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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Early evaluation of growth traits of Larix kaempferi clones显示文摘Early selection is an important method to shorten the breeding cycle for tree species, which may differ in the time for early selection.To evaluate the early selected time for Larix kaempferi, tree height and diameter at breast height of 57 L.kaempferi clones were measured over many different growth years.The results indicated that, except for age × clone interaction for diameter at breast height(P = 0.741), there were significant differences among all variation sources(P < 0.01).The coefficient of phenotypic variation ranged from 14.89 to 35.65%for height and from 19.17 to 23.86% for diameter at breast height in different growth years.The repeatability of height and of diameter at breast height among clones was high,ranging from 0.6181 to 0.8531(height) and from 0.8443 to0.8497(diameter at breast height), in different growth years.There were significant positive correlations between all pairs of growth traits except between height in the 2 nd growth year and height in the 30 th growth year; and between height in the 2 nd growth year × diameter at breast height in the 30 th growth year.With a comprehensive evaluation method and a selection ratio of 10%, L65,L1, L62, L9, L15, and L78 were selected as excellent clones in the 30 th growth year.Their average values of height and diameter at breast height were 9.81 and 16.57%higher than the overall average, representing genetic gains of 6.46 and 13.99%, respectively.This study provides a theoretical foundation for the genetic improvement of L.kaempferi. | Yanyan Pan Shuchun Li Chenglu Wang Wenjun Ma Guiyou Xu Lili Shao Kailong Li Xiyang Zhao Tingbo Jiang | 2018 | Journal of Forestry Research2018，29，4： | 10 |
| 3 | Lotus Leaf‑Derived Gradient Hierarchical Porous C/MoS2 Morphology Genetic Composites with Wideband and Tunable Electromagnetic Absorption Performance显示文摘Inspired by the nature,lotus leaf-derived gradient hierarchical porous C/MoS2 morphology genetic composites(GHPCM)were successfully fabricated through an in situ strategy.The biological microstructure of lotus leaf was well preserved after treatment.Different pores with gradient pore sizes ranging from 300 to 5μm were hierarchically distributed in the composites.In addition,the surface states of lotus leaf resulted in the Janus-like morphologies of MoS2.The GHPCM exhibit excellent electromagnetic wave absorption performance,with the minimum reflection loss of−50.1 dB at a thickness of 2.4 mm and the maximum effective bandwidth of 6.0 GHz at a thickness of 2.2 mm.The outstanding performance could be attributed to the synergy of conductive loss,polarization loss,and impedance matching.In particularly,we provided a brand-new dielectric sum-quotient model to analyze the electromagnetic performance of the non-magnetic material system.It suggests that the specific sum and quotient of permittivity are the key to keep reflection loss below−10 dB within a certain frequency range.Furthermore,based on the concept of material genetic engineering,the dielectric constant could be taken into account to seek for suitable materials with designable electromagnetic absorption performance. | Fei Pan Zhicheng Liu Baiwen Deng Yanyan Dong Xiaojie Zhu Chuang Huang Wei Lu | 2021 | Nano-Micro Letters2021，13，3： | 9 |
| 4 | Shale Gas Formation and Occurrence in China: An Overview of the Current Status and Future Potential显示文摘Shale gas is one of the most promising unconventional resources both in China and abroad. It is known as a form of self-contained source-reservoir system with large and continuous dimensions. Through years of considerable exploration efforts, China has identified three large shale gas fields in the Fuling, Changning and Weiyuan areas of the Sichuan Basin, and has announced more than 540 billion m^3 of proven shale gas reserves in marine shale systems. The geological theories for shale gas development have progressed rapidly in China as well. For example, the new depositional patterns have been introduced for deciphering the paleogeography and sedimentary systems of the Wufeng shale and Longmaxi shale in the Sichuan Basin. The shale gas storage mechanism has been widely accepted as differing from conventional natural gas in that it is adsorbed on organic matter or a mineral surface or occurs as free gas trapped in pores and fractures of the shale. Significant advances in the techniques of microstructural characterization have provided new insights on how gas molecules are stored in micro- and nano-scale porous shales. Furthermore, newly-developed concepts and practices in the petroleum industry, such as hydraulic fracturing, microseismic monitoring and multiwell horizontal drilling, have made the production of this unevenly distributed but promising unconventional natural gas a reality. China has 10–36 trillion m^3 of promising shale gas among the world's whole predicted technically recoverable reserves of 206.6 trillion m^3. China is on the way to achieving its goal of an annual yield of 30–50 billion m^3 by launching more trials within shale gas projects. | ZOU Caineng YANG Zhi PAN Songqi CHEN Yanyan LIN Senhu HUANG Jinliang WU Songtao DONG Dazhong WANG Shufang LIANG Feng SUN Shasha HUANG Yong WENG Dingwei | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 9 |
| 5 | Two-dimensional ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes for enhanced photocatalytic water splitting hydrogen production显示文摘Two-dimensional (2D) ultrathin MoS2-modified black Ti^3+-TiO2 nanotubes were fabricated using an electrospinning-hydrothermal treatment-reduction method.Bare TiO2 nanotubes were fabricated via electrospinning.Then,2D MoS2 lamellae were grown on the surface of the nanotubes and Ti^3+/Ov ions were introduced by reduction.The photocatalytic performance of the 2D MoS2/Ti^3+-TiO2 nanotubes was^15 times better than that of TiO2.The HER enhancement of the MoS2/Ti^3+-TiO2 nanotubes can be attributed to the Pt-like behavior of 2D MoS2 and the presence of Ti^3+-ions,which facilitated the quick diffusion of the photogenerated electrons to water,reducing the H2 activation barrier.The presence of Ov ions in the nanotubes and their hollow structure increased their solar utilization. | Wei Ou Jiaqi Pan Yanyan Liu Shi Li Hongli Li Weijie Zhao Jingjing Wang Changsheng Song Yingying Zheng Chaorong Li | 2020 | Journal of Energy Chemistry2020，29，4： | 7 |
| 6 | Design and Analysis of a New AUV's Sliding Control System Based on Dynamic Boundary Layer显示文摘The new AUV driven by multi-vectored thrusters not only has unique kinematic characteristics during the actual cruise but also exists uncertain factors such as hydrodynamic coefficients perturbation and unknown interference of tail fluid,which bring difficult to the stability of the AUV's control system.In order to solve the nonlinear term and unmodeled dynamics existing in the new AUV's attitude control and the disturbances caused by the external marine environment,a second-order sliding mode controller with double-loop structure that considering the dynamic characteristics of the rudder actuators is designed,which improves the robustness of the system and avoids the control failure caused by the problem that the design theory of the sliding mode controller does not match with the actual application conditions.In order to avoid the loss of the sliding mode caused by the amplitude and rate constraints of the rudder actuator in the new AUV's attitude control,the dynamic boundary layer method is used to adjust the sliding boundary layer thickness so as to obtain the best anti-chattering effects.Then the impacts of system parameters,rudder actuator's constraints and boundary layer on the sliding mode controller are computed and analyzed to verify the effectiveness and robustness of the sliding mode controller based on dynamic boundary layer.The computational results show that the original divergent second-order sliding mode controller can still effectively implement the AUV's attitude control through dynamically adjusting the sliding boundary layer thickness.The dynamic boundary layer method ensures the stability of the system and does not exceed the amplitude constraint of the rudder actuator,which provides a theoretical guidance and technical support for the control system design of the new AUV in real complex sea conditions. | GAO Fudong PAN Cunyun HAN Yanyan | 2013 | Chinese Journal of Mechanical Engineering2013，26，1： | 5 |
| 7 | Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats显示文摘Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. | Zheng Gong Lijuan Yang Hongmei Tang Rui Pan Sai Xie Luyan Guo Junbin Wang Qinyin Deng Guoyin Xiong Yanyan Xing Jun Dong | 2012 | Neural Regeneration Research2012，7，3： | 5 |
| 8 | Multi-view dimensionality reduction via canonical random correlation analysis显示文摘 | Yanyan ZHANG Jianchun ZHANG Zhisong PAN Daoqiang ZHANG | 2016 | Frontiers of Computer Science2016，10，5： | 3 |
| 9 | Curcumin ameliorates hippocampal neuron damage induced by human immunodeficiency virus-1显示文摘Our previous studies have shown that infection with the gp120 V3 loop can cause human immunodeficiency virus-1 associated neurocognitive disorders. Curcumin has been shown to improve these effects to some degree, but the precise mechanisms remain unknown. The present study analyzed the neuroprotective effect and mechanism of curcumin in relation to hippocampal neurons. Results showed that 1 nmol/L gp120 V3 loop suppressed the growth of synapses. After administration of 1 μmol/L curcumin, synaptic growth improved. Curcumin is neuroprotective against gp120 V3 loop-induced neuronal damage by inhibiting the activation of L-type calcium currents, relieving intracellular Ca2+ overload, promoting Bcl-2 expression, and inhibiting Bax activation. The effect of curcumin was identical to nimodipine, suggesting that curcumin has the same neuroprotective effects against gp120 V3 loop-induced neuronal damage. | Hongmei Tang Rui Pan Wenli Fang Yanyan Xing Dexi Chen Xiaobao Chen Yuanyuan Yu Junbing Wang Zheng Gong Guoyin Xiong Jun Dong | 2013 | Neural Regeneration Research2013，8，15： | 3 |
| 10 | Mixed-dimensional hierarchical configuration of 2D Ni_(2)P nanosheets anchored on 1D silk-derived carbon fiber for extraordinary electromagnetic wave absorption显示文摘Considering a series of electromagnetic pollution problems brought by the development of electronic communication technology,more attention has been paid to the research of electromagnetic wave(EMW)absorbing materials with unique composition and structure.Herein,under the inspiration of mixeddimensional hierarchical structure,2D Ni_(2)P nanosheets anchored on 1D silk-derived carbon fiber is successfully fabricated as a gratifying resistor-dielectric type absorber.By a controllable pyrolyzation strategy and disproportionated reaction,high-density 2D Ni_(2)P nanosheets were grown vertically and cross-linked on the surface of 1D silk-derived carbon fiber.The sample exhibited superior EMW absorption performance with maximum reflection loss value of–56.9 d B at the thickness of 2.32 mm and the effective absorption bandwidth can reach to 7.2 GHz at the thickness of 1.93 mm.In addition,the pure Ni_(2)P shows remarkable dielectric characteristic and EMW absorption ability as well.The integration of dualconductive loss,enhanced polarization relaxation loss and the multiple scattering in the composites was proved to contribute to the good EMW absorption performance.Therefore,this work confirms the great potentials of Ni_(2)P as a high-efficient EMW absorbing materials and light a new way in construction of multidimensional absorber. | Fei Pan Lei Cai Yanyan Dong Xiaojie Zhu Yuyang Shi Wei Lu | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 11 | Dimensionality reduction via kernel sparse representation显示文摘基于稀少的表示,作为最热的研究之一,话题在最近的年里在许多应用完成了显著性能的维数减小(医生) 方法。然而,它的为存在稀少的表示的挑战基于方法由于在原来的空格寻求数据的稀少的表示的限制解决非线性的问题。由核诡计激发了,我们建议一个新框架把实验的核称为稀少的表示(EKSR ) 解决非线性的问题。在这个框架,非线性的可分离的数据被印射直到非线性的类似能在被捕获的内核空格,然后在内核空格的数据被稀少的表示重建保存稀少的结构,它被最小化获得一<潜水艇class=“ a-plus-plus ”> 1 规则化相关的客观功能。EKSR 提供新卓见进维数减小并且扩大二个模型:1 ) 实验的核稀少保存设计(EKSPP ) 它基于保存设计(SPP ) 的稀少是一个特征抽取方法;2 ) 实验的核稀少分数(EKSS ) 基于稀少 20 是一个特征选择方法,。两个能自动地二个方法选择邻居为稀少的表示的自然歧视的力量。与几存在途径相比,建议框架能减少计算复杂性并且在实践更方便。 | Zhisong PAN Zhantao DENG Yibing WANG Yanyan ZHANG | 2014 | Frontiers of Computer Science2014，8，5： | 3 |
| 12 | Chinese SPRIGT realizes high temperature stability in the range of 5–25 K显示文摘The unit of thermodynamic temperature,the kelvin,is one of the seven base units of International System of Units.High accuracy measurements of thermodynamic temperature in the lowtemperature range,namely below the neon triple point at24.5561 K,are of strategic significance for the development of | Bo Gao Changzhao Pan Laurent Pitre Yanyan Chen Haiyang Zhang Yaonan Song Hui then Wenjing Liu Dongxu Han Ercang Luo | 2018 | Science Bulletin2018，63，12： | 3 |
| 13 | Tyrosine phosphatase Shp2 regulates pi 15RhoGEF/Rhodependent dendritic cell migration显示文摘The orchestrated migration of dendritic cells(DCs)to secondary lymphoid organs relies on C-C chemokine receptor type 7(CCR7)and its ligand C-C motif chemokine ligand 19(CCL19),and DC migration to lymph nodes is crucial for the initiation and progression of adaptive immune responses. | Yun Xu Yun Zhang Yanyan Yang Yanqi Liu Qiaoying Tian Pan Liu Zhifan Ding Hongqiang Cheng Xue Zhang Yuehai Ke | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 14 | G6:A web-based library for graph visualization显示文摘Authoring graph visualization poses great challenges to developers due to its high requirements on both domain knowledge and development skills.Although existing libraries and tools reduce the difficulty of generating graph visualization,there are still many challenges.We work closely with developers and formulate several design goals,then design and implement G6,a web-based library for graph visualization.It combines template-based configuration for high usability and flexible customization for high expressiveness.To enhance development efficiency,G6 proposes a range of optimizations,including state management and interaction modes.We demonstrate its capabilities through an extensive gallery,a quantitative performance evaluation,and an expert interview.G6 was first released in 2017 and has been iterated for 317 versions.It has served as a web-based library for thousands of applications and received 8312 stars on GitHub. | Yanyan Wang Zhanning Bai Zhifeng Lin Xiaoqing Dong Yingchaojie Feng Jiacheng Pan Wei Chen | 2021 | Visual Informatics2021，5，4： | 1 |
| 15 | Macroscopic Electromagnetic Cooperative Network‑Enhanced MXene/Ni Chains Aerogel‑Based Microwave Absorber with Ultra‑Low Matching Thickness显示文摘Electromagnetic cooperative strategy has been presented as a mainstream approach that can effectively optimize the matching thickness of dielectric loss dominant system.However,it is still challenging for dielectric–magnetic loss coexisting-type absorber to develop electromagnetic wave(EMW)performance with ultra-low matching thickness(≤1 mm).Breaking the limitation of traditional electromagnetic response at microscopic/mesoscopic scale,a ficus microcarpa-like magnetic aerogel with macroscopical electromagnetic cooperative effect was fabricated through highly oriented self-assembly engineering.The highly oriented Ni chains with unique macroscopic morphology(~1 cm in length)were achieved via a special magnetic field-induced growth.Strong magnetic coupling was observed in the Ni chains confirmed by the micromagnetic simulation.The deductive calculation validates that maintaining high value of electromagnetic parameters at high frequencies is the prerequisites of ultrathin absorber.The electromagnetic cooperative networks with uninterrupted and dual pathways spread through the entire aerogel skeleton,resulting in the impressive permittivity even at high frequencies.Consequently,the aerogel exhibits a remarkable EMW performance at an ultrathin thickness of 1 mm.Thus,based on the modulation of electromagnetic parameters,this work proposed a macroscopic ordered structure with the electromagnetic cooperative effect useful to develop a suitable strategy for achieving ultrathin EMW absorbers. | Fei Pan Yanping Rao Dan Batalu Lei Cai Yanyan Dong Xiaojie Zhu Yuyang Shi Zhong Shi Yaowen Liu Wei Lu | 2022 | Nano-Micro Letters2022，14，8： | 1 |
| 16 | New Gene Variants Associated with the Risk of Chronic HBV Infection显示文摘Some patients with chronic hepatitis B virus(HBV)infection failed to clear HBV,even persistently continue to produce antibodies to HBV.Here we performed a two stage genome wide association study in a cohort of Chinese patients designed to discover single nucleotide variants that associate with HBV infection and clearance of HBV.The first stage involved genome wide exome sequencing of 101 cases(HBsAg plus anti-HBs positive)compared with 102 control patients(antiHBs positive,HBsAg negative).Over 80%of individual sequences displayed 209 sequence coverage.Adapters,uncertain bases[10%or low-quality base calls([50%)were filtered and compared to the human reference genome hg19.In the second stage,579 chronic HBV infected cases and 439 HBV clearance controls were sequenced with selected genes from the first stage.Although there were no significant associated gene variants in the first stage,two significant gene associations were discovered when the two stages were assessed in a combined analysis.One association showed rs506121-“T”allele[within the dedicator of cytokinesis 8(DOCK8)gene]was higher in chronic HBV infection group than that in clearance group(P=0.002,OR=0.77,95%CI[0.65,0.91]).The second association involved rs2071676—A allele within the Carbonic anhydrase(CA9)gene that was significantly elevated in chronic HBV infection group compared to the clearance group(P=0.0003,OR=1.35,95%CI[1.15,1.58]).Upon replication these gene associations would suggest the influence of DOCK8 and CA9 as potential risk genetic factors in the persistence of HBV infection. | Mengjie Fan Jing Wang Sa Wang Tengyan Li Hong Pan Hankui Liu Huifang Xu Daria V.Zhernakova Stephen J.O’Brien Zhenru Feng Le Chang Erhei Dai Jianhua Lu Hongli Xi Yanyan Yu Jianguo Zhang Binbin Wang Zheng Zeng | 2020 | Virologica Sinica2020，35，4： | 1 |
| 17 | Heterointerface Engineering of β‑Chitin/Carbon Nano‑Onions/Ni-P Composites with Boosted Maxwell‑Wagner‑Sillars Effect for Highly Efficient Electromagnetic Wave Response and Thermal Management显示文摘The rational construction of microstructure and composition with enhanced Maxwell-Wagner-Sillars effect(MWSE)is still a challenging direction for reinforcing electromagnetic wave(EMW)absorption performance,and the related EMW attenuation mechanism has rarely been elucidated.Herein,MWSE boostedβ-chitin/carbon nano-onions/Ni–P composites is prepared according to the heterointerface engineering strategy via facile layer-by-layer electrostatic assembly and electroless plating techniques.The heterogeneous interface is reinforced from the aspect of porous skeleton,nanomaterials and multilayer construction.The composites exhibit competitive EMW response mechanism between the conductive loss and the polarization/magnetic loss,as describing like the story of“The Hare and the Tortoise”.As a result,the composites not only achieve a minimum reflection loss(RL_(min))of−50.83 dB and an effective bandwidth of 6.8 GHz,but also present remarkable EMW interference shielding effectiveness of 66.66 dB.In addition,diverse functions such as good thermal insulation,infrared shielding and photothermal performance were also achieved in the hybrid composites as a result of intrinsic morphology and chemicophysics properties.Therefore,we believe that the boosted MWSE open up a novel orientation toward developing multifunctional composites with high-efficient EMW response and thermal management. | Fei Pan Lei Cai Yuyang Shi Yanyan Dong Xiaojie Zhu Jie Cheng Haojie Jiang Xiao Wang Yifeng Jiang Wei Lu | 2022 | Nano-Micro Letters2022，14，5： | 1 |
| 18 | Prevalence and significance of Hepatitis B reverse transcriptase mutants in different disease stages of untreated patients显示文摘 | Jinxin Zheng Zheng Zeng Duyi Zhang Yanyan Yu Fang Wang Calvin Q. Pan | 2012 | Liver Int2012，，10： | 1 |
| 19 | Accelerating water dissociation kinetics of Ni3N by tuning interfacial orbital coupling显示文摘The high unoccupied d band energy of Ni_(3)N basically results in weak orbital coupling with water molecule,consequently leading to slow water dissociation kinetics.Herein,we demonstrate Cr doping can downshift the unoccupied d orbitals and strengthen the interfacial orbital coupling to boost the water dissociation kinetics.The prepared Cr-Ni_(3)N/Ni displays an impressive overpotential of 37 mV at 10 mA·cmgeo-2,close to the benchmark Pt/C in 1.0 M KOH solution.Refined structural analysis reveals the Cr dopant exists as the Cr-N_(6)states and the average d band energy of Ni_(3)N is also lowered.Density functional theory calculation further confirms the downshifted d band energy can strengthen the orbital coupling between the unpaired electrons in O 2p and the unoccupied state of Ni 3d,which thus facilitates the water adsorption and dissociation.The work provides a new concept to achieve on-demand functions for hydrogen evolution catalysis and beyond,by regulating the interfacial orbital coupling. | Yishang Wu Yufang Xie Shuwen Niu Yipeng Zang Jinyan Cai Zenan Bian Xuanwei Yin Yanyan Fang Da Sun Di Niu Zheng Lu Amirabbas Mosallanezhad Huijuan Wang Dewei Rao Hongge Pan Gongming Wang | 2021 | Nano Research2021，14，10： | 1 |
| 20 | Preparation and Osteogenic Efficacy of Emodin-loaded Hydroxyapatite Electrospun Fibers显示文摘Biological scaffolds have been the focus of bone tissue engineering research in recent years. In this paper, emodin (EM), macromolecular compound polycaprolactone (PCL), and hydroxyapatite (HA) were used as raw materials to prepare EM/PCL/HA fibers containing different EM ratios by electrospinning, and the properties and osteogenic efficacy of EM/PCL/HA were studied. Scanning electron microscopy, transmission electron microscopy, and atomic force microscopy were used to characterize the structures of HA and the electrospun fibers. Results showed that HA has high crystallinity and loose porous structure, and the electrospun fibers have a smooth and flat surface. In vitro release results showed that EM was slowly released from EM/PCL/HA within 216 h. Cell proliferation assay in mouse embryonic osteoblast precursor cells (MC3T3-E1) exhibited that 5% EM/PCL/HA had the best effect on promoting cell proliferation. Alkaline phosphatase (ALP) and mineralized nodules staining results also showed that 5% EM/PCL/HA had the best effect on promoting osteogenic differentiation. qRT-PCR results showed that the mRNA expression level of osteoblast differentiation markers, namely, bone morphogenetic protein (BMP)-2, BMP-9, and osteocalcin were significantly upregulated by 5% EM/PCL/HA treatment. These results indicate that EM/PCL/HA is a potential osteogenic material, which can provide a reference for the development of bone injury repair materials. | Yiwen Pan Mu He Shaoqing Chen Yanyan Meng Cheli Wang Xinye Ni | 2023 | Journal of Bionic Engineering2023，20，3： | 1 |
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