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| 1 | Role of contrast-enhanced ultrasonography in percutaneous radiofrequency ablation of liver metastases and efficacy evaluation显示文摘Objective: To retrospectively investigate the role of contrast-enhanced ultrasonography (CEUS) in percutaneous radiofrequency ablation (RFA) in patients with liver metastases and evaluate the therapeutic efficacy of RFA assisted by CEUS. Methods: From May 2004 to September 2010, 136 patients with 219 liver metastatic lesions received CEUS examination 1 h before RFA (CEUS group), and other 126 patients with 216 lesions without CEUS examination in the earlier period were served as a historical control group. The mean tumor size was 3.2 cm and the mean tumor number was 1.6 in the CEUS group, while 3.4 cm and 1.7 in the control group, respectively (P>0.05). The clinical characteristics, recurrence results and survival outcomes were compared between two groups. Results: In the CEUS group, two isoechoic tumors were not demonstrated on unenhanced ultrasonography (US), and 63 (47%) of 134 tumors examined with CEUS were 0.3 cm larger than with unenhanced US. Furthermore, in 18.4% of 136 patients, additional 1-3 tumors were detected on CEUS. The CEUS group showed higher early tumor necrosis and lower intrahepatic recurrence than the control group. The 3-year overall survival (OS) rate and the 3-year local recurrence-free survival (LRFS) rate in the CEUS group were 50.1% and 38.3%, in contrast to 25.3% and 19.3% in the control group, respectively (P=0.002 and P<0.001). Conclusions: CEUS provides important information for RFA treatment in patients with liver metastases and better therapeutic effect could be attained. | Jie Wu Wei Yang Shanshan Yin Jinyu Wu Wei Wu Kun Yan Minhua Chen | 2013 | Chinese Journal of Cancer Research2013，25，2： | 17 |
| 2 | Evaluation of contrast-enhanced ultrasound for diagnosis of dysplastic nodules with a focus of hepatocellular carcinoma in liver cirrhosis patients显示文摘Objective: To compare the enhancement features of dysplastic nodules with a focus of hepatocellular carcinoma(DN-HCC) versus HCC and regenerative nodules(RN) in cirrhotic patients.Methods: One hundred and ninety-three cirrhotic patients were enrolled in this study; they had 215 focal liver lesions, 1.0-3.5 cm in size, which were examined using contrast-enhanced ultrasound(CEUS) with Sono Vue?and diagnosed as HCC, RN or DN-HCC by biopsy. Samples were obtained using 18-gauge needles in the different enhanced areas. The enhancement features of DN-HCC, HCC and RN were evaluated.Results: There were 86 HCC lesions, 102 RN lesions, and 27 DN-HCC lesions diagnosed by biopsy. Of 86 HCC lesions, 87.2%(75/86) showed complete enhancement during the arterial phase, and 12.8%(11/86) had inhomogeneous enhancement, with no enhancement in the central area during the arterial phase; 100%(86/86) exhibited washout during the late phase. Of 102 RN lesions, 95.1%(97/102) had delayed or simultaneous enhancement during the arterial phase, and 4.9%(5/102) displayed slight enhancement during the arterial phase; 26.5%(27/102) exhibited washout and 73.5%(75/102) exhibited no washout during the late phase. In 27 DN-HCC lesions, only part of the lesions enhanced during the arterial phase and washed out during the late phase; the other areas had delayed or simultaneous enhancement during the arterial phase, and 29.6%(8/27) exhibited slight washout in the late phase. In 86 HCCs, the pathological feature was HCC in the enhanced area of 75 lesions, hepatocellular fatty degeneration in the slightly enhanced area of 7 lesions, and hepatocellular necrosis in the unenhanced area and HCC in the enhanced area of 4 lesions. In 102 RNs, the pathological diagnosis was hepatocyte proliferation with or without fatty degeneration. In 27 DN-HCCs, the pathological feature was HCC in the enhanced area and hepatocyte regeneration in the unenhanced area.Conclusions: CEUS is useful for the diagnosis of focal liver lesions in cirrhotic patients. CEUS can help determine the progression from RN to DN-HCC to HCC by analyzing the hemodynamics. CEUS can promote the diagnostic accuracy of a biopsy by providing more accurate information on the site of the biopsy. | Wei Wu Minhua Chen Kun Yan Yin Dai Shanshan Yin Wei Yang Zhihui Fan | 2015 | Chinese Journal of Cancer Research2015，27，1： | 15 |
| 3 | Effect of contrast-enhanced ultrasound on differential diagnosis of intrahepatic cholangiocarcinoma and arterial phase enhanced hepatic inflammatory lesions显示文摘Objective: To investigate differential diagnosis between intrahepatic cholangiocarcinoma(ICC) and arterial phase enhanced hepatic inflammatory lesions in patients without liver cirrhosis using contrast-enhanced ultrasound(CEUS).Methods: ICC and hepatic inflammatory lesions cases with CEUS and pathological diagnosis between Sep 2013 and Oct 2016 were investigated retrospectively. Imaging features of conventional ultrasound and CEUS were analyzed. The parameters of time intensity curve(TIC), including the arrival time, peak intensity(PI) in the lesions, the starting time for washout, and the intensity difference at 3 min(ΔI_3) after contrast agent infection between the lesion and the liver parenchyma, were compared between ICC and hepatic inflammatory lesions.Results: Twenty-five ICC and fifteen inflammatory patients were included in this study. Seventeen ICC(68.0%)and two inflammatory cases(13.3%) showed bile duct dilatation on conventional ultrasound. Using CEUS, three ICC cases(12.0%) were misdiagnosed as inflammatory lesions and three inflammatory lesions(20.0%) as ICC; two ICC(8.0%) and one inflammatory case(6.7%) could not be made definite diagnosis. Washout started at 34.5±3.5 s and 61.5±12.9 s for ICC and inflammatory lesions respectively(P<0.001). The intensity difference between lesion and liver parenchyma at 3 min after contrast agent injection was 10.8±3.1 dB in ICC and 4.2±2.3 dB in inflammatory group(P<0.001). The sensitivity and specificity differentiating ICC and inflammatory lesions were76% and 87% if the cut-off value of the intensity difference was 7.7 d B.Conclusions: Combined with TIC analysis, and particularly with the characteristic of the early-starting and obvious washout in ICC, CEUS can be useful in differential diagnosis between hepatic inflammatory lesions and ICC. | Shanshan Yin Qiuli Cui Kun Yan Wei Yang Wei Wu Liping Bao Minhua Chen | 2017 | Chinese Journal of Cancer Research2017，29，3： | 13 |
| 4 | One-pot synthesis of MoSe2 hetero-dimensional hybrid self-assembled by nanodots and nanosheets for electrocatalytic hydrogen evolution and photothermal therapy显示文摘我们基于铝硒化物设计了并且准备一个异种维的混血儿(HDH )(MoSe 2) nanodots (ND ) 经由一个一个壶在很少层 MoSe 2 nanosheets (NS )(MoSe 2 HDH ) 抛锚了热水的过程。MoSe 2 HDH 向氢进化反应展出优秀 electrocatalytic 活动(她的) 。这是因为在一方面,在 MoSe 2 NSs/NDs 的接口的 MoSe 2 ND 和唯一的充满缺点的结构的边丰富的特征能为她引进更活跃的地点;在另一方面,在支持的电极的表面上像薄片的 MoSe 2 NS 叠的随机可以完成有效费用运输。另外, MoSe 2 HDH 显示出好水稳定性,理想的 biocompatibility,和高度近红外线(NIR ) photothermal 变换效率。因此, MoSe 2 HDH 为癌症在 NIR photothermal 治疗(PTT ) 作为 nanomedicine 被调查。明确地, MoSe 2 HDH 能为计算断层摄影术(CT ) 和 photoacoustic 断层摄影术(PA ) 作为一根双形式的探针被使用由于它的强壮的 X 光检查变细能力和 NIR 吸收的成像。因此, MoSe 2 HDH,有进一个系统的 CT/PA 成像的联合 PTT,为指导成像的癌症 theranostics 的抓住伟人潜力。这个工作可以提供机灵的策略准备另外的异种维的分层的转变金属 dichalcogenides。 | Baoguang Mao Tao Bao Jie Yu Lirong Zheng Jinwen Qin Wenyan Yin Minhua Cao | 2017 | Nano Research2017，10，8： | 3 |
| 5 | Effects of mulches on water use in a winter wheat/summer maize rotation system in Loess Plateau, China显示文摘Limited water resources often result in reduced crop yield and low water productivity(WP). In northwestern China, crop production is generally dependent on precipitation. Therefore, a variety of agricultural rainwater harvesting(ARH) techniques have been used for conserving soil moisture, ameliorating soil environment, increasing crop yield, and improving water use efficiency. A two-year(2013–2015) field experiment was conducted under a typical sub-humid drought-prone climate in Yangling(108°24′E, 34°20′N; 521 m a.s.l.), Shaanxi Province, China, to explore the effects of mulching(same for summer maize and winter wheat) on soil moisture, soil temperature, crop water consumption, and crop yield with a winter wheat/summer maize rotation. Crops were planted in a ridge-furrow pattern and the treatments consisted of a transparent film mulch over the ridges(M1), a crop straw mulch in the furrows(M2), a transparent film mulch over the ridges and a crop straw mulch in the furrows(M3), a black film mulch over the ridges and a crop straw mulch in the furrows(M4), and a control with no mulch(CK). Results showed that M4 was the best treatment for improving soil water storage and content, and decreasing crop water consumption during the summer maize and winter wheat rotation. In both maize and wheat seasons, M1 had a higher soil temperature than M2 and CK, and M3 had a higher soil temperature than M4. In the maize seasons, M4 had the highest yield, WP, and precipitation productivity(PP), with the average values for these parameters increasing by 30.9%, 39.0%, and 31.0%, respectively, compared to those in CK. In the wheat seasons, however, M3 had the highest yield, WP, and PP, with the average values for these parameters being 23.7%, 26.7%, and 23.8% higher, respectively, than those in CK. Annual yield(maize and wheat yields combined) and WP did not differ significantly between M3 and M4. These results suggested that M3 and M4 may thus be the optimal ARH practices for the production of winter wheat and summer maize, respectively, in arid and semi-arid areas. | YIN Minhua LI Yuannong XU Yuanbo ZHOU Changming | 2018 | Journal of Arid Land2018，10，2： | 3 |
| 6 | Mussel-inspired fabrication of structurally stable chitosan/polyaerylonitrile composite membrane for pervaporation dehydration显示文摘 | Ma Jing Zhang Minhua Wu Hong Yin Xin Chen Jing Jiong Zhongyi | 2010 | Journal of Membrane Science2010，348，： | 1 |
| 7 | Intensifying esterification reaction between lactic acid and ethanol by pervaporation dehydration using chitosan-TEOS hybrid membranes 显示文摘 | Ma Jing Zhang Minhua Lu Lianyu Yin Xin Chen Jing Jiang Zhongyi | 2009 | Chemical Engineering Journal2009，155，3： | 1 |
| 8 | Effects of different ridge-furrow mulching systems on yield and water use efficiency of summer maize in the Loess Plateau of China显示文摘Ridge-furrow film mulching has been proven to be an effective water-saving and yield-improving planting pattern in arid and semi-arid regions.Drought is the main factor limiting the local agricultural production in the Loess Plateau of China.In this study,we tried to select a suitable ridge-furrow mulching system to improve this situation.A two-year field experiment of summer maize(Zea mays L.)during the growing seasons of 2017 and 2018 was conducted to systematically analyze the effects of flat planting with no film mulching(CK),ridge-furrow with ridges mulching and furrows bare(RFM),and double ridges and furrows full mulching(DRFFM)on soil temperature,soil water storage(SWS),root growth,aboveground dry matter,water use efficiency(WUE),and grain yield.Both RFM and DRFFM significantly increased soil temperature in ridges,while soil temperature in furrows for RFM and DRFFM was similar to that for CK.The largest SWS was observed in DRFFM,followed by RFM and CK,with significant differences among them.SWS was lower in ridges than in furrows for RFM.DRFFM treatment kept soil water in ridges,resulting in higher SWS in ridges than in furrows after a period of no water input.Across the two growing seasons,compared with CK,RFM increased root mass by 10.2%and 19.3%at the jointing and filling stages,respectively,and DRFFM increased root mass by 7.9%at the jointing stage but decreased root mass by 6.0%at the filling stage.Over the two growing seasons,root length at the jointing and filling stages was respectively increased by 75.4%and 58.7%in DRFFM,and 20.6%and 30.2%in RFM.Relative to the jointing stage,the increased proportions of root mass and length at the filling stage were respectively 42.8%and 94.9%in DRFFM,63.2%and 115.1%in CK,and 76.7%and 132.1%in RFM,over the two growing seasons,showing that DRFFM slowed down root growth while RFM promoted root growth at the later growth stages.DRFFM treatment increased root mass and root length in ridges and decreased them in 0-30 cm soil layer,while RFM increased them in 0-30 cm soil layer.Compared with CK,DRFFM decreased aboveground dry matter while RFM increased it.Evapotranspiration was reduced by 9.8%and 7.1%in DRFFM and RFM,respectively,across the two growing seasons.Grain yield was decreased by 14.3%in DRFFM and increased by 13.6%in RFM compared with CK over the two growing seasons.WUE in CK was non-significantly 6.8%higher than that in DRFFM and significantly 22.5%lower than that in RFM across the two growing seasons.Thus,RFM planting pattern is recommended as a viable water-saving option for summer maize in the Loess Plateau of China. | CHEN Pengpeng GU Xiaobo LI Yuannong QIAO Linran LI Yupeng FANG Heng YIN Minhua ZHOU Changming | 2021 | Journal of Arid Land2021，13，9： | 1 |
| 9 | Regulation effects of water and nitrogen on yield,water,and nitrogen use efficiency of wolfberry显示文摘Wolfberry(Lycium barbarum L.)is important for health care and ecological protection.However,it faces problems of low productivity and resource utilization during planting.Exploring reasonable models for water and nitrogen management is important for solving these problems.Based on field trials in 2021 and 2022,this study analyzed the effects of controlling soil water and nitrogen application levels on wolfberry height,stem diameter,crown width,yield,and water(WUE)and nitrogen use efficiency(NUE).The upper and lower limits of soil water were controlled by the percentage of soil water content to field water capacity(θ_(f)),and four water levels,i.e.,adequate irrigation(W0,75%-85%θ_(f)),mild water deficit(W1,65%-75%θ_(f)),moderate water deficit(W2,55%-65%θ_(f)),and severe water deficit(W3,45%-55%θ_(f))were used,and three nitrogen application levels,i.e.,no nitrogen(N0,0 kg/hm^(2)),low nitrogen(N1,150 kg/hm^(2)),medium nitrogen(N2,300 kg/hm^(2)),and high nitrogen(N3,450 kg/hm^(2))were implied.The results showed that irrigation and nitrogen application significantly affected plant height,stem diameter,and crown width of wolfberry at different growth stages(P<0.01),and their maximum values were observed in W1N2,W0N2,and W1N3 treatments.Dry weight per plant and yield of wolfberry first increased and then decreased with increasing nitrogen application under the same water treatment.Dry weight per hundred grains and dry weight percentage increased with increasing nitrogen application under W0 treatment.However,under other water treatments,the values first increased and then decreased with increasing nitrogen application.Yield and its component of wolfberry first increased and then decreased as water deficit increased under the same nitrogen treatment.Irrigation water use efficiency(IWUE,8.46 kg/(hm^(2)·mm)),WUE(6.83 kg/(hm^(2)·mm)),partial factor productivity of nitrogen(PFPN,2.56 kg/kg),and NUE(14.29 kg/kg)reached their highest values in W2N2,W1N2,W1N2,and W1N1 treatments.Results of principal component analysis(PCA)showed that yield,WUE,and NUE were better in W1N2 treatment,making it a suitable water and nitrogen management mode for the irrigation area of the Yellow River in the Gansu Province,China and similar planting areas. | GAO Yalin QI Guangping MA Yanlin YIN Minhua WANG Jinghai WANG Chen TIAN Rongrong XIAO Feng LU Qiang WANG Jianjun | 2024 | Journal of Arid Land2024，16，1： | 0 |
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