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| 1 | Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy显示文摘The prevalence of skin cancer is rising along with the rapid population aging in recent years.Traditional therapies,such as surgical treatment,radiotherapy,chemotherapy,photodynamic therapy,and immunotherapy,may accompany serious side effects,limiting their clinical benefits.According to the biological characteristics of skin cancer,we have already established two kinds of synergetic systems of photothermal therapy(microneedle)and chemotherapy,containing gold nanorods(GNR).Although the microneedle system exhibited great potential for skin cancer treatment,the system could be still improved further.So,we designed a near-infrared lightresponsive 5-fluorouracil(5-Fu)and indocyanine green(ICG)loaded monomethoxy-poly(ethylene glycol)-polycaprolactone(MPEG-PCL)nanoparticle(5-Fu-ICG-MPEG-PCL),and then 5-Fu-ICG-MPEG-PCL was integrated with a hyaluronic acid dissolvable microneedle system(HA MN)to get 5-Fu-ICG-MPEG-PCL loaded HA MN for treating skin cancers,including human epidermoid cancer and melanoma.In this system,hyaluronic acid,the microneedle carrier,possesses good skin penetration ability and is approved by FDA as a pharmaceutical adjuvant;5-Fu is recommended by FDA for skin cancer treatment;ICG,a photothermal agent,possesses a strong photothermal ability and is approved by FDA for its use in the human body.We hypothesized that 5-Fu-ICG-MPEG-PCL could be delivered by the dissolvable microneedle through the skin,and the release behavior of the drug in the nanoparticle could be controlled by near-infrared light for achieving a single-dose cure of skin cancer,improving the cure rate of skin cancer and providing a new idea and possibility for the clinical treatment of skin cancer. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2020 | Bioactive Materials2020，5，3： | 17 |
| 2 | MATLAB-Based Simulation of Buoyancy-Driven Underwater Glider Motion显示文摘The mass configuration of the buoyancy-driven underwater glider is decomposed and defined. The coupling between the glider body and its internal masses is addressed using the energy law. A glider motion model is established, and the corresponding simulation program is derived using MATLAB. The characteristics of the glider motion are explored using this program. The simula- tion results show that the basic characteristic of a buoyancy-driven underwater glider is the periodic alternation of downward and upward motions. The glider's spiral motion can be applied to missions in restricted regions. The glider's horizontal velocity, gliding depth and its motion radius in spiral motion can be changed to meet different application purposes by using different glider parameter designs. The simulation also shows that the model is appropriate and the program has strong simulation functions. | KAN Lei ZHANG Yuwen FAN Hui YANG Wugang CHEN Zhikun | 2008 | Journal of Ocean University of China2008，7，1： | 11 |
| 3 | Onset of Xiashu loess deposition in southern China by 0.9 Ma and its implications for regional aridification显示文摘The Xiashu loess is a typical Quaternary eolian deposit in southern China and represents an important terrestrial paleoclimate archive in this low-latitude monsoon region. However, the chronological framework of Xiashu loess deposition has yet to be established. Determining the timing of the onset of Xiashu loess deposition will allow researchers to better understand late Quaternary aridification across the Asian continent, the evolution of the East Asian monsoon and regional environmental changes in subtropical regions. Therefore, in this study, a systematic chronological study of the Xiashu loess is conducted to answer this question. For the first time, magnetostratigraphic classification reveals that the Matuyama/Brunhes(M/B) reversal is present in the Xiashu loess at two sites in Jiangsu Province, the Qingshan profile at Yizheng and the Dagang core in Zhenjiang.Based on the results of magnetostratigraphy and optically stimulated luminescence(OSL) dating, the age of the lower boundary of the Xiashu loess is estimated to be approximately 0.9 Ma. Consequently, this Xiashu loess deposit is the oldest reported to date and is comparable in age to the red soil deposit in Xuancheng, Anhui Province. The onset of Xiashu loess deposition by 0.9 Ma represents the further expansion of arid range in Asia in the late Quaternary in response to significant aridification and winter monsoon strengthening in this subtropical region. We suggest that these climate changes were primarily driven by global cooling and an increase in high-latitude ice volume in the Northern Hemisphere and that the initiation of Xiashu loess accumulation was a regional response of southern China to the 0.9 Ma global cooling event. | Xusheng LI Zhiyong HAN Huayu LU Yingyong CHEN Yang LI Xiaokang YUAN Yuwen ZHOU Mengyao JIANG Cunjuan LV | 2018 | Science China Earth Sciences2018，61，3： | 11 |
| 4 | Facile synthesis of graphene-supported Ni-CeOx nano-composites as highly efficient catalysts for hydrolytic dehydrogenation of ammonia borane显示文摘 | Qilu Yao Zhang-Hui Lu Yuwen Yang Yuzhen Chen Xiangshu Chen Hai-Long Jiang | 2018 | Nano Research2018，11，8： | 11 |
| 5 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 6 | COMPOSITE SOFT SWITCHING CONFIGURATION FOR INVERTERS USING BRIDGE LEG MODULES显示文摘The use of either lossless snubbers or resonant zero voltage switching (ZVS) and zero current switching (ZCS) techniques can increase efficiency and reduce electromagnetic inter ference (EMI) and noise of industrial power equipment at high switching frequencies. This paper presents an adaptive composite soft switching configuration which combines snubber functions and resonant ZCS circuits for switches in inverters using power bridge leg modules. Simulation and experimental results are included. | He Xiangning Yang Yuwen (Dept of Electrical Eng., Zhejiang University, Hangzhou 310027)Kuang Sheng(Department of Engineering, University of Cambridge, Cambridge, U.K.)Barry W. Williams Stephen J. Finney(Dept. of Computing & Electrical Eng., Heriot-Watt University, Edinburgh EH14 4AS, U.K.) | 2001 | Journal of Electronics(China)2001，18，1： | 7 |
| 7 | Hydrogen production from coke oven gas over LiNi/γ-Al_2O_3 catalyst modified by rare earth metal oxide in a membrane reactor显示文摘The performance of LiNi/γ-Al2O3 catalysts modified by rare earth metal oxide(La2O3 or CeO2 ) packed on BCFNO membrane reactor was discussed for the partial oxidation of methane(POM) in coke oven gas(COG) at 875 C. The NiO/γ-Al2O3 catalysts with different amounts of La2O3 and CeO2 were prepared with the same preparation method and under the same condition in order to compare the reaction performance(oxygen permeation,CH 4 conversion,H 2 and CO selectivity) on the membrane reactor. The results show that the oxygen permeation flux increased significantly with LiNiREO x /γ-Al2O3(RE = La or Ce) catalysts by adding the element of rare earth especially the Ce during the POM in COG. Such as,the Li15wt%CeO2 9wt%NiO/γ-Al2O3 catalyst with an oxygen permeation flux of 24.71 ml cm 2 min 1 and a high CH 4 conversion was obtained in 875 C. The resulted high oxygen permeation flux may be due to the added Ce that inhibited the strong interaction between Ni and Al2O3 to form the NiAl2O4 phase. In addition,the introduction of Ce leads up to an important property of storing and releasing oxygen. | Zhibin Yang Yunyan Zhang Weizhong Ding Yuwen Zhang Peijun Shen Yuding Zhou Yong Liu Shaoqing Huang Xionggang Lu | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 6 |
| 8 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 9 | Design of two-stage membrane reactor for the conversion of coke-oven gas to H_2 and CO显示文摘The catalyst function was achieved in two regions in an oxygen permeation membrane reactor: H2 dissociated and reacted with lattice oxygen or oxygen ions to form H2 O near the membrane surface. The H2 O formed could react with the residual CH4 away from the membrane surface area. | Zhibin Yang Yuwen Zhang Xueguang Wang Weizhong Ding | 2014 | Journal of Energy Chemistry2014，23，4： | 4 |
| 10 | Upcycling biomass waste into Fe single atom catalysts for pollutant control显示文摘Contaminants of heavy metals and antibiotics, which are frequently detected in water, soil and food chains with increasing prevalence in our current society, can cause potential harm to human health and disrupt human ecosystem irreversibly. Herein, we have successfully utilized biomass waste ferns contaminated by iron mines, to fabricate a first-of-its-kind high-performance class of Fe single-atom catalysts(FeSAC) by a facile pyrolysis. The optimal FeSAC-800 shows an excellent efficiency in the fastphotocatalytic degradation of six types of quinolone antibiotics(e.g., norfloxacin, levofloxacin, ciprofloxacin, enrofloxacin, lomefloxacin, flumequine) in 1 h under the simulated natural light irradiation. Based on advanced characterization, a well-defined structure of FeN_(4), confined in the porous carbon is elaborated for the FeSAC-800. Mechanism of the photodegradation is via a Fenton-like oxidation process whereas the reactive oxygen species play a key role. These findings open a new avenue for efficient, sustainable utilization of biomass waste in pollutant control. | Xin Li Kang Hu Yizhe Huang Qingqing Gu Yuwen Chen Bing Yang Rongliang Qiu Wenhao Luo Bert M.Weckhuysen Kai Yan | 2022 | Journal of Energy Chemistry2022，31，6： | 3 |
| 11 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 12 | Total conductivity,oxygen permeability and stability of perovskite-type oxide BaCo_(0.7)Fe_(0.2)Nb_(0.1)O_(3-δ)显示文摘The total conductivity,oxygen sorption property,oxygen permeability and stability of pure perovskite-type oxide BaCo0.7Fe0.2Nb0.1O3-δ (BCFNO) in real operating conditions were investigated. Its total conductivity was measured to be 3.6 S·cm-1 at 600°C. Though the total conductivity of the BCFNO membrane is much smaller than that of the Ba0.5Sr0.5Co0.8Fe0.2O3-δ (BSCFO) membrane,the oxygen permeability of the BCFNO membrane is similar to that of the BSCFO membrane. SEM observation and EDX analysis of the BCFNO and BSCFO membranes indicated that no segregation of metal ions was found for the used BCFNO membrane while the original perovskite phase of BSCFO decomposed under the experimental condition. The experimental results of oxygen permeability and stability were consistent with the analysis on the oxygen sorption property of perovskites. | Zhang, Yuwen Liu, Yong Wang, Chenglei Yang, Zhibin Ding, Weizhong Lu, Xionggang | 2009 | Rare Metals2009，28，2： | 2 |
| 13 | Characterization and Proteomic Analysis of Novel Rice Lesion Mimic Mutant with Enhanced Disease Resistance显示文摘Lesion mmic mutants(LMMs)are plants that spontaneously form lesions without pathogeninfection or external stimulus and exhibit resistance to pathogens.Here,a rice LMM was created by ethylmethane sulfonate mutagenesis,named as hpil(hydrogen peroxide induced lesion).Diaminobenzidineand trypan blue staining showed that large amounts of H_(2)O_(2) were produced and cell death was occurredat and around the parts of lesion mimic in the rice leaves.The phenotype of hpil is controlled by a singlerecessive gene,localized at a 2 Mb interval on chromosome 2.The data suggested that hpil is a novelLMM with enhanced bacterial and fungal disease resistance,and multiple pathogenesis-related proteins(PRs)were up-regulated.The proteomes of leaves at three positions(different degrees of lesion mimicseverity)were characterized in hpil compared with its wild type plant.Differentially expressed proteinswere detected by two dimensional difference gel electrophoresis and 274 proteins were identified byMALDITOF/TOFTM.These proteins were related to metabolic process,cellular process and response tostimulus,with mostly down-regulated in hpil leaves.Many of these proteins were related to the Calvincycle,photosynthetic electron transport chain,glycolysis/gluconeogenesis and phosphonates pathways.Some resistance-related proteins including 14-3-3 proteins,OsPR10 and antioxidases such asperoxidase,superoxide dismutase and ascorbate peroxidase were up-regulated in leaves with lesionmimic.These results provide the foundation for cloning of the target gene and shed light on themechanism involved in autaimmunity of rice. | Yang Yong Lin Qiujun Chen Xinyu Liang Weifang Fu Yuwen Xu Zhengjin Wu Yuanhua Wang Xuming Zhou Jie Yu Chulang Yan Chengqi Mei Qiong Chen Jianping | 2021 | Rice science2021，28，5： | 2 |
| 14 | Dietary ellagic acid supplementation attenuates intestinal damage and oxidative stress by regulating gut microbiota in weanling piglets显示文摘Intestinal oxidative stress triggers gut microbiota dysbiosis,which is involved in the etiology of postweaning diarrhea and enteric infections.Ellagic acid(EA)can potentially serve as an antioxidant supplement to facilitate weaning transition by improving intestinal oxidative stress and gut microbiota dysbiosis.Therefore,we aimed to investigate the effects of dietary EA supplementation on the attenuation of intestinal damage,oxidative stress,and dysbiosis of gut microbiota in weanling piglets.A total of126 piglets were randomly assigned into 3 groups and treated with a basal diet and 2 m L saline orally(Ctrl group),or the basal diet supplemented with 0.1%EA and 2 m L saline orally(EA group),or the basal diet and 2 m L fecal microbiota suspension from the EA group orally(FEA group),respectively,for 14 d.Compared with the Ctrl group,EA group improved growth performance by increasing average daily feed intake and average daily weight gain(P<0.05)and decreasing fecal scores(P<0.05).EA group also alleviated intestinal damage by increasing the tight junction protein occludin(P<0.05),villus height,and villus height-to-crypt depth ratio(P<0.05),while decreasing intestinal epithelial apoptosis(P<0.05).Additionally,EA group enhanced the jejunum antioxidant capacity by increasing the total antioxidant capacity(P<0.01),catalase(P<0.05),and glutathione/oxidized glutathione(P<0.05),but decreased the oxidative metabolite malondialdehyde(P<0.05)compared to the Ctrl group.Compared with the Ctrl group,EA and FEA groups increased alpha diversity(P<0.05),enriched beneficial bacteria(Ruminococcaceae and Clostridium ramosum),and increased metabolites short-chain fatty acids(P<0.05).Correspondingly,FEA group gained effects comparable to those of EA group on growth performance,intestinal damage,and intestinal antioxidant capacity.In addition,the relative abundance of bacteria shifted in EA and FEA groups was significantly related to the examined indices(P<0.05).Overall,dietary EA supplementation could improve growth performance and attenuate intestinal damage and oxidative stress by regulating the gut microbiota in weanling piglets. | Wenxia Qin Baoyang Xu Yuwen Chen Wenbo Yang Yunzheng Xu Juncheng Huang Ting Duo Yihua Mao Guozong Zhou Xianghua Yan Libao Ma | 2022 | Animal Nutrition2022，，4： | 2 |
| 15 | Kinetic studies of the calcination of ammonium metavanadate by thermal methods显示文摘 | Liu Yuwen Yang Xi | 2004 | Ind Eng Chem Res2004，43，： | 1 |
| 16 | Metal-resistant FCC catalysts : Effect of matrix显示文摘 | Yang Shienjen Chen Yuwen Li Chiuping | 1994 | Applied Catalysis A: Gen eral1994，115，： | 1 |
| 17 | Catalytic hy- drolysis of ammonia borane by cobalt nickel nanoparticles supported on reduced graphene oxide for hydrogen genera- tion 显示文摘 | Yang Yuwen Zhang Fei Wang Hualan | 2014 | J Nanomater2014，2014，29： | 1 |
| 18 | Anti-inflammatory activities of aqueous extract from Radix Ophiopogon japonicus and its two constituents 显示文摘 | Kou Junping Sun Yang Lin Yuwen | 2005 | Biol Pharm Bull2005，28，7： | 1 |
| 19 | Numerical study of periodically fully-developed convection in channels with periodically grooved parts显示文摘 | LI Ling YANG Mo ZHANG Yuwen | 2008 | International Journal of Heat and Mass Transfer2008，51，1112： | 1 |
| 20 | Facile in situ synthesis of copper nanoparticles supported on reduced graphene oxide for hydrolytic dehydrogenation of ammonia borane 显示文摘 | Yang Yuwen Lu Zhanghui Hu Yujuan | 2014 | RSC Adv2014，4，13： | 1 |
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