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| 1 | New insights into the roles of CHOP-induced apoptosis in ER stress显示文摘Endoplasmic 蜂窝胃应力(嗯应力) 在 ER 由于动态平衡的损失被触发,在 ER 腔导致累积 ofmisfolded 蛋白质。嗯因为 ER 的展开的蛋白质 response.Perturbation 是抄写因素 C/EBP 相应蛋白质(砍) 的强大的 inducer,应力激活知道的一系列适应机制。尽管它过时的人或物证明到 ER 的过多或不利的应力触发 apoptosis,由砍位于这些 processesinduced 下面的特定的机制仍然保持不清楚。现在,导致砍的 apoptosis 在嗯应力在众多的人的疾病被含有例如 neurodegenerative 疾病,糖尿病, ischemic 疾病,肿瘤等等。在这评论,我们从实验室在几疾病的发展总结了砍的角色的 currentunderstanding 到诊所。 | Yiming Li Yunshan Guo Juan Tang Jianli Jiang Zhinan Chen | 2014 | Acta Biochimica et Biophysica Sinica2014，46，8： | 45 |
| 2 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(https://ngdc.cncb.ac.cn/gsa/),GSA for Human(GSA-Human,https://ngdc.cncb.ac.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,https://ngdc.cncb.ac.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 3 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 4 | The Upper Devonian orbital cyclostratigraphy and numerical dating conodont zones from Guangxi,South China显示文摘The hierarchically organized laminae, bundles, bundlesets and superbundlesets which correspond to a sub-Milankovitch, obliquity or precession, eccentricity and long eccentricity cyclothems, respectively, have been distinguished from the Upper Devonian Frasnian-Famennian (F-F) transitional carbonate successions deposited in the carbonate-basin and slope facies of Guangxi, South China. The durations of cyclothems are 8000-10000a, 16667a or 33333a, 100000a and 400000a, respectively. The ratio of eccentricity to precession, eccentricity to obliquity, and long eccentricity to eccentricity is 1:6,1:3 and 1 : 4 in the Devonian,respectively. Orbital cyclostratigraphical studies show that the durations of the conodont falsiovalis Zone, transitans Zone, punctata Zone, Lower hassi Zone, Upper hassi Zone, jamieae Zone,Lower rhenana Zone, Upper rhenana Zone,linguiformis Zone, Lower triangularis Zone, Middle triangularis Zone and Upper triangularis Zone are 0.4, 0.4, 0.4, 0.3, 0.4, 0.2, 0.8, 0.6, 0.8, 0.3, 0.3and 0.3 Ma from bottom to top, respectively, and the duration of the Frasnian is 4.3 Ma. The conodont is the normal marine organism of the latest mass extinction (the latest linguiformis Zone)and the first recovery (including the whole Lower triangularis and Middle triangularis Zone) in the F-F transition. The conodont mass extinction and recovery lasted 200000-100000a and 0.6 Ma,respectively. We consider that average durations of the fossil zones calculated by reported numerical ages divided by fossil zone numbers within a stage or series or system cannot discovery complications and non-uniformity of evolutionary organisms and environments. | GONG Yiming, XU Ran, TANG Zhongdao & LI Baohua Faculty of Earth Science, China University of Geosciences, Wuhan 430074, China Laboratory of Marine Geology, Tongji University, Shanghai 200092, China | 2005 | Science China Earth Sciences2005，48，1： | 14 |
| 5 | Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data显示文摘Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs worldwide.Therefore,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference genome.As a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as pan-sequences.Of the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European pigs.One sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid metabolism.Using flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference genome.The supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for exploration of genetic diversity and promote pig breeding and biomedical research. | Xiaomeng Tian Ran Li Weiwei Fu Yan Li Xihong Wang Ming Li Duo Du Qianzi Tang Yudong Cai Yiming Long Yue Zhao Mingzhou Li Yu Jiang | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 6 | Source apportionment of PM_(2.5)and visibility in Jinan,China显示文摘Atmospheric extinction is impacted by the chemical composition of particles.To better understand the chemical composition of PM_(2.5)(particles with diameters of less than 2.5μm)and its relationship with extinction,one-month sampling campaigns were carried out in four different seasons from 2013 to 2014 in Jinan,China.The seasonal average concentrations of PM_(2.5)were 120.9(autumn),156.6(winter),102.5(spring),and 111.8μg/m^(3)(summer).The reconstructed PM_(2.5)chemical composition showed that sulfate,nitrate,chlorine salt,organic matter(OM),mineral dust,elemental carbon(EC)and others accounted for 25%,14%,2%,24%,22%,3%and 10%,respectively.The relationship between the chemical composition of PM_(2.5)and visibility was reconstructed by the IMPROVE method,and ammonium sulfate,ammonium nitrate,OM and EC dominated the visibility.Seven main sources were resolved for PM_(2.5),including secondary particles,coal combustion,biomass burning,industry,motor vehicle exhaust,soil dust and cooking,which accounted for 37%,21%,13%,13%,12%,3%and 1%,respectively.The contributions of different sources to visibility were similar to those to PM_(2.5).With increasing severity of air pollution,the contributions of secondary particles and coal combustion increased,while the contribution of motor vehicle exhaust decreased.The results showed that coal combustion and biomass burning were still the main sources of air pollution in Jinan. | Mengtian Cheng Guiqian Tang Bo Lv Xingru Li Xinrui Wu Yiming Wang Yuesi Wang | 2021 | Journal of Environmental Sciences2021，33，4： | 5 |
| 7 | Electro-conductive Nanocrystalline Cellulose Film Filled with TiO_2-ReducedGraphene Oxide Nanocomposite显示文摘Imparting electro-conductive properties to nanocellulosebased products may render them suitable for applications in electronics,optoelectronics, and energy storage devices. In the present work, an electroconductive nanocrystalline cellulose(NCC) film filled with TiO2-reducedgraphene oxide(TiO2-RGO) was developed. Initially, graphene oxide(GO) was prepared using the modified Hummers method and thereafter photocatalytically reduced using TiO2 as a catalyst. Subsequently, an electro-conductive NCC film was prepared via vacuum filtration with the as-prepared TiO2-RGO nanocomposite as a functional filler. The TiO2-RGO nanocomposite and the NCC/TiO2-RGO film were systematically characterized. The results showed that the obtained TiO2-RGO nanocomposite exhibited reduced oxygen-containing group content and enhanced electroconductivity as compared with those of GO. Moreover, the NCC film filled with TiO2-RGO nanocomposite displayed an electro-conductivity of up to 9.3 S/m and improved mechanical properties compared with that of the control. This work could provide a route for producing electro-conductive NCC films, which may hold significant potential as transparent flexible substrates for future electronic device applications. | RuoNan Zhao YanJun Tang XiaoChuang Shen XingHua Hong YiMing Zhou | 2018 | Paper And Biomaterials2018，3，4： | 5 |
| 8 | Differently implicational α-universal triple I restriction method of (1, 2, 2) type显示文摘From the viewpoints of both fuzzy system and fuzzy reasoning, a new fuzzy reasoning method which contains the α-triple I restriction method as its particular case is proposed. The previous α-triple I restriction principles are improved, and then the optimal restriction solutions of this new method are achieved, especially for seven familiar implications. As its special case, the corresponding results of α-triple I restriction method are obtained and improved. Lastly, it is found by examples that this new method is more reasonable than the α-triple I restriction method. | Yiming Tang Fuji Ren Yanxiang Chen | 2012 | Journal of Systems Engineering and Electronics2012，23，4： | 5 |
| 9 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 10 | Chemically Binding Scaffolded Anodes with 3D Graphene Architectures Realizing Fast and Stable Lithium Storage显示文摘Tree-dimensional(3D)graphene has emerged as an ideal platform to hybridize with electrochemically active materials for improved performances.However,for lithium storage,current anodic guests ofen exist in the form of nanoparticles,physically attached to graphene hosts,and therefore tend to detach from graphene matrices and aggregate into large congeries,causing considerable capacity fading upon repeated cycling.Herein,we develop a facile double-network hydrogel-enabled methodology for chemically binding anodic scafolds with 3D graphene architectures.Taking tin-based alloy anodes as an example,the doublenetwork hydrogel,containing interpenetrated cyano-bridged coordination polymer hydrogel and graphene oxide hydrogel,is directly converted to a physical-intertwined and chemical-bonded Sn−Ni alloy scafold and graphene architecture(Sn−Ni/G)dual framework.Te unique dual framework structure,with remarkable structural stability and charge-transport capability,enables the Sn−Ni/G anode to exhibit long-term cyclic life(701 mA h g^(−1) afer 200 cycles at 0.1 A g^(−1))and high rate performance(497 and 390 mA h g^(−1) at 1 and 2 A g^(−1),respectively).Tis work provides a new perspective towards chemically binding scafolded low-cost electrode and electrocatalyst materials with 3D graphene architectures for boosting energy storage and conversion. | Ping Wu Zhiwei Fang Anping Zhang Xiao Zhang Yawen Tang Yiming Zhou Guihua Yu | 2019 | Research2019，，1： | 4 |
| 11 | Automated generation and ensemble-learned matching of X-ray absorption spectra显示文摘X-ray absorption spectroscopy(XAS)is a widely used materials characterization technique to determine oxidation states,coordination environment,and other local atomic structure information.Analysis of XAS relies on comparison of measured spectra to reliable reference spectra.However,existing databases of XAS spectra are highly limited both in terms of the number of reference spectra available as well as the breadth of chemistry coverage.In this work,we report the development of XASdb,a large database of computed reference XAS,and an Ensemble-Learned Spectra IdEntification(ELSIE)algorithm for the matching of spectra.XASdb currently hosts more than 800,000 K-edge X-ray absorption near-edge spectra(XANES)for over 40,000 materials from the open-science Materials Project database.We discuss a high-throughput automation framework for FEFF calculations,built on robust,rigorously benchmarked parameters.FEFF is a computer program uses a real-space Green’s function approach to calculate X-ray absorption spectra.We will demonstrate that the ELSIE algorithm,which combines 33 weak“learners”comprising a set of preprocessing steps and a similarity metric,can achieve up to 84.2% accuracy in identifying the correct oxidation state and coordination environment of a test set of 19 K-edge XANES spectra encompassing a diverse range of chemistries and crystal structures.The XASdb with the ELSIE algorithm has been integrated into a web application in the Materials Project,providing an important new public resource for the analysis of XAS to all materials researchers.Finally,the ELSIE algorithm itself has been made available as part of veidt,an open source machine-learning library for materials science. | Chen Zheng Kiran Mathew Chi Chen Yiming Chen Hanmei Tang Alan Dozier Joshua J.Kas Fernando D.Vila John J.Rehr Louis F.J.Piper Kristin A.Persson Shyue Ping Ong | 2018 | npj Computational Materials2018，，1： | 3 |
| 12 | Preparation and Characterization of Co_(3)O_(4)/Graphene/Cellulose Nanofiber Composite Films显示文摘Nanocellulose has served as an eye-catching nanomaterial for constructing advanced functional devices with renewability,light weight,flexibility,and environmental friendliness.In this study,Co_(3)O_(4)/graphene/cellulose nanofiber(CNF)flexible composite films,in which the CNF acted as a spacer for the graphene,were prepared via a facile and scalable vacuum filtration method.The effects of the CNF on the microstructure,hydrophilicity,thermal stability,tensile strength,surface resistance,and electrochemical performance of the Co_(3)O_(4)/graphene/CNF composite films were systematically investigated.The results showed that the synergistic interaction of the CNF and graphene substantially improved the overall properties of the Co_(3)O_(4)/graphene/CNF composite films,particularly their hydrophilicity and tensile strength.Meanwhile,Co_(3)O_(4)/graphene/CNF composite films with a CNF content of 4%appeared to have the optimal electrochemical performance,with an area specific capacitance of 56 mF/cm^(2) and prominent capacitance retention of 95.6%at a current density of 1 A/g after 1000 cycles.This work demonstrated that the prepared Co_(3)O_(4)/graphene/CNF flexible composite films have great application potential in the field of flexible energy storage devices. | Zejun Ding Tianying Chen Yiming Zhou Peng Zhu Feiyun Li Yanjun Tang | 2022 | Paper And Biomaterials2022，7，2： | 2 |
| 13 | A RECTANGULAR SHELL ELEMENT FORMULATION WITH A NEW MULTI-RESOLUTION ANALYSIS显示文摘A multi-resolution rectangular shell element with membrane-bending based on the Kirchhoff-Love theory is proposed. The multi-resolution analysis(MRA) framework is formulated out of a mutually nesting displacement subspace sequence, whose basis functions are constructed of scaling and shifting on the element domain of basic node shape functions. The basic node shape functions are constructed from shifting to other three quadrants around a specific node of a basic element in one quadrant and joining the corresponding node shape functions of four elements at the specific node. The MRA endows the proposed element with the resolution level(RL) to adjust the element node number, thus modulating structural analysis accuracy accordingly. The node shape functions of Kronecker delta property make the treatment of element boundary condition quite convenient and enable the stiffness matrix and the loading column vectors of the proposed element to be automatically acquired through quadraturing around nodes in RL adjusting. As a result, the traditional 4-node rectangular shell element is a mono-resolution one and also a special case of the proposed element. The accuracy of a structural analysis is actually determined by the RL, not by the mesh. The simplicity and clarity of node shape function formulation with the Kronecker delta property, and the rational MRA enable the proposed element method to be implemented more rationally, easily and efficiently than the conventional mono-resolution rectangular shell element method or other corresponding MRA methods. | Yiming Xia Yuanxue Liu Shaolin Chen Gan Tang | 2014 | Acta Mechanica Solida Sinica2014，27，6： | 2 |
| 14 | Modulation of red-light emission from carbon quantum dots in acid-based environment and the detection of chromium(Ⅲ)ions显示文摘ⅢIn this study,the carbon quantum dots,which can emit sharp red light(R-CQDs)under optical excitation,were synthesized via simple heat treatment of wine lees.The features of the photoluminescence(PL)emission from R-CQDs in solutions with different p H values and with metal ions were examined.The intensity of the PL emission from R-CQDs depends sensitively on the p H values of the solutions with the R-CQDs.Interestingly,the p H-response of the PL intensity is reversible and can be enhanced linearly in the p H value range from 4 to 12,indicating that the R-CQDs can be applied for the p H sensor.Furthermore,the quench of the PL emission from R-CQDs can be observed when adding chromium(Ⅲ)ions into the solution with R-CQDs.This effect can be utilized for selective and quick detection of chromium(Ⅲ)ions in solutions simply via the standard PL measurement.The interesting and important findings from this work can be applied to explore more practical applications of the CQDs prepared cheaply and easily. | Ju Tang Jin Zhang Weizuo Zhang Yiming Xiao Yanli Shi Fanquan Kong Wen Xu | 2021 | Journal of Materials Science & Technology2021，，24： | 2 |
| 15 | Novel hemostatic agents based on gelatin-microbial transglutaminase mix显示文摘Hemostasis is a major challenge in surgical procedures and traumas. Conventional hemostatic methods have limited efficacy and may cause additional tissue damage. In this study, we designed a novel hemostatic agent based on the in situ gel formation of gelatin cross-linked by a novel microbial transglutaminase(mTGase), in which the amino acid sequences differed from commercial mTGases. The new hemostatic agent showed the same biochemical crosslinking chemistry as the final stages of the blood coagulation cascade while using gelatin as a 'structural' protein(rather than fibrin) and a calcium-independent mTGase as the crosslinking catalyst(rather than factor XIIIa). In rat liver hemostasis models, the hemostatic agent not only showed a similar hemostatic effect as that of SURGIFLO~(positive control), but also stronger adhesion strength and elasticity than SURGIFLO~.Therefore, this biomimetic gelatin-mTGase mix hemostatic is a novel and effective surgical sealant. | Fang Lv Xiaonan Cong Wenshu Tang Yiming Han Yu Tang Yongrui Liu Liqiang Su Mingyao Liu Mingfei Jin Zhengfang Yi | 2017 | Science China(Life Sciences)2017，60，4： | 2 |
| 16 | A Formal Model of Collaborative Discussion for Problem-Solving显示文摘 | LIU Xiaoping TANG Yiming SHEN Guanting CHEN Xin | 2012 | Chinese Journal of Electronics2012，21，3： | 1 |
| 17 | Moxa Wool in Different Purities and Different Growing Years Measured by Terahertz Spectroscopy显示文摘Moxa wool is a traditional Chinese herbal medicine,which can warm channels to dispel coldness.At present,there is no unified index to evaluate the purity and growing years of moxa wool in the market.Terpineol is one of the effective substances in the volatile oil of moxa wool.Here,we characterize the purity and growing years of moxa wool by studying terpineol.Gas chromatography-mass spectrometry(GC-MS)and high-performance liquid chromatography(HPLC)are the methods for monitoring terpineol at present,all of which have defects of complicated procedures. | Yongni Shao Di Zhu Yutian Wang Zhi Zhu Wenchao Tang Zhengan Tian Yan Peng Yiming Zhu | 2022 | Plant Phenomics2022，4，1： | 1 |
| 18 | Differently implicational universal triple Ⅰ method of (1,2,2) type显示文摘 | Tang Yiming | | 0，，： | 1 |
| 19 | Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes显示文摘Dear Editor,Obesity is caused by an imbalance between energy intake and expenditure,and has become a global epidemic with over 650 million adults affected.Adipose tissues in mammals are composed of white adipose tissue(WAT)and classical brown adipose tissue(BAT),and their balance is highly related to the occurrence of obesity.The browning of white adipocytes results in“beige”or“brite”adipocytes,which appear functionally similar to classical brown adipocytes,and can be detected in WAT deposits of animals that have been exposed to cold or other inducers(Fu et al.,2015). | Zhaomeng Cui Yang Liu Wei Wan Yuyan Xu Yehui Hu Meng Ding Xin Dou Ruina Wang Hailing Li Yongmei Meng Wei Li Wei Jiang Zengxia Li Yiming Li Minjia Tan Dengke KMa Yu Ding Jun OLiu Cheng Luo Biao Yu Qiqun Tang Yongjun Dang | 2021 | Protein & Cell2021，12，6： | 1 |
| 20 | Modeling of Quantum Effects for Ultra-thin Oxide MOS Structure With an Effective Potential显示文摘 | Yiming Li Ting-wei Tang Xinlin Wang | 2002 | IEEE Trans Electron Devices2002，1，： | 1 |
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