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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Investigation of influence of coal properties on dense-phase pneumatic conveying at high pressure显示文摘Experiments of dense-phase pneumatic conveying of pulverized coal using nitrogen were carried out in a test facility at pressures of up to 3.7 MPa to study the effects of coal type, particle size and moisture content on flow characteristics. The Jenike shear test and scanning electron microscopy (SEM) were employed to provide a better understanding of effects of the material properties on flow characteristics. Two kinds of pulverized coals, Yanzhou and Datong, with similar particle size, moisture content and density, were used in the test. Pressure drop increases with increasing the particle size at similar solid-gas ratio, superficial velocity and pressure in the receiving hopper, and pressure drops through different test sections decrease firstly and then rise with increasing the conveying velocity for the same particle size, mass flow rate and pressure in the receiving hopper. The flowability of pulverized coal decreases with increasing the moisture content in the range from 3.24% to 8.18%. Unconfined yield strength (UYS) increases and flow function (FF) decreases with increasing the moisture content. Results of the shearing tests are consistent with the results of the conveying study. Pressure drops through different test sections are discussed and analyzed. | Cai Liang Xiaoxu Xie Pan Xu Xiaoping Chen Changsui Zhao Xin Wu | 2012 | Particuology2012，10，3： | 8 |
| 4 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 5 | Field trial of an HTS filter system on a CDMA base station显示文摘This paper presents the field trial results of a high temperature superconductor filter system (HTSFS) in a code division multiple access (CDMA) mobile communication base station (BTS) in Tangshan, China. The center frequency of the HTSFS is 830 MHz with 1.4% fractional bandwidth. The noise figure (NF) of the HTSFS, including connectors and cables, is 0.8 dB. The field trial results show that after the HTSFS was installed in the receiver front-end of a CDMA base station, the transmitting power of handset was decreased by 3.1 dB on average. Up to now, the HTSFS has been running steadily in the base station for more than 22 months, demonstrating the reliability and stability of the system. | YIN ZheSheng WEI Bin CAO BiSong WANG Xin GUO XuBo ZHANG XiaoPing GAO LongMa PIAO YunLong ZHU MaFeng LIANG Yong WANG Fan H. PIEL B. AMINOV F. AMINOVA M. GETTA S. KOLESOV A. KNACK N. PUPETER D. WEHLER | 2007 | Chinese Science Bulletin2007，52，2： | 7 |
| 6 | Autotrophic and Heterotrophic Nitri?cation in a Highly Acidic Subtropical Pine Forest Soil显示文摘The occurrence of nitri?cation in some acidic forest soils is still a subject of debate.Identi?cation of main nitri?cation pathways in acidic forest soils is still largely unknown.Acidic yellow soil(Oxisol) samples were selected to test whether nitri?cation can occur or not in acidic subtropical pine forest ecosystems.Relative contributions of autotrophs and heterotrophs to nitri?cation were studied by adding selective nitri?cation inhibitor nitrapyrin.Soil NH^+_4-N concentrations decreased,but NO^-_3-N concentrations increased signi?cantly for the no-nitrapyrin control during the ?rst week of incubation,indicating that nitri?cation did occur in the acidic subtropical soil.The calculated net nitri?cation rate was 0.49 mg N kg^(-1)d^(-1)for the no-nitrapyrin control during the ?rst week of incubation.Nitrapyrin amendment resulted in a signi?cant reduction of NO^-_3-N concentration.Autotrophic nitri?cation rate averaged0.28 mg N kg^(-1)d^(-1)and the heterotrophic nitri?cation rate was 0.21 mg N kg^(-1)d^(-1)in the ?rst week.Ammonia-oxidizing bacteria(AOB) abundance increased slightly during incubation,but nitrapyrin amendment signi?cantly decreased AOB amo A gene copy numbers by about 80%.However,the ammonia-oxidizing archaea(AOA) abundance showed signi?cant increases only in the last 2weeks of incubation and it was also decreased by nitrapyrin amendment.Our results indicated that nitri?cation did occur in the present acidic subtropical pine forest soil,and autotrophic nitri?cation was the main nitri?cation pathway.Both AOA and AOB were the active biotic agents responsible for autotrophic nitri?cation in the acidic subtropical pine forest soil. | FAEFLEN J.Sarwee LI Shiwei XIN Xiaoping Alan L.WRIGHT JIANG Xianjun | 2016 | Pedosphere2016，26，6： | 6 |
| 7 | Litter mixing significantly affects decomposition in the Hulun Buir meadow steppe of Inner Mongolia, China显示文摘Aims We explored the decomposition rates of single-and mixed-species litter,the litter-mixing effect and the effect of component litters in a mixture on decomposition.Methods In a litter bag experiment,shoot litters from two dominant grasses(Leymus chinensis and Stipa baicalensis)and one legume(Melissitus ruthenica)were decomposed separately and as a mixture from May 2010 to September 2011 in the Hulun Buir meadow steppe of Inner Mongolia,China.We separated the litter mixture into its individual component litters(i.e.the different single-species litters)and analyzed the changes in litter mass remaining and litter nitrogen(N)remaining during single-and mixed-species litter decomposition.Important Findings(i)Litter mixing had significant positive effects on litter decomposition.The litter-mixing effect was strongest for the mixture of S.baicalensis and L.chinensis litters,followed by the mixture of S.baicalensis and M.ruthenica litters.(ii)Single-species component litters decomposed faster in the mixtures than separately(positive effect),but these effects were not significant for legume species M.ruthenica litter.Relative to single-species litter decomposition,the decomposition rates of the two grass(S.baicalensis and L.chinensis)litters significantly increased when they were mixed with each other or with M.ruthenica litter.(iii)For each species litter type,the percentage of litter N remaining during decomposition(NR)differed between the single-species litter and mixed litter treatments.The NR of S.baicalensis litter was higher when it was decomposed in the mixture than in isolation.However,the NR of L.chinensis litter was lowest in its mixture with M.ruthenica among the treatments.Regardless of its decomposition in the mixture or in isolation,the NR of M.ruthenica litter varied little among treatments.There was a significant positive relationship between the NR and percentage of initial litter mass remaining in both the single litter and mixed litter treatments.These results suggest that N transfer may happen among component litters in mixture and further affect the decomposition. | Caihong Zhang Shenggong Li Leiming Zhang Xiaoping Xin Xingren Liu | 2014 | Journal of Plant Ecology2014，7，1： | 6 |
| 8 | An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine显示文摘这研究试图由与病毒(HIV )/acquired 免疫不全症候群(爱滋病) 与 TCM 连续地对待 84 个月的人的免疫不全在 110 个盒子的 CD4 T 淋巴细胞房间计数观察变化评估繁体中文药(TCM ) 的治疗学的效果。从从 2004 ~ 2013 与 TCM 对待的 19 个省和城市的 110 个 HIV/AIDS 病人的信息是镇定的。在 CD4 计数的索引的变化( 200 , 201350 , 351500 并且> 500 房间/公里<啜class=“ a-plus-plus ”>在五次的 3 )指( 0 , 12 , 36 , 60 和 84 个月)并且不同治疗[加 antiretroviral 治疗(艺术)的 TCM 和 TCM ]被比较。重复措施测试没显示在组和时间之间的相互作用(P > 0.05 ) 。在四个不同框架增加和二个组的减少的 CD4 计数的学位与基线相比是统计上重要的。在二个组之间的 CD4 计数不是统计上重要的。为 200 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 21 和 28 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 201350 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 6 和 25 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 351500 房间 / 公里的 CD4 计数 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 13 和 7 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。为 CD4 计数 > 500 房间 / 公里 < 啜 class= “ a-plus-plus ” > 吝啬的 CD4 计数改变的 3 , 是 34 和 17 房间 / 公里 < 啜 class= “ a-plus-plus ” > 每为 TCM 的年,加艺术的组和 TCM 分别地组织的 3 。TCM 的长期的使用能与 HIV/AIDS 在病人维持或变慢,并且可以完成持续有效性衰退 CD4 计数的步。 | Jian Wang Biyan Liang Xiaoping Zhang Liran Xu Xin Deng Xiuhui Li Lu Fang Xinghua Tan Yuxiang Mao Guoliang Zhang Yuguang Wang | 2014 | Frontiers of Medicine2014，8，3： | 5 |
| 9 | High-throughput sequencing exclusively identified a novel Torque teno virus genotype in serum of a patient with fatal fever显示文摘Torque teno virus(TTV) has been found to be prevalent world-wide in healthy populations and in patients with various diseases, but its etiological role has not yet been determined. Using high-throughput unbiased sequencing to screen for viruses in the serum of a patient with persistent high fever who died of suspected viral infection and prolonged weakness, we identified the complete genome sequence of a TTV(isolate Hebei-1). The genome of TTV-Hebei-1 is 3649 bp in length, encoding four putative open reading frames, and it has a G+C content of 49%. Genomic comparison and a BLASTN search revealed that the assembled genome of TTV-Hebei-1 represented a novel isolate, with a genome sequence that was highly heterologous to the sequences of other reported TTV strains. A phylogenetic tree constructed using the complete genome sequence showed that TTV-Hebei-1 and an uncharacterized Taiwan Residents strain, TW53A37, constitute a new TTV genotype. The patient was strongly suspected of carrying a viral infection and died eventually without any other possible causes being apparent. No virus other than the novel TTV was identified in his serum sample. Although a direct causal link between the novel TTV genotype infection and the patient's disease could not be confirmed, the findings suggest that surveillance of this novel TTV genotype is necessary and that its role in disease deserves to be explored. | Zhiqiang Mi Xin Yuan Guangqian Pei Wei Wang Xiaoping An Zhiyi Zhang Yong Huang Fan Peng Shasha Li Changqing Bai Yigang Tong | 2014 | Virologica Sinica2014，29，2： | 4 |
| 10 | Therapeutic effect of natural melanin from edible fungus Auricularia auricula on alcohol-induced liver damage in vitro and in vivo显示文摘This study explored the therapeutic effects of Auricularia auricula melanin(AAM)on alcoholic liver damage in vitro and in vivo.Human normal liver L02 cells were pre-treated with ethanol and then treated with AAM to explore the therapeutic effect of AAM on ethanol-induced hepatocyte injury.The results show that AAM signifi cantly elevated the cell viability,ameliorated the cell morphology,reduced the ROS and increased the GSH/GSSG of ethanol-pretreated L02 cells.Then,mice were administered with ethanol to induce acute alcoholic liver damage,and administered with AAM to further study the therapeutic effect of AAM on alcoholic liver damage in mice.As a result,AAM reduced the levels of ALT,AST,TG,and MDA,increased the levels of ADH,SOD,and CAT in liver damage mice.The therapeutic effect of AAM may be related to inhibition of CYP2E1 expression and activation of Nrf2 and its downstream antioxidase.The research enriched the bioactivity of AAM and provided some ideas for the development of melanin-related health foods. | Ruolin Hou Xin Liu Xiaoping Wu Mingfeng Zheng Junsheng Fu | 2021 | Food Science and Human Wellness2021，10，4： | 4 |
| 11 | Microwave-assisted synthesis of ultrafine Au nanoparticles immobilized on MOF-199 in high loading as efficient catalysts for a three-component coupling reaction显示文摘极其细小的金属 nanoparticles (MNP ) 和金属器官的框架(MOF ) 的控制集成由于他们的唯一的物理、化学的性质引起了许多注意。然而,为在 MOF 以内准备极其细小的 MNP 的一步舞策略的发展仍然是大挑战。此处,向上述的 composites 的一条灵巧的合成途径被开发。与常规途径相对照,这些混血儿被在微波照耀帮助的反应答案的金属和 MOF 先锋的直接混合准备。给人深刻印象地,与一致地分布式的极其细小的 Au nanoparticles 合成的 Au/MOF-199 能在仅仅二分钟被制作,并且装载的 Au 能被增加直到 5.13% 的水平。多功能的 Au/MOF-199 催化剂在甲醛, phenylacetylene,和哌啶的三部件的联合反应展出了高周转数字(吨) 和周转频率(TOF )(3-coupling) 。由于 MOF-199 的监禁效果,没有活动的严肃的损失, 5.13%Au/MOF-199 催化剂能为五跑被再循环,没有检测的 Au NP 的明显的聚集。 | Yan Jiang Xin Zhang Xiaoping Dai Wen Zhang Qiang Sheng Hongying Zhuo Yun Xiao Hai Wang | 2017 | Nano Research2017，10，3： | 4 |
| 12 | Understanding livestock production and sustainability of grassland ecosystems in the Asian Dryland Belt显示文摘Background:Companioned by economic development,a dietary shift toward higher meat consumption is seen in developing countries and transitional economies,where the demand for livestock production has been increasing in response to such a dietary shift.In the Asian Dryland Belt,approaches to meet this demand have focused on grazing intensification,cropland conversion for animal feed,and supplemental feeding.With the scarcity of water,energy,and food in the region,a key question is whether or not the current approaches are sustainable.If not,what are the pathways to increase livestock production while protecting the region’s environment for a sustainable future?We provide our reviews and discuss current approaches in response to these dietary shifts and assess their environmental resilience with a focus on the grassland ecosystems in the Asian Dryland Belt.Results:While current approaches alleviate the urgent need for short-term livestock production,they lead to longterm vulnerability in food security.Trade-offs between short gains and long-term losses,between food for humans and for animals,and between agricultural intensification and environmental degradation need to be holistically examined for the sustainable development of the region.A grassland water,energy,and food nexus framework is proposed with specific recommendations to increase livestock production while considering other ecosystem services of the dryland grassland ecosystems in the Asian Dryland Belt.Conclusions:Current practices to increase livestock production are likely to lead to long-term,large-scale ecological degradation of the grassland ecosystems in the Asian Dryland Belt and are thus unsustainable.By considering the trade-offs in the nexus of water,land,food,and livelihoods,sustainable pathways were articulated and recommended.Future pilot studies are needed for validation and adoption. | Jiaguo Qi Xiaoping Xin Ranjeet John Pavel Groisman Jiquan Chen | 2017 | Ecological Processes2017，6，1： | 4 |
| 13 | Morphology-selective synthesis of active and durable gold catalysts with high catalytic performance in the reduction of 4-nitrophenol显示文摘由 nanosized Au 粒子组成的一系列新奇催化剂与血小板(PL ) 在 micro-mesoporous ZSM-5/SBA-15 (ZSBA ) 材料限制了,杆(RD ) ,并且六角形棱柱(HP ) 形态学在 situ 被综合了。这些催化剂拥有 SBA-15 和 ZSM-5 结构并且在 ZSBA 以内由 Au nanoparticles (NP ) 的监禁展出他们的活跃地点的优秀稳定性。催化剂深入地被描绘了理解他们的结构性质关系。金 NP 尺寸和催化剂的毛孔结构,被发现对锻烧温度和合成条件敏感,被显示在 4-nitrophenol 的减小起重要作用。与短 mesochannels (210 nm ) 和一条大毛孔直径(6.7 nm ) ,而与长 mesochannels 和相对更小的毛孔尺寸, Au/ZSBA-HP 和 Au/ZSBA-RD 给穷人看催化活动, Au/ZSBA-PL 在 4-nitrophenol 的减小展出高催化的性能。在有不同金 NP 尺寸的催化剂的情况中,有 4.0 nm 的一条 Au NP 直径的 Au/ZSBA-PL-350 展出最高的反应率常数(0.14 min -1) 和周转频率(0.0341 s -1) 。另外, 4-nitrophenol 的减小上的反应参数的效果系统地被调查了。为在 Au/ZSBA 催化剂上的 4-nitrophenol 减小的可能的机制被建议。 | Daowei Gao Xin Zhang Xiaoping Dai Yuchen Qin Aijun Duan Yanbing Yu Hongying Zhuo Hairui Zhao Pengfang Zhang Yan Jiang Jianmei Li Zhen Zhao | 2016 | Nano Research2016，9，10： | 4 |
| 14 | Casein kinase Ⅱ interacts with prion protein in vitro and forms complex with native prion protein in vivo显示文摘最必要、关键的步在能递送的海绵状的 encephalopathy 的致病期间是到病理学的 isoform 的细胞的 prion 蛋白质的 conformational 变化。酷蛋白 kinase II (CK2 ) 是一无所不在地表示了并且 evolutionarily 保存了为生存能力是必要的多种的蛋白质 kinase。探索在 CK2 和 prion 蛋白质(PrP ) 之间的可能的分子的相互作用,人的 CK2α 和 CK2β 的全身的序列互补 DNA 作为模板从房间线 SH-SY5Y 用彻底的送信人 RNA 与反向的抄写聚合酶链反应被放大;然后,熔化蛋白质 histidine-CK2α 和谷胱甘肽 S-transferase-histidine-CK2β 在 Escherichia 关口 i 被表示。在 CK2 和 PrP 之间的相互作用与 co-immunoprecipitation 和下拉试金被评估。结果证明 recombinant PrP 与 CK2α ,然而并非与 CK2β 明确地跳了。在仓鼠大脑的本国的 CK2 和 PrP 与对方一起交往了,形成蛋白质建筑群。从正常大脑的 PrP (diglycosylated, monoglycosylated 和 unglycosylated PrP ) 的三种不同 glycosylated 形式与 CK2α 子单元交往了,尽管 unglycosylated PrP 似乎与 CK2α 子单元有一个更强壮的有约束力的能力。负责与 CK2α 交往的领域在 PrP 的 C 终端片断被定位(残余 91 231 ) 。这研究为在 PrP 和 CK2α 之间的分子的相互作用建议了可靠试验性的数据(两个在 recombinant 和本国的范畴) ,为进一步估计 PrP-CK2 相互作用的潜在的生物意义的科学线索,和在 prion 疾病的致病的 CK2 的可能的角色。 | Jianming Chen Chen Gao Qi Shi Guirong Wang Yanjun Lei Bing Shan Baoyun Zhang Chenfang Dong SongShi Xin Wang Chan Tian Jun Han Xiaoping Dong | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 3 |
| 15 | Supported single Au(Ⅲ) ion catalysts for high performance in the reactions of 1,3-dicarbonyls with alcohols显示文摘 | Daowei Gao Xin Zhang Ying Yang Xiaoping Dai Hui Sun Yuchen Qin Aijun Duan | 2016 | Nano Research2016，9，4： | 3 |
| 16 | Doppel-induced cytotoxicity in human neuronal SH-SY5Y cells is antagonized by the prion protein显示文摘Doppel (Dpl ) 由于结构、生物化学的类似是象蛋白质一样的 prion (PrP ) ;然而, Dpl 和 PrP 的自然功能仍然保持不清楚。在这研究,编码 Dpl 蛋白质的一个 531-bp 人 PRND 基因序列从人的外部血白细胞被放大。全身、各种各样的截断的人的 Dpl 和 PrP 蛋白质从 Escherichia 被表示并且净化 coli。全身的 Dpl 的补充导致了显著 cytotoxicity,和负责的区域到人的 neuroblastoma 房间 SH-SY5Y 上因为它的 cytotoxicity 在 Dpl 的中间的片断被印射[氨基酸(aa ) 81122 ] 。有趣地,导致 Dpl 的 cytotoxicity 被全身的野类型的 PrP 的存在反对。PrP 异种的碎片上的分析证明 N 终端碎裂(aa 2390 ) PrP 为保护的活动负责。有 Dpl 在 SH-SY5Y 房间上导致了象 Dpl 一样 cytotoxicity 的类似的第二等的结构的截断的 PrP (PrP32121 ) 。而且,铜离子的绑定能在导致 Dpl 的 cytotoxicity 上提高 PrP 的反对效果。Apoptosis 试金表明 Dpl 导致的 cytotoxicity 通过 apoptotic 机制发生了。这些结果建议 Dpl 的功能对 PrP 而非 synergistic 对抗。 | Ping Li Chenfang Dong Yanjun Lei Bing Shan Xinli Xiao Huiying Jiang Xin Wang Chen Gao Qi Shi Kun Xu Chan Tian Jun Han Xiaoping Dong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 3 |
| 17 | Taxonomic composition, abundance and biomass of mesozooplankton in the Zhelin Bay—an estuary with intensive aquaculture显示文摘The Zhelin Bay is an estuary that supports intensive aquaculture in South China. Aside from traditional nutrient inputs derived from waste water and agriculture, the increased intensification of aquaculture has accelerated eutrophication during the past decade, jeopardizing aquacultural production. Annual variations of mesozooplankton in the Zhelin Bay were described, providing baseline data for long-term ecological studies. The taxonomic composition, abundance and biomass of mesozooplankton were studied monthly from July 2001 to July 2002 at 19 stations. Collections yielded 73 taxa, including 60 species of copepods, three species of cladocerans, as well as tunicates, chaetognaths, polychaetes, medusae, ostracods, rotatori, amphipods, planktonic mollusks, pelagic larvae, and planktonic shrimps. The Zhelin Bay was dominated by small mesozooplankton, with 76% of the species smaller than 1.4 mm, and 97% of the individuals smaller than 1.0 mm. Dominant species (Paracalanus crassirostris, Oithona brevicornis,and Penilia avirostris) accounting for 60% of the total abundance were less than 0.6 mm in body length. Species diversity, biomass, and total abundance of mesozooplankton were greater in the samples collected outside the bay than inside the bay. Samples from the outer and eastern boundaries of the bay had greater biomass, diversity, and abundance than those from the inner and western boundaries. Total abundance and biomass had a unimodal annual pattern and were the greatest in August 2001 when water temperature was maximum, and the least in February 2002 when water temperature was minimum. Canonical correspondence analysis (CCA) revealed that temperature, turbidity, nutrients and salinity were the main determinants of spatial and temporal distributions of mesozooplankton in the Zhelin Bay, and six distinct zones were identified across the 19 sampling stations. | DONG Qiaoxiang LIN Xiaoping HE Xin KELSO WE HUANG Changjiang | 2006 | Acta Oceanologica Sinica2006，25，5： | 3 |
| 18 | Metformin targets Clusterin to control lipogenesis and inhibit the growth of bladder cancer cells through SREBP-lc/FASN axis显示文摘Dear Editor,Metformin,a widely prescribed drug for treating typeⅡdiabetes,has shown an important anti-cancer property.1 However,new launched clinical trials did not achieve such desirable results.2 One explanation could be that metformin’s anti-cancer mechan-isms and precise therapeutic targets remain unclear.To identify potential therapeutic targets of metformin in bladder cancer,we screened differential proteins with metformin treatment in T24 cells by high-throughput protein chip. | Jun Deng Mei Peng Sichun Zhou Di Xiao Xin Hu Simeng Xu Jingtao Wu Xiaoping Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 19 | PM_(2.5)and water-soluble inorganic ion concentrations decreased faster in urban than rural areas in China显示文摘We investigated variations of PM_(2.5)and water-soluble inorganic ions chemical characteristics at nine urban and rural sites in China using ground-based observations.From 2015 to 2019,mean PM_(2.5)concentration across all sites decreased by 41.9μg/m~3with a decline of 46%at urban sites and 28%at rural sites,where secondary inorganic aerosol(SIAs)contributed to 21%(urban sites)and 17%(rural sites)of the decreased PM_(2.5).SIAs concentrations underwent a decline at urban locations,while sulfate(SO_(4)^(2–)),nitrate(NO_(3)^(–)),and ammonium(NH_(4)^(+))decreased by 49.5%,31.3%and 31.6%,respectively.However,only SO_(4)^(2–)decreased at rural sites,NO_(3)^(–)increased by 21%and NH_(4)^(+)decreased slightly.Those changes contributed to an overall SIAs increase in 2019.Higher molar ratios of NO_(3)^(–)to SO_(4)^(2–)and NH_(4)^(+)to SO_(4)^(2–)were observed at urban sites than rural sites,being highest in the heavily polluted days.Mean molar ratios of NH_(3)/NH_xwere higher in 2019 than 2015 at both urban and rural sites,implying increasing NH_xremained as free NH_(3).Our observations indicated a slower transition from sulfate-driven to nitrate-driven aerosol pollution and less efficient control of NO_(x)than SO_(2)related aerosol formation in rural regions than urban regions.Moreover,the common factor at urban and rural sites appears to be a combination of lower SO_(4)^(2–)levels and an increasing fraction of NO_(3)^(–)to PM_(2.5)under NH_(4)^(+)-rich conditions.Our findings imply that synchronous reduction in NO_(x)and NH_(3)emissions especially rural areas would be effective to mitigate NO_(3)^(–)-driven aerosol pollution. | Yangyang Zhang Aohan Tang Chen Wang Xin Ma Yunzhe Li Wen Xu Xiaoping Xia Aihua Zheng Wenqing Li Zengguo Fang Xiufen Zhao Xianlong Peng Yuping Zhang Jian Han Lijuan Zhang Jeffrey L.Collett Jr Xuejun Liu | 2022 | Journal of Environmental Sciences2022，34，12： | 2 |
| 20 | Isolation and rapid genetic characterization of a novel T4-like bacteriophage显示文摘无所不在在地球上,抗菌素是在每个生态系统,而是他们的人的知识的最丰富的实体仍然关于有机体的另外的形式与那相比被限制。充实人的知识并且支持抗菌素的利用,孤立并且描绘尽可能许多不同抗菌素是必要的。这里,我们为它的基因描述描述象 T4 一样抗菌素 IME08 和一个快速的方法的隔离。与这个方法,我们容易克隆抗菌素染色体的一些随机的碎片。这些随机的克隆的顺序分析证明抗菌素 IME08 与象 T4 一样 Enterobacteria 分享了最高的顺序类似噬菌体 T4 (94% 身份) , JS98 (95% 身份) , JS10 (95% 身份) 和 RB14 (94% 身份) 分别地,它建议 IME08 属于象 T4 一样抗菌素类。 | Wang Sheng Jiang Huanhuan Chen Jiankui Liu Dabin Li Cun Pan Bo An Xiaoping Zhang Xin Zhou Yusen Tong Yigang | 2010 | Journal of Medical Colleges of PLA(China)2010，25，6： | 2 |
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