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| 1 | Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication,metabolite traits,and antiinflammatory effects显示文摘Foxtail millet(Setaria italica),which was domesticatedfromthewild speciesgreenfoxtail(Setaria viridis),isa richsource of phytonutrientsfor humans.To evaluate how breeding changed themetabolome offoxtail millet grains,we generated and analyzed the datasets encompassing the genomes,transcriptomes,metabolomes,and anti-inflammatory indices from 398 foxtail millet accessions.We identified hundreds of common variants that influence numerous secondary metabolites.We observed tremendous differences in natural variations of the metabolites and their underlying genetic architectures between distinct sub-groups of foxtail millet.Furthermore,we found that the selection of the gene alleles associated with yellow grains led to altered profiles of metabolites such as carotenoids and endogenous phytohormones.Using CRiSPR-mediated genome editing wevalidated the function of PHYTOENE SYNTHASE1(PSY1)gene in affecting milletgrain colorand quality.Interestingly,our in vitro cell inflammation assays showed that 83 metabolites in millet grains have anti-inflammatory effects.Taken together,ourmulti-omics study illustrates how the breeding history of foxtail millet has shaped its metabolite profile.The datasets we generated in this study also provide important resources for further understanding how millet grain quality is affected by different metabolites,laying the foundations for future millet genetic research and metabolome-assisted improvement. | Xukai Li Jianhua Gao Jingyi Song Kai Guo Siyu Hou Xingchun Wang Qiang He Yanyan Zhang Yakun Zhang Yulu Yang Jiaoyan Tang Hailang Wang Staffan Persson Mingquan Huang Lishuai Xu Linlin Zhong Dongqin Li Yongming Liu Hua Wu Xianmin Diao Peng Chen Xiaowen Wang Yuanhuai Han | 2022 | Molecular Plant2022，15，8： | 8 |
| 2 | Characterization and evaluation of brittleness of deep bedded sandstone from the perspective of the whole life-cycle evolution process显示文摘The quantitative determination and evaluation of rock brittleness are crucial for the estimation of excavation efficiency and the improvement of hydraulic fracturing efficiency.Therefore,a“three-stage”triaxial loading and unloading stress path is designed and proposed.Subsequently,six brittleness indices are selected.In addition,the evolution characteristics of the six brittleness indices selected are characterized based on the bedding effect and the effect of confining pressure.Then,the entropy weight method(EWM)is introduced to assign weight to the six brittleness indices,and the comprehensive brittleness index Bcis defined and evaluated.Next,the new brittleness classification standard is determined,and the brittleness differences between the two stress paths are quantified.Finally,compared with the previous evaluation methods,the rationality of the proposed comprehensive brittleness index Bcis also verified.These results indicate that the proposed brittleness index Bccan reflect the brittle characteristics of deep bedded sandstone from the perspective of the whole life-cycle evolution process.Accordingly,the method proposed seems to offer reliable evaluations of the brittleness of deep bedded sandstone in deep engineering practices,although further validation is necessary. | Zhixiang Song Junwen Zhang Yang Zhang Xukai Dong Shanyong Wang | 2023 | International Journal of Mining Science and Technology2023，33，4： | 3 |
| 3 | State of China’s climate in 2021显示文摘2021年,中国气候暖湿特征明显,全国平均气温10.5℃,较常年偏高1.0℃,创下了1951年以来最高纪录;全国平均降水量672.1毫米,比常年偏多6.7%,其中北方地区平均降水量较常年偏多40.2%,为1961年以来第二多.汛期暴雨过程强度大,极端性显著,河南特大暴雨灾害影响重,黄河中下游流域秋汛明显;高温过程多,夏秋南方高温持续时间长;区域性,阶段性气象干旱明显,华南干旱影响较重;台风生成和登陆均偏少,“烟花”陆地滞留时间长,影响范围广;强对流天气强发,极端大风频发,局地致灾重;寒潮过程多,强度大,极端低温频现;沙尘天气出现早,强沙尘暴过程多. | Wei Li Shanshan Zhao Yu Chen Ling Wang Wei Hou Yundi Jiang Xukai Zou Shuai Shi | 2022 | Atmospheric and Oceanic Science Letters2022，15，4： | 2 |
| 4 | An Objective Identification Technique for Regional Extreme Events显示文摘 | Ren Fumin Cui Donglin Gong Zhiqiang Wang Yanjiao Zou Xukai Li Yiping Wang Shigong Wang Xiaoling | 2012 | EN2012，，20： | 1 |
| 5 | Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21显示文摘 | Ye Zhang Yan Wang Xukai Wang Yi Zhang Gilbert M. Eisner Laureano D. Asico Pedro A. Jose Chunyu Zeng | 2011 | Journal of Hypertension2011，，8： | 1 |
| 6 | An efficient scheme for removing compromised sensor nodes from wireless sensor networks显示文摘 | Yong Wang Byrav Ramamurthy Xukai Zou Yuyan Xue | 2010 | International Journal of Communication Systems2010，3，4： | 1 |
| 7 | Insulin promotes vascular smooth muscle cell proliferation via microRNA-208-mediated downregulation of p21显示文摘 | Ye Zhang Yan Wang Xukai Wang Yi Zhang Gilbert M. Eisner Laureano D. Asico Pedro A. Jose Chunyu Zeng | 2011 | Journal of Hypertension2011，，8： | 1 |
| 8 | Biofunctionalized composite scaffold to potentiate osteoconduction,angiogenesis,and favorable metabolic microenvironment for osteonecrosis therapy显示文摘Osteonecrosis is a common orthopedic disease in clinic,resulting in joint collapse if no appropriate treatment is performed in time.Core decompression is a general treatment modality for early osteonecrosis.However,effective bone regeneration in the necrotic area is still a significant challenge.This study developed a biofunctionalized composite scaffold(PLGA/nHA30VEGF)for osteonecrosis therapy through potentiation of osteoconduction,angiogenesis,and a favorable metabolic microenvironment.The composite scaffold had a porosity of 87.7%and compressive strength of 8.9 MPa.PLGA/nHA30VEGF had an average pore size of 227.6μm and a water contact angle of 56.5◦with a sustained release profile of vascular endothelial growth factor(VEGF).After the implantation of PLGA/nHA30VEGF,various osteogenic and angiogenic biomarkers were upregulated by 2-9 fold compared with no treatment.Additionally,the metabolomic and lipidomic profiling studies demonstrated that PLGA/nHA30VEGF effectively regulated the multiple metabolites and more than 20 inordinate metabolic pathways in osteonecrosis.The excellent performances reveal that the biofunctionalized composite scaffold provides an advanced adjuvant therapy modality for osteonecrosis. | Tongtong Zhu Mengyang Jiang Mingran Zhang Liguo Cui Xiaoyu Yang Xukai Wang Guangyao Liu Jianxun Ding Xuesi Chen | 2022 | Bioactive Materials2022，7，3： | 1 |
| 9 | An Objective Identification Technique for Regional Extreme Events显示文摘 | Ren Fumin Cui Donglin Gong Zhiqiang Wang Yanjiao Zou Xukai Li Yiping Wang Shigong Wang Xiaoling | 2012 | EN2012，，20： | 1 |
| 10 | Sliding mode fault tolerant consensus control for multi-agent systems based on super-twisting observer显示文摘The fault-tolerant consensus problem for leader-following nonlinear multi-agent systems with actuator faults is mainly investigated.A new super-twisting sliding mode observer is constructed to estimate the velocity and undetectable fault information simultaneously.The time-varying gain is introduced to solve the initial error problem and peak value problem,which makes the observation more accurate and faster.Then,based on the estimated results,an improved sliding mode fault-tolerant consensus control algorithm is designed to compensate the actuator faults.The protocol can guarantee the finite-time consensus control of multi-agent systems and suppress chattering.Finally,the effectiveness and the superiority of the observer and control algorithm are proved by some simulation examples of the multi-aircraft system. | YANG Pu HU Xukai WANG Zixin ZHANG Zhiqing | 2022 | Journal of Systems Engineering and Electronics2022，33，6： | 0 |
| 11 | Data-driven strategies for the computational design of enzyme thermal stability:trends,perspectives,and prospects显示文摘Thermal stability is one of the most important properties of enzymes,which sustains life and determines the potential for the industrial application of biocatalysts.Although traditional methods such as directed evolution and classical rational design contribute greatly to this field,the enormous sequence space of proteins implies costly and arduous experiments.The development of enzyme engineering focuses on automated and efficient strategies because of the breakthrough of high-throughput DNA sequencing and machine learning models.In this review,we propose a data-driven architecture for enzyme thermostability engineering and summarize some widely adopted datasets,as well as machine learning-driven approaches for designing the thermal stability of enzymes.In addition,we present a series of existing challenges while applying machine learning in enzyme thermostability design,such as the data dilemma,model training,and use of the proposed models.Additionally,a few promising directions for enhancing the performance of the models are discussed.We anticipate that the efficient incorporation of machine learning can provide more insights and solutions for the design of enzyme thermostability in the coming years. | Zhixin Dou Yuqing Sun Xukai Jiang Xiuyun Wu Yingjie Li Bin Gong Lushan Wang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，3： | 0 |
| 12 | Interactions of phenol and benzaldehyde in electrocatalytic upgrading process显示文摘Biomass pyrolysis oil can be improved effectively by electrocatalytic hydrogenation(ECH).However,the unclear interactions among different components lead to low bio-oil upgrading efficiency in the conversion process.Herein,benzaldehyde and phenol,as common compounds in bio-oil,were chosen as model compounds.The interactions between the two components were explored in the ECH process by combining experiments and theoretical calculations.Results showed that phenol could accelerate the conversion of benzaldehyde in the ECH.The selectivity of benzyl alcohol was increased from 60.9%of unadded phenol to 99.1%with 30 mmol/L phenol concentration at 5 h.Benzaldehyde inhibited the ECH of phenol.In the presence of benzaldehyde,the conversion rate of phenol was below 10.0%with no cyclohexanone and cyclohexanol formation at 5 h.The density functional theory(DFT)calculations revealed that the phenol could promote the adsorption of benzaldehyde and facilitate the targeted conversion of benzaldehyde on the active site by lowering the reaction energy barrier.The research on the interaction between phenol and benzaldehyde in the ECH provides a theoretical basis for the application of ECH in practical bio-oil upgrading. | Lan Liang Chuanbin Wang Xukai Lu Yunan Sun Beibei Yan Ning Li Guanyi Chen Li'an Hou | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 13 | State of China's climate in 2022显示文摘2022年我国气候暖干特征明显,年平均气温偏高0.62℃,位居1961年以来历史第二高;年降水量偏少5%,为2012年以来最少,冬春季降水偏多,夏秋季降水偏少.汛期(5-9月)降水量偏少11.9%,位居1961年以来第3少,中东部降水距平呈“北多南少”分布.雨季进程偏早,雨量空间差异大,华南前汛期,华北雨季,东北雨季降水量偏多,而长江中下游和江淮梅雨降水偏少.华南,东北洪涝灾害重,南方夏秋连旱严重,中东部遭遇最强高温过程,登录台风异常偏少. | Ling Wang Linhai Sun Wei Li Xianyan Chen Ying Li Xukai Zou Yundi Jiang | 2023 | Atmospheric and Oceanic Science Letters2023，16，6： | 0 |
| 14 | The evaluation of the hemangioma and vascular and maxillofacial region managements of: malformation in oral显示文摘 | Xukai Wang Xiaofeng Bai Kwangwei Wu Qiang Liu | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 15 | Expression of bcl-2 and survivin gene products in different stages of vessel differentiation in hemangiomas显示文摘 | Junlin Li Ye Xinping Qin Xingjun Wang Xukai | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 16 | Electro-catalytic activity of CeO_(x) modified graphite felt for carbamazepine degradation via E-peroxone process显示文摘E-peroxone(EP)was one of the most attractive AOPs for removing refractory organic compounds from water,but the high energy consumption for in situ generating H_(2)O_(2) and its low reaction efficiency for activating O_(3) under acidic conditions made the obstacles for its practical application.In this study,cerium oxide was loaded on the surface of graphite felt(GF)by the hydrothermal method to construct the efficient electrode(CeO_(x)/GF)for mineralizing carbamazepine(CBZ)via EP process.CeO_(x)/GF was an efficient cathode,which led to 69.4%TOC removal in CeO_(x)/GF-EP process with current intensity of 10 mA in 60 min.Moreover,CeO_(x)/GF had the flexible application in the pH range from 5.0 to 9.0,TOC removal had no obvious decline with decrease of pH.Comparative characterizations showed that CeO_(x)could enhance surface hydrophilicity and reduce the charge-transfer resistance of GF.About 5.4 mg/L H_(2)O_(2) generated in CeO_(x)/GF-EP process,which was 2.1 times as that in GF-EP process.The greater ozone utility was also found in CeO_(x)/GF-EP process.More O_(3) was activated into hydroxyl radicals,which accounted for the mineralization of CBZ.An interfacial electron transfer process was revealed,which involved the function of oxygen vacancies and Ce^(3+)/Ce^(4+)redox cycle.CeO_(x)/GF had the good recycling property in fifth times'use. | Xinyu Wang Ye Jin Weirui Chen Ruini Zou Jinxin Xie Yiming Tang Xukai Li Laisheng Li | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 0 |
| 17 | Application of the CatBoost Model for Stirred Reactor State Monitoring Based on Vibration Signals显示文摘Stirred reactors are key equipment in production,and unpredictable failures will result in significant economic losses and safety issues.Therefore,it is necessary to monitor its health state.To achieve this goal,in this study,five states of the stirred reactor were firstly preset:normal,shaft bending,blade eccentricity,bearing wear,and bolt looseness.Vibration signals along x,y and z axes were collected and analyzed in both the time domain and frequency domain.Secondly,93 statistical features were extracted and evaluated by ReliefF,Maximal Information Coefficient(MIC)and XGBoost.The above evaluation results were then fused by D-S evidence theory to extract the final 16 features that are most relevant to the state of the stirred reactor.Finally,the CatBoost algorithm was introduced to establish the stirred reactor health monitoring model.The validation results showed that the model achieves 100%accuracy in detecting the fault/normal state of the stirred reactor and 98%accuracy in diagnosing the type of fault. | Xukai Ren Huanwei Yu Xianfeng Chen Yantong Tang Guobiao Wang Xiyong Du | 2024 | Computer Modeling in Engineering & Sciences2024，140，7： | 0 |
| 18 | Mechanical behaviours of bedded sandstone under hydromechanical coupling显示文摘The combination of the dipping effect and hydromechanical(H-M)coupling effect can easily lead to water inrush disasters in water-rich roadways with different dip angles in coal mines.Therefore,H-M coupling tests of bedded sandstones under identical osmotic pressure and various confining pressures were conducted.Then,the evolution curves of stress-strain,permeability and damage,macro-and mesoscopic failure characteristics were obtained.Subsequently,the mechanical behaviour was characterized,and finally the failure mechanism was revealed.The results showed that:(1)The failure of the sandstone with the bedding angle of 45°or 60°was the structure-dominant type,while that with the bedding angle of 0°,30°or 90°was the force-dominant type.(2)When the bedding angle was in the range of(0°,30°)or(45°,90°),the confining pressure played a dominant role in influencing the peak strength.However,withinβ∈(30°,45°),the bedding effect played a dominant role in the peak strength.(3)With the increase in bedding angle,the cohesion increased first,then decreased and finally increased,while the internal friction angle was the opposite.(4)When the bedding angle was 0°or 30°,the“water wedging”effect and the“bedding buckling”effect would lead to the forking or converging shear failure.When the bedding angle was 45°or 60°,the sliding friction effect would lead to the shear slipping failure.When the bedding angle was 90°,the combination of the“bedding buckling”effect and shear effect would lead to the mixed tension-shear failure.The above conclusions obtained are helpful for the prevention of water inrush disasters in water-rich roadways with different dips in coal mines. | Junwen Zhang Zhixiang Song Lichao Zhang Shaokang Wu Shanyong Wang Yang Zhang Xukai Dong Jinxin Wang Yanbo Han Baohua Kan | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，4： | 0 |
| 19 | Insulin induces PKC-dependent proliferation of mesenteric vascular smooth muscle cells from hypertensive patients显示文摘Background and objectives Proliferation of human vascular smooth muscle cells (VSMCs) induced by hyperinsulinemia is a very common clinical pathology. Extensive research has focused on PKC (Protein kinase C)-MAPK (mitogen-activated protein kinase)intracellular signal transduction and the phenotypic modulation accompanied by reorganization of intracellular F-actins in VSMCs.Methods DNA synthesis, signaling of ERK1/2 MAPKs, and changes in α-smooth muscle (SM) actin and F-actin were studied in hypertensive and normotensive human arterial VSMCs exposed to insulin and PMA with and without the PKC inhibitor, GF109203X.Results Differences among cell types in MAPK signaling, α-SM actin, and F-actin isoforms in VSMCs harvested from the arteries of patients with essential hypertension (EH) and normotension (NT) were identified in response to insulin treatment. Proliferation and activation of MAPK were more pronounced in EH VSMCs than in NEH VSMCs. Insulin exposure decreased expression of α-SM actin and was accompanied by rearrangement of intracellular F-actins in VSMCs, especially in the EH group. These effects were reversed by treatment with the PKC inhibitor. Conclusions Human mesenteric VSMCs of EH and NT patients differed in proliferation, MAPK signaling, and degree of changes in α-SM actin and F-actin isoforms immediately following insulin exposure in vitro. | Xukai WANG Yan WANG Chenming YANG Ying WAN Xianwen JI | 2006 | Journal of Geriatric Cardiology2006，3，2： | 0 |
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