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| 1 | BRIF and CARIF progress显示文摘China Institute of Atomic Energy (CIAE) is currently constructing Beijing rare ion beam facility (BRIF) and is proposing China advanced rare ion beam facility (CARIF). This paper is aiming at introducing the progress of BRIF project and the con ceptual design CARIF. The ISOL type facility BRIF under construction is composed of a 100 MeV 300 ?A proton cyclotron, an ISOL with mass resolution of 20000, and a super-conducting LINAC of 2 MeV/q, and will be commissioned in 2013. CARIF facility proposed is planned to use both ISOL and PF techniques. It is based on a China advanced research reactor CARR that was critical, with ISOL separation of fission fragment, post acceleration to 150 MeV/u, and fragmentation of neu tron-rich fission fragment beam like 132Sn. Such unique combination will allow CARIF to deliver beam intensity better than the best world facilities by more than one order of magnitude. | LIU WeiPing, LI ZhiHong, BAI XiXiang, WANG YouBao, GUO Bing, PENG ChaoHua, YANG Yi, SU Jun, CUI BaoQun, ZHOU ShuHua, ZHU ShengYun, XIA HaiHong, GUAN XiaLing, ZENG Sheng, ZHANG HuanQiao, CHEN YongShou, TANG HongQing, HUANG Li & FENG BeiYuan China Institute of Atomic Energy, P. O. Box 275(1), Beijing 102413, China | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S1： | 8 |
| 2 | Rapid Assessment on Potential Risks of Schistosomiasis Transmission—7 PLADs,China,2019 and 2021显示文摘Summary What is already known about this topic?Oncomelania hupensis(O.hupensis)and livestock are main infection sources of schistosomiasis.The schistosome infected O.hupensis and livestock’s feces are important risk factors in the transmission of schistosomiasis.What is added by this report?The potential risks of schistosomiasis transmission remain prevalent,giving an early warning to local government with information on existing transmission risks.It is expected that the effectiveness and efficiency of schistosomiasis surveillance could be improved by conducting rapid risk assessment at the beginning of transmission season. | Junyi He Hongqing Zhu Ziping Bao Lijuan Zhang Yinlong Li Ting Feng Suying Guo Wangping Deng Can Wang Hui Dang Tiewu Jia Chao Lyu Zhiqiang Qin Chunli Cao Jing Xu Shizhu Li Xiaonong Zhou | 2021 | China CDC weekly2021，3，51： | 5 |
| 3 | Energy-efficient longitudinal driving strategy for intelligent vehicles on urban roads显示文摘Energy and environmental problems brought by automobiles are becoming more and more prominent. One promising way to solve these problems is to improve the energy efficiency of vehicles. The energy efficiency of a vehicle is not only related to vehicle performance, but also related to driving behavior. | Hongqing CHU Lulu GUO Yongjun YAN Bingzhao GAO Hong CHEN Ning BIAN | 2019 | Science China(Information Sciences)2019，62，6： | 5 |
| 4 | Histone Lysine Methyltransferase SDG8 Is Involved in Brassinosteroid-Regulated Gene Expression in Arabidopsis thaliana显示文摘植物类固醇荷尔蒙, brassinosteroids (BR ) ,在植物生长,开发,和对 environmentalstresses 的回答起重要作用。BR 通过对血浆膜和另外的发信号的部件局部性的受体发信号调整抄写因素的 BES1/BZR1family,它调制几千基因的表示。BES1/BZR1 和他们的 interactingproteins 怎么工作调整基因的大数字,完全没被理解。这里,我们报导那 histone lysinemethyltransferase SDG8,在 histone 含有 3 离氨酸 36 di- 和 trimethylation (H3K36me2 和 me3 ) ,涉及 BR-regulatedgene 表示。BES1 与 SDG8 交往,直接或间接地通过 IWS1,抄写延伸因素 involvedin 调整 BR 的基因表示。猛烈变异的 sdg8 与损害 BR 回答显示减少的生长显型。全球基因表示研究表明了那, whileBR 在野类型的植物调整大约 5000 基因,荷尔蒙在 sdg8 比 700 基因调整少数变异。另外,多于调整 BR 的基因的一半,差别在 sdg8 异种被影响。一个染色质 Immunoprecipitation (薄片) 实验证明 H3K36me3 在 sdg8 异种在调整 BR 的基因被减少。把结果基于这些,我们建议 SDG8 在调停起一个必要作用调整 BR 的基因表示。Ourresults 因此揭示 histone 修正由支配基因 expression.Key 词的神经质的规定的主要机制: | Xiaolei Wang Jiani Chen Zhouli Xie Sanzhen Liu Trevor Nolan Huaxun Ye Mingcai Zhang Hongqing Guo Patrick S. Schnable Zhaohu Li Yanhai Yin | 2014 | Molecular Plant2014，7，8： | 3 |
| 5 | Light Intensity Affects Chlorophyll Synthesis During Greening Process by Metabolite Signal from Mitochondrial Alternative Oxidase in Arabidopsis显示文摘Although mitochondrial alternative oxidase(AOX)has been proposed to play essential roles in high light stress tolerance,the effects of AOX on chlorophyll synthesis are unclear.Previous studies indicated that during greening,chlorophyll accumulation was largely delayed in plants whose mitochondrial cyanide-resistant respiration was inhibited by knocking out nuclear encoded AOX gene.Here we show that this delay of chlorophyll accumulation was more significant under high light condition.Inhibition of cyanide-resistant respiration was also accompanied by the increase of plastid NADPH/NADP^+ratio,especially under high light treatment which subsequently blocked the import of multiple plastidial proteins,such as some components of the photosynthetic electron transport chain,the Calvin-Benson cycle enzymes and malate/oxaloacetate shuttle components.Over expression of AOXla rescued the aoxla mutant phenotype,including the chlorophyll accumulation during greening and plastidial protein import.It thus suggests that light intensity affects chlorophyll synthesis during greening process by a metabolic signal,the AOX-derived plastidial NADPH/NADP^+ratio change.And our results thus revealed a molecular mechanism of chloroplast-mitochondria interactions. | ZHANG Dawei YUAN Shu 徐飞 ZHU Feng YUAN Ming YE Huaxun GUO Hongqing LV Xin YIN Yanhai 林宏辉 | 2015 | 武汉生物工程学院学报2015，，3： | 2 |
| 6 | Mycorrhizal colonization of chenopods and its influencing factors in different saline habitats, China显示文摘Chenopodiaceae is one of the most important families in arid and saline environments. Several studies have observed the mycorrhizal structure in Chenopodiaceae plants(i.e., chenopods), but the mycorrhizal colonization status of chenopods in saline habitats and the influencing factors are still not well understood. The mycorrhizal colonization of twenty chenopod species in three different saline habitats(a saline alkaline meadow in the Songnen Plain of northeastern China, a saline desert in the Junggar Basin of northwestern China, and a saline alpine meadow in the Tibetan Plateau of western China) and the chenopod-associated environmental factors(including soil moisture, soil available phosphorous(P) concentration, pH, and salt content) were analyzed. Our results showed that approximately 60% of the studied chenopods were colonized by arbuscular mycorrhizal(AM) fungi with a colonization percentage ranging from 5% to 33%. Structural analysis of mycorrhizal association indicated that vesicles were quite common, while arbuscules and hyphal coils were relatively rare. In addition, a positive correlation between mycorrhizal colonization rate and soil electrical conductivity(r=0.920, P<0.01) and two negative correlations of mycorrhizal colonization rates with soil moisture(r= –0.818, P<0.01) and the soil available P concentration(r= –0.876, P<0.01) confirmed that mycorrhizal colonization rate in the roots of chenopods was environment-dependent. | ZHAO Yinan YU Hongqing ZHANG Tao GUO Jixun | 2017 | Journal of Arid Land2017，9，1： | 2 |
| 7 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 8 | PCR-based isolation and identification of full-length low-molecular-weight glutenin subunit genes in bread wheat (Triticum aestivum L.)显示文摘 | Xiaofei Zhang Dongcheng Liu Wei Jiang Xiaoli Guo Wenlong Yang Jiazhu Sun Hongqing Ling Aimin Zhang | 2011 | Theoretical and Applied Genetics2011，，8： | 1 |
| 9 | Optimal car-following control for intelligent vehicles using online road-slope approximation method显示文摘The design of a car-following control system is a multiobjective optimization problem that involves issues in rider safety,ride comfort,and fuel economy.This study proposes a hierarchical design of optimal car-following control where the system is intuitively split into two subsystems with different dynamic properties.Specifically,the high-level subsystem is a linear car-following system with a measurable disturbance of the preceding vehicle’s acceleration,while the low-level subsystem is a nonlinear accelerationtracking system with an unmeasurable road slope.In the design of optimal car-following control,the measurable disturbance of the preceding vehicle’s acceleration is considered from a theoretical perspective,and the unmeasurable road slope is estimated by a novel engineering-oriented approximation method to reduce the influence of driveline oscillation.The performance of the proposed optimal control scheme is evaluated through simulation and real-vehicle experiments,which show that the proposed control algorithm provides a satisfactory road-slope approximation accuracy and that the car-following performance of the proposed optimal control system is better than that of a factory-installed adaptive cruise controller. | Hongqing CHU Lulu GUO Hong CHEN Bingzhao GAO | 2021 | Science China(Information Sciences)2021，64，1： | 1 |
| 10 | Not All Side Population Cells Contain Cancer Stem-Like Cells in Human Gastric Cancer Cell Lines显示文摘 | Haihong Zhang Hongqing Xi Aizhen Cai Qijun Xia Xin Xin Wang Canrong Lu Yong Zhang Zhou Song Hua Wang Qinfang Li Lin Chen Zikuan Guo | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 11 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 12 | Redesigning green revolution trait with increased grain yield and nitrogen utilization efficiency by reducing brassinosteroid signaling in semidwarf wheat显示文摘Securing food and feed for the increasing world population and decreasing arable land is one of the major challenges of our time.Green revolution or agriculture revolution was propelled by the use of semidwarf rice and wheat varieties around the world since the 1960s(Peng et al.,1999;Sasaki et al.,2002).The semi-dwarfness leads to lodging resistance and thus allows planting of crops in high densities。 | Hongqing Guo Yanhai Yin | 2023 | Science China(Life Sciences)2023，66，10： | 0 |
| 13 | Rationally optimized generation of integrated Escherichia coli with stable and high yield lycopene biosynthesis from heterologous mevalonate(MVA)and lycopene expression pathways显示文摘The stability and high productivity of heterogeneous terpenoid production in Escherichia coli expression system is one of the most key issues for its large scale industrialization.In the current study on taking lycopene biosynthesis as an example,an integrated Escherichia coli system has been generated successfully,which resulted into stable and high lycopene production.In this process,two modules of mevalonate(MVA)pathway and one module of lycopene expression pathway were completely integrated in the chromosome.Firstly,the copy number and integrated position of three modules of heterologous pathways were rationally optimized.Later,a strain DH416 equipped with heterogeneous expression pathways through chromosomal integration was efficiently derived from parental strain DH411.The evolving DH416 strain efficiently produced the lycopene level of 1.22 g/L(49.9 mg/g DCW)in a 5 L fermenter with mean productivity of 61.0 mg/L/h.Additionally,the integrated strain showed more genetic stability than the plasmid systems after successive 21st passage. | Muhammad Hammad Hussain Qi Hong Waqas Qamar Zaman Ali Mohsin Yanlong Wei Ning Zhang Hongqing Fang Zejian Wang Haifeng Hang Yingping Zhuang Meijin Guo | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 0 |
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