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| 1 | Olfactory ecto-mesenchymal stem cell-derived exosomes ameliorate murine Sjögren’s syndrome by modulating the function of myeloid-derived suppressor cells显示文摘Sjögren’s syndrome(SS)is a systemic autoimmune disease characterized by progressive inflammation and tissue damage in salivary glands and lacrimal glands.Our previous studies showed that myeloid-derived suppressor cells(MDSCs)exhibited impaired immunosuppressive function during disease progression in patients with SS and mice with experimental Sjögren’s syndrome(ESS),but it remains unclear whether restoring the function of MDSCs can effectively ameliorate the development of ESS.In this study,we found that murine olfactory ecto-mesenchymal stem cell-derived exosomes(OE-MSC-Exos)significantly enhanced the suppressive function of MDSCs by upregulating arginase expression and increasing ROS and NO levels.Moreover,treatment with OE-MSC-Exos via intravenous injection markedly attenuated disease progression and restored MDSC function in ESS mice.Mechanistically,OE-MSC-Exo-secreted IL-6 activated the Jak2/Stat3 pathway in MDSCs.In addition,the abundant S100A4 in OE-MSC-Exos acted as a key factor in mediating the endogenous production of IL-6 by MDSCs via TLR4 signaling,indicating an autocrine pathway of MDSC functional modulation by IL-6.Taken together,our results demonstrated that OE-MSC-Exos possess therapeutic potential to attenuate ESS progression by enhancing the immunosuppressive function of MDSCs,possibly constituting a new strategy for the treatment of Sjögren’s syndrome and other autoimmune diseases. | Ke Rui Yue Hong Qiugang Zhu Xiaofei Shi Fan Xiao Hailong Fu Qing Yin Yida Xing Xinfeng Wu Xiaodan Kong Huaxi Xu Jie Tian Shengjun Wang Liwei Lu | 2021 | Cellular & Molecular Immunology2021，18，2： | 12 |
| 2 | Adsorption of 17β-estradiol from aqueous solution by raw and direct/pre/post-KOH treated lotus seedpod biochar显示文摘Five biochars derived from lotus seedpod(LSP)were applied to examine and compare the adsorption capacity of 17β-estradiol(E2)from aqueous solution.The effect of KOH activation and the order of activation steps on material properties were discussed.The effect of contact time,initial concentration,p H,ionic strength and humic acid on E2 adsorption were investigated in a batch adsorption process.Experimental results demonstrated that the pseudo second-order model fitted the experimental data best and that adsorption equilibrium was reached within 20 hr.The efficiency of E2 removal increased with increasing E2 concentration and decreased with the increase of ionic strength.E2 adsorption on LSP-derived biochar(BCs)was influenced little by humic acid,and slightly affected by the solution p H when its value ranged from 4.0 to 9.0,but considerably affected at p H 10.0.Low environmental temperature is favorable for E2 adsorption.Chemisorption,π–πinteractions,monolayer adsorption and electrostatic interaction are the possible adsorption mechanisms.Comparative studies indicated that KOH activation and the order of activation steps had significant impacts on the material.Post-treated biochar exhibited better adsorption capacity for E2 than direct treated,pretreated,and raw LSP biochar.Pyrolyzed biochar at higher temperature improved E2 removal.The excellent performance of BCs in removing E2 suggested that BCs have potential in E2 treatment and that the biochar directly treated by KOH would be a good choice for the treatment of E2 in aqueous solution,with its advantages of good efficiency and simple technology. | Ni Liu Yunguo Liu Guangming Zeng Jilai Gong Xiaofei Tan Jun Wen Shaobo Liu Luhua Jiang Meifang Li Zhihong Yin | 2020 | Journal of Environmental Sciences2020，32，1： | 4 |
| 3 | Growth inhibition and oxidative damage of Microcystis aeruginosa induced by crude extract of Sagittaria trifolia tubers显示文摘Aquatic macrophytes are considered to be promising in controlling harmful cyanobacterial blooms. In this research, an aqueous extract of Sagittaria trifolia tubers was prepared to study its inhibitory effect on Microcystis aeruginosa in the laboratory. Several physiological indices of M. aeruginosa, in response to the environmental stress, were analyzed. Results showed that S. trifolia tuber aqueous extract significantly inhibited the growth of M. aeruginosa in a concentration-dependent way. The highest inhibition rate reached 90% after 6 day treatment. The Chlorophyll-a concentration of M. aeruginosa cells decreased from 343.1 to314.2 μg/L in the treatment group. The activities of superoxide dismutase and peroxidase and the content of reduced glutathione in M. aeruginosa cells initially increased as a response to the oxidative stress posed by S. trifolia tuber aqueous extract, but then decreased as time prolonged. The lipid peroxidation damage of the cyanobacterial cell membranes was reflected by the malondialdehyde level, which was notably higher in the treatment group compared with the controls. It was concluded that the oxidative damage of M. aeruginosa induced by S.trifolia tuber aqueous extract might be one of the mechanisms for the inhibitory effects. | Jiang Li Yunguo Liu Pingyang Zhang Guangming Zeng Xiaoxi Cai Shaobo Liu Yicheng Yin Xinjiang Hu Xi Hu Xiaofei Tan | 2016 | Journal of Environmental Sciences2016，28，5： | 3 |
| 4 | Geochemical characteristics of hadal sediment in the northern Yap Trench显示文摘Two sediment cores were retrieved in the hadal zone of the Yap Trench,and their concentrations of six major elements Mg,Al,Ca,Ti,Mn and Fe and nine trace elements Sr,Ba,Pb,V,Cr,Co,Ni,Cu and Zn were determined in inductively coupled plasma atomic emission spectrometry(ICP-AES).According to the vertical distribution profiles of the 15 elements,the correlation of their concentrations,the ratios of Ni/Co,V/Cr,Fe/Al,and Ti/Al,and morphological characteristics of the sediment samples,the implications of the depositional environment and the sediment provenance were analyzed.The results show that the ratio of Ni/Co in all depths of the two sediment cores were below 5,and the ratio of V/Cr were lower than 2,indicating that the depositional environment of the hadal zone in the trench was oxidative and might have inflow of the Antarctic bottom oxygen-rich water.The sediment samples on the eastern side of the trench were siliceous mud mainly composed of diatoms,radiolarian,and sponge needles from surface to deep layer.The vertical profile of the elements,the concentration of TOC and the fossil record indicated that the sediment sample from station Dive113 was well mixed from surface to bottom layer.Based on the correlation of concentrations of the elements,the morphological characteristics of the sediment,and the ratios of Fe/Al and Ti/Al,we inferred that the sediment in the hadal zone of the trench had terrestrial,volcanic,biological,and authigenic sources.Major source of the sediment in the eastern side of the trench were terrestrial;whereas the sediment in the western side of the trench received more volcaniclastic input. | HUANG Yuhuan SUN Chengjun YANG Guipeng YUE Xin’an JIANG Fenghua CAO Wei YIN Xiaofei GUO Chaonan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 3 |
| 5 | In situ nitrogen removal processes in intertidal wetlands of the Yangtze Estuary显示文摘Estuarine and intertidal wetlands are important sites for nitrogen transformation and elimination.However,the factors controlling nitrogen removal processes remain largely uncertain in the highly dynamic environments.In this study,continuous-flow experiment combined with 15 N isotope pairing technique was used to investigate in situ rates of denitrification and anaerobic ammonium oxidation(anammox)and their coupling with nitrification in intertidal wetlands of the Yangtze Estuary.The measured rates varied from below the detection limit to 152.39μmol N/(m^2·hr)for denitrification and from below the detection limit to 43.06μmol N/(m^2·hr)for anammox.The coupling links of nitrogen removal processes with nitrification were mainly dependent on nitrate,organic carbon,sulfide,dissolved oxygen and ferric iron in the estuarine and intertidal wetlands.Additionally,it was estimated that the actual nitrogen removal processes annually removed approximately 5%of the terrigenous inorganic nitrogen discharged into the Yangtze Estuary.This study gives new insights into nitrogen transformation and fate in the estuarine and intertidal wetlands. | Cheng Liu Lijun Hou Min Liu Yanling Zheng Guoyu Yin Hongpo Dong Xia Liang Xiaofei Li Dengzhou Gao Zongxiao Zhang | 2020 | Journal of Environmental Sciences2020，32，7： | 2 |
| 6 | Removal of phosphate by mesoporous ZrO 2显示文摘 | Honglei Liu Xiaofei Sun Chengqing Yin Chun Hu | 2007 | Journal of Hazardous Materials2007，，2： | 2 |
| 7 | Assessment of strong earthquake risk in the Chinese mainland from 2021 to 2030显示文摘The long-term earthquake prediction from 2021 to 2030 is carried out by researching the active tectonic block boundary zones in the Chinese mainland.Based on the strong earthquake recurrence model,the cumulative probability of each target fault in the next 10 years is given by the recurrence period and elapsed time of each fault,which are adopted from relevant studies such as seismological geology,geodesy,and historical earthquake records.Based on the long-term predictions of large earthquakes throughout the world,this paper proposes a comprehensive judgment scheme based on the fault segments with the seismic gap,motion strongly locked,sparse small-moderate earthquakes,and apparent Coulomb stress increase.This paper presents a comprehensive analysis of the relative risk for strong earthquakes that may occur in the coming 10 years on the major faults in the active tectonic block boundary zones in the Chinese mainland.The present loading rate of each fault is first constrained by geodetic observations;the cumulative displacement of each fault is then estimated by the elapsed time since the most recent strong earthquake. | Zhigang Shao Yanqiang Wu Lingyun Ji Faqi Diao Fuqiang Shi Yujiang Li Feng Long Hui Zhang Wuxing Wang Wenxin Wei Peng Wang Xiaoxia Liu Qi Liu Zhengyang Pan Xiaofei Yin Yue Liu Wei Feng Zhenyu Zou Jia Cheng Renqi Lu Yueren Xu Xi Li | 2023 | Earthquake Research Advances2023，3，1： | 2 |
| 8 | The study of the adductor muscle-shell interface structure in three Mollusc species显示文摘The adductor muscle scar(AMS) is the fixation point of adductor muscle to the shell. It is an important organicinorganic interface and stress distribution area. Despite recent advances, our understanding of the structure and composition of the AMS remain limited. Here, we report study on the AMS of three bivalves: Mytilus coruscus,Chlamys farreri and Ruditapes philippinarum. Results showed that there were significant differences among their AMS structures. Both M. coruscus and C. farreri were found to have a columnar layer above the nacreous platelet shell structure at the AMS and this layer was more organized in M. coruscus. There was no distinguishable twolayer structure in R. philippinarum. Atomic force microscopy(AFM) and Fourier transform infrared spectroscopy(FT-IR) results showed that the AMS was much smoother than the nacreous inner shell in all the three species and the AMS had minor different compositions from the nacreous shell layer. SDS-PAGE(sodium dodecyl-sulfate polyacrylamide gel electophoresis) study of the proteins isolated from the interface indicated that there was a 70 k Da protein which seemed to be specifically located to the highly organized columnar AMS structure in Mytilus coruscus. Further analysis of this protein showed it contained high level of Asx(Asp+Asn), Glx(Glu+Gln) and Gly.The special structure and composition of the AMS might play important roles in the stability, adhesion and function at this stress distribution site. | ZHU Yaoyao SUN Chengjun SONG Yingfei JIANG Fenghua YIN Xiaofei TANG Min DING Haibing | 2016 | Acta Oceanologica Sinica2016，35，8： | 1 |
| 9 | Template synthesized molecularly imprinted polymer nanotube membranes for chemical separations显示文摘 | Wang Hai - juan Zhou Wen - hui Yin Xiaofei | 2006 | J Am Chem Soc2006，128，15： | 1 |
| 10 | Evaluation of the Efficacy of Laparoscopic Resection for the Management of Exogenous Cesarean Scar Pregnancy显示文摘 | guangwei Wang xiaofei Liu fangfang Bi lili Yin rina Sa dandan Wang qing Yang | 2014 | Fertility and Sterility2014，，： | 1 |
| 11 | 长征八号运载火箭减载效果评估及验证显示文摘LM-8 inherited mature modules from other launch vehicles,adapting the overall design through the combination of engine throttling,wind compensation and load relief control,so as to reduce the aerodynamic load during flight.This paper proposes a rapid evaluation method for load relief performance,which takes launch vehicle’s characteristics,wind field,control parameters,aerodynamic deviation and structure deviation into consideration,and provides a quick estimation method for load relief performance.The load relief performance of the LM-8 launch vehicle estimated by this method achieved 10%-20%in pitch and 20%-40%in yaw.The specific results are related to parameter deviation,the altitude of wind shear and the relationship between wind direction and trajectory angle.Simulation results for a typical case with six degrees of dynamic freedom of flight proves that the comprehensive load relief performance would be between 14%to 34%,which is in line with the aforementioned method.In addition,simulation results indicate that the more severe the wind shear is,the better performance of load relief can be achieved. | ZHAO Yongzhi CHEN Xiaofei LIU Yin LI Jinglin | 2021 | Aerospace China2021，22，2： | 1 |
| 12 | Synthesis of magnetic molecularly imprinted polymer nanowires using a nanoporous alumina template显示文摘 | Li Yong Yin Xiaofei Chen Fa-Rong | 2006 | Macromotecules2006，39，13： | 1 |
| 13 | Vertical variations of dissolved carbohydrates in the North Yap Trench显示文摘The concentrations of dissolved monosaccharides(MCHO),polysaccharides(PCHO),and total carbohydrates(TCHO)in the seawater samples collected from the north of the Yap Trench in the western Pacific Ocean were measured by 2,4,6-tripyridine-s-triazine(TPTZ)spectrophotometry method.The results show that the concentrations of MCHO,PCHO,and TCHO ranged from 4.6 to 22.1μmol C/L,3.5 to 27.3μmol C/L,and 13.8 to 36.3μmol C/L,respectively.In different sampling stations,the concentrations of MCHO,PCHO,and TCHO with water depth showed complex variation patterns.In the study area,the maximum concentrations of MCHO,PCHO,and TCHO occurred in the euphotic layer and the minimum concentrations occurred in mesopelagic seawater layer.Generally,the concentrations of MCHO,PCHO,and TCHO decreased with water depth from the euphotic layer to the hadal zone.The average value of PCHO/TCHO was higher than the average value of MCHO/TCHO,indicating that PCHO was the main component of TCHO in north of the Yap Trench. | GUO Chaonan SUN Chengjun YANG Guipeng ZHANG Honghai CHEN Yan YIN Xiaofei JIANG Fenghua HUANG Yuhuan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 1 |
| 14 | Targeting TM4SF1 exhibits therapeutic potential via inhibition of cancer stem cells显示文摘Dear Editor,Cancer stem cells(CSCs)are thought to be responsible for cancer initiation,growth,recurrence,metastasis,and drug resistance.1 Therefore,targeting CSCs is an effective therapeutic approach for cancer.2 However,there are few CSC-specific targets with functional extracellular domains for the development of antibody drugs.3 Our published paper demonstrated that transmembrane 4 L six family member 1(TM4SF1)coupled discoidin domain receptor tyrosine kinase 1(DDR1)under collagen I stimulation activated JAK2-STAT3 signaling.This noncanonical DDR1 signaling sustained the manifestation of CSC traits by inducing SOX2 and NANOG expression and drove multiorgan metastases. | Guang Chen Xiaofei She Yanxin Yin Junxian Ma Yaqun Gao Hua Gao Huanlong Qin Jianmin Fang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 1 |
| 15 | Degradation potential and diversity of oil-degrading bacteria isolated from the sediments of the Jiaozhou Bay, China显示文摘A great deal of oil contaminated the shoreline by the Qingdao oil pipeline explosion in 2013. The four oildegrading consortia were enriched from sediment samples with crude oil as sole carbon and energy sources. The biodiversity and community analysis showed that the Luteibacter, Parvibaculum and a genus belonging to Alcanivoracaceae were found predominant bacteria in the four consortia, which belonged to Proteobacteria. Nine strains exhibiting distinct 16S rRNA gene sequences were isolated from the consortia. These strains were identified to eight genera based on 16S rRNA gene sequences. Five of the nine strains degraded more than 30% of the crude oil in two weeks by gravimetric method. From the analysis of GC-MS, most of the isolated strains tended to degrade n-alkanes rather than PAHs. Five strains showed high degrading ability of the total n-alkanes. Only Strain D2 showed great PAHs degrading ability and the degrading rates ranged from 34.9% to 77.5%. The sequencing analysis of the oil-degrading consortia confirmed that the genus of Alcanivorax was one of the dominant bacteria in Consortia A and E and Strain E4 might be one of the dominant bacteria. The strains obtained in this study demonstrated the potential for oil bioremediation in oil-contaminated beach ecosystems. | Wei Gao Xiangxing Gao Tiezhu Mi Bin Han Yiran Zhang Xinzi Li Xiaofei Yin Chengjun Sun Qian Li Zhisong Cui Xiao Luan Zhigang Yu Li Zheng | 2019 | Acta Oceanologica Sinica2019，38，6： | 1 |
| 16 | Removal of phos- phate by mesoporous ZrO2 显示文摘 | Liu Honglei Sun Xiaofei Yin Chengqing | 2008 | Journal of Hazardous Materials2008，151，23： | 1 |
| 17 | Biogenic amine and quality changes in lightly salt- and sugar-salted black carp (Mylopharyngodon piceus) fillets stored at 4℃ 显示文摘 | Fan Hongbing Luo Yongkang Yin Xiaofei | 2014 | Food Chern2014，159，： | 1 |
| 18 | Effects of salt concentration on biogenic amine formation and quality changes in grass carp (Ctenopharyngodon idellus) fillets stored at 4 and 20 ℃显示文摘 | Wang Hang Lou Yongkang Yin Xiaofei | 2014 | J Food Protect2014，77，5： | 1 |
| 19 | Adaptive evolution of rbcL in Reaumuria soon garica(Tamaricaceae)显示文摘In the field of phylogenetic analyses, the rbc L gene encoded large subunit Ribulose-1,5-biphosphate carboxylase/oxygenase(Rubisco, EC4.1.1.39), which plays a crucial role in the process of photosynthesis for most terrestrial plants, has been considered to be conserved; however, recent controversy regarding rbc L conservation has appeared since it was proposed to be under natural selection within all principal lineages of land plants. In this study, by examining the variation of DNA and protein sequences among 17 species in the family Tamaricaceae, three nonsynonymous mutations were identified to be under positive selection. The favored sites were located in the alph-helix domains of Rubisco, with decreased hydrophobicity and increased entropy, which could facilitate CO2 penetration into the active site of Rubisco. We also found that the expression level of rbc L in different genotypes of Reaumuria soongarica shifted in response to various stresses such as drought, temperature, salt, and light. This study not only sheds light on the functional/structural features of Rubisco in the evolution scenarios from C3-like into C4 in Tamaricaceae but also provides useful information on directing genetic performance to enhance photosynthesis efficiency of desert plants for sustaining fragile desert ecosystems; furthermore, it promotes the ability to cope with desert aridification and global warming. | ChaoJu Qian MengHe Gu HengXia Yin Yong Shi ChengLiang Yin Xia Yan XiaoFei Ma | 2017 | Research in Cold and Arid Regions2017，9，1： | 1 |
| 20 | Grape seed and clovebud extracts as natural antioxidants in silver carp( Hypo-phthalmichthys molitrix) fillets during chilled storage:Effect on lipid and protein oxidation 显示文摘 | Ce Shi Jianyun Cui Xiaofei Yin etal | 2014 | Food Control2014，40，： | 1 |
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