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| 1 | Onset of the Meissner effect at 65 K in Fe Se thin film grown on Nb-doped Sr TiO_3 substrate显示文摘We report the Meissner effect studies on an Fe Se thin film grown on Nb-doped Sr Ti O3 substrate by molecular beam epitaxy. Two-coil mutual inductance measurement clearly demonstrates the onset of diamagnetic screening at 65 K, which is consistent with the gap opening temperature determined by previous angle-resolved photoemission spectroscopy results. The applied magnetic field causes a broadening of the superconducting transition near the onset temperature, which is the typical behavior for quasi-two-dimensional superconductors. Our results provide direct evidence that Fe Se thin film grown on Nb-doped Sr Ti O3 substrate has an onset TC* 65 K,which is the highest among all iron-based superconductors discovered so far. | Zuocheng Zhang Yi-Hua Wang Qi Song Chang Liu Rui Peng K.A.Moler Donglai Feng Yayu Wang | 2015 | Science Bulletin2015，60，14： | 10 |
| 2 | Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia–legume symbiosis显示文摘Plants establish symbioses with mutualistic fungi,such as arbuscular mycorrhizal(AM)fungi,and bacteria,such as rhizobia,to exchange key nutrients and thrive.Plants and symbionts have coevolved and represent vital components of terrestrial ecosystems.Plants employ an ancestral AM signaling pathway to establish intracellular symbioses,including the legume–rhizobia symbiosis,in their roots.Nevertheless,the relationship between the AM and rhizobial symbioses in native soil is poorly understood.Here,we examined how these distinct symbioses affect root-associated bacterial communities in Medicago truncatula by performing quantitative microbiota profiling(QMP)of 16S rRNA genes.We found that M.truncatula mutants that cannot establish AM or rhizobia symbiosis have an altered microbial load(quantitative abundance)in the rhizosphere and roots,and in particular that AM symbiosis is required to assemble a normal quantitative root-associated microbiota in native soil.Moreover,quantitative microbial co-abundance network analyses revealed that AM symbiosis affects Rhizobiales hubs among plant microbiota and benefits the plant holobiont.Through QMP of rhizobial rpoB and AM fungal SSU rRNA genes,we revealed a new layer of interaction whereby AM symbiosis promotes rhizobia accumulation in the rhizosphere of M.truncatula.We further showed that AM symbiosis-conditioned microbial communities within the M.truncatula rhizosphere could promote nodulation in different legume plants in native soil.Given that the AM and rhizobial symbioses are critical for crop growth,our findings might inform strategies to improve agricultural management.Moreover,our work sheds light on the co-evolution of these intracellular symbioses during plant adaptation to native soil conditions. | Xiaolin Wang Huan Feng Yayu Wang Mingxing Wang Xingguang Xie Huizhong Chang Like Wang Jicheng Qu Kai Sun Wei He Chunyan Wang Chuanchao Dai Zhaohui Chu Changfu Tian Nan Yu Xuebin Zhang Huan Liu Ertao Wang | 2021 | Molecular Plant2021，14，3： | 6 |
| 3 | Study of establishing disease-syndrome combined with animal model for immune thrombocytopenic purpura without additional conditions显示文摘Objective:To explore the feasibility of establishing the disease-syndrome combined animal model for immune thrombocytopenic purpura(ITP)without additional conditions.Methods:Three batches of data related to the ITP model mice obtained by replication at different time were analyzed,and whether the APS-injected model mice replicated through the passive immune modeling method could simulate the pathogenesis and clinical characteristics of human ITP was evaluated according to the differentiation criteria for diseasesyndrome combined model.Results:The APS-injected replicated ITP model mice possessed the following traits:(1)Compared with the normal group,the platelet count was significantly decreased,and coagulation time was significantly increased in the model group(P<.01).(2)Compared with the normal group,the medullary thrombocytogenous megakaryocytes were significantly decreased(P<.05,.01,.001).(3)The APS-injected sites and other parts of the model mice had spontaneous hemorrhage.(4)Behavioral changing signs were observed 1 week after the modeling(i.e.low activity,delayed activity,poor appetite,skin petechia/hemorrhage and spontaneous hemorrhage at the injected sites or other parts),and were getting more and more severe.Conclusion:According to the syndrome differentiation criteria for disease-syndrome combined model of ITP,the APS-injected animal model of ITP replicated through the passive immune modeling method without additional conditions possesses the characteristics of disease-syndrome combined model.It provides an ideal tool for the development of traditional Chinese medicine pharmacology experiment. | Haiyan Lang Ming Guo Yuting Chu Wei Ma Yayue Zhang Ling Zhang Xinyi Chen | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，3： | 2 |
| 4 | Growth kinetics of MgH2 nanocrystallites prepared by ball milling显示文摘MgH2 is one of promising hydrogen storage materials due to its high hydrogen capacity of 7.6 wt%.However,MgH2 nanocrystallites easilygrow up during hydrogen absorption-desorption cycling,leading to deterioration of hydrogen storage properties.To clarify the growth kinetics of MgH2 crystallites,the growth characteristics of MgH2 nanocrystallites are investigated in this work.The growth exponents of MgH2 nanocrystallites in pure MgH2 and MgH2-10 wt% Pr3 Al11 samples are evaluated to be n=5 and n=6,respectively.Meanwhile,their activation energies for crystallite growth are also determined to be109.2 and 144.2 kJ/mol,respectively.The increase of growth exponent and rise of activation energy for crystallite growth in MgH2-10 wt% Pr3 Al11 composite are ascribed to the presence of nano-sized Pr3 Al11phase. | Caiqin Zhou Yayu Peng Qingan Zhang | 2020 | Journal of Materials Science & Technology2020，47，15： | 2 |
| 5 | An infrared thermographic analysis of the sensitization acupoints of women with primary dysmenorrhea显示文摘OBJECTIVE:To explore the sensitization acupoints of women with primary dysmenorrhea(PD)by comparing infrared radiation temperatures between acupoints and non-acupoints.METHODS:We tested 10 acupoints of every woman with PD and healthy subjects on premenstrual,menstrual,and postmenstrual days using an infrared imaging device.The primary outcome was the absolute value of body surface temperature difference(AVTD)between the left and right sides of the same testing point.RESULTS:A total of 58 PD patients and 57 healthy volunteers completed the test from May 2016 to May 2017.Compared with the healthy group,we observed a significant reduction and increase in the AVTD in Taichong(LR3)and Sanyinjiao(SP6),respectively,during menstrual days in the PD group(P=0.01;P=0.04);while during postmenstrual days,all AVTDs of Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)were diminished in the PD group(P=0.01;P=0.03;P=0.01,respectively).No significant differences in AVTD were detected at any other points or testing times.CONCLUSIONS:Compared with the healthy group,the AVTDs of Taichong(LR3),Sanyinjiao(SP6),Shuiquan(KI5),Diji(SP8),and Xuehai(SP10)at menstruationrelevant points of PD patients were sensitized,providing a reference for the selection of acupoints in the treatment of PD. | FAN Xisheng DU Xiaoyi PAN Lijia SONG Xiaodan LIU Jun ZHANG Juncha CHEN Hao GAO Yayu ZHANG Mingjian SHI Xuliang SHE Yanfen | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 2 |
| 6 | Acetylcholinesterase inhibitors and antioxidants mining from marine fungi:bioassays,bioactivity coupled LC-MS/MS analyses and molecular networking显示文摘Marine fungi are potentially important resources for bioactive lead compounds for discovering new drugs for diseases such as Alzheimer's disease.In this paper,the combined bioassay model of acetylcholinesterase(AChE)inhibition,1,1-diphenyl-2-picrylhydrazyl(DPPH)free radical scavenging,and Artemi ci larval lethality was used to evaluate the activity and toxicity of 35 n narine fun gal strains from seas around China.Their bioactive constitue nfs were revealed by thin layer chromatography(TLC)autography,bioactivity coupled LC-MS/MS and Global Natural Products Social Molecular Networking(GNPS).The results show that the extracts of five strains exhibited higher AChE inhibition ratios than the positive control compound,'tacrine;for which the ratio was 89.8%at 200 pig/ml.Six strains displayed both AChE inhibition(inhibition ratios>20%at 200 pg/ml)and DPPH scavenging activity(scavenging ratios>30%at 200 pg/ml)together with low Artemia larval toxicity(lethal rates<12%).TLC autography showed that the fractioned extracts of four strains contained highly diverse and different bioactive constituents,includi ng strains Talaromyces sp.C2\-\,Aspergillus ter re us C23-3,Trichoderma harzianum DLEN2008005,and Penicillium corylophilum TBG1-17.From the most potent sample F-l 1-1-b(derived from Aspergillus tern us C23-3),five AChE inhibitors and seven antioxida nts were recognized as bioactive molecules by AChE coupled ultrafiltration followed by LC-MS/MS,and LC-MS/MS coupled with DPPH incubation.Furthermore,with the aid of GNPS,the AChE inhibitors were plausibly annotated as territrem analogues including territrems A-C/D,arisugacin A and an unknown compound 4,and the seven antioxidants were assigned as butyrolactone I.aspernolide E,a phenolic derivative and possibly unknown compounds 8-10 and 12. | Yingying Nie Wencong Yang Yayue Liu Jingming Yang Xiaoling Lei William HGerwick Yi Zhang | 2020 | Marine Life Science & Technology2020，2，4： | 2 |
| 7 | Investigation of hemostatic effect of Spleeninvigorating,Qi-replenishing and Bloodarresting Formula on simvastatin-induced zebrafish hemorrhage model显示文摘Blood-arresting Formula on simvastatin-induced zebrafish hemorrhage model compared with that of the Heat-clearing and Blood-cooling Formula.Methods:AB strain wild type zebrafish were treated with 0.5 mM simvastatin for 24 hours to establish the zebrafish hemorrhage model.Under strictly blind experimental conditions,the zebrafish were then treated with experimental agents in different concentration within the maximum non-lethal dose.The intervention effect of the Spleen-invigorating,Qi-replenishing and Blood-arresting Formula was comprehensively assessed by examining the main observational parameters such as the bleeding reduction rate and hemostatic rate while referring to the additional parameters such as blood flow,improvement rate of blood flow,velocity of movement,improvement rate of motion under spleen-qi deficiency.Results:Hemostatic effect:The bleeding rate and hemostatic rate in the zebrafish were respectively,30%,15%,45%,40%and 60%,80%,40%,47%when equal concentration of 500 mg/mL,1000 mg/mL were used.This showed that the experimental herbs B1 was superior to B2 in decreasing the bleeding rate and improving hemostatic effect in the zebrafish.Improvement of blood flow:With equal concentration,the experimental herb B1 was superior to B2 in increasing the blood flow and improvement rate of blood flow in hemorrhagic zebrafish.Promotion of the improvement of motion:With equal concentration of 500 mg/mL and 1000 mg/mL,the experimental herb B1 was superior to B2 in promoting the velocity of motion in the zebrafish and promoting the improvement rate of motion.Conclusion:The manifestations of simvastatin-induced zebrafish hemorrhage are basically similar to that of failure of the spleen to control blood in human beings.The Spleeninvigorating,Qi-replenishing and Blood-arresting Formula has good hemostatic effect on simvastatin-induced hemorrhage in the zebrafish.It also boasts the functions of improving blood flow and velocity of motion in the hemorrhagic zebrafish.Such a conclusion provides the experimental basis for the treatment of the syndrome of failure of the spleen to control blood by this formula. | Yuting Chu Ling Zhang Xiaoyu Zhu Yayue Zhang Bo Xia Li Hou Rushun Song Tiantian Li Chunqi Li Qing Dong a Xinyi Chen | 2016 | Journal of Traditional Chinese Medical Sciences2016，3，4： | 1 |
| 8 | Cold-induced Yes-associated-protein expression through miR-429 mediates the browning of white adipose tissue显示文摘Targeting the white-to-brown fat conversion is important for developing potential strategies to counteract metabolic diseases;yet the mechanisms are not fully understood.Yes-associated-protein(YAP),a transcription co-activator,was demonstrated to regulate adipose tissue functions;however,its effects on browning of subcutaneous white adipose tissue(sWAT)are unclear.We demonstrated that YAP was highly expressed in cold-induced beige fat.Mechanistically,YAP was found as a target gene of miR-429,which downregulated YAP expression in vivo and in vitro.In addition,miR-429 level was decreased in cold-induced beige fat.Additionally,pharmacological inhibition of the interaction between YAP and transcriptional enhanced associate domains by verteporfin dampened the browning of sWAT.Although adipose tissue-specific YAP overexpression increased energy expenditure with increased basal uncoupling protein 1 expression,it had no additional effects on the browning of sWAT in young mice.However,we found age-related impairment of sWAT browning along with decreased YAP expression.Under these circumstances,YAP overexpression significantly improved the impaired WAT browning in middle-aged mice.In conclusion,YAP as a regulator of sWAT browning,was upregulated by lowering miR-429 level in cold-induced beige fat.Targeting the miR-429-YAP pathway could be exploited for therapeutic strategies for age-related impairment of sWAT browning. | Chenji Ye Jinjie Duan Xuejiao Zhang Liu Yao Yayue Song Guangyan Wang Qi Li Biqing Wang Ding Ai Chunjiong Wang Yi Zhu | 2021 | Science China(Life Sciences)2021，64，3： | 1 |
| 9 | Hemostatic mechanism of the effect of Jianpi Yiqi Shexue decoction on vascular factors in immune thrombocytopenia model mice显示文摘Objective: To explore the hemostatic mechanism of Jianpi Yiqi Shexue decoction(JYSD) by regulating vascular factors in an immune thrombocytopenia(ITP) mouse model.Methods: An ITP mouse model was established by the passive-immune modeling method, and interventional drugs used were prednisone tablets and JYSD. The platelet count;vascular activity-related factors v WF, VCAM-1, and TM;and VEGF and b FGF were used as observational indicators.Results: On the 8th day of administration, compared with the model group, platelet counts in the prednisone and JYSD groups increased(both P <.001). Compared with the control group, the levels of v WF, VCAM-1, and TM in the other groups were lower(all P <.05). The VCAM-1 level in the JYSD group was higher than that in the prednisone group(P =.012), but without significant difference compared with the model group(P =.051). The TM level in the JYSD group was the lowest(vs. the model group,P =.047;vs. the prednisone group, P =.006). Compared with the control group, the IOD values of VEGF and b FGF in the other three groups were lower(all P <.01). The IOD values of VEGF in the prednisone and JYSD groups were both higher than those in the model group(P =.002 and P <.001, respectively). The IOD values of b FGF among the model, prednisone, and JYSD groups were not statistically significant(P >.05).Conclusion: A vascular factor disorder is involved in the pathogenesis of ITP. JYSD can increase the platelet count, upregulate VEGF expression, and reduce the TM level. JYSD has the same effect as prednisone tablets in regulating platelet, v WF, VEGF, and b FGF, with a stronger effect in normalizing VCAM-1 and TM levels. The hemostatic mechanism of JYSD is closely related to the effective balance of vascular factors. | Ruibai Li Wei Ma Haiyan Lang Hao He Liyuan Lv Yayue Zhang Xinyi Chen Li Hou | 2022 | Journal of Traditional Chinese Medical Sciences2022，9，2： | 1 |
| 10 | Superconductivity in One-atomic-layer Metal Films显示文摘Superconductivity is a peculiar quantum phenomenon which originates from the pairing of conduction electrons, followed by phase coherent condensation. Since the discovery by K. Onnes in 1911, superconductivity has been one of the hottest topics in physics for an entire century, and still attracts people's great interest. One of the intriguing issues is | ZHANG Tong CHENG Peng LI Wenjuan SUN Yujie WANG Guang ZHU Xiegang HE Ke WANG Lili MA Xucun CHEN Xi WANG Yayu LIU Ying LIN Haiqing JIA Jinfeng XUE Qikun | 2011 | Bulletin of the Chinese Academy of Sciences2011，25，4： | 1 |
| 11 | A new benzaldehyde from the coral-derived fungus Aspergillus terreus C23-3 and its anti-inflammatory effects via suppression of MAPK signaling pathway in RAW264.7 cells显示文摘Marine fungi are important members of the marine microbiome,which have been paid growing attention by scientists in recent years.The secondary metabolites of marine fungi have been reported to contain rich and diverse compounds with novel structures(Chen et al.,2019).Aspergillus terreus,the higher level marine fungus of the Aspergillus genus(family of Trichocomaceae,order of Eurotiales,class of Euro・tiomycetes,phylum of Ascomycota). | Minqi CHEN Jinyue LIANG Yuan WANG Yayue LIU Chunxia ZHOU Pengzhi HONG Yi ZHANG Zhong-Ji QIAN | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 1 |
| 12 | Atomic scale electronic structure of the ferromagnetic semiconductor Cr2Ge2Te6显示文摘Cr_2Ge_2Te_6is an intrinsic ferromagnetic semiconductor with van der Waals type layered structure,thus represents a promising material for novel electronic and spintronic devices.Here we combine scanning tunneling microscopy and first-principles calculations to investigate the electronic structure of Cr_2Ge_2Te_6.Tunneling spectroscopy reveals a surprising large energy level shift and change of energy gap size across the ferromagnetic to paramagnetic phase transition,as well as a peculiar double-peak electronic state on the Cr-site defect.These features can be quantitatively explained by density functional theory calculations,which uncover a close relationship between the electronic structure and magnetic order.These findings shed important new lights on the microscopic electronic structure and origin of magnetic order in Cr_2Ge_2Te_6. | Zhenqi Hao Haiwei Li Shunhong Zhang Xintong Li Gaoting Lin Xuan Luo Yuping Sun Zheng Liu Yayu Wang | 2018 | Science Bulletin2018，63，13： | 1 |
| 13 | Metal-organic frameworks with mixed-ligands strategy as heterogeneous nucleation center to assist crystallization for efficient and stable perovskite solar cells显示文摘Deep-level defects and random oriented configuration in perovskite crystallization process would cause the nonradiative recombination and further affect the performance of perovskite solar cells(PSCs).Herein,two metal-organic frameworks(MOFs)with tunable Lewis-base passivation sites have been constructed(Cd-Httb and Cd-Httb-BDC,Httb=5-(4-(1H-1,2,4-triazole-1-yl)benzyl)-1h-tetrazole,BDC=1,4-dicarboxybenzene)to eliminate deep-level defects and simultaneously as nanostructured heterogeneous nucleation seed to assist the growth of large-grained perovskite films.Compared with the control and Cd-Httb,Cd-Httb-BDC designed with mix-ligands strategy exhibited the enhanced inducted effect on the crystallization and nucleation of high-quality perovskite films during annealing process.Consequently,the resultant Cd-Httb-BDC-modified device achieved higher power conversion efficiency(PCE)(22.18%)than the control(20.89%)and Cd-Httb(21.56%).Meanwhile,the unencapsulated Cd-Httb-BDC-modified device still maintained 90%of initial PCE after 1500 h in ambient conditions and exhibited enhanced thermal stability(85℃ in N_(2) atmosphere).This work presented a successful example of mixligands strategy on construction of high-quality MOF-assisted perovskite films for high-efficient and stable PSCs. | Yayu Dong Shuang Gai Jian Zhang Ruiqing Fan Boyuan Hu Wei Wang Wei Cao Jiaqi Wang Ke Zhu Debin Xia Lin Geng Yulin Yang | 2023 | Journal of Energy Chemistry2023，，2： | 0 |
| 14 | Quantized anomalous Hall resistivity achieved in molecular beam epitaxy-grown MnBi_(2)Te_(4)thin films显示文摘The intrinsic magnetic topological insulator MnBi_(2)Te_(4)provides a feasible pathway to the high-temperature quantum anomalous Hall(QAH)effect as well as various novel topological quantum phases.Although quantized transport properties have been observed in exfoliated MnBi_(2)Te_(4)thin flakes,it remains a big challenge to achieve molecular beam epitaxy(MBE)-grown MnBi_(2)Te_(4)thin films even close to the quantized regime.In this work,we report the realization of quantized anomalous Hall resistivity in MBE-grown MnBi_(2)Te_(4)thin films with the chemical potential tuned by both controlled in situ oxygen exposure and top gating.We find that elongated post-annealing obviously elevates the temperature to achieve quantization of the Hall resistivity,but also increases the residual longitudinal resistivity,indicating a picture of high-quality QAH puddles weakly coupled by tunnel barriers.These results help to clarify the puzzles in previous experimental studies on MnBi_(2)Te_(4)and to find a way out of the big difficulty in obtaining MnBi_(2)Te_(4)samples showing quantized transport properties. | Yunhe Bai Yuanzhao Li Jianli Luan Ruixuan Liu Wenyu Song Yang Chen Peng-Fei Ji Qinghua Zhang Fanqi Meng Bingbing Tong Lin Li Yuying Jiang Zongwei Gao Lin Gu Jinsong Zhang Yayu Wang Qi-Kun Xue Ke He Yang Feng Xiao Feng | 2024 | National Science Review2024，11，2： | 0 |
| 15 | 1.42-fold enhancement of formate selectivity by linker conversion on the Zn-based metal organic framework catalyst显示文摘Electro-reduction of carbon dioxide(ERCO_(2)) is considered an effective method to alleviate the greenhouse effect and produce value-added chemicals.Achieving the dominant selectivity of Zn-based catalysts for formate remains a challenge.In this article,the ZnIn-E_(12) catalyst is successfully prepared by solvent assisted ligand exchange(SALE) method to convert organic ligands,achieving a Faradaic efficiency of 72.28% for formate at-1.26 V vs.RHE(V_(RHE)),which is 1.42 times higher than the original catalyst.Evidence shows that the successful conversion of organic ligands can transform the catalyst from the original large size polyhedron to cross-linked network of particles with a diameter of about 30 nm.The increased specific surface area can expose more active sites and facilitate the electrocatalytic conversion of CO_(2) to formate.This work is expected to provide inspiration for the regulation of formate selectivity and catalyst size in Zn-based catalysts. | Yayu Guan Yuyu Liu Fanghua Ning Jin Yi Jiujun Zhang | 2024 | Journal of Energy Chemistry2024，90，3： | 0 |
| 16 | Heat diffusion optimization in high performance perovskite solar cells integrated with zeolite显示文摘Heat accumulation inside perovskite solar cells causes the decomposition of the perovskite layer and hole transport materials(HTMs)under working conditions,yielding a decrease in long-term stability.Here,we present a zeolite-assisted heat conduction strategy by introducing economic zeolite crystals(e.g.,NaX,NaY,and ZSM-5)as a cooling filter to induce heat diffusion.The fitted thermal diffusion kinetic equation from real-time infrared thermal imaging technology reveals the zeolite skeleton assisted thermal co nduction mechanism of internal lattice vibration.Additionally,the nearly twofold improved conductivity of the modified HTM film is benefited from Na^(+)hopping on the supercages of the zeolite,therefore,the best-performed device with a rapid heat diffusion and defect inhibition obtains a remarkable power conversion efficiency of 23.42%.Both of NaX modified sprio-OMeTAD and PTAA based devices exhibit excellent operational stability after heating 1000 h at 85℃under N_(2)condition.This work demonstrates the potential application of economical porous zeolite materials in improving the thermal stability of PSCs. | Wei Wang Jian Zhang Kaifeng Lin Jiaqi Wang Boyuan Hu Yayu Dong Debin Xia Yulin Yang | 2023 | Journal of Energy Chemistry2023，，11： | 0 |
| 17 | Positive Effects of Isopropanol as a Co-Precipitant in Glycerol-3-Phosphate Acyltransferase Crystallization显示文摘Glycerol-3-phosphate acyltransferase(GPAT) is considered as the rate-limiting enzyme of glycerolipid synthesis pathway and the core element in lysophosphatidic acid(LPA) synthesis. For understanding its catalytic mechanism, the structural biology study is expected, but is always hindered by obtaining crystals for X-ray diffraction analysis. In this study, a progressive strategy to optimize the crystal of microalgae plastidial GPAT was presented. After the expression and purification of GPAT, the crystals were screened by hanging-drop and only clusters were obtained. The crystals were optimized by adjusting temperature, pH, protein concentration, or precipitant, but little improvement. To improve the interaction between protein and precipitant, the isopropanol was applied as co-precipitant. The qualified crystals formed. It's suggested that isopropanol is critical to affect protein crystallization by altering polyethylene glycol(PEG)-water-protein interaction when PEG serves as precipitant. The resulting crystal diffracted to a resolution of 2.75 ? and belonged to space group P1, with unit-cell parameters a = 50.79, b = 80.09, c = 88.21 ?, and α = 62.85, β = 73.04, γ = 80.53?. This work introduced a new strategy to optimize the crystal of the heterogeneous catalysis enzymes like GPAT and provided the fundamental structural information for the oriented synthesis of marine microalgae glycerolipid. | ZHANG Yunxiu FENG Yanbin WANG Yayue LIU Yinghui CAO Xupeng XUE Song | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 18 | Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat显示文摘Neural stem progenitor cell(NSPC)transplantation has been regarded as a promising therapeutic method for spinal cord injury(SCI)repair.However,different NSPCs may have different therapeutic effects,and it is therefore important to identify the optimal NSPC type.In our study,we compared the transcriptomes of human fetal brain-derived NSPCs(BNSPCs),spinal cord-derived NSPCs(SCNSPCs)and H9 embryonic stem-cell derived NSPCs(H9-NSPCs)in vitro and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model in vivo.In vitro data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types.In vivo,compared with BNSPCs and H9-NSPCs,SCNSPCs exhibited the best therapeutic effects;in fact,SCNSPCs facilitated electrophysiological and hindlimb functional recovery.This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair,which is of great clinical significance. | Bai Xu Man Yin Yaming Yang Yunlong Zou Wenbin Liu Lianyong Qiao Jixiang Zhang Zhan Wang Yayu Wu He Shen Minghan Sun Weiyuan Liu Weiwei Xue Yongheng Fan Qi Zhang Bing Chen Xianming Wu Ya Shi Falong Lu Yannan Zhao Zhifeng Xiao Jianwu Dai | 2023 | Bioactive Materials2023，，5： | 0 |
| 19 | Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys显示文摘Transplanting human neural progenitor cells is a promising method of replenishing the lost neurons after spinal cord injury (SCI), but differentiating neural progenitor cells into the diverse types of mature functional spinal cord neurons in vivo is challenging. In this study, engineered human embryonic spinal cord-like tissues with dorsal and ventral neuronal characters (DV-SC) were generated by inducing human neural progenitor cells (hscNPCs) to differentiate into various types of dorsal and ventral neuronal cells on collagen scaffold in vitro. Transplantation of DV-SC into complete SCI models in rats and monkeys showed better therapeutic effects than undifferentiated hscNPCs, including pronounced cell survival and maturation. DV-SC formed a targeted connection with the host’s ascending and descending axons, partially restored interrupted neural circuits, and improved motor evoked potentials and the hindlimb function of animals with SCI. This suggests that the transplantation of pre-differentiated hscNPCs with spinal cord dorsal and ventral neuronal characteristics could be a promising strategy for SCI repair. | Bai Xu Dingyang Liu Weiyuan Liu Ge Long Wenbin Liu Yayu Wu Xinghui He Yeyu Shen Peipei Jiang Man Yin Yongheng Fan He Shen Liyang Shi Qi Zhang Weiwei Xue Chen Jin Zhenni Chen Bing Chen Jiayin Li Yali Hu Xing Li Zhifeng Xiao Yannan Zhao Jianwu Dai | 2023 | Bioactive Materials2023，，9： | 0 |
| 20 | Fine-Grained Features for Image Captioning显示文摘Image captioning involves two different major modalities(image and sentence)that convert a given image into a language that adheres to visual semantics.Almost all methods first extract image features to reduce the difficulty of visual semantic embedding and then use the caption model to generate fluent sentences.The Convolutional Neural Network(CNN)is often used to extract image features in image captioning,and the use of object detection networks to extract region features has achieved great success.However,the region features retrieved by this method are object-level and do not pay attention to fine-grained details because of the detection model’s limitation.We offer an approach to address this issue that more properly generates captions by fusing fine-grained features and region features.First,we extract fine-grained features using a panoramic segmentation algorithm.Second,we suggest two fusion methods and contrast their fusion outcomes.An X-linear Attention Network(X-LAN)serves as the foundation for both fusion methods.According to experimental findings on the COCO dataset,the two-branch fusion approach is superior.It is important to note that on the COCO Karpathy test split,CIDEr is increased up to 134.3%in comparison to the baseline,highlighting the potency and viability of our method. | Mengyue Shao Jie Feng Jie Wu Haixiang Zhang Yayu Zheng | 2023 | Computers, Materials & Continua2023，，6： | 0 |
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