|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cold adaptation in pigs depends on UCP3 in beige adipocytes显示文摘 | Jun Lin Chunwei Cao Cong Tao Rongcai Ye Meng Dong Qiantao Zheng Chao Wang Xiaoxiao Jiang Guosong Qin Changguo Yan Kui Li John R. Speakman Yanfang Wang Wanzhu Jin Jianguo Zhao | 2017 | Journal of Molecular Cell Biology2017，9，5： | 20 |
| 2 | Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies显示文摘Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the underlying immune mechanism in the antiviral response of patients treated with nucleoside or nucleotide analogs is not clearly understood.In this study,regulatory T cells(Tregs)and intracellular cytokines,including IL-2,interferon(IFN)-γ,tumor-necrosis factor(TNF)-α and IL-4,were measured prior to and at 12,24,36 and 48 weeks after treatment with ETV or ADV.The cytokines were increased from 24 to 48 weeks after treatment.Higher levels of Th1 cytokines were observed with ETV(n=29)versus ADV(n=28)treatment.By contrast,the numbers of Tregs in both groups were decreased.The altered cytokine profile and cellular component was accompanied by a decrease in HBV DNA levels in both groups,which may contribute to their therapeutic effect in CHB infection.Our findings suggest that the antiviral effect of the drugs may be attributed not only to their direct effect on virus suppression but also to their immunoregulatory capabilities. | Yanfang Jiang Wanyu Li Lei Yu Jingjing Liu Guijie Xin Hongqing Yan Pinghui Sun Hong Zhang Damo Xu Junqi Niu | 2011 | Cellular & Molecular Immunology2011，8，1： | 16 |
| 3 | M1 muscarinic acetylcholine receptor in Alzheimer's disease显示文摘The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease(AD). Muscarinic acetylcholine receptors(mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes(M1–M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment. | Shangtong Jiang Yanfang Li Cuilin Zhang Yingjun Zhao Guojun Bu Huaxi Xu Yun-Wu Zhang | 2014 | Neuroscience Bulletin2014，30，2： | 10 |
| 4 | Economic Value Evaluation of Wetland Service in Yeyahu Wetland Nature Reserve,Beijing显示文摘Based on multi-source data,this paper evaluated the economic value of ecological services in the Yeyahu Wetland Nature Reserve,Beijing,China.The ecological services of wetland included gas regulation,water quality im-provement,biodiversity maintenance,erosion control,water supply,recreational opportunity,raw material supply and existence value.Multiple conventional evaluation methods were used to calculate the value of eight wetland services.The results showed that significant values came from biodiversity maintenance and recreational opportunity.The main reasons were as follows.Firstly,Yeyahu Wetland Nature Reserve was the habitat for migrant birds,and government had payed more efforts to protect precious birds.Secondly,the population is large in Beijing.People enjoyed going outside and enjoyed the natural and artificial wetland scenes.At the same time,most people were prepared to pay for wetland conservation.The decline of vegetation cover made the economic value of erosion control the lowest.While the shrink of water resource and the deteriorative water quality caused the economic value of water supply lower.The evaluation results could help decision-makers understand the present status of the Yeyahu Wetland Nature Reserve and provide a scientific basis for strategic decision. | ZHU Lin CHEN Yun GONG Huili JIANG Weiguo ZHAO Wenji XIAO Yanfang | 2011 | Chinese Geographical Science2011，21，6： | 7 |
| 5 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 6 | Inflammation-induced CD69^+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1显示文摘Kupffer cells,tissue-resident macrophage lineage cell,are enriched in vertebrate liver.The mouse F4/80^+ Kupffer cells have been subclassified into two subpopulations according to their phenotype and function:CD68^+ subpopulation with potent reactive oxygen species(ROS) production and phagocytic capacities,and CD11b^+ subpopulation with a potent capacity to produce T helper 1 cytokines.In addition,CD11b^+ Kupffer cells/macrophages may be migrated from the bone marrow or spleen,especially in inflammatory conditions of the liver.For analyzing diverse Kupffer cell subsets,we infected mice with Listeria monocytogenes and analyzed the phenotype variations of hepatic Kupffer cells.During L.monocytogenes infection,hepatic CD69^+ Kupffer cells were significantly induced and expanded,and CD69^+ Kupffer cells expressed higher level of CD11 b,and particularly high level of membrane-bound TGF-β1(mTGF-β1) but lower level of F4/80.We also found that clodronate liposome administration did not eliminate hepatic CD69^+ Kupffer cell subset.We consider the hepatic CD69^+ Kupffer cell population corresponds to CD11b^+Kupffer cells,the bone marrow-derived population.Hepatic CD69^+ Kupffer cells suppressed Ag-nonspecific and OVA-specific CD4 T cell proliferation through mTGF-β1 both in vitro and in vivo,meanwhile,they did not interfere with activation of CD4 T cells.Thus,we have identified a new subset of inflammation-induced CD69^+ Kupffer cells which can feedback inhibit CD4 T cell response via cell surface TGF-β1 at the late stage of immune response against infection.CD69^+ Kupffer cells may contribute to protect host from pathological injure by preventing overactivation of immune response. | Xiang Zhang Zhengping Jiang Yan Gu Yanfang Liu Xuetao Cao Yanmei Han | 2016 | Science China(Life Sciences)2016，59，12： | 5 |
| 7 | Feasibility of Tea Saponin-Enhanced Soil Washing in a Soybean Oil-Water Solvent System to Extract PAHs/Cd/Ni Efficiently from a Coking Plant Site显示文摘Mixed contaminated brownfield sites have brought serious risks to human health and environmental safety. With the purpose of removing polycyclic aromatic hydrocarbons(PAHs) and heavy metals from a coking plant site, an innovative technology for ex-situ washing was developed in the present work. The combination of 15.0 mL L^(-1) soybean oil and 7.5 g L^(-1) tea saponin proved an effective method to extract co-pollutants from soil. After two consecutive washing cycles, the efficiency rates of removal for 3-, 4-,5(+6)-ring, and total PAHs, Cd, and Ni were approximately 98.2%, 96.4%, 92.3%, 96.3%, 94.1%, and 89.4%, respectively. Meanwhile,as evaluated by Tenax extraction method and metal stability indices, the residual PAHs and heavy metals after consecutive washing mainly existed in the form with extremely low bioaccessibility in the soil. Thus, in the soil after two washing cycles, there appeared limited environmental transfer risk of co-pollutants. Moreover, a subsequent precipitation method with alkaline solution and PAHdegrading strain Sphingobium sp. PHE9 inoculation effectively removed 84.6%–100% of Cd, 82.5%–91.7% of Ni, and 92.6%–98.4% of PAHs from the first and second washing solvents. The recovered solvents also exhibited a high recycling effectiveness. Therefore, the combined cleanup strategy proposed in this study proved environmentally friendly, which also played a major role in risk assessment and management in mixed polluted sites. | YE Mao SUN Mingming XIE Shanni LIU Kuan FENG Yanfang ZHAO Yu WAN Jinzhong HU Feng LI Huixin ZONG Lianggang JIANG Xin | 2017 | Pedosphere2017，27，3： | 5 |
| 8 | Effect of artificially accelerated aging on the vigor of Metasequoia glyptostroboides seeds显示文摘Metasequoia glyptostroboides is an endangered relict plant native to China that has been widely introduced into many countries and areas around the world. However,its seeds germinate at a very low percentage. Consequently,population regeneration by seed is low under natural conditions, which probably contributes to the endangered status of this plant species. The present study aimed to describe the aging mechanism of M. glyptostroboides seeds. Our objective was to elucidate causes of the low germination rate in an effort to enhance potential for conservation of the species. We used germination tests,relative electrical conductivity and malondialdehyde content determination, ultrastructural observation of embryo cells, and analysis of superoxide dismutase, catalase,ascorbate peroxidase, and dehydroascorbate reductase activities during accelerated aging treatment. We found that M. glyptostroboides seeds have a low level of vigorand poor ability to maintain vigor, which is probably associated with the inefficiency of its enzymatic antioxidative system. | Huan Liu Yanfang Zhu Xia Liu Yu Jiang Shiming Deng Xunru Ai Zhijun Deng | 2020 | Journal of Forestry Research2020，31，3： | 5 |
| 9 | Fabrication of gelatin methacryloyl hydrogel microneedles for transdermal delivery of metformin in diabetic rats显示文摘Injection therapy for diabetes has poor patient compliance,and the pain occurring at the site of subcutaneous injections causes significant inconvenience to diabetic patients.In this work,to demonstrate the benefits of an alternative drug delivery technique that overcomes these issues,methacrylated gelatin hydrogel-forming microneedles integrated with metformin were developed to adjust blood glucose levels in diabetic rats.Gelatin methacryloyl microneedles(GelMA-MNs)with different degrees of substitution were successfully prepared by a micro-molding method.The resultant GelMA-MNs exhibited excellent mechanical properties and moisture resistance.Metformin,an anti-diabetic drug,was further encapsulated into the GelMA-MNs,and its release rate could be controlled by the three-dimensional cross-linked network of microneedles,thereby exhibiting sustained drug release behaviors in vitro and implying a better therapeutic effect compared with that of subcutaneous injection in diabetic rats.The drug release period could be significantly prolonged by improving the cross-link density of GelMA-MNs.The results of hypoglycemic effect evaluation show that the application of GelMA-MNs for transdermal delivery in diabetic rats has promising benefits for diabetes treatment. | Zhiyong Zeng Guohua Jiang Tianqi Liu Gao Song Yanfang Sun Xueya Zhang Yanting Jing Mingjia Feng Yufei Shi | 2021 | Bio-Design and Manufacturing2021，4，4： | 4 |
| 10 | Global SH-wave propagation in a 2D whole Moon model using the parallel hybrid PSM/FDM method显示文摘We present numerical modeling of SH-wave propagation for the recently proposed whole Moon model and try to improve our understanding of lunar seismic wave propagation. We use a hybrid PSM/FDM method on staggered grids to solve the wave equations and implement the calculation on a parallel PC cluster to improve the computing efficiency. Features of global SH-wave propagation are firstly discussed for a 100-km shallow and900-km deep moonquakes, respectively. Effects of frequency range and lateral variation of crust thickness are then investigated with various models. Our synthetic waveforms are finally compared with observed Apollo data to show the features of wave propagation that were produced by our model and those not reproduced by our models. Our numerical modeling show that the low-velocity upper crust plays significant role in the development of reverberating wave trains. Increasing frequency enhances the strength and duration of the reverberations.Surface multiples dominate wavefields for shallow event.Core–mantle reflections can be clearly identified for deep event at low frequency. The layered whole Moon model and the low-velocity upper crust produce the reverberating wave trains following each phases consistent with observation. However, more realistic Moon model should be considered in order to explain the strong and slow decay scattering between various phases shown on observation data. | Xianghua Jiang Yanbin Wang Yanfang Qin Hiroshi Takenaka | 2015 | Earthquake Science2015，28，3： | 3 |
| 11 | CIMDS: A- dapting Postprocessing Techniques of Associative Classifi- cation for Malware Detection 显示文摘 | YE Yanfang LI Tao JIANG Qingshan | 2010 | IEEE Transactions On Systems Man And Cybernetics-Part C : Applications And Reviews2010，40，3： | 1 |
| 12 | CIMDS: a- dapting post-processing techniques of associative classifica- tion for virus detection 显示文摘 | YE Yanfang LI Tao JIANG Qingshan | 2010 | IEEE Transactions on Sys- tems Man and Cybernetics Part C: Applications and Reviews2010，40，3： | 1 |
| 13 | Anti-inflammatory Effects of Rebamipide According to Helicobacter pylori Status in Patients with Chronic Erosive Gastritis: A Randomized Sucralfate-Controlled Multicenter Trial in China—STARS Study显示文摘 | Yiqi Du Zhaoshen Li Xianbao Zhan Jie Chen Jun Gao Yanfang Gong Jianlin Ren Liping He Zhijian Zhang Xiaozhong Guo Jianshen Wu Zibin Tian Ruihua Shi Bo Jiang Dianchun Fang Youming Li | 2008 | Digestive Diseases and Sciences2008，，11： | 1 |
| 14 | Identification of natural splice variants of SAMHD1 in virus-infectedHCC显示文摘 | Yunpeng Shi Guoyue Lv Zhe Chu Liling Piao Xingkai Liu Tuo Wang Yanfang Jiang Ping Zhang | 2014 | Oncology Reports2014，，2： | 1 |
| 15 | Body Size but Not Food Size Determined Head Sexual Dimorphism in Rana kukunoris from the Tibetan Plateau显示文摘Sexual dimorphism between males and females is a common pattern observed in the natural world and has become one of the main focuses of evolutionary biology.Amphibian head size and shape are important factors that may influence food acquisition,but knowledge about the sexual differences between amphibian head size and shape is relatively scant.Here,intersexual differences in the head size and shape of Rana kukunoris,which is a high-elevation frog from the Qinghai-Tibet Plateau,were investigated.Significant differences were found in the head shape but not the head size between sexes.A significant correlation was also observed between prey size and head size.However,these correlations disappeared when individual body size was controlled,suggesting that body size but not food size was the main factor resulting in intersexual differences in head size/shape.The results suggested that food competition between sexes did not result in sexual dimorphism of head shape among these frogs. | Hongzhou CHEN Haifen QIN Zhenkun ZHAO Jiahong LIAO Yanfang WU Xueyan LIU Lichun JIANG Buddhi DAYANANDA Wei CHEN | 2023 | Asian Herpetological Research2023，14，2： | 1 |
| 16 | Excitatory effects of motilin in the hippocampus on gastric motility in rats显示文摘 | Yanfang Guan Ming Tang Zhengyao Jiang Theo L Peeters | 2003 | Brain Research2003，，1： | 1 |
| 17 | AN LBP-BASED MULTI-SCALE ILLUMINATION PREPROCESSING METHOD FOR FACE RECOGNITION显示文摘It is one of the major challenges for face recognition to minimize the disadvantage of il- lumination variations of face images in different scenarios. Local Binary Pattern (LBP) has been proved to be successful for face recognition. However, it is still very rare to take LBP as an illumination preprocessing approach. In this paper, we propose a new LBP-based multi-scale illumination pre- processing method. This method mainly includes three aspects: threshold adjustment, multi-scale addition and symmetry restoration/neighborhood replacement. Our experiment results show that the proposed method performs better than the existing LBP-based methods at the point of illumination preprocessing. Moreover, compared with some face image preprocessing methods, such as histogram equalization, Gamma transformation, Retinex, and simplified LBP operator, our method can effectively improve the robustness for face recognition against illumination variation, and achieve higher recog- nition rate. | Jiang Guoxing Cheng Yanfang | 2009 | Journal of Electronics(China)2009，26，4： | 1 |
| 18 | Coseismic deformation of the 2021 M_(W)7.4 Maduo earthquake from joint inversion of InSAR, GPS, and teleseismic data显示文摘The M_(W)7.4 Maduo earthquake occurred on 22 May 2021 at 02:04 CST with a large-expansion surface rupture.This earthquake was located in the Bayan Har block at the eastern Tibetan Plateau,where eight earthquakes of M_(S)>7.0 have occurred in the past 25 years.Here,we combined interferometric synthetic aperture radar,GPS,and teleseismic data to study the coseismic slip distribution,fault geometry,and dynamic source rupture process of the Maduo earthquake.We found that the overall coseismic deformation field of the Maduo earthquake is distributed in the NWW-SEE direction along 285°.There was slight bending at the western end and two branches at the eastern end.The maximum slip is located near the eastern bending area on the northern branch of the fault system.The rupture nucleated on the Jiangcuo fault and propagated approximately 160 km along-strike in both the NWW and SEE directions.The characteristic source rupture process of the Maduo earthquake is similar to that of the 2010 M_(W)6.8 Yushu earthquake,indicating that similar earthquakes with large-expansion surface ruptures and small shallow slip deficits can occur on both the internal fault and boundary fault of the Bayan Har block. | Chaoya Liu Ling Bai Shunying Hong Yanfang Dong Yong Jiang Hongru Li Huili Zhan Zhiwen Chen | 2021 | Earthquake Science2021，34，5： | 1 |
| 19 | Th1 and Th2 Immune Response in Chronic Hepatitis B Patients during a Long-Term Treatment with Adefovir Dipivoxil显示文摘 | Yanfang Jiang Zhenhua Ma Guijie Xin Hongqing Yan Wanyu Li Huining Xu Chunhai Hao Junqi Niu Pingwei Zhao Dennis Daniel Taub | 2010 | Mediators of Inflammation2010，，： | 1 |
| 20 | Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity显示文摘Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been explored.Genetic ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism. | Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang Yang Jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao Jiang Cen Xie Xiuwei Yang Frank J.Gonzalez | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员