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| 1 | Plant abiotic stress response and nutrient use efficiency显示文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies. | Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.Herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu | 2020 | Science China(Life Sciences)2020，63，5： | 94 |
| 2 | Soil carbon pool in China and its global significance显示文摘SoilcarbonpoolinChinaanditsglobalsignificance￥FangJingyun,LiuGuohua,XuSongling(ResearchCenterforEco-EnvironmentalScience,Chin... | Fang Jingyun, Liu Guohua, Xu Songling(Research Center for Eco-Environmental Science, ChineseAcademy of Sciences, Beijing 100085, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 46 |
| 3 | Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface water and sediments from Baiyangdian Lake in North China显示文摘Persistent organochlorine compounds,including hexachlorocyclohexanes (HCHs),dichlorodiphenyltrichloroethanes (DDTs) and polychlorinated biphenyls (PCBs) were analyzed in surface water and sediments from Baiyangdian Lake,North China.Total concentrations of HCHs,DDTs and PCBs in surface water were in the range of 3.13-10.60,4.05-20.59 and 19.46-131.62 ng/L,respectively,and total concentrations of HCHs,DDTs and PCBs in sediments were 1.75-5.70,0.91-6.48 and 5.96-29.61 ng/g dry weight,respectively.Among the groups of HCHs (sum of α-HCH,β-HCH,γ-HCH and δ-HCH) and DDTs (sum of DDT,DDD and DDE),the predominance of β-HCH,DDE and DDD in water and sediment samples was clearly observed.This observation suggested that β-HCH was resistant to biodegradation and the DDTs had been transformed to its metabolites,DDE and DDD.For PCBs,penta-,hexa-and hepta-chlorinated congeners were the most abundant compounds in the both phases.Furthermore,the partitioning of chlorinated compounds between sediment and water was investigated to understand their transport and fates in aquatic ecosystems.The results indicated that average logs of organic carbon-normalized sediment-water partition coefficients (logK'oc) for OCPs varied between 3.20 and 5.53,and for PCBs,logK'oc values ranged from 3.19 to 5.57.The observed logK'oc was lower than their equilibrium logKoc predicted from linear model,which may be attributed to the solubility enhancement effect of colloidal matter in water phase and the disequilibrium between sediment and water. | Guohua Dai Xinhui Liu Gang Liang Xu Han Liu Shi Dengmiao Cheng Wenwen Gong | 2011 | Journal of Environmental Sciences2011，23，10： | 44 |
| 4 | Expansion of the Cathaysian Oldland through the Ordovician-Silurian transition:Emerging evidence and possible dynamics显示文摘Located northwest of the Jiangshan-Shaoxing Fault Zone,western and northwestern Zhejiang and northeastern Jiangxi provinces experienced major changes in bio-and litho-facies and paleogeography through the Ordovician-Silurian transition (late Katian,Hirnantian,and early Rhuddanian),as manifested by stratigraphic,paleontologic and synecologic records.Three geographic units under consideration are South,Central,and North areas.The western margin of the South area was occupied by the Huaiyu Mountains,whereas the other two parts were covered by the Zhe-Gan Sea during late Katian (Late Ordovician) time.In the early stage of the Changwu Formation deposition (late Katian),the sea was deepening northeastward,but with shallower conditions in the southwest and deeper conditions in the northeast.During mid to late stages of Changwu Formation deposition (latest Katian),the sea became much shallower and the sea bottom was uplifted substantially,which occurred somewhat prior to the global trend.During the Hirnantian (latest Ordovician) and early Rhuddanian (earliest Silurian),the study region became a shallow bay under expansion of the Cathaysian Oldland.There occurred a major drop of sea level and great changes in benthic biota with the occurrence of many new immigrants through the Ordovician-Silurian transition,which are closely related to a unique regional orogeny.The Yangtze and Cathaysian blocks may have amalgamated within the South China Paleoplate during this interval to cause the continuous uplifting and northwestward expansion of the Cathaysian Oldland. | RONG JiaYu ZHAN RenBin XU HongGen HUANG Bing YU GuoHua | 2010 | Science China Earth Sciences2010，53，1： | 37 |
| 5 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 6 | Complex Regulation of Plant Phosphate Transporters and the Gap between Molecular Mechanisms and Practical Application: What Is Missing?显示文摘自从编码高亲密关系的磷酸盐 transporter (磅) 的基因的第一份报告,现在是几乎 25 年, PHO84,在里面酵母。从那以后,与磷酸盐(Pi ) 编码蛋白质的越来越多的酵母 PHO84 相当或相同的事物以及另外的基因搬运活动在多样的植物种类被识别了并且机能上地描绘了。大进步在译解也被取得了位于这些基因和他们的产品的丰富或活动的规定下面的分子的机制。规章的基因在不同层次通过许多磅的直接或间接的规定通常影响植物 Pi 动态平衡。然而,很少为与高磷使用效率(PUE ) 开发遗传上修改的庄稼在磅的使用被完成了。这可能是在 Pi 运输从磅的角色的知识的根围和缺乏过分强调 Piuptake 并且在被要求优化 PUE 的植物以内再循环的后果。这里,我们主要集中了于与 Pi 运输活动和新兴的 understandingof 编码蛋白质的基因他们的 regulationat transcriptional, post-transcriptional,翻译,并且 translational 以后层次。另外,我们建议为在改善的磅的有效使用的潜在的策略种生长和开发。 | Mian Gu Aiqun Chen Shubin Sun Guohua Xu | 2016 | Molecular Plant2016，9，3： | 22 |
| 7 | A putative 6-transmembrane nitrate transporter OsNRT1.1b plays a key role in rice under low nitrogen显示文摘OsNRT1.1a is a low-affinity nitrate(NO_3^-) transporter gene. In this study, another mRNA splicing product, OsNRT1.1b,putatively encoding a protein with six transmembrane domains, was identified based on the rice genomic database and bioinformatics analysis. OsNRT1.1a/OsNRT1.1b expression in Xenopus oocytes showed OsNRT1.1a-expressing oocytes accumulated ^(15)N levels to about half as compared to OsNRT1.1bexpressing oocytes. The electrophysiological recording of OsNRT1.1b-expressing oocytes treated with 0.25 mM NO_3^- confirmed ^(15)N accumulation data. More functional assays were performed to examine the function of OsNRT1.1b in rice. The expression of both OsNRT1.1a and OsNRT1.1b was abundant in roots and downregulated by nitrogen(N) deficiency. The shoot biomass of transgenic rice plants with OsNRT1.1a or OsNRT1.1b overexpression increased under various N supplies under hydroponic conditions compared to wild-type(WT). The OsNRT1.1a overexpression lines showed increased plant N accumulation compared to the WT in 1.25 mM NH_4NO_3 and 2.5 mM NO_3^- or NH_4^+ treatments, but not in 0.125 mM NH_4NO_3.However, OsNRT1.1b overexpression lines increased total N accumulation in all N treatments, including 0.125 m M NH_4NO_3,suggesting that under low N condition, OsNRT1.1b would accumulate more N in plants and improve rice growth, but also that OsNRT1.1a had no such function in rice plants. | Xiaorong Fan Huimin Feng Yawen Tan Yanling Xu Qisong Miao Guohua Xu | 2016 | Journal of Integrative Plant Biology2016，58，6： | 21 |
| 8 | Genetic analysis and molecular mapping of a presenescing leaf gene psll in rice (Oryza sativa L.)显示文摘A rice psl1 (presenescing leaf) mutant was obtained from a japonica variety Zhonghua 11 via radiation of 60Co-γ in M2 generation. Every leaf of the mutant began to wither after it reached the big-gest length,while the leaves of the wild variety could keep green for 25―35 d. In this study,genetic analysis and gene mapping were carried out for the mutant identified. The SSR marker analysis showed that the mutant was controlled by a single recessive gene (psl1) located on chromosome 2. Fine mapping of the psl1 locus was conducted with 34 new STS markers developed around psl1 anchored region based on the sequence diversity between Nippon-bare and 93-11. The psl1 was further mapped be-tween two STS markers,STS2-19 and STS2-26,with genetic distances of 0.43 and 0.11 cM,respectively,while cosegregated with STS2-25. A BAC contig was found to span the psl1 locus,the region being delim-ited to 48 kb. This result was very useful for cloning of the psl1 gene. | WANG dun WU Shujun ZHOU Yong ZHOU Lihui XU Jiefen HU Jing FANG Yunxia GU Minghong LIANG Guohua | 2006 | Chinese Science Bulletin2006，51，24： | 16 |
| 9 | The OsAMT1.1 gene functions in ammonium uptake and ammoniumepotassium homeostasis over low and high ammonium concentration ranges显示文摘Rice(Oryza sativa) grown in paddy fields is an ammonium(NH^+_4)-preferring crop;however,its AMT-type NH^+_4transporters that mediate root N acquisition have not been well characterized yet.In this study,we analyzed the expression pattern and physiological function of the OsAMT1.1 gene of the AMT1 subfamily in rice.Os AMT1.1 is located in the plasma membrane and is mainly expressed in the root epidermis,stele and mesophyll cells.Disruption of the Os AMT1.1 gene decreased the uptake of NH^+_4,and the growth of roots and shoots under both low NH^+_4and high NH^+_4conditions.Os AMT1.1 contributed to the short-term(5 min)^(15)NH^+_4influx rate by approximately one-quarter,irrespective of the NH^+_4concentration.Knockout of Os AMT1.1 significantly decreased the total N transport from roots to shoots under low NH^+_4conditions.Moreover,compared with the wild type,the osamt1.1 mutant showed an increase in the potassium(K)absorption rate under high NH^+_4conditions and a decrease under low NH^+_4conditions.The mutants contained a significantly high concentration of K in both the roots and shoots at a limited K(0.1 mmol/L)supply when NH^+_4was replete.Taken together,the results indicated that OsAMT1.1 significantly contributes to the NH^+_4uptake under both low and high NH^+_4conditions and plays an important role in Ne K homeostasis in rice. | Chang Li Zhong Tang Jia Wei Hongye Qu Yanjie Xie Guohua Xu | 2016 | Journal of Genetics and Genomics2016，43，11： | 12 |
| 10 | NUMERICAL SIMULATION OF PARTICLE MOTION IN TURBO CLASSIFIER显示文摘Research on the flow field inside a turbo classifier is complicated though important. According to the stochastic trajectory model of particles in gas-solid two-phase flow, and adopting the PHOENICS code, numerical simulation is carried out on the flow field, including particle trajectory, in the inner cavity of a turbo classifier, using both straight and backward crooked elbow blades. Computation results show that when the backward crooked elbow blades are used, the mixed stream that passes through the two blades produces a vortex in the positive direction which counteracts the attached vortex in the opposite direction due to the high-speed turbo rotation, making the flow steadier, thus improving both the grade efficiency and precision of the turbo classifier. This research provides positive theoretical evidences for designing sub-micron particle classifiers with high efficiency and accuracy. | Ning xu Guohua Li Zhichu Huang | 2005 | China Particuology2005，3，5： | 12 |
| 11 | Elevated expression of mature miR-21 and miR-155 in cancerous gastric tissues from Chinese patients with gastric cancer显示文摘Objective:MicroRNA (miRNA) expression is deregulated in many types of human cancers.We sought to investigate the expression patterns of the miRNAs,miR-21,miR-145 and miR-155 in sporadic gastric cancer in a Chinese population.Methods:Total RNA was extracted from archived gastric cancer tissues and adjacent non-cancerous tissues from 20 pairs of paraffin-embedded specimens.Expression levels of miR-21,miR- 145 and miR-155 were detected by quantitative reverse transcriptase PCR using a specific stem-loop primer,with U6 as the internal reference gene.Results:The expression of miR-21 and miR-155 in gastric cancer samples was significantly higher than in paired non-cancerous samples(P<0.05).There was no statistically significant difference in expression levels of miR-145 between cancerous and non-cancerous tissues(P>0.05).Conclusion:In Chinese sporadic gastric cancer tissues,the expressions of the oncogenic miR-21 and miR-155 were significantly up-regulated,while the expression of the tumor suppressor miR-145 was decreased,although this decrease was not statistically significant.Thus there is specificity in the miRNA expression pattern in gastric cancers in the Chinese population. | Li Liu Qi Chen Rensheng Lai Xiaobin Wu Xiaoyu Wu Fukun Liu Guohua Xu Yong Ji | 2010 | The Journal of Biomedical Research2010，24，3： | 11 |
| 12 | Horizontal crustal movement before the great Wenchuan earthquake obtained from GPS observations in the regional network显示文摘The great Wenchuan earthquake of M8.0 on May 12,2008,occurred in an area with dense GPS observation stations in the regional network of the Crustal Movement Observation Network of China(CMONOC).Non-continuous observations were carried out at the 1 000 GPS stations of the regional network in 1999,2001,2004 and 2007.The horizontal displacements at GPS stations in the regional network before the Wenchuan earthquake show that the main driving tectonic force of the earthquake was the northward pushing of the Indian plate,added at the same time by the pushing of plates on the east and south.In comparison to the displacements in other regions,the horizontal displacements near and around the seismic area is characterized by diverging eastward displacements,that is,the stations to the north of the epicenter moved in the ENE direction while those to the south of epicenter moved in ESE direction with smaller displacements at stations near the epicenter.The accuracy of the estimated strain results is briefly discussed.In order to obtain the anomalous information before the earthquake,the methods of both best fits by trend surface and statistics have been used in the study for finding the future epicentral area from the strain accumulations in the regional network observed from 1999 to 2007 before the Wenchuan earthquake.Besides the epicentral area of the western Kunlun mountain pass earthquake of M8.1 in 2001,the results of best fits by trend surfaces of the strain accumulations from 1999 to 2007 in the regional network show that the Wenchuan earthquake occurred at the eastern fringe of a large area with relatively large accumulations of the first shear strains and also at the northeastern fringe of a smaller area with significant accumulated areal compressions.The statistics of the accumulations of the strain components demonstrates that they also showed anomalous distribution patterns in this area and its neighborhood with increasing accumulations of both shear strains and areal compressions. | Guohua Gu Wuxing Wang Yueren Xu Wenjun Li | 2009 | Earthquake Science2009，22，5： | 9 |
| 13 | Robust adaptive control for a nonholonomic mobile robot with unknown parameters显示文摘A robust adaptive controller for a nonholonomic mobile robot with unknown kinematic and dynamic parameters is proposed.A kinematic controller whose output is the input of the relevant dynamic controller is provided by using the concept of backstepping.An adaptive algorithm is developed in the kinematic controller to approximate the unknown kinematic parameters,and a simple single-layer neural network is used to express the highly nonlinear robot dynamics in terms of the known and unknown parameters.In order to attenuate the effects of the uncertainties and disturbances on tracking performance,a sliding mode control term is added to the dynamic controller.In the deterministic design of feedback controllers for the uncertain dynamic systems,upper bounds on the norm of the uncertainties are an important clue to guarantee the stability of the closed-loop system.However,sometimes these upper bounds may not be easily obtained because of the complexity of the structure of the uncertainties.Thereby,simple adaptation laws are proposed to approximate upper bounds on the norm of the uncertainties to address this problem.The stability of the proposed control system is shown through the Lyapunov method.Lastly,a design example for a mobile robot with two actuated wheels is provided and the feasibility of the controller is demonstrated by numerical simulations. | Jinbo WU Guohua XU Zhouping YIN | 2009 | 控制理论与应用(英文版)2009，7，2： | 9 |
| 14 | A New Single-blade Based Hybrid CFD Method for Hovering and Forward-flight Rotor Computation显示文摘A hybrid Euler/full potential/Lagrangian wake method,based on single-blade simulation,for predicting unsteady aerodynamic flow around helicopter rotors in hover and forward flight has been developed.In this method,an Euler solver is used to model the near wake evolution and transonic flow phenomena in the vicinity of the blade,and a full potential equation(FPE) is used to model the isentropic potential flow region far away from the rotor,while the wake effects of other blades and the far wake are incorporated into the flow solution as an induced inflow distribution using a Lagrangian based wake analysis.To further reduce the execution time,the computational fluid dynamics(CFD) solution and rotor wake analysis(including induced velocity up-date) are conducted parallelly,and a load balancing strategy is employed to account for the information exchange between two solvers.By the developed method,several hover and forward-flight cases on Caradonna-Tung and Helishape 7A rotors are per-formed.Good agreements of the loadings on blade surface with available measured data demonstrate the validation of the method.Also,the CPU time required for different computation runs is compared in the paper,and the results show that the pre-sent hybrid method is superior to conventional CFD method in time cost,and will be more efficient with the number of blades increasing. | SHI Yongjie ZHAO Qijun FAN Feng XU Guohua | 2011 | Chinese Journal of Aeronautics2011，24，2： | 9 |
| 15 | Robust Navier-Stokes method for predicting unsteady flowfield and aerodynamic characteristics of helicopter rotor显示文摘A robust unsteady rotor flowfield solver CLORNS code is established to predict the complex unsteady aerodynamic characteristics of rotor flowfield. In order to handle the difficult problem about grid generation around rotor with complex aerodynamic shape in this CFD code,a parameterized grid generated method is established, and the moving-embedded grids are constructed by several proposed universal methods. In this work, the unsteady Reynolds-Averaged Navier-Stokes(RANS) equations with Spalart-Allmaras are selected as the governing equations to predict the unsteady flowfield of helicopter rotor. The discretization of convective fluxes is accomplished by employing the second-order central difference scheme, third-order MUSCL-Roe scheme, and fifth-order WENO-Roe scheme. Aimed at simulating the unsteady aerodynamic characteristics of helicopter rotor, the dual-time scheme with implicit LU-SGS scheme is employed to accomplish the temporal discretization. In order to improve the computational efficiency of holecells and donor elements searching of the moving-embedded grid technology, the ‘‘disturbance diffraction method' and ‘‘minimum distance scheme of donor elements method' are established in this work. To improve the computational efficiency, Message Passing Interface(MPI) parallel method based on subdivision of grid, local preconditioning method and Full Approximation Storage(FAS) multi-grid method are combined in this code. By comparison of the numerical results simulated by CLORNS code with test data, it is illustrated that the present code could simulate the aerodynamic loads and aerodynamic noise characteristics of helicopter rotor accurately. | Qijun ZHAO Guoqing ZHAO Bo WANG Qing WANG Yongjie SHI Guohua XU | 2018 | Chinese Journal of Aeronautics2018，31，2： | 9 |
| 16 | Investigation on Uniaxial Tensile Instability of USIBOR1500 Steel Sheets at Elevated Temperature显示文摘In the sheet forming process with stretch, diffuse instability and localized instability usually occur in the process one after another. The necking rate has a great impact on the instability process and the forming limits of the rate sensitive material, such as USIBOR1500 steel sheets at elevated temperature. The available reports about this steel mainly focus on hot uniaxial tensile, martensitic transformation and forming process, but there are few investigations on instability behavior and forming limits. Based on Inoue Kachiro’s flow stress constitutive model at elevated temperature, combined with Swift’s diffuse instability rule and Hill’s localized instability rule, the relation is theoretically deduced between the diffuse necking rate along with the localized necking rate and the exponent of strain rate sensitivity together with the strain rate in the case of the USIBOR1500 steel sheets at elevated temperature. According to the time–temperature characteristics of the hot stamping process, tensile tests of the steel sheets were carried out on Gleeble3800, and the stress–strain curves were obtained at different temperatures and different strain rates. Then the values of the exponent of strain rate sensitivity and the hardening exponent were obtained through fitting the curves by least squares. The tests also helped to provide the distribution laws of the major strain of the specimens and the uniform strains as well as the necking width. The uniform strains obtained from the tests are matched well with the theoretical calculations. | MIN Junying LIN Jianping TIAN Haobin SUN Guohua XU Zhou | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 9 |
| 17 | Analysis of key microbial community during the start-up of anaerobic ammonium oxidation process with paddy soil as inoculated sludge显示文摘A sequencing batch reactor(SBR)-anaerobic ammonium oxidation(anammox) system was started up with the paddy soil as inoculated sludge. The key microbial community structure in the system along with the enrichment time was investigated by using molecular biology methods(e.g., high-throughput 16 S r RNA gene sequencing and quantitative PCR). Meanwhile,the influent and effluent water quality was continuously monitored during the whole start-up stage. The results showed that the microbial diversity decreased as the operation time initially and increased afterwards, and the microbial niches in the system were redistributed. The anammox bacterial community structure in the SBR-anammox system shifted during the enrichment, the most dominant anammox bacteria were Candidatus Jettenia. The maximum biomass of anammox bacteria achieved 1.68 × 10~9 copies/g dry sludge during the enrichment period, and the highest removal rate of TN achieved around 75%. | Xianglong Xu Guohua Liu Yuanyuan Wang Yuankai Zhang Hao Wan Lu Qi Hongchen Wang | 2018 | Journal of Environmental Sciences2018，30，2： | 8 |
| 18 | Numerical analysis on noise of rotor with unconventional blade tips based on CFD/Kirchhoff method显示文摘A solver is developed aiming at efficiently predicting rotor noise in hover and forward flight. In this solver, the nonlinear near-field solutions are calculated by a hybrid approach which includes the Navier-Stokes and Euler equations based on a moving-embedded grid system and adaptive grid methodology. A combination of the third-order upwind scheme and flux-difference splitting scheme, instead of the second-order center-difference scheme which may cause larger wake dissipation, has been employed in the present computational fluid dynamics (CFD) method. The sound pressure data in the near field can be calculated directly by solving the Navier-Stokes equations, and the sound propagation can be predicted by the Kirchhoff method. A harmonic expansion approach is presented for rotor far-field noise prediction, which gives an analytical expression for the integral function in the Kirchhoff formula. As a result, the interpolation process is simplified and the efficiency and accuracy of the interpolation are improved. Then, the high-speed impulsive (HIS) noise of a helicopter rotor at different tip Mach numbers and on different observers is calculated and analyzed in hover and forward flight, which shows a highly directional characteristic of the rotor HIS noise with a maximum value in the rotor plane, and the HSI noise weakens rapidly with the increasing of the directivity angle. In order to investigate the effects of the rotor blade-tip shape on its aeroacoustic characteristics, four kinds of blade tips are designed and their noise characteristics have been simulated. At last, a new unconventional CLOR-II blade tip has been designed, and the noise characteristics of the presented CLOR-II model rotor have been simulated and measured compared to the reference rotors with a rectangular or swept-back platform blade tip. The results demonstrate that the unconventional CLOR-II blade tip can significantly reduce the HSI noise of a rotor. | Wang Bo Zhao Qijun Xu Guohua Ye Liang Wang Junyi | 2013 | Chinese Journal of Aeronautics2013，26，3： | 8 |
| 19 | Whole genome sequencing of 10K patients with acute ischaemic stroke or transient ischaemic attack: design, methods and baseline patient characteristics显示文摘Background and purpose Stroke is the second leading cause of death worldwide and the leading cause of mortality and long-term disability in China,but its underlying risk genes and pathways are far from being comprehensively understood.We here describe the design and methods of whole genome sequencing(WGS)for 10914 patients with acute ischaemic stroke or transient ischaemic attack from the Third China National Stroke Registry(CNSR-III).Methods Baseline clinical characteristics of the included patients in this study were reported.DNA was extracted from white blood cells of participants.Libraries are constructed using qualified DNA,and WGS is conducted on BGISEQ-500 platform.The average depth is intended to be greater than 30×for each subject.Afterwards,Sentieon software is applied to process the sequencing data under the Genome Analysis Toolkit best practice guidance to call genotypes of single nucleotide variants(SNVs)and insertion-deletions.For each included subject,21 fingerprint SNVs are genotyped by MassARRAY assays to verify that DNA sample and sequencing data originate from the same individual.The copy number variations and structural variations are also called for each patient.All of the genetic variants are annotated and predicted by bioinformatics software or by reviewing public databases.Results The average age of the included 10914 patients was 62.2±11.3 years,and 31.4%patients were women.Most of the baseline clinical characteristics of the 10914 and the excluded patients were balanced.Conclusions The WGS data together with abundant clinical and imaging data of CNSR-III could provide opportunity to elucidate the molecular mechanisms and discover novel therapeutic targets for stroke. | Si Cheng Zhe Xu Yang Liu Jinxi Lin Yong Jiang Yilong Wang Xia Meng Anxin Wang Xinying Huang Zhimin Wang Guohua Chen Songdi Wu Zhengchang Jia Yongming Chen Xuerong Qiu Jun Wu Binbin Song Weizhong Ji Zhongping An Wenjun Xue Lili Zhao Yu Geng Hongyan Li Hao Li Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，2： | 8 |
| 20 | Microstructural evolution,mechanical properties and corrosion behavior of as-cast Mg-5Li-3Al-2Zn alloy with different Sn and Y addition显示文摘Influences of Sn and Y on the microstructure,mechanical properties,and corrosion behavior of as-cast Mg-5 Li-3 Al-2 Zn(LAZ532)alloy were investigated.The addition of Sn and Y refines grains and results in the formation of Mg2 Sn and Al2 Y phases,thus improving the mechanical properties of alloy by second phase strengthening and grain refinement strengthening.As-cast LAZ532 alloy shows typical filiform corrosion morphology,and the addition of Sn and Y does not change the corrosion mode of alloy.Ascast LAZ532-0.8 Sn-1.2 Y alloy shows excellent mechanical properties with yield strength of 166.2 MPa,ultimate tensile strength of 228.6 MPa and elongation of 14.8%,and exhibits the best corrosion resistance with the smallest corrosion current density and the lowest anodic dissolution rate. | Xiang Peng Shihao Xu Dehua Ding Guanglan Liao Guohua Wu Wencai Liu Wenjiang Ding | 2021 | Journal of Materials Science & Technology2021，，13： | 7 |
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