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| 1 | LncRNA-MALAT1 mediates cisplatin resistance via miR-101-3p/VEGF-C pathway in bladder cancer显示文摘The mitotically associated lncRNA(MANCR)participates in breast cancer cell proliferation,while its involvement in other cancers is still unknown.In this study,we therefore studied the role of MANCR in mantle cell lymphoma(MCL).We found that serum MANCR and Runt-related transcription factor 2(RUNX2)were upregulated in MCL patients when compared with those in healthy controls.A positive correlation between serum MANCR and RUNX2 was found in MCL patients but not in controls.Upregulation of serum MANCR distinguished MCL patients from controls.MANCR overexpression promoted RUNX2 expression in MCL cells,while RUNX2 overexpression failed to significantly change the expression levels of MANCR.MANCR overexpression promoted the proliferation of MCL cells,while MANCR silencing inhibited the proliferation of MCL cells.In addition,RUNX2 overexpression attenuated the inhibitory effects of MANCR silencing on cell proliferation.However,MANCR overexpression and silencing had no significant effects on cell migration and invasion.Further bioinformatics analysis showed that MANCR may sponge miR-218 to upregulate RUNX2.Therefore,we conclude that downregulation of MANCR may inhibit cancer cell proliferation in MCL possibly by interacting with RUNX2. | Peihua Liu Xiaozhou Li Yu Cui Jinbo Chen Chao Li Qiaqia Li Huihuang Li Xiangyang Zhang Xiongbing Zu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 6 |
| 2 | Dependence of nitrogen concentration in type Ib diamonds on synthesis temperature显示文摘Type Ib diamonds were grown by the temperature gradient method (TGM) at 5.5 GPa and 1500-1560 K in a china-type cubic anvil high pressure apparatus using Ni70Mn25Co5 alloy as solvent/catalyst. The concentration of nitrogen (CN) in type Ib diamonds synthesized at different synthesis temperatures was measured by a Fourier transform infrared (FTIR) spectrometer. The dependence of CN in diamond on synthesis temperature was studied. For the type Ib diamonds synthesized using Ni70Mn25Co5 as catalyst, its CN decreases along with the increase of synthesis temperature. | TIAN Yu JIA XiaoPeng ZANG ChuanYi LI ShangSheng XIAO HongYu ZHANG YaFei HUANG GuoFeng LI Rui HAN QiGang MA LiQiu LI Yong CHEN XiaoZhou ZHANG Chong MA HongAn | 2009 | Chinese Science Bulletin2009，54，9： | 5 |
| 3 | A randomized phase II study of autologous cytokine-induced killer cells in treatment of hepatocelluar carcinoma显示文摘 | Xiaozhou Yu Hua Zhao Liang Liu Shui Cao Baozhu Ren Naining Zhang Xiumei An Jinpu Yu Hui Li Xiubao Ren | 2014 | Journal of Clinical Immunology2014，，2： | 5 |
| 4 | Estimation of clear-sky longwave downward radiation from HJ-1B thermal data显示文摘To satisfy the requirement of surface energy budget research on the meso-and micro-scale,a parameterization is developed to calculate high spatial resolution,clear-sky downward longwave radiation(DLR)from HJ-1B thermal data.The DLR algorithm is established based on extensive radiative transfer simulation and statistical analysis.To address the problem that HJ-1B has a single thermal channel and lacks atmospheric information,the brightness temperature of HJ-1B and water vapor content are used in the algorithm.An accuracy evaluation and error analysis for the algorithm is conducted using a simulated radiation dataset.The result shows that the algorithm performs well in most circumstances,but there is obvious underestimation when water vapor content is greater than 4g/cm2 .Error analysis indicates the accuracy of estimated DLRs is affected by uncertainties in input parameters,including water vapor content and top-of-atmosphere radiance.It is also affected by the difference between ground and near-surface air temperature.The algorithm is applied to actual HJ-1B data,and validated by ground data from six stations in the Heihe River and Haihe River basins.The estimated DLRs have good consistency with measured data except at Huazhaizi,and root mean square errors at most sites are around 20W/m2 ,which is slightly better than the result of MODIS. There is significant overestimation of DLR at Huazhaizi during summer,which is mainly produced by the large ground-air temperature difference.A correction process based on temperature difference is proposed and applied at Huazhaizi.The result shows that the positive bias is largely diminished after correction. | YU ShanShan XIN XiaoZhou LIU QinHuo | 2013 | Science China Earth Sciences2013，56，5： | 5 |
| 5 | Effect of Taichong(LR 3) acupuncture in spontaneously hypertensive rats显示文摘OBJECTIVE: To evaluate the effects of Taichong(LR3) acupuncture points(acupoints) on the expression of glucose transporter protein 1(GLUT1) in the hypothalamus of spontaneously hypertensive rats(SHRs) as measured by combined positron emission tomography and computed tomography(PETCT).METHODS: Spontaneously hypertensive rats(SHR)were divided into model, Taichong(LR 3) acupuncture, and sham groups. Additionally, Tokyo Wistar rats were used as the control group. Changes in blood pressure were recorded in different groups of rats before and after the corresponding treatment. Hematoxylin and eosin(HE) staining was used to study basic morphological changes, and immunohistochemistry was used to determine GLUT1 expression in the hypothalamus. Further,PET-CT was utilized to elucidate the antihypertensive mechanism after acupuncture at the Taichong(LR 3) acupoints.RESULTS: PET-CT indicated activation of the hypothalamus. Measurement of blood pressure showed that acupuncture at the Taichong(LR 3) acupoints lowered blood pressure. HE staining did not show any significant pathological changes, although differences in cell number were observed. Immunohistochemical analysis indicated a GLUT1 downregulation in the SHRs of the Taichong(LR 3) acupuncture group after the treatment.CONCLUSION: Acupuncture at Taichong(LR 3) acupoints lowered blood pressure in SHRs, with possible mechanisms being changes in cell number and GLUT1 expression in the hypothalamus. | Luo Xiaozhou Huang Jianting Yu Juan Tang Chunzhi | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 2 |
| 6 | Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells显示文摘 | Xiaozhou Ying Kehe Yu Xiaowei Chen Hua Chen Jianjun Hong Shaowen Cheng Lei Peng | 2013 | Cellular Immunology . 2013 (1-2)2013，，： | 1 |
| 7 | QB50 Project and the Development of Cube Sat Technology in China显示文摘The Cube Sat refers to the low-cost nano satellite produced by international standards. The QB50 project is 'an International Network of 50 double Cube Sats for multi-point, in-situ, long-duration measurements in the lower thermosphere and re-entry research'. There are 23 countries and region participated in the QB50 Project. 38 Cube Sats were developed and launched. Among them, four Cube Sats developed by Chinese universities were sent to orbit(Three were deployed from the International Space Station, and one was launched by the Polar Satellite Launch Vehicle, PLSV). They are Aoxiang-1(Northwestern Polytechnical University, the Asia coordinator), Lilac Sat-1(Harbin Institute of Technology), NJUST-2(Nanjing University of Science and Technology) and NUDTsat(National University of Defense Technology). Through the development of the QB50 Project, Chinese researchers and students got in touch with the concept of Cube Sat and gained experience of international scientific cooperation. A lot of students took part in the assembly, integration, and test of spacecraft, which is helpful to the training of space talents. Now, many universities and institutes have the capabilities to develop Cube Sats and the subsystems independently. | ZHOU Jun LIU Yingying LIU Guanghui BAI Bo PANG Weijian ZHU Peijie YU Xiaozhou | 2018 | Aerospace China2018，19，2： | 1 |
| 8 | Analytical Solution for an Elastic Sphere Indenting a Layered Half-Space显示文摘The contact problem for the elastic sphere indenting a layered half-space is considered. Analytical methods for solving this problem have been developed on the basis of the 3-D fundamental solution of a half space with a single coating layer under a normal concentrated force on the surface. The normal pressure distribution within the contact zone is assumed as Hertzian type. The solutions are constructed using superposition principle in the form of infinite series. Through comparing with the numerical results of FEM,it can be verified that the exact solutions have a rapid convergence rate and the stresses and displacements are mainly determined by the first term,which is corresponding to the solution of homogeneous half-space under Hertzian loading. The contact radius can be predicted applying the method. | Yiquan Li Xiaozhou Li Jinkai Xu Huadong Yu | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，4： | 0 |
| 9 | Science Missions Using CubeSats显示文摘As the role of missions and experiments carried out in outer space becomes more and more essential in our understanding of many earthly problems,such as resource management,environmental problems,and disaster management,as well as space science questions,thanks to their lower cost and faster development process CubeSats can benefit humanity and therefore,young scientists and engineers have been motivated to research and develop new CubeSat missions.Not very long after their inception,CubeSats have evolved to become accepted platforms for scientific and commercial applications.The last couple of years showed that they are a feasible tool for conducting scientific experiments,not only in the Earth orbit but also in the interplanetary space.For many countries,a CubeSat mission could prompt the community and young teams around the world to build the national capacity to launch and operate national space missions.This paper presents an overview of the key scientific and engineering gateways opened up to the younger scientific community by the advent and adaptation of new technology into CubeSat missions.The role of cooperation and the opportunities for capacity-building and education are also explored.Thus,the present article also aims to provide useful recommendations to scientists,early-career researchers,engineers,students,and anyone who intends to explore the potential and opportunities offered by CubeSats and CubeSats-based missions. | SEYEDABADI M E FALANGA M AZAM M BARESI N FLÉRON R JANTARACHOTE V JUAREZ ORTIZ V A JULCA YAYA J J LANGER M MANUTHASNA S MARTINOD N MUGHAL M R NOMAN M PARK J PIMNOO A PRAKS J REYNERI L SANNA A ŞIŞMAN TÇ SOME J ULAMBAYAR T YU Xiaozhou DONG Xiaolong BALDIS L | 2020 | 空间科学学报2020，40，4： | 0 |
| 10 | A Shape-Memory Deployable Subsystem with a Large Folding Ratio in China’s Tianwen-1 Mars Exploration Mission显示文摘Once China’s Tianwen-1 Mars probe arrived in a Mars orbit after a seven-month flight in the deep cold space environment,it would be urgently necessary to monitor its state and the surrounding environment.To address this issue,we developed a flexible deployable subsystem based on shape memory polymer composites(SMPC-FDS)with a large folding ratio,which incorporates a camera and two temperature telemetry points for monitoring the local state of the Mars orbiter and the deep space environment.Here,we report on the development,testing,and successful application of the SMPC-FDS.Before reaching its Mars remote-sensing orbit,the SMPC-FDS is designed to be in a folded state with high stiffness;after reaching orbit,it is in a deployed state with a large envelope.The transition from the folded state to the deployed state is achieved by electrically heating the shape memory polymer composites(SMPCs);during this process,the camera on the SMPC-FDS can capture the local state of the orbiter from multiple angles.Moreover,temperature telemetry points on the SMPC-FDS provide feedback on the environment temperature and the temperature change of the SMPCs during the energization process.By simulating a Mars on-orbit space environment,the engineering reliability of the SMPC-FDS was comprehensively verified in terms of the material properties,structural dynamic performance,and thermal vacuum deployment feasibility.Since the launch of Tianwen-1 on 23 July 2020,scientific data on the temperature environment around Tianwen-1 has been successfully acquired from the telemetry points on the SMPCFDS,and the local state of the orbiter has been photographed in orbit,showing the national flag of China fixed on the orbiter. | Chengjun Zeng Liwu Liu Yang Du Miao Yu Xiaozhou Xin Tianzhen Liu Peilei Xu Yu Yan Dou Zhang Wenxu Dai Xin Lan Fenghua Zhang Linlin Wang Xue Wan Wenfeng Bian Yanju Liu Jinsong Leng | 2023 | Engineering2023，，9： | 0 |
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