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| 1 | The Beishan underground research laboratory for geological disposal of high-level radioactive waste in China:Planning, site selection,site characterization and in situ tests显示文摘With the rapid development of nuclear power in China, the disposal of high-level radioactive waste(HLW) has become an important issue for nuclear safety and environmental protection. Deep geological disposal is internationally accepted as a feasible and safe way to dispose of HLW, and underground research laboratories(URLs) play an important and multi-faceted role in the development of HLW repositories. This paper introduces the overall planning and the latest progress for China's URL. On the basis of the proposed strategy to build an area-specific URL in combination with a comprehensive evaluation of the site selection results obtained during the last 33 years, the Xinchang site in the Beishan area,located in Gansu Province of northwestern China, has been selected as the final site for China's first URL built in granite. In the process of characterizing the Xinchang URL site, a series of investigations,including borehole drilling,geological mapping, geophysical surveying,hydraulic testing and in situ stress measurements, has been conducted. The investigation results indicate that the geological,hydrogeological, engineering geological and geochemical conditions of the Xinchang site are very suitable for URL construction. Meanwhile, to validate and develop construction technologies for the Beishan URL, the Beishan exploration tunnel(BET), which is a 50-m-deep facility in the Jiujing sub-area, has been constructed and several in situ tests, such as drill-and-blast tests, characterization of the excavation damaged zone(EDZ), and long-term deformation monitoring of surrounding rocks, have been performed in the BET. The methodologies and technologies established in the BET will serve for URL construction.According to the achievements of the characterization of the URL site, a preliminary design of the URL with a maximum depth of 560 m is proposed and necessary in situ tests in the URL are planned. | Ju Wang Liang Chen Rui Su Xingguang Zhao | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 62 |
| 2 | DEVELOPMENT AND MOTION ANALYSIS OF MINIATURE WHEEL-TRACK-LEGGED MOBILE ROBOT显示文摘A miniature wheel-track-legged mobile robot to carry out military and civilian missions in both indoor and outdoor environments is presented. Firstly, the mechanical design is discussed, which consists of four wheeled and four independently controlled tracked arms, embedded control system and teleoperation. Then the locomotion modes of the mobile robot and motion analysis are analyzed. The mobile robot can move using wheeled, tracked and legged modes, and it has the characteristics of posture-recovering, high mobility, small size and light weight. Finally, the effectiveness of the deve-loped mobile robot is confirmed by experiments such as posture recovering when tipped over, climb-ing stairs and traversing the high step. | DUAN Xingguang HUANG Qiang XU Yan RAHMAN N ZHENG Change | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 11 |
| 3 | Global approximation based adaptive RBF neural network control for supercavitating vehicles显示文摘A global approximation based adaptive radial basis function(RBF) neural network control strategy is proposed for the trajectory tracking control of supercavitating vehicles(SV).A nominal model is built firstly with the unknown disturbance.Next, the control scheme is established consisting of a computed torque controller(CTC) for the practical vehicle and an RBF neural network controller to estimate model error between the practical vehicle and the nominal model. The network weights are adapted by employing a Lyapunov-based design. Then it is shown by the Lyapunov theory that the trajectory tracking errors asymptotically converge to a small neighborhood of zero. The control performance of the proposed controller is illustrated by simulation. | LI Yang LIU Mingyong ZHANG Xiaojian PENG Xingguang | 2018 | Journal of Systems Engineering and Electronics2018，29，4： | 11 |
| 4 | Synthesis of CNT film on the surface of micro-pyramid array and its intense pulsed emission characteristics显示文摘We developed a new scheme to suppress the electric-field-screening effect in high growth density of a carbon nanotube(CNT) film during its intense pulsed emission.We synthesize the CNT film on a tridimensional surface(t-CNT film).The tridimensional surface includes wet etched silicon pyramids,and the Ni layer is electroless plated thereon.The intense pulsed emission characteristics of the t-CNT and planar-grown CNT(p-CNT) films were measured using a diode structure in single-pulse mode.The even turn-on field decreased from 5.5 V/μm for p-CNTs to 2.8 V/m for t-CNTs,and the peak emission current increased from 232 A for p-CNTs to 324 A for t-CNTs at a peak field intensity ~12.2 V/m.The peak current of the t-CNT film increased by ~39.7% over the p-CNT film.It is clear that the micro-pyramid array can effectively suppress the field screening effect to improve the electron-emission of CNT films. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2012 | Chinese Science Bulletin2012，57，14： | 10 |
| 5 | Experimental Study on Characteristics of Cathode Fan Systems of Proton Exchange Membrane Fuel Cells显示文摘对自制的阴极开放式自增湿型质子交换膜燃料电池阴极风扇系统不同工作模式下电池的空气流量分布及温度分布开展了实验研究。采用testo435多功能测量仪测量不同工作模式下电池阴极的空气流速;采用FLUKETi25红外温度成像仪测量不同操作模式下电池的表面温度分布。实验结果表明:阴极风扇系统不同的工作模式(“吸”和“吹”)会造成空气流量分布及温度分布不同。风扇工作在“吸.”模式下,燃料电池的表面工作温度分布和空气流量分布更均匀,性能更好;电池表面工作温度分布与流过电池阴极的空气流量具有一致性。该研究对于阴极开放式燃料电池性能研究及寻求电池系统效率、性能、温湿度等整体最优具有一定的指导和参考价值。 | ZHU Xingguang JIA Qiuhong CHEN Tanglong HAN Ming DENG Bin | 2013 | 中国电机工程学报2013，33，11： | 9 |
| 6 | Cooperative path planning for multi-AUV in time-varying ocean flows显示文摘For low-speed underwater vehicles, the ocean currents has a great influence on them, and the changes in ocean currents is complex and continuous, thus whose impact must be taken into consideration in the path planning. There are still lack of authoritative indicator and method for the cooperating path planning. The calculation of the voyage time is a difficult problem in the time-varying ocean, for the existing methods of the cooperating path planning, the computation time will increase exponentially as the autonomous underwater vehicle(AUV) counts increase, rendering them unfeasible. A collaborative path planning method is presehted for multi-AUV under the influence of time-varying ocean currents based on the dynamic programming algorithm. Each AUV cooperates with the one who has the longest estimated time of sailing, enabling the arrays of AUV to get their common goal in the shortest time with minimum timedifference. At the same time, they could avoid the obstacles along the way to the target. Simulation results show that the proposed method has a promising applicability. | Mingyong Liu Baogui Xu Xingguang Peng | 2016 | Journal of Systems Engineering and Electronics2016，27，3： | 8 |
| 7 | Interferon-inducible cytoplasmic lncLrrc55-AS promotes antiviral innate responses by strengthening IRF3 phosphorylation显示文摘Type I interferon (IFN-I) production is efficiently induced to ensure a potent innate immune response to viral infection. How this response can be enhanced, however, remains to be explored. Here, we identify a new cytoplasmic long non-coding RNA (lncRNA), lncLrrc55-AS, that drives a positive feedback loop to promote interferon regulatory factor 3 (IRF3) signaling and IFN-I production. We show that lncLrrc55-AS is virus-induced in multiple cell types via the IFN-JAK-STAT pathway. LncLrrc55-AS-deficient mice display a weakened antiviral immune response and are more susceptible to viral challenge. Mechanistically, lncLrrc55-AS binds phosphatase methylesterase 1 (PME-1), and promotes the interaction between PME-1 and the phosphatase PP2A, an inhibitor of IRF3 signaling. LncLrrc55-AS supports PME-1-mediated demethylation and inactivation of PP2A, thereby enhancing IRF3 phosphorylation and signaling. Loss of PME-1 phenocopies lncLrrc55-AS deficiency, leading to diminished IRF3 phosphorylation and IFN-I production. We have identified an IFN-induced lncRNA as a positive regulator of IFN-I production, adding mechanistic insight into lncRNA-mediated regulation of signaling in innate immunity and inflammation. | Yumei Zhou Mengxuan Li Yiquan Xue Zhiqing Li Weitao Wen Xingguang Liu Yuanwu Ma Lianfeng Zhang Zhongyang Shen Xuetao Cao | 2019 | Cell Research2019，29，8： | 8 |
| 8 | Time-varying fault-tolerant formation tracking based cooperative control and guidance for multiple cruise missile systems under actuator failures and directed topologies显示文摘This paper studies time-varying fault-tolerant formation tracking problems for the multiple cruise missile system under directed topologies subjected to actuator failures. Firstly, the timevarying fault-tolerant formation tracking process for the multiple cruise missile system is divided into the guidance loop and the control loop. Then protocols are constructed to accomplish distributed fault-tolerant formation tracking in the guidance loop with the adaptive updating mechanism, in the condition where neither the knowledge about actuator malfunctions nor any global information of the communication topology remains available. Moreover, sufficient conditions to accomplish formation tracking are presented, and it is shown that the multiple cruise missile system can carry on the predefined time-varying fault-tolerant control (FTC) formation tracking through the active disturbances rejection controller (ADRC) and the proportion integration (PI) controller by the way of the fault-tolerant protocol utilizing the designed strategies, in the event of actuator failures. At last, numerical analysis and simulation are designed to verify the theoretical results. | XU Xingguang WEI Zhenyan REN Zhang LI Shusheng | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 8 |
| 9 | Improvement in the intense pulsed emission stability of grown CNT films via an electroless plated Ni layer显示文摘Carbon nanotube(CNT)films were grown on silicon wafers with and without a nickel layer(Si-CNT and Ni-CNT)via the pyrolysis of iron phthalocyanine.The nickel layer was prepared using the electroless plating method.To study the emission stability of Si-CNT and Ni-CNT cathodes during intense pulsed emission,emission characteristics were measured repeatedly with a diode structure using a Marx generator as a voltage source.For the peak values of the pulsed voltage,which were in the range between 1.62-1.66 MV(corresponding to electric field intensities between 11.57-11.85 V/μm),the first cycle emission current was 109.4 A for Si-CNT and 180.5 A for Ni-CNT.By comparing the normalized emission currents of the Si-CNT and Ni-CNT cathodes,the improvement in the emission stability can be easily quantified.The number of emission cycles necessary for the peak current to decay from 100%to 50%increased from^3 for Si-CNT to^11 for a Ni-CNT film. | ZENG FanGuang LI Xin LIU WeiHua QIAO ShuZhen MA HuaLi ZHANG Rui XIA LianSheng CHEN Yi LIU XingGuang ZHANG Huang | 2011 | Chinese Science Bulletin2011，56，22： | 7 |
| 10 | Considerations of rock dilation on modeling failure and deformation of hard rocks-a case study of the mine-by test tunnel in Canada显示文摘For the compressive stress-induced failure of tunnels at depth, rock fracturing process is often closely associated with the generation of surface parallel fractures in the initial stage, and shear failure is likely to occur in the final process during the formation of shear bands, breakouts or V-shaped notches close to the excavation boundaries. However, the perfectly elastoplastic, strain-softening and elasto-brittle-plastic models cannot reasonably describe the brittle failure of hard rock tunnels under high in-situ stress conditions. These approaches often underestimate the depth of failure and overestimate the lateral extent of failure near the excavation. Based on a practical case of the mine-by test tunnel at an underground research laboratory (URL) in Canada, the influence of rock mass dilation on the depth and extent of failure and deformation is investigated using a calibrated cohesion weakening and frictional strengthening (CWFS) model. It can be found that, when modeling brittle failure of rock masses, the calibrated CWFS model with a constant dilation angle can capture the depth and extent of stress-induced brittle failure in hard rocks at a low confinement if the stress path is correctly represented, as demonstrated by the failure shape observed in the tunnel. However, using a constant dilation angle cannot simulate the nonlinear deformation behavior near the excavation boundary accurately because the dependence of rock mass dilation on confinement and plastic shear strain is not considered. It is illustrated from the numerical simulations that the proposed plastic shear strain and confinement-dependent dilation angle model in combination with the calibrated CWFS model implemented in FLAC can reasonably reveal both rock mass failure and displacement distribution in vicinity of the excavation simultaneously. The simulation results are in good agreement with the field observations and displacement measurement data. | Xingguang Zhao Meifeng Cai MCai | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，4： | 7 |
| 11 | Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia–legume symbiosis显示文摘Plants establish symbioses with mutualistic fungi,such as arbuscular mycorrhizal(AM)fungi,and bacteria,such as rhizobia,to exchange key nutrients and thrive.Plants and symbionts have coevolved and represent vital components of terrestrial ecosystems.Plants employ an ancestral AM signaling pathway to establish intracellular symbioses,including the legume–rhizobia symbiosis,in their roots.Nevertheless,the relationship between the AM and rhizobial symbioses in native soil is poorly understood.Here,we examined how these distinct symbioses affect root-associated bacterial communities in Medicago truncatula by performing quantitative microbiota profiling(QMP)of 16S rRNA genes.We found that M.truncatula mutants that cannot establish AM or rhizobia symbiosis have an altered microbial load(quantitative abundance)in the rhizosphere and roots,and in particular that AM symbiosis is required to assemble a normal quantitative root-associated microbiota in native soil.Moreover,quantitative microbial co-abundance network analyses revealed that AM symbiosis affects Rhizobiales hubs among plant microbiota and benefits the plant holobiont.Through QMP of rhizobial rpoB and AM fungal SSU rRNA genes,we revealed a new layer of interaction whereby AM symbiosis promotes rhizobia accumulation in the rhizosphere of M.truncatula.We further showed that AM symbiosis-conditioned microbial communities within the M.truncatula rhizosphere could promote nodulation in different legume plants in native soil.Given that the AM and rhizobial symbioses are critical for crop growth,our findings might inform strategies to improve agricultural management.Moreover,our work sheds light on the co-evolution of these intracellular symbioses during plant adaptation to native soil conditions. | Xiaolin Wang Huan Feng Yayu Wang Mingxing Wang Xingguang Xie Huizhong Chang Like Wang Jicheng Qu Kai Sun Wei He Chunyan Wang Chuanchao Dai Zhaohui Chu Changfu Tian Nan Yu Xuebin Zhang Huan Liu Ertao Wang | 2021 | Molecular Plant2021，14，3： | 6 |
| 12 | Excavation of underground research laboratory ramp in granite using tunnel boring machine: Feasibility study显示文摘Underground research laboratory(URL)plays an important role in safe disposal of high-level radioactive waste(HLW).At present,the Xinchang site,located in Gansu Province of China,has been selected as the final site for China’s first URL,named Beishan URL.For this,a preliminary design of the Beishan URL has been proposed,including one spiral ramp,three shafts and two experimental levels.With advantages of fast advancing and limited disturbance to surrounding rock mass,the tunnel boring machine(TBM)method could be one of the excavation methods considered for the URL ramp.This paper introduces the feasibility study on using TBM to excavation of the Beishan URL ramp.The technical challenges for using TBM in Beishan URL are identified on the base of geological condition and specific layout of the spiral ramp.Then,the technical feasibility study on the specific issues,i.e.extremely hard rock mass,high abrasiveness,TBM operation,muck transportation,water drainage and material transportation,is investigated.This study demonstrates that TBM technology is a feasible method for the Beishan URL excavation.The results can also provide a reference for the design and construction of HLW disposal engineering in similar geological conditions.2020 Institute of Rock and Soil Mechanics,Chinese Academy of Sciences.Production and hosting by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/). | Hongsu Ma Ju Wang Ke Man Liang Chen Qiuming Gong Xingguang Zhao | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 6 |
| 13 | Permeability and pressure distribution characteristics of the roadway surrounding rock in the damaged zone of an excavation显示文摘Research on the permeability and pressure distribution characteristics of the roadway surrounding rock in the excavation damaged zone(EDZ) is beneficial for the development of gas control technology. In this study, analytical solutions of stress and strain of the roadway surrounding rock were obtained, in which the creep deformation and strain softening were considered. Using the MTS815 rock mechanics testing system and a gas permeability testing system, permeability tests were conducted in the complete stress-strain process, and the evolution characteristics of permeability and strain were studied over the whole loading process. Based on the analytical solutions of stress and strain and the governing equation of gas seepage flow, this paper proposes a hydro-mechanical(HM) model, which considers three different zones around the roadway. Then the gas flow process in the roadway surrounding rock in three different zones was simulated according to the engineering geological conditions, thus obtaining the permeability and pressure distribution characteristics of the roadway surrounding rock in three different zones. These results show that the surrounding rock around the roadway can be divided into four regions-the full flow zone(FFZ), flow-shielding zone(FSZ), transitive flow zone(TFZ), and in-situ rock flow zone(IRFZ). These results could provide theoretical guidance for the improvement of gas extraction and gas control technology. | Xue Yi Gao Feng Liu Xingguang Liang Xin | 2017 | International Journal of Mining Science and Technology2017，27，2： | 5 |
| 14 | Flexible Multiplexing Mechanism for Coexistence of URLLC and EMBB Services in 5G Networks显示文摘5G mobile networks are envisioned to support both evolved mobile broadband(eMBB) and ultra-reliable and low latency communications (URLLC), which may coexistand interfere with each other in the same service cell in many scenarios. In this paper, wepropose a dynamic 2-dimension bitmap resource indication to cancel eMBB services witha finer uplink cancellation granularity and a lower probability of false cancellation. Meanwhile,a resource indication based power control method is introduced to dynamically indicatedifferent power control parameters to the user equipment (UE) based on differenttime-frequency resource groups and the proportion of overlapping resources, by which thereliability of URLLC transmission is guaranteed while the impact on the performance ofthe eMBB service is minimized. Furthermore, a dynamic selection mechanism is proposedto accommodate the varying cases in different scenarios. Extensive system level simulationsare conducted and the results show that about 10.54% more URLLC UE satisfy therequirements, and the perceived throughput of eMBB UE is increased by 23.26%. | XIAO Kai LIU Xing HAN Xianghui HAO Peng ZHANG Junfeng ZHOU Dong WEI Xingguang | 2021 | ZTE Communications2021，19，2： | 3 |
| 15 | Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages显示文摘Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated,whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored.Di/tri-methylation modifications of histone 3 lysine 79(H3K79me2/3)have been shown to be associated with gene transcriptional activation.Disruptor of telomeric silencing-1-like(Dot1l)is the only known exclusive H3K79 methyltransferase and regulates the proliferation and differentiation of tumor cells.However,the roles of Dot1l and Dot1l-mediated H3K79 methylation in innate immunity and inflammatory responses remain unclear.Here,we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters,as well as H3K79me2 modification at the Tnfαpromoter,were increased in macrophages activated by Toll-like receptor(TLR)ligands or virus infection.The innate signals upregulated Dot1l expression in macrophages and THP1 cells.Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon(IFN)-βbut not of TNFαin macrophages and THP1 cells triggered by TLR ligands or virus infection.Dot1l was recruited to the proximal promoter of the Il6 and Ifnb1 but not Tnfαgene and then mediated H3K79me2/3 modification at the Il6 and Ifnb1 promoters,consequently facilitating the transcription and expression of Il6 and Ifnb1.Thus,Dot1l-mediated selective H3K79me2/3 modifications at the Il6 and Ifnb1 promoters are required for the full activation of innate immune responses.This finding adds new insights into the epigenetic regulation of inflammatory responses and pathogenesis of autoimmune diseases. | Xiang Chen Xingguang Liu Yunkai Zhang Wanwan Huai Qingqing Zhou Sheng Xu Xi Chen Nan Li Xuetao Cao | 2020 | Cellular & Molecular Immunology2020，17，1： | 3 |
| 16 | Composition of fish species in the Bering and Chukchi Seas and their responses to changes in the ecological environment显示文摘Based on trawl surveys in the Bering Sea and Chukchi Sea during the 2010 Chinese National Arctic Research Expedition, fish biodiversity characteristics, such as fish composition, dominant species, biodiversity, and faunal characteristics were conducted. We also discussed the responses of fishes to the quick changes in Arctic climate. The results showed that a total of 41 species in 14 families were recorded in these waters. The dominant species were Hippoglossoides robustus, Boreogadus saida, Myoxocephalus scorpius, Lumpenus fabricii, and Artediellus scaber. There were 35 coldwater species, accounting for 85.37%, and six cold temperate species, occupying 14.63%. The habitat types of fish could be grouped as follows: 35 species of demersal fishes, five benthopelagic fishes, and one pelagic fish. The Shannon–Wiener diversity index(H)(range between 0 and 2.18, 1.21 on average) was not high, and descended from south to north. Climate change has caused some fishes to shift along their latitudinal and longitudinal distribution around the Arctic and Subarctic areas, and this could lead to the decline of Arctic fishery resources. | LIN Longshan CHEN Yongjun LIAO Yunchih ZHANG Jing SONG Puqing YU Xingguang WU Risheng SHAO Kwang-tsao | 2014 | Acta Oceanologica Sinica2014，33，6： | 3 |
| 17 | Identification of IFN-γ-producing innate B cells显示文摘 | Yan Bao Xingguang Liu Chaofeng Han Sheng Xu Bin Xie Qian Zhang Yan Gu Jin Hou Li Qian Cheng Qian Huanxing Han Xuetao Cao | 2014 | Cell Research2014，24，2： | 3 |
| 18 | The distribution and characteristics of suspended particulate matter in the Chukchi Sea显示文摘Samples taken from the ChukchiSea(CS) during the 4th Chinese National Arctic Research Expedition, 2010, were analyzed to determine the content and composition of suspended particulate matter(SPM) to improve our understanding of the distribution, sources and control factors of the SPM there. The results show that the SPM in the water column is highest in the middle and near the bottom in the south and central–north CS, followed by that off the Alaskan coast and in Barrow Canyon. The SPM content is lowest in the central CS. Scanning electron microscope(SEM) analysis shows that the SPM in the south and central–north CS is composed mainly of diatoms, but the dominant species in those two areas are different. The SPM off the Alaskan coast and in Barrow Canyon is composed mainly of terrigenous material with few bio-skeletal clasts. The distribution of temperature and salinity and the correlation between diatom species in SPM indicate that the diatom dominant SPM in the south CS is from the Pacific Ocean via the Bering Strait in summer. The diatom dominant SPM in the central–north CS is also from Pacific water, which reaches the CS in winter. The SPM in the middle and near the bottom of the water column off the Alaskan coast and in Barrow Canyon is from Alaskan coastal water and terrigenous material transported by rivers in Alaska. | WANG Weiguo FANG Jianyong CHEN Lili WU Risheng YU Xingguang | 2014 | Advances in Polar Science2014，25，3： | 3 |
| 19 | A new cytosolic DNA-recognition pathway for DNA-induce~ inflammatory responses显示文摘 | Jun Meng Xingguang Liu Xuetao Cao | 2014 | Cellular & Molecular Immunology2014，11，6： | 2 |
| 20 | Effect of Tongluojiunao injection made from Sanqi(Radix Notoginseng) and Zhizi(Fructus Gardeniae) on brain microvascular endothelial cells and astrocytes in an in vitro ischemic model显示文摘OBJECTIVE: To explore the effect of Tongluojiunao injection(TLJN) prepared with Sanqi(Radix Notoginseng) and Zhizi(Fructus Gardeniae) on the interaction between brain microvascular endothelial cells(BMECs) and astrocytes in an in vitro ischemic model.METHODS: First, an in vitro model of cerebral ischemia in BMECs or astrocytes was established by oxygen-glucose deprivation(OGD). TLJN was used as a medicine of intervention. The OGD-injuredBMECs were cultured in various astrocyte-conditioned media. Cell activity, alkaline phosphatase(AKP) and γ-glutamyl transpeptidase(γ-GT) activity,interleukin-1 beta(IL-1β), and tumor necrosis factor alpha(TNF-α) content in BMECs were determined.Additionally, OGD-injured astrocytes were cultured in various BMEC-conditioned media. Cell activity, as well as expression of brain-derived neurotrophic factor(BDNF) and glial cell-derived neurotrophic factor(GDNF) in astrocytes, were detected.RESULTS: The results of paracrine signaling of normal BMECs or astrocytes showed a protective effect on each other: conditioned media from normal astrocytes improved cell viability, AKP, and γ-GT activity, and reduced IL-1β and TNF-α content of injured BMECs; conditioned media from normal BMECs improved cell viability and expression of BDNF and GDNF in injured astrocytes. However, once the BMECs or astrocytes were injured by OGD, the protective effect decreased or disappeared. The above-mentioned protective induction was effectively recovered by TLJN intervention.CONCLUSION: The therapeutic benefit of TLJN was achieved by recovering two-way induction between BMECs and astrocytes, enhancing activity of injured BMECs and astrocytes, stabilizing enzymatic barriers, promoting expression of neurotrophic factors, and inhibiting inflammatory cytokines. | Weihong Li Xingguang Li Qinghong Du Feng Li Yuan zhu Yang Liu Jie Ma Liangqin Wan Fanghe Li Sai Zhang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
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