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| 1 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 2 | Pifithrin-α reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat显示文摘背景:服的血管痉挛追随者潜水艇 arachnoid 出血(SAH ) 的机制没被理解。这里,我们假设了 p53 导致的 endothelial 的那 apoptosis,它在 apoptosis (美洲狮) 的调整调节的人上面的目标基因他们破折号 p53 在服的血管痉挛的开发起了一个重要作用。我们也观察了一个 p53 禁止者的效果, pifithrin-alpha (PFT-alpha ) 在减少 p53 和美洲狮的表示以后,因而减少 endothelial 的 apoptosis 和减轻的服的血管痉挛。方法:称 300-350 g 的男 Sprague-Dawley 老鼠随机被划分成五个组:一个控制组(假冒的外科) ,一个 SAH 组,一个 SAH+dimethyl 硫氢化物(DMSO ) 组, SAH + PFT-alpha (0.2 mg/kg ) 组织, SAH + PFT-alpha (2.0 mg/kg ) 组织。PFT-alpha 在 SAH 以后立即 intraperitoneally 被注射。老鼠被牺牲在 SAH 以后的 24 个小时。西方的污点和免疫组织化学的染色被用来检测 p53,美洲狮和 caspase-3 蛋白质的层次。另外,死亡和神经病学的分数为每个组被估计。统计意义被 ANOVA 由 Tukey 测试跟随了的以一个方法执行的变化的分析保证。神经病学并且死亡分数被 Dunn 的方法和菲希尔分析准确测试分别地。结果:在 SAH ,西方的污点和免疫以后,组织化学的染色在 endothelial 和积极 endothelial 都是的标记的调停的 dUTP 刻痕结束( TUNEL )显著地在基部的动脉( P<0.05 )增加了的 TdT 的数字显示出 p53 ,美洲狮和 caspase-3 的层次,但是显著地由 PFT-alpha ( P<0.05 )减少了。这些变化被增加直径和基部的动脉(P<0.05 ) 的衰退的墙厚度伴随,以及减少了死亡和老鼠(P<0.05 ) 的神经病学的赤字。结论:PFT-alpha 能保护服的容器免受血管痉挛的开发的伤害并且改进神经病学的结果以及经由压制 p53 在服的容器的 endothelial 导致的 apoptosis 减少死亡。 | YAN Jun-hao YANG Xiao-mei CHEN Chun-hua HU Qin ZHAO Jing SHI Xian-zhong LUAN Li-ju YANG Lei QIN Li-hua ZHOU Chang-man | 2008 | Chinese Medical Journal2008，，5： | 13 |
| 3 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 4 | Nitrogen and Phosphorus Dual-Doped Multilayer Graphene as Universal Anode for Full Carbon-Based Lithium and Potassium Ion Capacitors显示文摘Lithium/potassium ion capacitors(LICs/PICs) have been proposed to bridge the performance gap between high-energy batteries and high-power capacitors.However,their development is hindered by the choice,electrochemical performance,and preparation technique of the battery-type anode materials.Herein,a nitrogen and phosphorus dual-doped multilayer graphene(NPG) material is designed and synthesized through an arc discharge process,using low-cost graphite and solid nitrogen and phosphorus sources.When employed as the anode material,NPG exhibits high capacity,remarkable rate capability,and stable cycling performance in both lithium and potassium ion batteries.This excellent electrochemical performance is ascribed to the synergistic effect of nitrogen and phosphorus doping,which enhances the electrochemical conductivity,provides a higher number of ion storage sites,and leads to increased interlayer spacing.Full carbon-based NPG‖LiPF6‖active carbon(AC) LICs and NPG‖KPF6‖AC PICs are assembled and show excellent electrochemical performance,with competitive energy and power densities.This work provides a route for the large-scale production of dual-doped graphene as a universal anode material for high-performance alkali ion batteries and capacitors. | Yuting Luan Rong Hu Yongzheng Fang Kai Zhu Kui Cheng Jun Yan Ke Ye Guiling Wang Dianxue Cao | 2019 | Nano-Micro Letters2019，11，2： | 6 |
| 5 | Distribution patterns of octylphenol and nonylphenol in the aquatic system at Mai Po Marshes Nature Reserve,a subtropical estuarine wetland in Hong Kong显示文摘Spatial and temporal distribution of octylphenol(OP)and nonylphenol(NP)in Mai Po Marshes,a subtropical estuarine wetlandin Hong Kong,were investigated.Surface water samples were collected every month from 11 sites during the period of September-December 2004.Concentrations of OP and NP ranged from 11.3 to 348 ng/L and from 29 to 2591 ng/L,respectively.The high levelsof NP and OP were found in November and December than in September and October.The levels of OP and NP have no significantspatial differences except September.Total organic matter in the sediments appeared to be an important factor in controlling the fate ofthese compounds in the aquatic environment. | LI Xiang-li LUAN Tian-gang LIANG Yan WONG Ming-hung LAN Chong-yu | 2007 | Journal of Environmental Sciences2007，19，6： | 6 |
| 6 | Application of Stable Isotope Tracing Technologies in Identification of Transformation among Waters in Sanjiang Plain,Northeast China显示文摘In order to investigate the transformation among the precipitation,groundwater,and surface water in the Sanjiang Plain,Northeast China,precipitation and groundwater samples which were collected at the meteorological station of the Sanjiang Mire Wetland Experimental Station,Chinese Academy of Sciences and the surface water which collected from the Wolulan River were used to identify the transformation of three types of water.The isotope composition of different kinds of water sources were analyzed via stable isotope(deuterium and oxygen-18) investigation of natural water.The results show a clear seasonal difference in the stable isotopes in precipitation.During the cold half-year,the mean stable isotope in precipitation in the Sanjiang Plain reaches its minimum with the minimum temperature.The δ18O and δD values are high in the rainy season.In the Wolulan River,the evaporation is the highest in August and September.The volume of evaporation and the replenishment to the river is mostly same.The groundwater is recharged more by the direct infiltration of precipitation than by the river flow.The results of this study indicate that the water bodies in the Sanjiang Plain have close hydrologic relationships,and that the transformation among each water system frequently occurs. | XU Yingying YAN Baixing LUAN Zhaoqing ZHU Hui WANG Lixia | 2013 | Chinese Geographical Science2013，23，4： | 6 |
| 7 | Synthesis of novel chiral N,P-containing multidentate ligands and their applications in asymmetric transfer hydrogenation显示文摘Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium(I) complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee. | Shen Luan Yu Yan Yun Li Zhen Rong Dong Juan Ni Zhang Qi Li Jing Xing Gao | 2011 | Chinese Chemical Letters2011，22，11： | 5 |
| 8 | Glycosylation-independent binding to extracellular domains 11-13 of mannose-6-phosphate/insulin-like growth factor-2 receptor mediates the effects of soluble CREG on the phenotypic proliferation of vascular smooth muscle cells显示文摘Background The present study aimed to investigate the detailed mode and specific sites for their binding as well as the functional relevance of this binding in the phenotypic proliferation of vascular smooth muscle cells(SMCs). Methods CREG knocked-down SMCs were employed to evaluate the biological activity of wtCREG and mCREG.Expressions of SMC differentiation markers SM myosin heavy chain(SM-MHC),SM-actin,heavy caldesmon and myocardin were determined by Western blotting using specific antibodies. Cellular growth of SMCs was assessed by bromide dewuridine (BrdU) incorporation and cell cycle analysis on fluorescence-activated cell sorting(FACS).A solid-phase binding assay was used to study the binding of CREG to extracellular domains of M6P/IGF2R.The cellular co-localization of the two recombinant CREGs with M6P/IGF2R was detected on SMC surface by immunoprecipitation and immunofluorescence analysis.Results The molecular weight of wtCREG was around 30 kD while that of the mCREG was~25 kD.Treatment of wtCREG with PNGase F reduced its molecular weight from~30 kD to~25 kD,whereas PNGase F treatment had no effect on the molecular weight of mCREG.Both wtCREG and mCREG proteins enhanced SMC differentiation,inhibited BrdU incorporation,and arrested cell cycle progression when added to the culture medium.In CREG knocked-down SMCs,the amount of CREG detected by immunoblotting in M6P/IGF2R immunoprecipitates was significantly reduced when compared to normal cells.Both recombinant CREGs co-immunoprecipitated with M6P/IGF2R, although slightly reduced amount of the mutant CREG was detected in M6P/IGF2R immunoprecipitates.Immunostaining revealed that His-tagged CREGs co-localized with IGF2R on the cell surface in a glycosylation-independent manner.In vitro binding assay showed that CREGs bound to M6P/ IGF2R extracellular domains 7-10 and 11-13 in a glycosylation -dependent and -independent manner,respectively.Further blocking experiments using soluble M6P/IGF2R fragments and M6P/IGF2R neutralizing antibody indicated that the biological activities of recombinant CREGs in SMC growth and the up-regulation of SMC differentiation markers were all abolished by treatment with the M6P/IGF2R neutralizing antibody. However,although the growth inhibitory effect of wtCREG was nearly abolished by D7-10 or D11-13,the effect of mCREG was only reversed by Dll-13,indicating that the binding to domains 11-13 is required for CREG to modulate the proliferation of SMCs.Conclusions These data suggest that solubleCREG proteins can exert their biological function via binding to the extracellular domains 7-10 and 11-13 of cell surface M6P/IGF2R in both a glycosylation-dependent and -independent manner. | LUAN Bo~1,HAN Ya-ling~1,SUN Ming-yu~1,GUO Liang~1,GUO Peng~1,TAO Jie~1,DENG Jie~1,WU Guang-zhe~1,YAN Cheng-hui~1, LI Shao-hua~2 (1.Department of Cardiology,Shenyang Northern Hospital, Shenyang,China 2.Division of Vascular Surgery,Robert Wood Johnson Medical School-UMDNJ,New Jersey,USA) | 2011 | 岭南心血管病杂志2011，17，S1： | 5 |
| 9 | Morphology and multifractal features of a guyot in specific topographic vicinity in the Caroline Ridge,West Pacific显示文摘Massive seamounts have been surveyed and documented in the last decades.However,the morphologies of seamounts are usually described in qualitative manners,yet few quantitative detections have been carried out.Here,based on the high-re solution multi-beam bathymetric data,we report a recentlysurveyed guy ot on the Caroline Ridge in the West Pacific,and the large-scale volcanic structures and smallscale erosive-depositional landforms in the guyot area have been identified.The multifractal features of the guyot are characterized for the first time by applying multifractal detrended fluctuation analysis on the surveyed bathymetric data.The results indicate that the multifractal spectrum parameters of the seafloor have strong spatial dependency on the fluctuations of local landforms.Both small-and large-scale components contribute to the degree of asymmetry of the multifractal spectrum(B),while the fluctuations of B are mostly attributed to the changes in small-scale roughness.The maximum singularity strength(α0)correlates well with the roughness of large-scale landforms and likely reflects the large-scale topographic irregularity.Comparing to traditional roughness parameters or monofractal exponents,multifractal spectra are able to depict not only the multiscale characteristics of submarine landforms,but also the spatial variations of scaling behaviors.Although more comparative works are required for various seamounts,we hope this study,as a case of quantifying geomorphological characters and multiscale behaviors of seamounts,can encourage further studies on seamounts concerning geomorphological processes,ocean bottom circulations,and seamount ecosystems. | Yu GAN Xiaochuan MA Zhendong LUAN Jun YAN | 2021 | Journal of Oceanology and Limnology2021，39，5： | 4 |
| 10 | Preparation of high concentration polyaluminum chloride by chemical synthesis-membrane distillation method with self-made hollow fiber membrane显示文摘A method of direct contact membrane distillation (DCMD) with a self-made hollow polyvinylidene fluoride membrane was applied to prepare high concentration polyaluminum chloride (PACl) with high Alb content based on chemical synthesis. The permeate flux and Al species distribution were investigated. The experimental results showed that the permeate flux decreased from 14 to 6 kg/(m2·hr) at the end of the DCMD process, which can be mainly attributed to the formation of NaCl deposits on the membrane surface. The Alb content decreased slightly, only from 86.3% to 84.4%, when the DCMD experiment finished, correspondingly the Alc content increased slightly from 7.2% to 8.5%, and the Ala content remained at 7% during the whole DCMD process. A PACl with Alb content of 84% at total aluminum concentration 2.2 mol/L was successfully prepared by the chemical synthesis-DCMD method. | Changwei Zhao Yong Yan Deyin Hou Zhaokun Luan Zhiping Jia | 2012 | Journal of Environmental Sciences2012，24，5： | 3 |
| 11 | Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons显示文摘Deep brain stimulation of the subthalamic nucleus(STN)is an effective therapy for motor deficits in Parkinson’s disease(PD),but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation.It is unclear how STN neurons represent and modulate feeding behavior in different internal states.In the present study,we found that feeding caused a robust activation of STN neurons in mice(GCaMP6 signal increased by 48.4%±7.2%,n=9,P=0.0003),and the extent varied with the size,valence,and palatability of food,but not with the repetition of feeding.Interestingly,energy deprivation increased the spontaneous firing rate(8.5±1.5 Hz,n=17,versus 4.7±0.7 Hz,n=18,P=0.03)and the depolarization-induced spikes in STN neurons,as well as enhanced the STN responses to feeding.Optogenetic experiments revealed that stimulation and inhibition of STN neurons respectively reduced(by 11%±6%,n=6,P=0.02)and enhanced(by 36%±15%,n=7,P=0.03)food intake only in the dark phase.In conclusion,our results support the hypothesis that STN neurons are activated by feeding behavior,depending on energy homeostatic status and the palatability of food,and modulation of these neurons is sufficient to regulate food intake. | Haichuan Wu Xiang Yan Dongliang Tang Weixin Gi Yiwen Luan Haijiang Cai Chunyi Zhou Cheng Xiao | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 12 | A review on vasohibin and ocular neovascularization显示文摘Ischemic and neovascular disease is one of the most difficult ocular diseases to deal with nowadays.Redundancy,poor visual acuity and decreased life quality are bothering patients and ophthalmologists for decades.After vascular endothelial growth factor(VEGF)was found to be a primary factor in promoting retinal angiogenesis,intravitreal injection of anti-VEGF drugs has been the firstline treatment.Whereas,some patients are refractory to this therapy and problems of economic burden,local complications and adverse effects promote researches into other possible targets.The vasohibin(VASH)family is a newly-investigated factor in modulating ocular angiogenesis.The family includes VASH1 and VASH2,which show opposite effects of inhibiting and accelerating angiogenesis respectively.Positive results have been reported in cellular and animal experiments.With further researches,it can be a promising future target of treating ocular neovascular diseases. | Xiao-Nan Hu Yan Ni Jie Luan Yu-Zhi Ding | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 3 |
| 13 | Formation and evolution of the tertiary carbonate reefs in the Madura Strait Basin of Indonesia显示文摘Analysis of 2 D seismic data over 4 500 km in length from the Madura Strait Basin in the East Java Sea reveals seismic re?ection characteristics of reefs and associated sedimentary bodies, including asymmetrical or symmetrical dome re?ections, slope progradational re?ections, chaotic re?ections and discontinuous strong re?ections inside the reef, which onlap the ?ank of the reef. It is concluded that the developmental paleo-environment of most reefs is mainly conducive to shallow marine carbonate platform facies and platform margin facies, based on well core data, variations in seismic facies and strata thickness.The formation and evolution of all reefs are primarily in?uenced by the tectonic framework of the Madura Strait Basin. Platform margin reefs are principally controlled by two types of structures: one is a series of E-W trending Paleogene normal faults, and the other is an E-W trending Neogene inversion structures. In addition, wave actions, tidal currents and other ocean currents play an accelerated role in sorting, rounding and redeposition for the accumulation and evolution of reefs. Tertiary reefs in the MSB can be divided into four types: 1) an open platform coral reef of Late Oligocene to Early Miocene, 2) a platform margin coral reef controlled by normal faults in Late Oligocene to Early Miocene, 3) a platform margin Globigerina moundreef controlled by a 'hidden' inversion structure in Early Pliocene, and 4) a platform margin Globigerina mound-reef controlled by thrust faults in the early Pliocene. Patterns of the formation and evolution of reefs are also suggested. | RAN Weimin LUAN Xiwu LU Yintao LIU Hong YANG Jiajia ZHAO Yang HE Wenchang YAN Zhonghui | 2019 | Journal of Oceanology and Limnology2019，37，1： | 3 |
| 14 | Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data显示文摘Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium(WTCCC) SNP datasets of CAD and control samples were used to assess the jointeffect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene–gene interactions involved in these susceptible pathways with their protein–protein interaction(PPI)knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer's disease, non-alcoholic fatty liver disease, and Huntington's disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer's disease.These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer's disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases. | Xiang Zhao Yi-Zhao Luan Xiaoyu Zuo Ye-Da Chen Jiheng Qin Lv Jin Yiqing Tan Meihua Lin Naizun Zhang Yan Liang Shao-Qi Rao | 2016 | Genomics, Proteomics & Bioinformatics2016，14，6： | 3 |
| 15 | Formation and crystallization behavior of Fe-based amorphous precursors with pre-existingα-Fe nanoparticles-Structure and magnetic properties of high-Cu-content Fe-Si-B-Cu-Nb nanocrystalline alloys显示文摘Structure,crystallization behavior,and magnetic properties of as-quenched and annealed Fe_(81.3)Si_(4)O_(13)Cu_(1.7)(Cu1.7)alloy ribbons and effects of Nb alloying have been studied.Three-dimensional atom probe and transmission electron microscopy analyses reveal that high-number-density Cu-clusters and Pre-existing Nano-sized a-Fe Particles(PN-a-Fe)are coexistence in the melt-spun Cu1.7 amorphous matrix,and the PN-α-Fe form by manners of one-direction adjoining and enveloping the Cu-clusters.Two-step crystallization behavior associated with growth of the PN-a-Fe and subsequent nucleation and growth of newly-formedα-Fe is found in the primary crystallization stage of the Cu1.7 alloy.The number densities of the Cu-clusters and PN-a-Fe in melt-spun Fe8_(1.3-x)Si_(4)B_(13)Cu_(1.7)Nb_(x)alloys are gradually reduced with enriching of Nb,and a fully amorphous structure forms at 4 at.%Nb,although smaller Cu-clusters still exist.After annealing,2 at.%Nb coarsens the average size(D_(α-F)e)of theα-Fe grains from 14.0 nm of the Nb-free alloy to 21.6 nm,and 4 at.%Nb refines the D_(α-Fe)to 8.9 nm.The mechanisms of theα-Fe nucleation and growth during quenching and annealing for the alloys with large quantities of PN-α-Fe as well as after Nb alloying have been discussed,and an annealing-induced oc-Fe growth mechanism in term of the barrier co-contributed by competitive growth among the PN-a-Fe and diffusion-suppression effect of Nb atoms has been proposed.A coercivity(HC)αDα-Fe^(3)correlation has been found for the nanocrystalline alloys,and the permeability is inverse with the H_(C). | Yanhui Li Xingjie Jia Wei Zhang Yan Zhang Guoqiang Xie Zhiyong Qiu Junhua Luan Zengbao Jiao | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 16 | Mathematical simulation and observation of ground subsidence basin in coal mining area显示文摘Based on a great amount of practically observational data and by computer simulation, a formula for estimating the ground subsidence caused by coal mining was derived. Meanwhile, an empirical mathematical model for ground subsidence basin in coal mining was given. | JIANG Chen-guang~1, HE Yong~2, YAN Li-ming~3, LIAO Ming-quan~4, LUAN Yong-jian~2, LIU Yu-rong~3 (1. Southern Yangtze University, Jiangsu Wuxi 214063, China 2. Laiyang Agricultural College, Shandong 265200, China 3. Kangping Supervision Agent Co. of Laiyang City, Shandong 265200, China 4. Chongqing Coal Mine Design and Research Institute, Chongqing 400037, China) | 2005 | 中国有色金属学会会刊:英文版2005，15，S1： | 3 |
| 17 | The Influence of Diabetes, Hypertension, and Hyperlipidemia on the Onset of Age-Related Macular Degeneration in North China: The Kailuan Eye Study显示文摘Objective To analyze the prevalence of dry and wet age-related macular degeneration(AMD)in patients with diabetes,hypertension and hyperlipidemia,and to analyze the risk factors for AMD.Methods A population-based cross-sectional epidemiologic study was conducted involving 14,440 individuals.We assessed the prevalence of dry and wet AMD in diabetic and non-diabetic subjects and analyzed the risk factors for AMD.Results The prevalence of wet AMD in diabetic and non-diabetic patients was 0.3%and 0.5%,respectively,and the prevalence of dry AMD was 17%and 16.4%,respectively.The prevalence of wet AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 0.5%,0.3%,0.2%,and 0.7%,respectively.The prevalence of dry AMD in healthy,hypertensive,hyperlipidemic,and hypertensive/hyperlipidemic populations was 16.6%,16.2%,15.2%,and 17.2%,respectively.Age,sex,body mass index,and use of hypoglycemic drugs or lowering blood pressure drugs were corrected in the risk factor analysis of AMD.Diabetes,diabetes/hypertension,diabetes/hyperlipidemia,and diabetes/hypertension/hyperlipidemia were analyzed.None of the factors analyzed in the current study increased the risk for the onset of AMD.Conclusion There was no significant difference in the prevalence of wet and dry AMD among diabetic and non-diabetic subjects.Similarly,there was no significant difference in the prevalence of wet and dry AMD among subjects with hypertension and hyperlipidemia.Diabetes co-existing with hypertension and hyperlipidemia were not shown to be risk factors for the onset of dry AMD. | ZHANG Yong Peng WANG Ya Xing ZHOU Jin Qiong WANG Qian YAN Yan Ni YANG Xuan YANG Jing Yan ZHOU Wen Jia WANG Ping SHEN Chang YANG Ming LUAN Ya Nan WANG Jin Yuan WU Shou Ling CHEN Shuo Hua WANG Hai Wei FANG Li Jian WAN Qian Qian ZHU Jing Yuan NIE Zi Han CHEN Yu Ning XIE Ying JONAS JB WEI Wen Bin | 2022 | Biomedical and Environmental Sciences2022，35，7： | 2 |
| 18 | Al 1060/Pure Iron Clad Materials by Vacuum Roll Bonding and Their Solderability显示文摘Al 1060/pure iron clad materials were produced by vacuum roll bonding.The effects of preheating temperature,vacuum roll reduction and initial thickness of the Al 1060 sheet on the metal interface and bonding strength were investigated.The interfacial microstructure was investigated and the mechanical properties of the joint were evaluated by shear testing.The bonding strength of the clad materials was generally enhanced by increasing the total reduction or preheating temperature,which caused the metal interface to flatten.No obvious reaction or diffusion layer was observed at the interface between Al 1060 and pure iron.The bonding strength increased with decreasing the initial thickness of the Al 1060 sheets.The Al 1060/pure iron clad materials were soldered with ZneAl alloy by using an ultrasonic-assisted method.Strong bonding of the Al1060 layer and Al 7N01 was realized without obvious Al 1060 dissolution or effect on the initial interface of Al 1060/pure iron clad materials by soldering at relatively low temperature. | Qian Wang Xuesong Leng Jiuchun Yan Weibing Guo Yu Fu Tianming Luan | 2013 | Journal of Materials Science & Technology2013，29，10： | 2 |
| 19 | A Biomimetic Surface for Infection-resistance through Assembly of Metal-phenolic Networks显示文摘Despite the fact that numerous infection-resistant surfaces have been developed to prevent bacterial colonization and biofilm formation, developing a stable, highly antibacterial and easily produced surface remains a technical challenge. As a crucial structural component of biofilm, extracellular DNA(eDNA) can facilitate initial bacterial adhesion, subsequent development, and final maturation. Inspired by the mechanistic pathways of natural enzymes(deoxyribonuclease), here we report a novel antibacterial surface by employing cerium(Ce(Ⅳ)) ion to mimic theDNA-cleavage ability of natural enzymes. In this process, the coordination chemistry of plant polyphenols and metal ions was exploited to create an in situ metal-phenolic film on substrate surfaces. Tannic acid(TA) works as an essential scaffold and Ce(Ⅳ) ion acts as both a cross-linker and a destructor of eDNA. The Ce(Ⅳ)-TA modified surface exhibited highly enhanced bacteria repellency and biofilm inhibition when compared with those of pristine or Fe(Ⅲ)-TA modified samples. Moreover, the easily produced coatings showed high stability under physiological conditions and had nontoxicity to cells for prolonged periods of time. This as-prepared DNA-cleavage surface presents versatile and promising performances to combat biomaterial-associated infections. | Ru-Jian Jiang Shun-Jie Yan Li-Mei Tian Shi-Ai Xu Zhi-Rong Xin Shi-Fang Luan Jing-Hua Yin Lu-Quan Ren Jie Zhao | 2018 | Chinese Journal of Polymer Science2018，36，5： | 2 |
| 20 | Genetic diversity center of cultivated soybean(Glycine max) in China——New insight and evidence for the diversity center of Chinese cultivated soybean显示文摘Information on the center of genetic diversity of soybean(Glycine max) will be helpful not only for designing efficient strategies for breeding programs, but also for understanding the domestication and origin of this species. Here, we describe an analysis of genetic diversity based on simple-sequence repeat(SSR) variations within a core collection of 2 111 accessions of Chinese soybean landraces. Prior to the diversity assessment, the geographic origin of each accession was mapped. The map was then divided into grids each 2.5° in latitude and 5° in longitude. We found two regions that had higher number of alleles(NA) and greater polymorphic information content(PIC) values than the others. These regions are adjacently located within grid position of 30°–35°N×105°–110°E, which includes the valley of the middle and lower reaches of the Wei River, and the valley of the upper reaches of the Hanjiang River. It was also observed that in many regions, genetic diversity decreased with the increase in distance from the center. Another region, in northern Hebei Province(115°–120°E×40°–42.5°N), was observed having higher diversity than any surrounding regions, indicating that this is a sub-center of soybean diversity. Based on the presented results, the domestication and origin of soybean are also discussed. | WANG Li-xia LIN Fan-yun LI Lin-hai LI Wei YAN Zhe LUAN Wei-jiang PIAO Ri-hua GUAN Yuan NING Xue-cheng ZHU Li MA Yan-song DONG Zhi-min ZHANG Hai-yan ZHANG Yue-qiang GUAN Rong-xia LI Ying-hui LIU Zhang-xiong CHANG Ru-zhen QIU Li-juan | 2016 | Journal of Integrative Agriculture2016，15，11： | 2 |
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