechanisms underlying gut microbiota functions in cardiovascular diseases is the microbiota-derived metabolites such as short-chain fatty acids(SCFAs).And emerging evidence demonstrated gut microbiota-derived metabolites——SCFAs maintained stable blood pressure.[1]However,there is no large cohort study on the correlation of SCFAs with hypertension. | Xiao-Feng Chen Si-Chong Ren Guo Tang Chuan Wu Xiangqi Chen Xiao-Qiang Tang | 2021 | Chinese Medical Journal2021，，19： | 2 |
| 18 | Numerical analysis of blockage and optimization of heat transfer performance of fractalllke microchannel nets 显示文摘 | Wang Xiangqi Mujumdar A S Yap C | 2006 | Journal of Electronic Packaging2006，128，3： | 1 |
| 19 | Thermal characteris- tics of tree - shaped microchannel nets for cooling of a rectangular heat sink显示文摘 | Wang Xiangqi Arun S Mujumdar | 2006 | Christopher Yap International Journal of Thermal Sciences2006，45，11： | 1 |
| 20 | Identification of new T1BL.1RS translocation lines derived from wheat (Triticum aestivum L. cultivar “Xiaoyan No. 6”) and rye hybridization显示文摘 | Jun Ji Zhiguo Wang Jiazhu Sun Junming Li Xiangqi Zhang Daowen Wang Aimin Zhang | 2008 | Acta Physiologiae Plantarum2008，，5： | 1 |
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