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| 1 | Recent Advances in the Regulation of Brassinosteroid Signaling and Biosynthesis Pathways显示文摘Brassinosteroids(BRs) play important roles in plant growth,develop-ment and responses to environmental cues.BRs signal through plasma membrane receptor BRI1 and co-receptor BAK1,and several positive(BSK1,BSU1,PP2A) and negative(BKI1,BIN2 and 14-3-3) regulators to control the activities of BES1 and BZR1 family transcription factors,which regulate the expression of hundreds to thousands of genes for various BR responses.Recent studies identified novel signaling components in the BR pathways and started to establish the detailed mechanisms on the regulation of BR signaling.In addition,the molecular mechanism and transcriptional network through which BES1 and BZR1 control gene expression and various BR responses are beginning to be revealed.BES1 recruits histone demethylases ELF6 and REF6 as well as a transcription elongation factor IWS1 to regulate target gene expression.Identification of BES1 and BZR1 target genes established a transcriptional network for BR response and crosstalk with other signaling pathways.Recent studies also revealed regulatory mechanisms of BRs in many developmental processes and regulation of BR biosynthesis.Here we provide an overview and discuss some of the most recent progress in the regulation of BR signaling and biosynthesis pathways. | Huaxun Ye Lei Li Yanhai Yin | 2011 | Journal of Integrative Plant Biology2011，53，6： | 21 |
| 2 | A cryptic inhibitor of cytokinin phosphorelay controls rice grain size显示文摘Plant hormone cytokinin signals through histidine-aspartic acid(H-D)phosphorelay to regulate plant growth and development.While it is well known that the phosphorelay involves histidine kinases,histidine phosphotransfer proteins(HPs),and response regulators(RRs),how this process is regulated by external components remains unknown.Here we demonstrate that protein phosphatase with kelch-like domains(PPKL1),known as a signaling component of steroid hormone brassinosteroid,is actually a cryptic inhibitor of cytokinin phosphorelay in rice(Oryza sativa).Mutation at a specific amino acid D364 of PPKL1 activates cytokinin response and thus enlarges grain size in a semi-dominant mutant named s48.Overexpression of PPKL1 containing D364,either with the deletion of the phosphatase domain or not,rescues the s48 mutant phenotype.PPKL1 interacts with OsAHP2,one of authentic HPs,and D364 resides in a region resembling the receiver domain of RRs.Accordingly,PPKL1 can utilize D364 to suppress OsAHP2-to-RR phosphorelay,whereas mutation of D364 abolishes the effect.This function of PPKL1 is independent of the phosphatase domain that is required for brassinosteroid signaling.Importantly,editing of the D364-residential region produces a diversity of semi-dominant mutations associated with variously increased grain sizes.Further screening of the edited plants enables the identification of two genotypes that confer significantly improved grain yield.Collectively,our study uncovers a noncanonical cytokinin signaling suppressor and provides a robust tool for seed rational design. | Dapu Liu He Zhao Yunhua Xiao Guoxia Zhang Shouyun Cao Wenchao Yin Yangwen Qian Yanhai Yin Jinsong Zhang Shouyi Chen Chengcai Chu Hongning Tong | 2022 | Molecular Plant2022，15，2： | 3 |
| 3 | Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana显示文摘植物类固醇荷尔蒙, brassinosteroids (BR ) ,在植物生长,开发,和对 environmentalstresses 的回答起重要作用。BR 通过对血浆膜和另外的发信号的部件局部性的受体发信号调整抄写因素的 BES1/BZR1family,它调制几千基因的表示。BES1/BZR1 和他们的 interactingproteins 怎么工作调整基因的大数字,完全没被理解。这里,我们报导那 histone lysinemethyltransferase SDG8,在 histone 含有 3 离氨酸 36 di- 和 trimethylation (H3K36me2 和 me3 ) ,涉及 BR-regulatedgene 表示。BES1 与 SDG8 交往,直接或间接地通过 IWS1,抄写延伸因素 involvedin 调整 BR 的基因表示。猛烈变异的 sdg8 与损害 BR 回答显示减少的生长显型。全球基因表示研究表明了那, whileBR 在野类型的植物调整大约 5000 基因,荷尔蒙在 sdg8 比 700 基因调整少数变异。另外,多于调整 BR 的基因的一半,差别在 sdg8 异种被影响。一个染色质 Immunoprecipitation (薄片) 实验证明 H3K36me3 在 sdg8 异种在调整 BR 的基因被减少。把结果基于这些,我们建议 SDG8 在调停起一个必要作用调整 BR 的基因表示。Ourresults 因此揭示 histone 修正由支配基因 expression.Key 词的神经质的规定的主要机制: | Xiaolei Wang Jiani Chen Zhouli Xie Sanzhen Liu Trevor Nolan Huaxun Ye Mingcai Zhang Hongqing Guo Patrick S. Schnable Zhaohu Li Yanhai Yin | 2014 | Molecular Plant2014，7，8： | 3 |
| 4 | Light Intensity Affects Chlorophyll Synthesis During Greening Process by Metabolite Signal from Mitochondrial Alternative Oxidase in Arabidopsis显示文摘Although mitochondrial alternative oxidase(AOX)has been proposed to play essential roles in high light stress tolerance,the effects of AOX on chlorophyll synthesis are unclear.Previous studies indicated that during greening,chlorophyll accumulation was largely delayed in plants whose mitochondrial cyanide-resistant respiration was inhibited by knocking out nuclear encoded AOX gene.Here we show that this delay of chlorophyll accumulation was more significant under high light condition.Inhibition of cyanide-resistant respiration was also accompanied by the increase of plastid NADPH/NADP^+ratio,especially under high light treatment which subsequently blocked the import of multiple plastidial proteins,such as some components of the photosynthetic electron transport chain,the Calvin-Benson cycle enzymes and malate/oxaloacetate shuttle components.Over expression of AOXla rescued the aoxla mutant phenotype,including the chlorophyll accumulation during greening and plastidial protein import.It thus suggests that light intensity affects chlorophyll synthesis during greening process by a metabolic signal,the AOX-derived plastidial NADPH/NADP^+ratio change.And our results thus revealed a molecular mechanism of chloroplast-mitochondria interactions. | ZHANG Dawei YUAN Shu 徐飞 ZHU Feng YUAN Ming YE Huaxun GUO Hongqing LV Xin YIN Yanhai 林宏辉 | 2015 | 武汉生物工程学院学报2015，，3： | 2 |
| 5 | The first strain of monkeypox isolated in the Chinese Mainland and preserved at the National Pathogen Resource Center of China显示文摘On September 16,2022,the first imported monkeypox case was reported in the Chinese Mainland.Laboratory tests including nucleic acid detection were carried out in Chongqing Nan’an Centre for Disease Control and Prevention and Chongqing Center for Disease Control and Prevention.After that,monkeypox virus was isolated by the Institute for Viral Disease Control and Prevention and preserved at the National Pathogen Resource Center on September 18,2022.The National Pathogen Resource Center shared the basic information of monkeypox virus strain,samples,biosafety,strain imaging,RT-PCR primers,and probes sequence timely to support the prevention and control of monkeypox epidemic and facilitate the scientific research on vaccine development,drug screening and evaluation of monkeypox virus in the future. | Qiang Wei Baoying Huang Wei Huang Jingdong Song Li Mei Li Zhao Jing Yin Juan Zhang Wenling Wang Fei Ye Caiyun Li Liling Bai Yanhai Wang Yao Deng Bo Liu Mengnan Jiang Guizhen Wu Jun Han Hua Zhao Hua Ling Wenjie Tan Jianjun Liu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 6 | BES1 Accumulates in the Nucleus in Response to Brassinosteroids to Regulate Gene Expression and Promote Stem Elongation显示文摘 | Yanhai Yin Zhi-Yong Wang Santiago Mora-Garcia Jianming Li Shigeo Yoshida Tadao Asami Joanne Chory | 2002 | Cell2002，，2： | 1 |
| 7 | Redesigning green revolution trait with increased grain yield and nitrogen utilization efficiency by reducing brassinosteroid signaling in semidwarf wheat显示文摘Securing food and feed for the increasing world population and decreasing arable land is one of the major challenges of our time.Green revolution or agriculture revolution was propelled by the use of semidwarf rice and wheat varieties around the world since the 1960s(Peng et al.,1999;Sasaki et al.,2002).The semi-dwarfness leads to lodging resistance and thus allows planting of crops in high densities。 | Hongqing Guo Yanhai Yin | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 8 | E3泛素连接酶SINAT通过光信号调控BR转录因子BES1的蛋白稳定性显示文摘文章简介油菜素甾醇(BRs)是一类促进植物生长的类固醇激素,可以调控植物多方面的生长发育过程。已有的研究表明,BES1/BZR1的活性和功能主要取决于对其磷酸化状态和蛋白稳定性的调控,但对于BES1/BZR1的调控机制尤其是降解机制,仍需进一步探究。 | Mengran Yang Chengxiang Li Zhenying Cai Yinmeng Hu Trevor Nolan Feifei Yu Yanhai Yin Qi Xie Guiliang Tang 王学路 | 2018 | 科学新闻2018，0，4： | 0 |
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