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| 1 | Spatiotemporal variations of PM_(2.5) and PM_(10) concentrations between31 Chinese cities and their relationships with SO_2,NO_2,CO and O_3显示文摘The variations of mass concentrations of PM_(2.5),PM_(10),SO_2,NO_2,CO,and O_3 in 31 Chinese provincial capital cities were analyzed based on data from 286 monitoring sites obtained between March 22,2013 and March 31,2014.By comparing the pollutant concentrations over this length of time,the characteristics of the monthly variations of mass concentrations of air pollutants were determined.We used the Pearson correlation coefficient to establish the relationship between PM_(2.5),PM_(10),and the gas pollutants.The results revealed significant differences in the concentration levels of air pollutants and in the variations between the different cities.The Pearson correlation coefficients between PMs and NO_2 and SO_2 were either high or moderate(PM_(2.5) with NO_2:r=0.256-0.688,mean r=0.498;PM_(10) with NO_2:r = 0.169-0.713,mean r = 0.493;PM2.5 with SO_2:r= 0.232-0.693,mean r=0.449;PM_(10) with SO_2:r = 0.131-0.669,mean r=0.403).The correlation between PMs and CO was diverse(PM_(2.5):r = 0.156-0.721,mean r=0.437;PM_(10):r=0.06-0.67,mean r= 0.380).The correlation between PMs and O_3 was either weak or uncorrelated(PM_(2.5):r--0.35 to 0.089,mean r=-0.164;PM_(10):r=-0.279 to 0.078,mean r=-0.127),except in Haikou(PM2.5:r=0.500;PM_(10):r-0.509). | Yangyang Xie Bin Zhao Lin Zhang Rong Luo | 2015 | Particuology2015，13，3： | 56 |
| 2 | An alternating direction algorithm for matrix completion with nonnegative factors显示文摘这份报纸为 nonnegative 矩阵 factorization-and-completion 问题介绍一个算法,它试图发现 nonnegative 低等级的矩阵 X 和 Y 以便产品 XY 接近其元素部分被知道的 nonnegative 数据矩阵 M (到某个精确性) 。这个问题聚集二个存在问题:M 的所有条目被给的(i) nonnegative 矩阵因式分解,并且(ii ) nonnegativity 没被要求的低等级的矩阵结束。由拿 nonnegativity 的优点并且低繁茂,一个人能通常就使用二个性质之一比那些获得优异结果。我们建议基于古典轮流出现方向用一个算法解决非凸的抑制最少平方的问题扩充 Lagrangian 方法。算法和数字模拟结果的初步的集中性质被介绍。为 nonnegative 矩阵因式分解比作一个最近的算法,建议算法生产仅仅关于矩阵条目的一半使用的类似的质量的因式分解。在恢复不完全的灰度和 hyperspectral 图象的任务,建议算法比不利用 nonnegativity 的二个最近的矩阵结束算法生产的那些产出全面更好的质量。 | Yangyang XU Wotao YIN Zaiwen WEN Yin ZHANG | 2012 | Frontiers of Mathematics in China2012，7，2： | 23 |
| 3 | Seasonal variations in leaf capturing of particulate matter, surface wettability and micromorphology in urban tree species显示文摘在叶微粒物质(下午) 的季节的变化在城市的树种类的累积,表面 wettability 和 micromorphology,包括 Sophora 装饰用的梨树(S。装饰用的梨树) , Platanus acerifolia (P。acerifolia ) 并且 Cedrus deodara (C。deodara ) ,在一个单个成长季节期间被学习。三种在下午累积显示出不同季节的趋势,从春天增加到秋天(或冬季) 甚至在雨季期间,但是以不同的率。在学习期间, P 的叶下午保留数量。acerifolia,有隆起的叶的种出现,比 S 的显著地高。装饰用的梨树和 C。deodara,有蜡制的叶表面的种类。除了在 S 的离开轴心的表面上,在叶子的水微滴的接触角度与叶年龄减少了。装饰用的梨树,它仍然保持在整个成长季节非可湿或高度非可湿;在 S 的近轴的表面上的接触角度的减少。装饰用的梨树更大什么时候与 P 相比。acerifolia 和 C。deodara。一种重要、否定的关系在所有三种的叶子的近轴的表面上在叶下午保留数量和接触角度之间存在。wettability 的增加,当 epicuticular 蜡被机械、化学的磨损破坏时,可能引起了,似乎是在叶下午累积导致季节的变化的主要因素。 | Huixia WANG Hui SHI Yangyang LI Ya YU Jun ZHANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，4： | 15 |
| 4 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 5 | Recombinant CC16 protein inhibits the production of pro-inflammatory cytokines via NF-KB and p38 MAPK pathways in LPS-activated RAW264,7 macrophages显示文摘积累的证据显示克莱拉房间 protein-16 (CC16 ) 有反煽动性的功能,尽管深奥分子的小径完全没被阐明。这里,我们评估了效果肿瘤坏死因素 alpha (TNF-) 的表示上的 recombinant 老鼠 CC16 (rCC16 ) , interleukin-6 (IL-6 ) ,和在 lipopolysaccharide (LPS ) 的 IL-8 刺激了老鼠巨噬细胞(RAW264.7 房间) 并且探索了内在的分子的机制。rCC16 在两个禁止了导致 LPS 的 TNF- , IL-6,和 IL-8 表示,这被发现送信人 ribonucleicacid (mRNA ) 水平和蛋白质以一种集中依赖者方式铺平,由即时反向的 transcriptase 聚合酶链反应和连接酶的 immunosorbent 试金示威了。如此的镇压效果被 transcriptional 活动和原子因素(NF ) 的脱氧核糖核酸酸绑定活动的抑制伴随 -B 然而并非使活跃之物蛋白质(AP )-1。西方的污点分析进一步表明 rCC16 禁止了原子 NF-B 和 NF-B 禁止的蛋白质 IB,和 p38 的 cytosolic NF-B, phosphorylation 和减小的减小的增加激活 mitogen 的蛋白质 kinase (MAPK ) 依赖者由在它的 p65 子单元的 Ser276 的 phosphorylation 的 NF-B 激活。而且, rCC16 被发现没另外在c6月N终端 kinase ,c6月,或c-Jun.的原子 translocation 的 phosphorylation 上有效果,TNF-的减小, IL-6 ,并且 IL-8 被颠倒内长的uteroglobin有约束力的蛋白质的水平什么时候被 RNA 干扰在 对待rCC16 、 对待LPS 的 RAW264.7 房间减少。我们的数据建议 rCC16 由在 RAW264.7 房间使 NF-B 和 p38 MAPK 然而并非 AP-1 失去活性压制调停 LPS 的煽动性的调停人 TNF- , IL-6,和 IL-8 生产。 | Min Pang Yangyang Yuan Dong Wang Ting Li Dan Wang Xiaohong Shi Min Guo Chunfang Wang Xinri Zhang Guoping Zheng Baofeng Yu Hailong Wang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 14 |
| 6 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 7 | Assessing the Dynamics of Grassland Net Primary Productivity in Response to Climate Change at the Global Scale显示文摘Understanding the net primary productivity(NPP) of grassland is crucial to evaluate the terrestrial carbon cycle. In this study, we investigated the spatial distribution and the area of global grassland across the globe. Then, we used the Carnegie-Ames-Stanford Approach(CASA) model to estimate global grassland NPP and explore the spatio-temporal variations of grassland NPP in response to climate change from 1982 to 2008. Results showed that the largest area of grassland distribution during the study period was in Asia(1737.23 × 104 km^2), while the grassland area in Europe was relatively small(202.83 × 10~4 km^2). Temporally, the total NPP increased with fluctuations from 1982 to 2008, with an annual increase rate of 0.03 Pg C/yr. The total NPP experienced a significant increasing trend from 1982 to 1995, while a decreasing trend was observed from 1996 to 2008. Spatially, the grassland NPP in South America and Africa were higher than the other regions, largely as a result of these regions are under warm and wet climatic conditions. The highest mean NPP was recorded for savannas(560.10 g C/(m^2·yr)), whereas the lowest was observed in open shrublands with an average NPP of 162.53 g C/(m^2·yr). The relationship between grassland NPP and annual mean temperature and annual precipitation(AMT, AP, respectively) varies with changes in AP, which indicates that, grassland NPP is more sensitive to precipitation than temperature. | LIU Yangyang YANG Yue WANG Qian KHALIFA Muhammad ZHANG Zhaoying TONG Linjing LI Jianlong SHI Aiping | 2019 | Chinese Geographical Science2019，29，5： | 12 |
| 8 | Q-switched and mode-locked Er-doped fiber laser using PtSe2 as a saturable absorber显示文摘We report a passively Q-switched and mode-locked erbium-doped fiber laser(EDFL) based on PtSe_2, a new two-dimensional material, as a saturable absorber(SA). Self-started Q-switching at 1560 nm in the EDFL was achieved at a threshold pump power of 65 mW, and at the maximum pump power of 450 m W, the maximum single Q-switched pulse energy is 143.2 n J. Due to the polarization-dependent characteristics of the PtSe_2-based SA, the laser can be switched from the Q-switched state to the mode-locked state by adjusting the polarization state. A mode-locked pulse train with a repetition rate of 23.3 MHz and a pulse width of 1.02 ps can be generated when the pump power increases to about 80 m W, and the stable mode-locked state is maintained until the pump power reaches its maximum 450 m W. The maximum single mode-locked pulse energy is0.53 nJ. This is the first time to our knowledge that successful generation of stable Q-switched and mode-locked pulses in an Er-doped fiber laser has been obtained by using PtSe_2 as a saturable absorber. | KANG ZHANG MING FENG YANGYANG REN FANG LIu XINGSHUO CHEN JIE YANG XIAO-QING VAN FENG SONG JIANGUO TIAN | 2018 | Photonics Research2018，6，9： | 10 |
| 9 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 10 | Local icariin application enhanced periodontal tissue regeneration and relieved local inflammation in a minipig model of periodontitis显示文摘Periodontitis is an inflammatory autoimmune disease. Treatment should alleviate inflammation, regulate the immune reaction and promote periodontal tissue regeneration. Icariin is the main active ingredient of Epimedii Folium, and it is a promising compound for the enhancement of mesenchymal stem cell function, promotion of bone formation, inhibition of bone resorption, alleviation of inflammation and regulation of immunity. The study investigated the effect of icariin on periodontal tissue regeneration in a minipig model of periodontitis. The minipig model of periodontitis was established. Icariin was injected locally. The periodontal clinical assessment index, a computed tomography(CT) scan, histopathology and enzyme-linked immune sorbent assay(ELISA)were used to evaluate the effects of icariin. Quantitative analysis results 12 weeks post-injection demonstrated that probing depth,gingival recession, attachment loss and alveolar bone regeneration values were(3.72 ± 1.18) mm vs.(6.56 ± 1.47) mm,(1.67 ± 0.59)mm vs.(2.38 ± 0.61) mm,(5.56 ± 1.29) mm vs.(8.61 ± 1.72) mm, and(25.65 ± 5.13) mm3 vs.(9.48 ± 1.78) mm3 in the icariin group and0.9% NaCl group, respectively. The clinical assessment, CT scan, and histopathology results demonstrated significant enhancement of periodontal tissue regeneration in the icariin group compared to the 0.9% NaCl group. The ELISA results suggested that the concentration of interleukin-1 beta(IL-1β) in the icariin group was downregulated compared to the 0.9% NaCl group, which indicates that local injection of icariin relieved local inflammation in a minipig model of periodontitis. Local injection of icariin promoted periodontal tissue regeneration and exerted anti-inflammatory and immunomodulatory function. These results support the application of icariin for the clinical treatment of periodontitis. | Xiuli Zhang Nannan Han Guoqing Li Haoqing Yang Yangyang Cao Zhipeng Fan Fengqiu Zhang | 2018 | International Journal of Oral Science2018，10，3： | 9 |
| 11 | Defects enriched hollow porous Co-N-doped carbons embedded with ultrafine CoFe/Co nanoparticles as bifunctional oxygen electrocatalyst for rechargeable flexible solid zinc-air batteries显示文摘The construction and design of highly efficient and inexpensive bifunctional oxygen electrocatalysts substitute for noble-metal-based catalysts is highly desirable for the development of rechargeable Zn-air battery(ZAB).In this work,a bifunctional oxygen electrocatalysts of based on ultrafine CoFe alloy(4-5 nm)dispersed in defects enriched hollow porous Co-N-doped carbons,made by annealing SiO2 coated zeolitic imidazolate framework-67(ZIF-67)encapsulated Fe ions.The hollow porous structure not only exposed the active sites inside ZIF-67,but also provided efficient charge and mass transfer.The strong synergetic coupling among high-density CoFe alloys and Co-N_(x) sites in Co,N-doped carbon species ensures high oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)activity.First-principles simulations reveal that the synergistic promotion effect between CoFe alloy and Co-N site effectively reduced the formation energy of from O^(*)to OH^(*).The optimized CoFe-Co@PNC exhibits outstanding electrocatalytic stability and activity with the overpotential of only 320 mV for OER at 10 mA·cm^(−2) and the half-wave potential of 0.887 V for ORR,outperforming that of most recent reported bifunctional electrocatalysts.A rechargeable ZAB constructed with CoFe-Co@PNC as the air cathode displays long-term cyclability for over 200 h and high power density(152.8 mW·cm^(−2)).Flexible solid-state ZAB with our CoFe-Co@PNC as the air cathode possesses a high open circuit potential(OCP)up to 1.46 V as well as good bending flexibility.This universal structure design provides an attractive and instructive model for the application of nanomaterials derived from MOF in the field of sustainable flexible energy applications device. | Zhao Lei Yangyang Tan Zeyi Zhang Wei Wu Niancai Cheng Runzhe Chen Shichun Mu Xueliang Sun | 2021 | Nano Research2021，14，3： | 9 |
| 12 | Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice显示文摘The purpose of this study was to investigate the effects of salvianolic acid A(SAA) in systemic lupus erythematosus(SLE) induced by pristane in BALB/c mice.Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane.Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls.The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin(H&E) and periodic acid-Schiff(PAS) staining.Western blot analysis of renal tissue was also employed.SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects.SAA treatment also significantly inhibited the phosphorylation of IKK,IκB and NFκB in renal tissues of lupus mice.In conclusion,the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK,IκB and NFκB. | Yihuang Lin Yu Yan Huifang Zhang Yucai Chen Yangyang He Shoubao Wang Lianhua Fang Yang Lv Guanhua Du | 2017 | Acta Pharmaceutica Sinica B2017，7，2： | 8 |
| 13 | Ultra-sensitive graphene strain sensor for sound signal acquisition and recognition显示文摘为健全信号获得和识别的一个便携、高精确的传感器从编织的特殊设计的 graphene 的薄电影被制作织物(GWF ) 。在被拉长之上,随机的裂缝的高密度出现在网络,它减少当前的小径,从而增加电阻。因此,这部电影能对人的喉咙作为一个紧张传感器起作用以便测量通过肌肉运动,一个声音是否被生产的讲话。超离频敏感允许由提取声波的签名特征的快速、低频率的讲话采样的实现。在这研究, 26 封英语信,典型汉字和音调的代表性的信号,甚至短语和句子被测试,揭示在电阻的明显、典型的变化。而且, graphene 传感器的电阻变化与预告录下的声音完美地反应了。由把人工智能与数字信号处理相结合,我们期望以后,这个 graphene 传感器将能成功地达成复杂声学的系统和听觉的数据的大数量。 | Yan Wang Tingting Yang Junchao Lao Rujing Zhang Yangyang Zhang Miao Zhu Xiao Li Xiaobei Zang Kunlin Wang Wenjian YU Hu Jin Li Wang Hongwei Zhu | 2015 | Nano Research2015，8，5： | 8 |
| 14 | Nitrogen doping and graphitization tuning coupled hard carbon for superior potassium-ion storage显示文摘Hard carbon material is one of the most promising anode materials for potassium ion batteries(PIBs)due to its distinct disordered and non-expandable framework.However,the intrinsically disordered microarchitecture of hard carbon results in low electric conductivity and poor rate capability.Herein,nitrogendoped and partially graphitized hard carbons(NGHCs)derived from commercial coordination compound precursor-ethylenediaminetetraacetic acid(EDTA)disodium cobalt salt hydrate are designed and prepared as high-performance PIBs anode materials.By means of a facile annealing method,nitrogen elements and graphitic domains can be controllably introduced to NGHCs.The resulting NGHCs show structural merits of mesoporous construction,nitrogen doping and homogeneous graphitic domains,which ensures fast kinetics and electron transportation.Applying in anode for PIBs,NGHCs exhibit robust rate capability with high reversible capacity of 298.8 m Ah g^-1 at 50 m A g^-1,and stable cycle stability of 137.6 mAh g^-1 at 500 m A g^-1 after 1000 cycles.Moreover,the ex situ Raman spectra reveal a mixture'adsorption-intercalation mechanism'for potassium storage of NGHCs.More importantly,full PIBs by pairing with perylenetetracarboxylic dianhydride(PTCDA)cathode demonstrate the promising potential of practical application.In terms of commercial precursor,facile synthesis and long cycle lifespan,NGHCs represent a brilliant prospect for practical large-scale applications. | Junxian Hu Yangyang Xie Meng Yin Zhian Zhang | 2020 | Journal of Energy Chemistry2020，29，10： | 8 |
| 15 | Circular Formation Flight Control for Unmanned Aerial Vehicles With Directed Network and External Disturbance显示文摘This paper proposes a new distributed formation flight protocol for unmanned aerial vehicles(UAVs)to perform coordinated circular tracking around a set of circles on a target sphere.Different from the previous results limited in bidirectional networks and disturbance-free motions,this paper handles the circular formation flight control problem with both directed network and spatiotemporal disturbance with the knowledge of its upper bound.Distinguishing from the design of a common Lyapunov fiunction for bidirectional cases,we separately design the control for the circular tracking subsystem and the formation keeping subsystem with the circular tracking error as input.Then the whole control system is regarded as a cascade connection of these two subsystems,which is proved to be stable by input-tostate stability(ISS)theory.For the purpose of encountering the external disturbance,the backstepping technology is introduced to design the control inputs of each UAV pointing to North and Down along the special sphere(say,the circular tracking control algorithm)with the help of the switching function.Meanwhile,the distributed linear consensus protocol integrated with anther switching anti-interference item is developed to construct the control input of each UAV pointing to east along the special sphere(say,the formation keeping control law)for formation keeping.The validity of the proposed control law is proved both in the rigorous theory and through numerical simulations. | Yangyang Chen Rui Yu Ya Zhang Chenglin Liu | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，2： | 7 |
| 16 | Recent progress in fingerprint recognition显示文摘指纹识别逐渐地被用来认识到在平民的日常生活的个人鉴定例如身份证,等等采指纹硬盘。大改进在察觉到技术和自动指纹识别算法的联机指纹被完成了。各种各样的指纹识别技术包括指纹获得,分类,改进并且匹配,高度被改进。这篇论文概述最近在指纹识别进展并且总结与低质量的指纹并且匹配弄歪的指纹图象的改进的特殊焦点为每步建议的算法。两个问题被相信是重要、挑战性的任务。另外,我们也为指纹确认比赛 2004 的指纹识别算法(FVC2004 ) 和指纹供应商技术评估讨论普通评估 2003 (FpVTE2003 ) ,基于哪个我们能客观地并且一致地测量识别算法的表演。 | TIAN Jie CHEN Xinjian ZHANG Yangyang YANG Xin HE Yuliang LI Liang XIE Weihua ZHENG Zhipeng | 2006 | Progress in Natural Science:Materials International2006，16，3： | 7 |
| 17 | Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis显示文摘Cisplatin resistance is a major challenge for bladder cancer(BC).Evidence indicates that exosome derived from cancer-associated fibroblasts(CAF-Exo)can promote chemotherapy resistance in various human tumors by delivering bioactive molecules.We have previously demonstrated that CAF-derived exosomal LINC00355 promotes BC cell proliferation and invasion.However,the underlying mechanisms are still unclear.In this study,we aimed to investigate the role and mechanisms of CAF-derived exosomal LINC00355 in BC cell resistance to cisplatin.Exosomes were isolated from normal fibroblasts(NFs)and BC tumor-derived CAFs,namely,NF-Exo and CAF-Exo.CAFs were transfected with si-Ctrl or si-LINC00355 and then different exosomes were isolated,namely,CAF^(si-Ctrl)-Exo and CAF^(si-LINC00355)-Exo.The human BC cell lines(T24 and 5367)were incubated with NF-Exo,CAF-Exo,CAF^(si-Ctrl)-Exo,and CAF^(si-LINC00355)-Exo in the presence of cisplatin.MTT proliferation assay and flow cytometric analysis showed that CAF-Exo promoted BC cell resistance to cisplatin and upregulated ABCB1 expression in BC cells by transferring LINC00355 to BC cells.Luciferase activity assay confirmed the interaction between miR-34b-5p and LINC00355 or ABCB1.qRT-PCR and western blot analysis further showed that LINC00355 sponged miR-34b-5p to upregulate ABCB1 expression.However,the promoting effects of CAF-Exo on BC cell resistance to cisplatin were abolished by miR-34b-5p overexpression and ABCB1 silencing.In conclusion,exosomal LINC00355 derived from CAFs promotes BC cell resistance to cisplatin by regulating the miR-34b-5p/ABCB1 axis. | Guangyue Luo Yangyang Zhang Zhonghui Wu Ligang Zhang Chaozhao Liang Xianguo Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 18 | Comparison of the very high cycle fatigue behaviors of INCONEL 718 with different loading frequencies显示文摘In order to clarify the differences of very high cycle fatigue(VHCF) behavior of nickel based superalloy IN718 with different loading frequencies,stress-controlled fatigue tests were carried out by using ultrasonic testing method(20 KHz) and rotary bending testing method(52.5 Hz),both at room temperatures,to establish stress versus cycles to failure(S-N) relationships.Results disclosed that cycles to failure at a given stress level increased with an increase of the applied frequency,i.e.,the higher frequency produced an upper shift of the S-N curves.Fractographic analysis suggested that crack initiation and propagation behaviors had large differences:cracks in low-frequency tests preferentially initiated from multiple sources on the specimen surface,while in high-frequency tests,cracks mostly originated from a unique source of subsurface inclusions.Subsequently,frequency-involved modeling was proposed,based on the damage accumulation theory,which could well illustrate qualitatively those comparisons due to different loading frequencies. | ZHANG YangYang DUAN Zheng SHI HuiJi | 2013 | Science China Chemistry2013，56，3： | 6 |
| 19 | Eye movement indices in the study of depressive disorder显示文摘 | YU LI Yangyang XU Mengqing XIA Tianhong ZHANG Junjie WANG Xu LIU Yongguang HE Jijun WANG | 2016 | 上海精神医学2016，28，6： | 6 |
| 20 | A Heterogeneous Information Fusion Deep Reinforcement Learning for Intelligent Frequency Selection of HF Communication显示文摘The high-frequency(HF) communication is one of essential communication methods for military and emergency application. However, the selection of communication frequency channel is always a difficult problem as the crowded spectrum, the time-varying channels, and the malicious intelligent jamming. The existing frequency hopping, automatic link establishment and some new anti-jamming technologies can not completely solve the above problems. In this article, we adopt deep reinforcement learning to solve this intractable challenge. First, the combination of the spectrum state and the channel gain state is defined as the complex environmental state, and the Markov characteristic of defined state is analyzed and proved. Then, considering that the spectrum state and channel gain state are heterogeneous information, a new deep Q network(DQN) framework is designed, which contains multiple sub-networks to process different kinds of information. Finally, aiming to improve the learning speed and efficiency, the optimization targets of corresponding sub-networks are reasonably designed, and a heterogeneous information fusion deep reinforcement learning(HIF-DRL) algorithm is designed for the specific frequency selection. Simulation results show that the proposed algorithm performs well in channel prediction, jamming avoidance and frequency channel selection. | Xin Liu Yuhua Xu Yunpeng Cheng Yangyang Li Lei Zhao Xiaobo Zhang | 2018 | China Communications2018，15，9： | 6 |
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