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| 1 | Temporal variation of soil carbon stock and its controlling factors over the last two decades on the southern Song-nen Plain,Heilongjiang Province显示文摘对全球气候变化的当前的背景,在土壤碳水池和它的控制因素的变化的学习可以在温室气体的缓解或改进帮助土壤角色的评估。这份报纸在 Heilongjiang 省在南部的 Song-nen 平原在土壤碳水池和他们的控制因素学习空间、时间的变化,用在二个不同时期由上收集的土壤数据在 20052007 的多种用途的地区性的 Geochemical 调查,和另外一个玷污在 19821990 进行的调查。学习区域是 1479 t/km2 并且在过去的 20 年里的碳来源,从直到 2005 的 1980 年代,从土壤的实际的碳排放是 0.12 Gt。温度,被发现了线性地被相关玷污器官的碳,是控制器官的碳满足的土壤的主导的 climatologic 因素。我们的学习在器官的碳由升起的温度引起了的土壤的潜在的损失是的相关区域和时间时期显示出那 0.10 Gt ,源于陆地使用变化的潜在的土壤碳排放是 0.09 Gt ,并且温暖和陆地使用变化引起的土壤碳( 0.19 Gt )的联合潜在的损失比得上石块燃料燃烧( 0.21 Gt )的。由于在土壤碳水池变化的时间延期,仍然在温暖和以后将逐渐地被释放的陆地使用变化引起的潜在的排放有 0.07 Gt。 | Xueqi Xia Zhongfang Yang Yan Liao Yujun Cui Yansheng Li | 2010 | Geoscience Frontiers2010，1，1： | 19 |
| 2 | Investigation of Mg–Zn–Y–Nd alloy for potential application of biodegradable esophageal stent material显示文摘In recent years,due to unhealthy dietary habits and other reasons,advanced esophageal cancer patients are on the rise,threatening human health and life safety at all times.Stents implantation as an important complementary or alternative method for chemotherapy has been widely applied in clinics.However,the adhesion and proliferation of pathological cells,such as tumor cells,fibroblasts and epithelial cells,may interfere the efficacy of stents.Further multiple implantation due to restenosis may also bring pain to patients.In this contribution,we preferred a biodegradable material Mg–Zn–Y–Nd alloy for potential application of esophageal stent.The hardness testing showed that Mg–Zn–Y–Nd alloy owned less mechanical properties compared with the commercial esophageal stents material,317L stainless steel(317L SS),while Mg–Zn–Y–Nd displayed significantly better biodegradation than 317L SS.Cell apoptosis assay indicated Mg–Zn–Y–Nd inhibited adhesion and proliferation of tumor cells,fibroblasts and epithelial cells.Our research suggested potential application of Mg–Zn–Y–Nd alloy as a novel material for biodegradable esophageal stent. | Shuo Wang Xueqi Zhang Jingan Li Changsheng Liu Shaokang Guan | 2020 | Bioactive Materials2020，5，1： | 7 |
| 3 | Potential risks and challenges of climate change in the arid region of northwestern China显示文摘In the arid region of northwestern China(ARNC),water resources are the most critical factor restricting socioeconomic development and influencing the stability of the area’s ecological systems.The region’s complex water system and unique hydrological cycle show distinctive characteristics.Moreover,the intensified hydrological cycle and extreme climatic and hydrological events resulting from global warming have led to increased uncertainty around water resources as well as heightened conflict between water supply and water demand.All of these factors are exerting growing pressures on the socioeconomic development and vulnerable ecological environment in the region.This research evaluates the impacts of climate change on water resources,hydrological processes,agricultural system,and desert ecosystems in the ARNC,and addresses some associated risks and challenges specific to this area.The temperature is rising at a rate of 0.31C per decade during 1961–2017 and hydrological processes are being significantly influenced by changes in glaciers,snow cover,and precipitation form,especially in the rivers recharged primarily by melt water.Ecosystems are also largely influenced by climate change,with the Normalized Difference Vegetation Index(NDVI)of natural vegetation exhibited an increasing trend prior to 1998,and then reversed in Xinjiang while the Hexi Corridor of Gansu showed the opposite trends.Furthermore,the desert-oasis transition zone showed a reduction in area due to the warming trend and the recent rapid expansion of irrigated area.Both the warming and intensified drought are threatening agriculture security.The present study could shed light on sustainable development in this region under climate change and provides scientific basis to the construction of the“Silk Road Economic Belt”. | Yaning Chen Xueqi Zhang Gonghuan Fang Zhi Li Fei Wang Jingxiu Qin Fan Sun | 2020 | Regional Sustainability2020，1，1： | 6 |
| 4 | Burden of Disease Due to Cancer——China,2000-2019显示文摘Summary What is already known about this topic?Cancer is a major global public health problem and the leading cause of death in China.China has a large population,and therefore has a significant proportion of the global burden of cancer.What is added by this report?The age-standardized incidence of cancer has increased in China,while the cancer mortality rate has decreased.Compared with younger age groups,individuals over 70 have a greater burden of cancer.Digestive tract cancer and breast cancer should be targeted for prevention,treatment,and control. | Xueqi Fan Bin Zhang Yuan He Xiaolong Zhou Yingying Zhang Li Ma Xudong Li Jing Wu | 2022 | China CDC weekly2022，4，15： | 3 |
| 5 | Hepatitis B virus evades immune recognition via RNA adenosine deaminase ADAR1-mediated viral RNA editing in hepatocytes显示文摘HBV is considered as a“stealth”virus that does not invoke interferon(IFN)responses;however,the mechanisms by which HBV bypasses innate immune recognition are poorly understood.In this study,we identified adenosine deaminases acting on RNA 1(ADAR1),which is a key factor in HBV evasion from IFN responses in hepatocytes.Mechanically,ADAR1 interacted with HBV RNAs and deaminated adenosine(A)to generate inosine(I),which disrupted host immune recognition and thus promoted HBV replication.Loss of ADAR1 or its deficient deaminase activity promoted IFN responses and inhibited HBV replication in hepatocytes,and blocking the IFN signaling pathways released the inhibition of HBV replication caused by ADAR1 deficiency.Notably,the HBV X protein(HBx)transcriptionally promoted ADAR1 expression to increase the threshold required to trigger intrinsic immune activation,which in turn enhanced HBV escape from immune recognition,leading to persistent infection.Supplementation with 8-azaadenosine,an ADAR1 inhibitor,efficiently enhanced liver immune activation to promote HBV clearance in vivo and in vitro.Taken together,our results delineate a molecular mechanism by which HBx promotes ADAR1-derived HBV immune escape and suggest a targeted therapeutic intervention for HBV infection. | Liyuan Wang Yang Sun Xiaojia Song Zehua Wang Yankun Zhang Ying Zhao Xueqi Peng Xiaodong Zhang Chunyang Li Chengjiang Gao Nailin Li Lifen Gao Xiaohong Liang Zhuanchang Wu Chunhong Ma | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 6 | Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection显示文摘Oxymatrine(OMT), as the main active component of Sophoraflavescens, exhibits a variety of pharmacological properties,including anti-oxidative, anti-inflammatory, anti-tumor, and anti-viral activities, and currently is extensively employed to treat viral hepatitis; however, its effects on parvovirus infection have yet to be reported. In the present study, we investigated the effects of OMT on cell viability, virus DNA replication, viral gene expression, cell cycle, and apoptosis in Walter Reed canine cells/3873 D infected with minute virus of canines(MVC). OMT, at concentrations below 4 mmol/L(no cellular toxicity), was found to inhibit MVC DNA replication and reduce viral gene expression at both mRNA and protein levels, which was associated with the inhibition of cell cycle S-phase arrest in early-stage of MVC infection.Furthermore, OMT significantly increased cell viability, decreased MVC-infected cell apoptosis, and reduced the expression of activated caspase 3. Our results suggest that OMT has potential application in combating parvovirus infection. | Yanqin Ding Na Li Jinhan Sun Linran Zhang Jianhui Guo Xueqi Hao Yuning Sun | 2019 | Virologica Sinica2019，34，1： | 2 |
| 7 | SOD1^(G93A) Induces a Unique PSAP-Dependent Mitochondrial Apoptosis Pathway via Bax-Bak Interaction显示文摘Amyotrophic lateral syndrome(ALS)is a progressive degenerative disorder characterized by motor neuron death and axon degeneration.Mitochondrial dysfunction plays a key role in the pathogenesis of ALS,the mechanism of which remains poorly understood.The B-cell lymphoma-2(Bcl-2)family of proteins that control and mediate mitochondrial function and apoptosis,including the pro-apoptotic members Bcl2-Associated X(Bax),are involved in ALS development.The death receptor 6(DR6)regulates motor neuron death in ALS,and DR6 antibodies can prevent axon degeneration and motor neuron damage by blocking DR6.Previous studies demonstrated that PSAP localized to mitochondria and was required for DR6-induced apoptosis.In this study,SOD1^(G93A) was transfected into the motor neuron cell line NSC-34 to serve as an ALS cell model in vitro.The data assessed the role of PSAP in SOD1^(G93A)induced apoptosis and demonstrated that the overexpression of SOD1^(G93A),but not wtSOD1,induced PARP cleavage,caspase-3 activation,cytochrome c release,and Bax translocation.PSAP,Bax,and Bak were necessary for SOD1^(G93A)induced apoptosis,as silencing PSAP inhibited SOD1^(G93A)-mediated cell death that was dependent on Bax-Bak interaction. | HAN NIU XIN CHEN XUEQI FU JINGTIAN ZHANG GUODONG LI YUXIANG WANG JIAYUE SONG XUETING MA CHEN HU XUEMIN XU FUQIANG ZHANG LINLIN ZENG | 2021 | BIOCELL2021，45，4： | 2 |
| 8 | Primary tumor location in lung cancer:the evaluation and administration显示文摘Lung cancer continues to be the leading cause of cancer-related death in the world,which is classically subgrouped into two major histological types:Non-small cell lung cancer(NSCLC)(85%of patients)and small-cell lung cancer(SCLC)(15%).Tumor location has been reported to be associated with the prognosis of various solid tumors.Several types of cancer often occur in a specific region and are more prone to spread to predilection locations,including colorectal cancer,prostate cancer,gastric cancer,ovarian cancer,cervical cancer,bladder cancer,lung tumor,and so on.Besides,tumor location is also considered as a risk factor for lung neoplasm with chronic obstructive pulmonary disease/emphysema.Additionally,the primary lung cancer location is associated with specific lymph node metastasis.And the recent analysis has shown that the primary location may affect metastasis pattern in metastatic NSCLC based on a large population.Numerous studies have enrolled the“location”factor in the risk model.Anatomy location and lobe-specific location are both important in prognosis.Therefore,it is important for us to clarify the characteristics about tumor location according to various definitions.However,the inconsistent definitions about tumor location among different articles are controversial.It is also a significant guidance in multimode therapy in the present time.In this review,we mainly aim to provide a new insight about tumor location,including anatomy,clinicopathology,and prognosis in patients with lung neoplasm. | Xueqi Xie Xiaolin Li Wenjie Tang Peng Xie Xuefen Tan | 2022 | Chinese Medical Journal2022，，2： | 2 |
| 9 | A non-aqueous all-cobalt redox flow battery using 1,10-phenanthrolinecobalt(11)hexafluorophosphate as active species显示文摘 | Xing Xueqi Zhang Dapeng Li Yongdan | 2015 | Journal of Power Sources2015，279，： | 1 |
| 10 | Alpha-lipoic acid enhances DMSO-induced cardiomyogenic differentiation of P19 cells显示文摘Alpha-lipoic 酸(-LA) 是在 mitochondrial 脱氢酶反应充当一个必要余因子的一种有势力抗氧化剂。-LA 被显示了拥有反煽动性并且 cytoprotective 性质,并且被用来改进糖尿病的神经病的症状。然而,在干细胞区别和未知的内在的分子的机制遗体的 -LA 的角色。在现在的学习,我们证明 -LA 显著地支持了导致的 dimethyl sulfoxide (DMSO ) 老鼠的 cardiomyogenic 区别胚胎的癌 P19 房间。-LA 剂量依赖地增加了区分 DMSO 的 P19 房间的跳动的胚胎的身体(EB ) 百分比。心脏的特定的基因 TNNT2, Nkx2.5, GATA4, MEF2C,和 MLC2V 和 troponin T (cTnT ) 的心脏的 isoform 的表情断然染色了房间人口由 -LA 的增加是显著地起来调整的。我们也证明在 EB 形成以后的区别时间是批评的让 -LA 生效。没有 DMSO 处理,有趣地, -LA 没刺激 P19 房间的 cardiomyogenic 区别。进一步的调查显示了那骨胶原而不是抗氧化的性质,提高合成的活动在 cardiomyogenic 起一个重要作用 -LA 的支持区别的功能。这些调查结果热点为在心疾病的再生治疗的 -LA 的潜在的使用。 | Xinghua Shen Qinghui Yang Peng Jin Xueqi Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，9： | 1 |
| 11 | Annual net input fluxes of heavy metals of the agro-ecosystem in the Yangtze River delta, China显示文摘 | Qingye Hou Zhongfang Yang Junfeng Ji Tao Yu Guoguang Chen Juan Li Xueqi Xia Ming Zhang Xuyin Yuan | 2013 | Journal of Geochemical Exploration2013，，： | 1 |
| 12 | Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR system with non-viral carrier remains a major issue to be solved.Here,we report a kind of targeted core-shell nanoparticles(NPs)carrying dual plasmids(pHR-pCas9)for precise CCCTC-binding factor(CTCF)gene insert to circumvent metastatic breast cancer.The targeted core-shell NPs carrying pHR-pCas9 can accomplishγGTP-mediated cellular uptake and endosomal escape,facilitate the precise insert and stable expression of CTCF gene,inhibit the migration,metastasis,and colonization of metastatic breast cancer cells.Besides,the finding further reveals that the inhibitory mechanism of metastasis could be associated with up-regulating CTCF protein,followed by down-regulating stomatin(STOM)protein.The study offers a universal nanostrategy enabling the robust non-viral delivery of gene-editing system for treatment of severe illness. | Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu | 2022 | Bioactive Materials2022，7，5： | 1 |
| 13 | Ti–Cu–N hard nanocomposite films prepared by pulse biased arc ion plating显示文摘 | Yanhui Zhao Xueqi Wang Jinquan Xiao Baohai Yu Fengqi Li | 2011 | Applied Surface Science2011，，1： | 1 |
| 14 | Maybe Absolutely Green -with Traditional Chinese Medicine as Wood Pre- servative显示文摘 | Wang Yamei Wang Ximing Li Xueqi | | 0，，239： | 1 |
| 15 | Gut dysbiosis of bacteria and fungi associated with human immunodeficiency virus infection显示文摘To the Editor:There have been growing concerns about the gut bacterial dysbiosis associated with HIV infection,addressing a critical role of gut bacteria in persistent chronic inflammation and severe intestinal dysfunction among the human immunodeficiency virus(HIV)infected population.However,little is known about the gut fungal dysbiosis caused by HIV-infection.Therefore,we launched a case-control study aiming to explore the gut dysbiosis of bacteria and fungi in HIV infection,which may reveal a more comprehensive feature of HIV infection-related gut dysbiosis of bacteria and fungi that possibly play a role in the chronic systemic immune activation observed in HIV infection. | Xueqi Wu Yuanhong Xu Qingfeng Li Fengjiao Yang Shenghua He Yingjie Li Shujuan Yang Peibin Zeng | 2022 | Chinese Medical Journal2022，，11： | 1 |
| 16 | Changes of sex hor- mones in pregnancy hypertension patients 显示文摘 | Zhang Xueqi Li Junguang Zhang Lifeng | 2010 | Shandong Medicine2010，50，40： | 1 |
| 17 | Numerical Investigation of a Centrifugal Compressor with a Pre-Compression Wedge Diffuser under High Subsonic Conditions显示文摘As the total pressure ratio of centrifugal compressors increases, the diffuser inlet flow becomes highly subsonic or even supersonic, which causes additional shock loss. The shock loss leads the stage performance to drop greatly. Pre-compression is an efficient method for reducing shock loss and improving the stage performance. To study the effect of wedge diffusers with pre-compression blades on centrifugal compressor performance, wedge diffusers with various pre-compression angles, divergence angles and numbers of blades were designed and investigated via a numerical method. As a result, it is found that the compressor stage achieves high peak efficiency when the pre-compression angle ranges from 2.5° to 5.5° and when the divergence angle ranges from 7° to 9°. As the number of blades increases, the total pressure ratio and adiabatic efficiency of the compressor stage increase slightly, whereas the surge margin of the stage decreases. | WANG Yi LI Qingkuo BAI Huan ZHOU Xueqi LU Xin’gen | 2020 | Journal of Thermal Science2020，29，4： | 1 |
| 18 | TASC: Topic-adaptive Sentiment Classification on Dynamic Tweets 显示文摘 | Liu Shenghua Cheng Xueqi Li Fuxin | 2015 | IEEE Transacations on Knowledge and Data Engineering2015，27，6： | 1 |
| 19 | Stochastic game net and applications in security analysis for enterprise network显示文摘 | Yuanzhuo Wang Min Yu Jingyuan Li Kun Meng Chuang Lin Xueqi Cheng | 2012 | International Journal of Information Security2012，，1： | 1 |
| 20 | Effect of so lution chemistry on membrane resistance and flux decline显示文摘 | Li Xiufen Fu Xueqi | 2002 | Filtration &Separation2002，10，39： | 1 |
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