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| 1 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 2 | Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa显示文摘To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the control of the promoter for the erythromycin resistance gene by splicing using overlapping extension PCR. This was cloned into the integrating vector pSET152, yielding the Vitreoscilla hemoglobin gene expression plasmid pSET152EVHB. This was then introduced into S. spinosa SP06081 by conjugal transfer, and integrated into the chromosome by site-specific recombination at the integration site ΦC31 on pSET152EVHB. The resultant conjugant, S. spinosa S078-1101, was genetically stable. The integration was further confirmed by PCR and Southern blotting analysis. A carbon monoxide differential spectrum assay showed that active Vitreoscilla hemoglobin was successfully expressed in S. spinosa S078-1101. Fermentation results revealed that expression of the Vitreoscilla hemoglobin gene significantly promoted spinosad biosynthesis under normal oxygen and moderately oxygen-limiting conditions (P<0.01). These findings demonstrate that integrating expression of the Vitreoscilla hemoglobin gene improves oxygen uptake and is an effective means for the genetic improvement of S. spinosa fermentation. | LUO YuShuang KOU XiaoXiao DING XueZhi HU ShengBiao TANG Ying LI WenPing HUANG Fan YANG Qi CHEN HanNa XIA LiQiu | 2012 | Science China(Life Sciences)2012，55，2： | 14 |
| 3 | Sequential therapy according to distinct disease progression patterns in advanced ALK-positive non-small-cell lung cancer after crizotinib treatment显示文摘Objective: Crizotinib is recommended as the first-line therapy for advanced anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC). Despite its initial efficacy, patients ultimately acquire resistance to crizotinib within 1 year. In such patients, the optimal sequential therapy after crizotinib treatment remains unknown. This study explored which sequential therapy option confers the greatest benefit.Methods: A total of 138 patients with advanced ALK-positive NSCLC resistant to crizotinib were studied. Based on patterns of disease progression of metastases, patients were divided into 3 groups: brain progression, non-liver progression, and liver progression. Sequential therapies included crizotinib continuation plus local therapy, nextgeneration ALK inhibitors(ALKi's), and chemotherapy. The primary endpoint was overall survival(OS) from the time of crizotinib resistance to death or last follow-up.Results: The 138 patients included 64 cases with progression in brain, 57 cases in non-liver sites and 17 cases in liver. A significant difference in OS was observed among the distinct progression pattern(median OS, 25.4 months in brain, 15.8 months in non-liver, and 10.8 months in liver, respectively, P=0.020). The difference in OS among sequential therapies was statistically significant in the non-liver progression group(median OS, 27.6 months with next-generation ALKi's, 13.3 months with crizotinib continuation, and 10.8 months with chemotherapy,respectively, P=0.019). However, crizotinib continuation plus local therapy seems to provide non-inferior median OS compared with next-generation ALKi's for patients with brain progression(median OS, 28.9 months vs.32.8 months, P=0.204). And no significant differences in OS were found in patients with progression in liver(P=0.061).Conclusions: Crizotinib continuation together with local therapy might be a feasible strategy for patients with progression in brain beyond crizotinib resistance, as well as next-generation ALKi's. Next-generation ALKi's tended to provide a survival benefit in patients with non-liver progression. | Haiyan Xu Di Ma Guangjian Yang Junling Li Xuezhi Hao Puyuan Xing Lu Yang Fei Xu Yan Wang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 6 |
| 4 | Failure probability estimation of overhead transmission lines considering spatial and temporal variation in severe weather显示文摘Estimation for weather-related failure probability of overhead transmission lines is essential in the reliability assessment of a power system.This paper analyzes the outage and weather data of 110 kV overhead transmission lines in the Guangxi Zhuang Autonomous Region of China during 2011–2014.The result reveals obvious uneven distributions of outage events for time and space due to the spatial and temporal variation of severe weather.Based on the results, an estimation method is proposed in this paper.Split and aggregation is used to smooth the outage and weather data.The poisson model is adopted in our method to investigate the statistic characteristics of transmission line outage events.Regression analysis is applied to obtain the correlation between the weather intensity and history failure rate.Furthermore the method proposed is validated against the empirical outage data. | Shuai YANG Wenjun ZHOU Shiyang ZHU Le WANG Lisha YE Xuezhi XIA Han LI | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，1： | 5 |
| 5 | Effects of ionic strength and temperature on the aggregation and deposition of multi-walled carbon nanotubes显示文摘The aggregation and deposition of carbon nanotubes(CNTs) determines their transport and fate in natural waters.Therefore,the aggregation kinetics of humic-acid treated multi-walled carbon nanotubes(HA-MWCNTs) was investigated by time-resolved dynamic light scattering in NaCl and CaCl_2 electrolyte solutions.Increased ionic strength induced HA-MWCNT aggregation due to the less negative zeta potential and the reduced electrostatic repulsion.The critical coagulation concentration(CCC) values of HA-MWCNTs were 80 mmol/L in NaCl and 1.3 mmol/L in CaCl_2 electrolyte,showing that Ca^(2+) causes more serious aggregation than Na^+.The aggregation behavior of HA-MWCNTs was consistent with Derjaguin-Landau-Verwey-Overbeek theory.The deposition kinetics of HA-MWCNTs was measured by the optical absorbance at 800 ran.The critical deposition concentrations for HA-MWCNT in NaCl and CaCl_2 solutions were close to the CCC values,therefore the rate of deposition cannot be increased by changing the ionic strength in the diffusion-limited aggregation regime.The deposition process was correlated to the aggregation since larger aggregates increased gravitational deposition and decreased random Brownian diffusion.HA-MWCNTs hydrodynamic diameters were evaluated at 5,15 and 25℃.Higher temperature caused faster aggregation due to the reduced electrostatic repulsion and increased random Brownian motion and collision frequency.HA-MWCNTs aggregate faster at higher temperature in either NaCl or CaCl_2electrolyte due to the decreased electrostatic repulsion and increased random Brownian motion.Our results suggest that CNT aggregation and deposition are two correlated processes governed by the electrolyte,and CNT transport is favored at low ionic strength and low temperature. | Lixin Wang Xuezhi Yang Qi Wang Yuxuan Zeng Lei Ding Wei Jiang | 2017 | Journal of Environmental Sciences2017，29，1： | 5 |
| 6 | Application of Traditional Chinese Medicine Four-diagnostic auxilia-ry apparatus in evaluation of health status and clinical treatment显示文摘OBJECTIVE: To evaluate the application of Traditional Chinese Medicine(TCM) Four-diagnostic Auxiliary Apparatus in disease diagnosis.METHODS: The liver cancer patients and healthy controls were recruited from Shanghai Integrated Chinese and Western Medicine Hospital and Beijing University of Traditional Chinese Medicine, respectively. Then, the included subjects were diagnosed by the Four-diagnostic auxiliary apparatus.RESULTS: Thirty liver cancer patients and 30 paired healthy controls were enrolled in this study. Based on the apparatus, the pulse wave velocity was significantly higher in patients compared with controls(P < 0.05). The number of patients with purple tongue and ecchymosis were more than controls(P < 0.05). The number of patients(10%) with yellow tongue coating were higher than the controls(0%). Patients were inclined to be with water type and fire type constitution.CONCLUSION: TCM Four-diagnostic auxiliary apparatus can be applied in clinical diagnosis of body constitution and health status of subjects. It promotes the accuracy and speed for disease diagnosis and TCM standardization. | Chen Tianyu Niu Tingli Niu Xin Si Yingchu Yang Xuezhi Ma Liangxiao | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 5 |
| 7 | Cytotoxicity of the soluble and insoluble fractions of atmospheric fine particulate matter显示文摘Inhaled atmospheric fine particulate matter(PM2.5)includes soluble and insoluble fractions,and each fraction can interact with cells and cause adverse effects.PM2.5 samples were collected in Jinan,China,and the soluble and insoluble fractions were separated.According to physiochemical characterization,the soluble fraction mainly contains watersoluble ions and organic acids,and the insoluble fraction mainly contains kaolinite,calcium carbonate and some organic carbon.The interaction between PM2.5 and model cell membranes was examined with a quartz crystal microbalance with dissipation(QCM-D)to quantify PM2.5 attachment on membranes and membrane disruption.The cytotoxicity of the total PM2.5 and the soluble and insoluble fractions,was investigated.Negatively charged PM2.5 can adhere to the positively charged membranes and disrupt them.PM2.5also adheres to negatively charged membranes but does not cause membrane rupture.Therefore,electrostatic repulsion does not prevent PM2.5 attachment,but electrostatic attraction induces remarkable membrane rupture.The human lung epithelial cell line A549 was used for cytotoxicity assessment.The detected membrane leakage,cellular swelling and blebbing indicated a cell necrosis process.Moreover,the insoluble PM2.5 fraction caused a higher cell mortality and more serious cell membrane damage than the soluble fraction.The levels of reactive oxygen species(ROS)enhanced by the two fractions were not significantly different.The findings provide more information to better understand the mechanism of PM2.5 cytotoxicity and the effect of PM2.5 solubility on cytotoxicity. | Ling Liu Qiuhua Zhou Xuezhi Yang Gang Li Jingzhu Zhang Xuehua Zhou Wei Jiang | 2020 | Journal of Environmental Sciences2020，32，5： | 4 |
| 8 | Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus-Eluting Stents in “Real-World” Practice显示文摘 | Yaling Han Quanmin Jing Bo Xu Lixia Yang Huiliang Liu Xiaoming Shang Tieming Jiang Zhanquan Li Hua Zhang Hui Li Jian Qiu Yingfeng Liu Yi Li Xuezhi Chen Runlin Gao | 2009 | JACC: Cardiovascular Interventions2009，，4： | 2 |
| 9 | Impact of crizotinib on long-term survival of ALK-positive advanced non-small-cell lung cancer: A Chinese multicenter cohort study显示文摘Objective: Crizotinib has demonstrated promising efficacy in patients with anaplastic lymphoma kinase(ALK)-positive non-small-cell lung cancer(NSCLC) in clinical trials. We conducted this retrospective multicenter study to assess the outcomes of crizotinib therapy in, to our knowledge, a large sample cohort of patients with ALKpositive advanced NSCLC.Methods: We reviewed the medical records of 484 unselected ALK-positive NSCLC patients treated with crizotinib at 5 cancer centers in China from January 2013 to November 2017. Clinical data were collected from the initiation of crizotinib therapy to Response Evaluation Criteria in Solid Tumors(RECIST)-defined progressive disease(PD).Results: A total of 428 eligible ALK-positive NSCLC patients were enrolled, 273(63.8%) of whom received crizotinib as first-line treatment. The median progression-free survival(PFS) and overall survival(OS) from the initiation of crizotinib treatment were 14.4 [95% confidence interval(95% CI), 12.4-16.4] months and 53.4(95%CI, 33.7-73.1) months, respectively. In subgroup analyses, patients who received crizotinib as first-line treatment showed a higher disease control rate(DCR) and a longer median OS compared with second-/later-line crizotinib treatment(94.8% and OS not reached vs. 89.0% and 40.5 months, respectively). For 261 patients with RECISTdefined PD, multivariate Cox analysis revealed that in patients who received first-line crizotinib therapy, continued crizotinib beyond progressive disease(CBPD) and next-generation ALK inhibitors after crizotinib failure were associated with improved survival.Conclusions: This study has demonstrated the clinically meaningful benefit of crizotinib treatment in a large cohort of Chinese ALK-positive NSCLC patients. CBPD and next-generation ALK inhibitor treatment may provide improved survival after RECIST-defined progression on crizotinib. | Puyuan Xing Di Ma Qiang Wang Xuezhi Hao Mengzhao Wang Yan Wang Li Shan Tao Xin Li Liang Hongge Liang Yang Du Zhaohui Zhang Junling Li | 2019 | Chinese Journal of Cancer Research2019，31，3： | 2 |
| 10 | Discrimi native training approaches to fabric defect classi fication based on wavelet transform显示文摘 | YANG XUEZHI GRANTHAM PANG NELSON YUNG | 2004 | Pattern Recognition2004，，37： | 1 |
| 11 | Robust Fabric Defect Detection and Classification Using Multiple Adaptive Wave- lets显示文摘 | YANG Xuezhi PANG G YUNG N | 2005 | IEEE Proceedings on Image Signal Process2005，152，6： | 1 |
| 12 | Efficient registration of optical and IR images for automatic plant water stress assessment显示文摘 | Wang Xuezhi Yang Weiping Wheaton Ashley | 2010 | Computers and Electronics in Agriculture2010，74，2： | 1 |
| 13 | Robust fabric defect detection and classification using multiple adaptive wavelets显示文摘 | YANG Xuezhi PANG G K H YUNG N | 2005 | Vision Image and Signal Processing2005，152，6： | 1 |
| 14 | Efficient registration of optical and infrared images via modified Sobel edging for plant canopy temperature es- timation显示文摘 | YANG Weiping WANG Xuezhi MORAN B | 2012 | Computers & Electrical Engineering2012，38，5： | 1 |
| 15 | Ganjiang granule regulates cecal microflora and serum biochemical components in a rat model of constipation-predominant irritable bowel syndrome显示文摘Objective:To investigate the effects of Ganjiang granule(GG)on cecal microflora and serum biochemical components in rats with constipation-predominant irritable bowel syndrome(IBSeC).Methods:Twenty-four SpragueeDawley rats were randomly divided into four groups:control,model,GG,and probiotics.Rats in the model,GG,and probiotics groups received 3℃ tap water intragastrically;rats in the GG group were treated with GG;rats in the probiotics group were treated with probiotics.For all rats,enzyme-linked immunosorbent assay and colorimetry were used to assess serum biochemical components related to gastrointestinal function;16S rRNA high-throughput sequencing was used to analyze the cecal microflora.Results:The serum level of 5-hydroxytryptamine(HT)was higher in the model group than in the control group(Z=-2.082,P=.037).The model group exhibited changes in cecal microflora:the relative abundances of Lactobacillus decreased(Z=-2.882,P=.004)and Dorea increased(t=-3.030,P=.023),compared with the control group.The GG and probiotics groups exhibited normal serum levels of 5-HT.The GG and probiotics groups exhibited improved serum levels of gastrin;the probiotics group exhibited an improved serum level of vasoactive intestinal peptide.Compared with the model group,The GG group exhibited greater relative abundance of Ruminococcus(Z=-2.402,P=.016);the probiotics group exhibited greater relative abundance of SMB53(Z=-2.823,P=.005)and lower relative abundances of Desulfovibrio(Z=-2.823,P=.005)and Facklamia(Z=-2.608,P=.009).Conclusion:The effects of GG on IBS-C may be related to regulation of the serum level of 5-HT,as well as elevated relative abundance of beneficial bacteria in cecal microflora. | Lujiao Gao Xin Niu Tingli Niu Xuan Wang Xiaoyan Lu Jiewei Hong Qianjin Feng Xuezhi Yang Roberto Gonzalez | 2020 | Journal of Traditional Chinese Medical Sciences2020，7，2： | 1 |
| 16 | Life - cycle analysis on biodiesel production from microalgae:Water fiotprint and nutrients balance 显示文摘 | Yang Jia Xu Ming Zhang Xuezhi | 2010 | Bioresonree Technology2010，102，1： | 1 |
| 17 | Coupling non-isothermal trickle-bed reactor with catalyst pellet models to understand the reaction and diffusion in gas oil hydrodesulfurization显示文摘In this work,a trickle-bed reactor coupled with catalyst pellet model is employed to understand the effects of the temperature and catalyst pellet structures on the reaction-diffusion behaviors in gas oil hydrodesulfurization(HDS).The non-isothermal reactor model is determined to be reasonable due to non-negligible temperature variation caused by the reaction heat.The reaction rate along the reactor is mainly dominated by the temperature,and the sulfur concentration gradient in the catalyst pellet decreases gradually along the reactor,leading to the increased internal effectiveness factor.For the fixed catalyst bed volume,there exists a compromise between the catalyst reaction rate and effectiveness factor.Under commonly studied catalyst pellet size of 0.8-3 mm and porosity of 0.4-0.8,an optimization of the temperature and catalyst pellet structures is carried out,and the optimized outlet sulfur content decreases to 7.6 wppm better than the commercial level at 0.96 mm of the catalyst pellet size and 0.40 of the catalyst porosity. | Xingqiang Zhao Changfeng Yang Mengke Lu Yao Shi Gang Qian Xinggui Zhou Xuezhi Duan | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 1 |
| 18 | The Therapeutic Effect of Negative Pressure in Treating Femoral Head Necrosis in Rabbits显示文摘 | Yin-gang Zhang Xuezhi Wang Zhi Yang | 2013 | PLoS One2013，8，55： | 1 |
| 19 | Side-polished SMS based RI sensor employing macro-bending perfluorinated POF显示文摘A refractive index(RI)sensor based on perfluorinated plastic optical fiber(PF-POF)is introduced in this paper.The PF-POF as multi-mode fiber was side-polished(SP)to form a macro-bending single-mode-multimode-single-mode(SMS)structure.Both ends of the sensor were closely connected to single-mode quartz optical fiber(SMF).The spectral char-acteristics of the sensor are measured,analyzed and discussed.The results show that when the length of PF-POF is 8 cm,the macro-bending radius is 3 cm,and the SP-depth is 20μm.The intensity sensitivity reaches−219.504 dBm/RIU in the range of RI=1.330~1.356.A reference is provided for the application of PF-POF in RI sensor in the future.The sensor is featured with low-cost,good flexibility and high efficiency. | Xuezhi Zhang Boyue Yang Junfeng Jiang Kun Liu Xiaojun Fan Zhaozhu Liu Min Peng Guanlong Chen Tiegen Liu | 2021 | Opto-Electronic Advances2021，4，10： | 1 |
| 20 | Life-cycle analysis on biodiesel production from microalgae:Water footprint and nutrients balance显示文摘 | Jia Yang Ming Xu Xuezhi Zhang | 2011 | Bioresource Technology2011，102，： | 1 |
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