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| 1 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis显示文摘Aim Cerebral venous sinus thrombosis(CVST)is a less common cerebrovascular disease that predominantly affects young patients.The incidence of CVST is 2-5/10000000/year,accounting for 0.5%-1%of all stroke.To reduce mortality and morbidity associated with CVST,Chinese Stroke Association commissioned the authors to write the current guideline on the management of CVST.Methods PubMed(MEDLINE),CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July 2019.Data were synthesised by evidence tables.Each recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow Committees.Levels of evidence grading algorithm of Chinese Stroke Association was used to grade each recommendation.results This guideline mainly focuses on the diagnostic evaluation,therapeutic strategies and secondary prevention of CVST.CT/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected CVST.Anticoagulation therapy with low-molecular weight heparin should be initiated in patients with CVST immediately.After the acute stage,warfarin is recommended for 3-6 months to prevent the recurrence of CVST and other venous thromboembolic events.Conclusions The guideline summarises the current evidence regarding the management of CVST,and provides references for diagnosis,treatment and secondary prevention of CVST in China. | Yuhua Fan Jian Yu Hongbing Chen Jian Zhang Jiangang Duan Dapeng Mo Wenhao Zhu Bo Wang Fubing Ouyang Yicong Chen Linfang Lan Jinsheng Zeng Chinese Stroke Association Stroke Council CVST Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020,5,2: | 14 |
| 2 | Waste oyster shell as a kind of active filler to treat the combined wastewater at an estuary显示文摘Estuaries have been described as one of the most difcult environments on Earth. It is difcult to know how to treat the combined wastewater in tidal rivers at the estuary, where the situation is very diferent from ordinary fresh water rivers. Waste oyster shell was used as the active filler in this study in a bio-contact oxidation tank to treat the combined wastewater at the Fengtang Tidal River. With a middle-experimental scale of 360 m3/day, the average removal efciency of COD, BOD, NH3-N, TP and TSS was 80.05%, 85.02%,86.59%, 50.58% and 85.32%, respectively, in this bio-contact oxidation process. The living microbes in the biofilms on the waste oyster shell in this bio-contact oxidation tank, which were mainly composed of zoogloea, protozoa and micro-metazoa species, revealed that waste oyster shell as the filler was suitable material for combined wastewater degradation. This treatment method using waste oyster shell as active filler was then applied in a mangrove demonstration area for water quality improvement near the experiment area, with a treatment volume of 5 × 103m3/day. Another project was also successfully applied in a constructed wetland, with a wastewater treatment volume of 1 × 103m3/day. This technology is therefore feasible and can easily be applied on a larger scale. | Hongbing Luo Gu Huang Xiaoying Fu Xiaoling Liu Daocai Zheng Jian Peng Ke Zhang Bo Huang Liangqian Fan Fenghui Chen Xiubo Sun | 2013 | Journal of Environmental Sciences2013,25,10: | 11 |
| 3 | Origin and evolution of oilfield brines from Tertiary strata in western Qaidam Basin:Constraints from ^(87)Sr/^(86)Sr,δD,δ^(18)O,δ^(34)S and water chemistry显示文摘Chemistry of major and minor elements,87Sr/86Sr,δD,δ18O and δ34S of brines were measured from Tertiary strata and Quaternary salt lakes in the western Qaidam Basin.The water chemistry data show that all oilfield brines are CaCl2 type.They were enriched in Ca2+,B3+,Li+,Sr2+,Br-,and were depleted in Mg2+,SO42-,which indicated that these brines had the characteristics of deeply circulated water.The relationship between δD and δ18O shows that all data of these brines decline towards the Global Meteoric Water Line(GWL) and Qaidam Meteoric Water Line(QWL),and that the intersection between oilfield brines and Meteoric Water Lines was close to the local spring and fresh water in the piedmont in the western Qaidam Basin.The results suggest that oilfield brines has initially originated from meteoric water,and then might be affected by water-rock metamorphose,because most oilfield brines distribute in the range of metamorphosing water.The 87Sr/86Sr values of most oilfield brines range from 0.71121 to 0.71194,and was less than that in salt lake water(>0.712),but close to that of halite in the study area.These imply that salt dissolution occurred in the process of migration.In addition,all oilfield brines have obviously much positive δ34S values(ranging from 26.46‰ to 54.57‰) than that of salt lake brines,which was caused by bacterial sulfate reduction resulting in positive shift of δ34S value and depleteed SO42-in oilfield brines.Combined with water chemical data and δD,δ18O,87Sr/86Sr,δ34S values,we concluded that oilfield brines mainly originate from the deeply circulated meteoric waters,and then are affected by salt dissolution,water-rock metamorphose,sulfate reduction and dolomitization during the process of migration.These processes alter the chemical compositions of oilfield brines and accumulate rich elements(such as B,Li,Sr,Br,K and so on) for sustainable utilization of salt lake resources in the Qaidam Basin. | FAN Qishun MA Haizhou LAI Zhongping TAN Hongbing LI Tingwei | 2010 | Chinese Journal Of Geochemistry2010,29,4: | 10 |
| 4 | A highly durable catalyst based on CoxMn3-xO4 nanosheets for low-temperature formaldehyde oxidation显示文摘为不稳定的有机化合物(VOC ) 的氧化的划算的催化剂对精力变换应用和环境保护批评。这个过程的主要瓶颈是能氧化的有效、稳定、划算的催化剂的发展在低温度的 HCHO。这里,一致地由锰钴氧化物 nanosheet 数组组成的先进材料在一件碳纺织品上盖住被与帖子退火相结合的一个简单阳极的电极淀积方法成功地制作处理,和罐头直接为 HCHO 作为高效的催化材料被使用消除。得益于增加的表面氧种类和改进氧化还原作用性质,同样准备的锰钴氧化物 nanosheets 为 HCHO 氧化显示出实质地更高的催化活动。催化剂完全在象 100 一样低的温度把 HCHO 变换成公司 2 | Yongchao Huang Kaihang Ye Haibo Li Wenjie Fan FengyiZhao Yuanming Zhang Hongbing Ji | 2016 | Nano Research2016,9,12: | 10 |
| 5 | Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia显示文摘Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations(AVHs) in schizophrenia(SZ) remains unclear. In this study, we used stochastic dynamic causal modeling(s DCM) to quantify connections among the left dorsolateral prefrontal cortex(inner speech monitoring), auditory cortex(auditory processing), hippocampus(memory retrieval), thalamus(information filtering), and Broca's area(language production) in 17 first-episode drug-na?¨ve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging.Finally, we performed receiver operating characteristic(ROC) analysis and correlation analysis between image measures and symptoms. s DCM revealed an increasedsensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca's area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVHspecific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence. | Baojuan Li Long-Biao Cui Yi-Bin Xi Karl J.Friston Fan Guo Hua-Ning Wang Lin-Chuan Zhang Yuan-Han Bai Qing-Rong Tan Hong Yin Hongbing Lu | 2017 | Neuroscience Bulletin2017,33,3: | 8 |
| 6 | Monitoring result analyses of high slope of five-step ship lock in the Three Gorges Project显示文摘The construction of the double-lane fi ve-step ship lock of the Three Gorges Project(TGP)was commenced in 1994,the excavation of the ship lock was completed by the end of 1999,and the ship lock was put in operation in June 2003.The side slopes of the ship lock are characterized by great height(170 m),steepness(70 m in height of upright slope),and great length(over 7000 m in total length).In association with the ship lock,the surrounding rocks in slope have a high potential to deform,with which the magnitude of deformation is restricted.Monitoring results show that the deformation of the fi ve-step ship lock high slopes of the TGP primarily occurred in excavation period,and deformation tended to be stable and convergent during operation period,suggesting the allowable ranges of deformation.At present,the slopes and lock chambers are stable,and the ship lock works well under normal operation condition,enabling the social and economic bene fi ts of the TGP. | Qixiang Fan Hongbing Zhu Jun Gen | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015,7,2: | 4 |
| 7 | Key issues in rock mechanics of the Three Gorges Project in China显示文摘The Three Gorges Project is one of the essential key projects for flood controlling and water resources regulation in the Yangtze River.The project includes a river-crossing dam,underground powerhouses,and navigation structures.Because of the huge size and complicated construction technologies,the project faced a series of challenging engineering issues.In terms of rock mechanics,there are many key technical issues,including the sliding resistance and stability of the dam section along the foundations of powerhouses No.1-5,the slope stability of the double-line five-stage shiplock,excavation of large-scale underground powerhouses,and curtain grouting under the dam.With decades of scientific research and 16 years of practical construction experiences and reservoir operations,these key technical issues in construction of the Three Gorges Project are successfully resolved,which will attribute to the development of hydropower technology.On the basis of the monitoring data during construction and normal operation periods of the Three Gorges Project,this paper presents a systematic analysis of these key rock mechanical issues in terms of behaviors,solutions,dynamic controlling,monitoring arrangement and integrated assessment. | Qixiang Fan Hongbing Zhu Xuchun Chen | 2011 | Journal of Rock Mechanics and Geotechnical Engineering2011,3,4: | 2 |
| 8 | Predicted methylation landscape of all CpG islands on the human genome显示文摘CpG island methylation plays important role in various biological processes. To investigate methylation landscape of all CpG islands on the human genome, we develop a model for predicting the CpG island methylation status. This model outperforms other existing methods. We apply the model on the whole human genome and predict the landscape of DNA methylation of all CpG islands. Based on the methylation profile, we find that about 31% of CpG islands are methylation-prone and CpG islands located in promoter regions are seldom methylated. There is no significant difference in the CpG island methylation level between R and G bands among the chromosomes. The occupancy of RNA polymerase II is significantly higher in methylation-resistant promoter CpG islands, indicating that genes with such promoter CpG islands tend to be more active. | FAN ShiCai ZOU JianXiao XU HongBing ZHANG XueGong | 2010 | Chinese Science Bulletin2010,55,22: | 2 |
| 9 | Potentially functional genetic variants in microRNA processing genes and risk of HBV‐related hepatocellular carcinoma显示文摘 | Li Liu Jiaze An Jibin Liu Juan Wen Xiangjun Zhai Yao Liu Shandong Pan Jie Jiang Yang Wen Zheng Liu Yixin Zhang Jianguo Chen Jinliang Xing Guozhong Ji Hongbing Shen Zhibin Hu Zhining Fan | 2013 | Mol Carcinog2013,,1: | 1 |
| 10 | Poly(vinyl alcohol)/sodium alginate/layered silicate based nanofibrous mats for bacterial inhibition显示文摘 | Wei Li Xueyong Li Yang Chen Xiaoxia Li Hongbing Deng Ting Wang Rong Huang Gang Fan | 2013 | Carbohydrate Polymers2013,,2: | 1 |
| 11 | Curcumin enhances the radiosensitivity in nasopharyngeal carcinoma cellsinvolving the reversal of differentially expressed long non-coding RNAs显示文摘 | Qirui Wang Haoning Fan Ying Liu Zhixin Yin Hongbing Cai Jie Liu Zhiyuan Wang Meng Shao Xuegang Sun Jianxin Diao Yuanliang Liu Li Tong Qin Fan | 2014 | International Journal of Oncology2014,,3: | 1 |
| 12 | Wiener filtering and LMS algorithm of periodicnonuniformly sampled stochastic sequence显示文摘 | Fan Laiyao Zhang Congxia and Ji Hongbing | 1995 | Electronics Letters1995,31,17: | 1 |
| 13 | Micro RNA let‐7e is associated with the pathogenesis of experimental autoimmune encephalomyelitis显示文摘 | Hongbing Guan Daping Fan Davit Mrelashvili Haiping Hao Narendra P. Singh Udai P. Singh Prakash S. Nagarkatti Mitzi Nagarkatti | 2012 | Eur J Immunol2012,,1: | 1 |
| 14 | Wiener Filtering and LMS Algorithm of Periodicnonuniformly Sampled Stochastic Sequence显示文摘 | Fan Laiyao Zhang Congxia Ji Hongbing | 1995 | Electronics Letters IEE1995,31,20: | 1 |
| 15 | Phase equilibria of pseudo-binary systems LiF-CaAlF5 and LiFSrAlF5显示文摘 | Chen Hongbing Fan Shiji Xia Haiping | 2001 | J Crystal Growth2001,235,14: | 1 |
| 16 | Minimal regular 2-graphs and applications显示文摘A 2-graph is a hypergraph with edge sizes of at most two. A regular 2-graph is said to be minimal if it does not contain a proper regular factor. Let f2(n) be the maximum value of degrees over all minimal regular 2-graphs of n vertices. In this paper, we provide a structure property of minimal regular 2-graphs, and consequently, prove that f2(n) = n+3-i/3where 1 ≤i≤6, i=n (mod 6) andn≥ 7, which solves a conjecture posed by Fan, Liu, Wu and Wong. As applications in graph theory, we are able to characterize unfactorable regular graphs and provide the best possible factor existence theorem on degree conditions. Moreover, f2(n) and the minimal 2-graphs can be used in the universal switch box designs, which originally motivated this study. | FAN Hongbing, LIU Guizhen & LIU Jiping Department of Physics and Computer Science, Wilfrid Laurier University, Waterloo, ON., N2L 3C5 Canada School of Mathematics and System Science, Shandong University, Jinan 250100, China Department of Mathematics and Computer Science, University of Lethbridge, Lethbridge, AB., T1K 3M4, Canada | 2006 | Science China Mathematics2006,49,2: | 1 |
| 17 | On reconstructible local subgraphs显示文摘 | Xie Litong Fan Hongbing | 1996 | Advances in Mathematics1996,25,1: | 1 |
| 18 | Formal Specification of Role Assignment for Open Multi Agent System显示文摘 | WANG Hongbing FAN Zhihua SHE Chundong | 2007 | Chinese Journal of Electronics2007,16,2: | 1 |
| 19 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022,65,1: | 1 |
| 20 | HyperDB:A Hyperspectral Land Class Database Designed for an Image Processing System显示文摘Hyperspectral remote sensing is becoming more and more important amongst remote sensing techniques. In this paper, we present a hyperspectral database(Hyper DB) designed to cooperate with an embedded hyperspectral image processing system developed by the authors. Hyperspectral data are recognized and categorized by their land coverage class and band information, and can be imported from various sources such as airborne and spaceborne sensors carried by airplanes or satellites, as well as handhold instruments based on in situ ground observations. Spectral library files can be easily stored, indexed, viewed, and exported. Since Hyper DB follows standard design principles—independence, data safety, and compatibility—it satisfies the practical demand for managing categorized hyperspectral data, and can be readily expanded to other peripheral applications. | Yizhou Fan Ding Ni Hongbing Ma | 2017 | Tsinghua Science and Technology2017,22,1: | 1 |