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| 1 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation显示文摘Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels. Structural studies revealed the molecular basis underlying H3K9me-specific recognition by tandem Agenet of ADCP1. Similar to human HP1α and fly HP1a, ADCP1 mediates heterochromatin phase separation. Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. | Shuai Zhao Lingling Cheng Yifei Gao Baichao Zhang Xiangdong Zheng Liang Wang Pilong Li Qianwen Sun Haitao Li | 2019 | Cell Research2019，29，1： | 10 |
| 2 | Computational and experimental analysis of Mach 2 air flow over a blunt body with plasma aerodynamic actuation显示文摘According to the mechanism of the arc plasma heating effect,and from a phenomenological perspective of view,the plasma actuation was simplified as heating energy injected into the supersonic flow field for the numerical research on controlling detached shock of the blunt body in non-center symmetrical positions.Besides,experimental research on the form and strength of detached shock wave control by plasma aerodynamic actuation in non-center symmetrical positions was conducted in a high-speed shock tunnel(M=2).The results showed that the detached distance of shock wave increased and the strength of normal shock wave ahead of the detached shock wave reduced when plasma actuation was applied.The control effect was greatly improved after the magnetic field was applied and the effect of upwind-direction flow was the best one.When the upwind-direction flow was applied with 1000 V voltage actuation,the distance of detached shock wave would increase from 3.4 to 7.6 mm and the time average strength of normal shock wave was weaken by 5.5%.At last,the mechanism of plasma actuation on controlling the detached shock wave was briefly analyzed. | SUN Quan CHENG BangQin LI YingHong KONG WeiSong LI Jun ZHU YiFei JIN Di | 2013 | Science China(Technological Sciences)2013，56，4： | 9 |
| 3 | Donor-Derived CD19-Targeted T Cell Infusion Eliminates B Cell Acute Lymphoblastic Leukemia Minimal Residual Disease with No Response to Donor Lymphocytes after Allogeneic Hematopoietic Stem Cell Transplantation显示文摘Leukemia relapse is still the leading cause of treatment failure after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for B cell acute lymphoblastic leukemia (B-ALL). Relapsed patients with BALL after allo-HSCT have a very short median survival. Minimal residual disease (MRD) is predictive of forthcoming hematological relapse after hematopoietic stem cell transplantation (HSCT);furthermore, eliminating MRD effectively prevents relapse. Donor lymphoblastic infusion (DLI) is the main established approach to treat B-ALL with MRD after allo-HSCT. However, about one-third of patients with MRD are non-responsive to DLI and their prognosis worsens. Although donor-derived cluster of differentiation (CD)19-directed chimeric antigen receptor-modified (CAR) T cells (CART19s) can potentially cure leukemia, the efficiency and safety of infusions with these cells have not yet been investigated in patients with MRD after HSCT. Between September 2014 and February 2018, six patients each received one or more infusions of CART19s from HSCT donors. Five (83.33%) achieved MRD-negative remission, and one case was not responsive to the administration of CAR T cells. Three of the six patients are currently alive without leukemia. No patient developed acute graft-versus-host disease (aGVHD), and no patient died of cytokine release syndrome. Donor-derived CAR T cell infusions seem to be an effective and safe intervention for patients with MRD in B-ALL after allo-HSCT and for those who were not responsive to DLI. | Yifei Cheng Yuhong Chen Chenhua Yan Yu Wang Xiangyu Zhao Yao Chen Wei Han Lanping Xu Xiaohui Zhang Kaiyan Liu Shasha Wang Lungji Chang Lei Xiao Xiaojun Huang | 2019 | Engineering2019，5，1： | 7 |
| 4 | Investigation on Frequency Stirring in Reverberation Chamber显示文摘 | CHENG Erwei WANG Qingguo LIU Yifei XU Xin | 2014 | 高电压技术2014，40，3： | 2 |
| 5 | A spatiotemporal data collection of viral cases for COVID-19 rapid response显示文摘Under the global health crisis of COVID-19,timely,and accurate epi-demic data are important for observation,monitoring,analyzing,modeling,predicting,and mitigating impacts.Viral case data can be jointly analyzed with relevant factors for various applications in the context of the pandemic.Current COVID-19 case data are scattered across a variety of data sources which may consist of low data quality accompanied by inconsistent data structures.To address this short-coming,a multi-scale spatiotemporal data product is proposed as a public repository platform,based on a spatiotemporal cube,and allows the integration of different data sources by adopting various data standards.Within the spatiotemporal cube,a comprehensive data processing workflow gathers disparate COVID-19 epidemic data-sets at the global,national,provincial/state,county,and city levels.This proposed framework is supported by an automatic update with a 2-h frequency and the crowdsourcing validation team to produce and update data on a daily time step.This rapid-response dataset allows the integration of other relevant socio-economic and environ-mental factors for spatiotemporal analysis.The data is available in Harvard Dataverse platform(https://dataverse.harvard.edu/dataset.xhtml?persistentId=doi:10.7910/DVN/8HGECN)and GitHub open source repository(https://github.com/stccenter/COVID-19-Data). | Dexuan Sha Yi Liu Qian Liu Yun Li Yifei Tian Fayez Beaini Cheng Zhong Tao Hu Zifu Wang Hai Lan You Zhou Zhiran Zhang Chaowei Yang | 2021 | Big Earth Data2021，5，1： | 2 |
| 6 | Signal Clipping at Transmitter and Receiver of O-OFDM for VLC under Optical Power Constraint显示文摘Visible light communications(VLC)is considered as an effective supplement technology for next-generation(6G)communications due to its abundant spectrum,high power efficiency and easy deployment.Optical orthogonal frequency division multiplexing(O-OFDM)is a common technology to obtain further promotion.In this paper,two typical O-OFDM schemes direct current biased O-OFDM(DCO-OFDM)and asymmetrically clipped O-OFDM(ACO-OFDM)are analyzed in terms of signal clipping at both transmitter and receiver under the constraints of maximum optical power and non-negative optical power.And effective electrical SNR models after signal clipping are proposed and verified by link simulation.Then a noise cancellation scheme is proposed based on received signal clipping and is proved to bring a significant gain for ACO-OFDM.By system simulation,we find that under a certain optical power limitation,most users can achieve above 4 Gbps in indoor scenario when modulation bandwidth of the light emit diode(LED)or laser diode(LD)is 1 GHz.Therefore,it can be expected that the throughput could reach tens Gbps when the LED/LD modulation bandwidth is increased and multiple LEDs/LDs are deployed. | Liang Xia Xiaoqian Wang Zhiwen Sun Zhitian Cheng Jing Jin Yifei Yuan Guangyi Liu Tao Jiang Yuhong Huang | 2022 | China Communications2022，19，6： | 2 |
| 7 | Taking the pulse of COVID-19:a spatiotemporal perspective显示文摘The sudden outbreak of the Coronavirus disease(COVID-19)swept across the world in early 2020,triggering the lockdowns of several billion people across many countries,including China,Spain,India,the U.K.,Italy,France,Germany,Brazil,Russia,and the U.S.The transmission of the virus accelerated rapidly with the most confirmed cases in the U.S.,India,Russia,and Brazil.In response to this national and global emergency,the NSF Spatiotemporal Innovation Center brought together a taskforce of international researchers and assembled implementation strategies to rapidly respond to this crisis,for supporting research,saving lives,and protecting the health of global citizens.This perspective paper presents our collective view on the global health emergency and our effort in collecting,analyzing,and sharing relevant data on global policy and government responses,human mobility,environmental impact,socioeconomical impact;in developing research capabilities and mitigation measures with global scientists,promoting collaborative research on outbreak dynamics,and reflecting on the dynamic responses from human societies. | Chaowei Yang Dexuan Sha Qian Liu Yun Li Hai Lan Weihe Wendy Guan Tao Hu Zhenlong Li Zhiran Zhang John Hoot Thompson Zifu Wang David Wong Shiyang Ruan Manzhu Yu Douglas Richardson Luyao Zhang Ruizhi Hou You Zhoua Cheng Zhong Yifei Tian Fayez Beaini Kyla Carte Colin Flynn Wei Liu Dieter Pfoser Shuming Bao Mei Li Haoyuan Zhang Chunbo Liu Jie Jiang Shihong Du Liang Zhao Mingyue Lu Lin Li Huan Zhou Andrew Ding | 2020 | International Journal of Digital Earth2020，13，10： | 2 |
| 8 | Distributed Consensus for Blockchains in Internet-of-Things Networks显示文摘In recent years,due to the wide implementation of mobile agents,the Internet-of-Things(IoT) networks have been applied in several real-life scenarios,servicing applications in the areas of public safety,proximity-based services,and fog computing.Meanwhile,when more complex tasks are processed in IoT networks,demands on identity authentication,certifiable traceability,and privacy protection for services in IoT networks increase.Building a blockchain system in IoT networks can greatly satisfy such demands.However,the blockchain building in IoT brings about new challenges compared with that in the traditional full-blown Internet with reliable transmissions,especially in terms of achieving consensus on each block in complex wireless environments,which directly motivates our work.In this study,we fully considered the challenges of achieving a consensus in a blockchain system in IoT networks,including the negative impacts caused by contention and interference in wireless channel,and the lack of reliable transmissions and prior network organizations.By proposing a distributed consensus algorithm for blockchains on multi-hop IoT networks,we showed that it is possible to directly reach a consensus for blockchains in IoT networks,without relying on any additional network layers or protocols to provide reliable and ordered communications.In our theoretical analysis,we showed that our consensus algorithm is asymptotically optimal on time complexity and is energy saving.The extensive simulation results also validate our conclusions in the theoretical analysis. | Li Yang Yifei Zou Minghui Xu Yicheng Xu Dongxiao Yu Xiuzhen Cheng | 2022 | Tsinghua Science and Technology2022，27，5： | 2 |
| 9 | Smart heightened-containment biological laboratory:Technologies,modules,and aims显示文摘With the rapid development of intelligent technology,the smart heightened-containment biological laboratory(sHCBL)has moved from concept to reality.Experimental activities and laboratory construction,operation,and management will undoubtedly lead to disruptive changes.Conventional laboratories are increasingly being replaced by smart laboratories;however,the key technologies involved in this transition remain at an exploratory stage.It is necessary for HCBLs to absorb the advanced ideas of smart laboratories to guarantee the establishment of biosafety and biosecurity in a more automated way.This study examines in detail sHCBL module structures,the functions of each module,laboratory operation processes,and the advanced nature of smart laboratories.It may provide a theoretical foundation for the future transformation and smart construction of sHCBLs. | Jiaming Li Zhongyi Wang Gang Tao Yingying Fu Yifei Jin Hongliang Cheng Jingjing Li Xinrong Shu Jianjian Yang Jiuxiang Yang Bing Lu | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 10 | Water transport through subnanopores in the ultimate size limit: Mechanism from molecular dynamics显示文摘Ab initio and classical molecular dynamics simulations show that water can flow through graphdiyne—an experimentally fabricated graphene-like membrane with highly dense (2.4 × 10^18 pores/m^2), uniformly ordered, subnanometer pores (incircle diameter 0.57 nm and van der Waals area 0.06 nm^2). Water transports through subnanopores via a chemical-reaction-like activated process. The activated water flow can be precisely controlled through fine adjustment of working temperature and pressure. In contrast to a linear dependence on pressure for conventional membranes, here pressure directly modulates the activation energy, leading to a nonlinear water flow as a function of pressure. Consequently, high flux (1.6 L/Day/cm^2/MPa) with 100% salt rejection efficiency is achieved at reasonable temperatures and pressures, suggesting graphdiyne can serve as an excellent membrane for water desalination. We further show that to get through subnanopores water molecule must break redundant hydrogen bonds to form a two-hydrogen-bond transient structure. Our study unveils the principles and atomistic mechanism for water transport through pores in ultimate size limit, and offers new insights on water permeation through nanochannels, design of molecule sieving and nanofluidic manipulation. | Jiyu Xu Chongqin Zhu Yifei Wang Hui Li Yongfeng Huang Yutian Shen Joseph S. Francisco Xiao Cheng Zeng Sheng Meng | 2019 | Nano Research2019，12，3： | 1 |
| 11 | Preparation and characterization of high refractive index thin films of TiO2/ epoxy resin nanocomposites显示文摘 | Guan Cheng LV Changli Liu Yifei | 2006 | J Appl Polym Sci2006，102，： | 1 |
| 12 | Haploidentical hematopoietic stem cell transplantation may improve long-term survival for children with high-risk T-cell acute lymphoblastic leukemia in first complete remission显示文摘Background: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with high-risk (HR) T-cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under evaluation. Moreover, relapse is the main factor affecting survival. This study aimed to explore the effect of allo-HSCT (especially haploidentical HSCT [haplo-HSCT]) on improving survival and reducing relapse for HR childhood T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.Methods: A total of 74 newly diagnosed pediatric T-ALL patients between January 1, 2012 and June 30, 2018 were enrolled in this retrospective study. Patients were stratified into the low-risk chemotherapy cohort (n = 16), HR chemotherapy cohort (n = 31), and HR transplant cohort (n = 27). Characteristics, survival outcomes, and prognostic factors of all patients were then analyzed.Results: Patient prognosis in the HR chemotherapy cohort was significantly worse than that in the low-risk chemotherapy cohort (5-year overall survival [OS]: 58.5%vs. 100%,P = 0.003;5-year event-free survival [EFS]: 54.1%vs. 83.4%,P = 0.010;5-year cumulative incidence of relapse [CIR]: 45.2%vs. 6.3%,P = 0.011). In HR patients, allo-HSCT improved the 5-year EFS and CIR compared to that of chemotherapy (5-year EFS: 80.1%vs. 54.1%,P = 0.041;5-year CIR: 11.6%vs. 45.2%,P = 0.006). The 5-year OS was higher in the HR transplant cohort than that in the HR chemotherapy cohort (81.0%vs. 58.5%,P = 0.084). Minimal residual disease re-emergence was an independent risk factor for 5-year OS, EFS, and CIR;age ≥10 years was an independent risk factor for OS and EFS;and high white blood cell count was an independent risk factor for EFS and CIR.Conclusion: Allo-HSCT, especially haplo-HSCT, could effectively reduce relapse of children with HR T-ALL in CR1. | Zhang Yongzhan Bai Lu Cheng Yifei Lu Aidong Wang Yu Wu Jun Zhang Xiaohui Zuo Yingxi Xu Lanping Jia Yueping Huang Xiaojun Zhang Leping | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 13 | Dual active sites over Cu-ZnO-ZrO_(2) catalysts for carbon dioxide hydrogenation to methanol显示文摘CO_(2) hydrogenation to methanol is a significant approach to tackle the problem of global warming and simultaneously meet the demand for the portable fuel.Cu-ZnO catalysts with various kinds of promoters have received wide attention.However,the role of promoter and the form of active sites in CO_(2) hydrogenation are still in debate.Here,various molar ratios of ZrO_(2) were added into the Cu-ZnO catalysts to tune the distributions of Cu^(0) and Cu+species.A volcano-like trend between the ratio of Cu+/(Cu++Cu^(0))and the amount of ZrO_(2) is presented,among which the CuZn10Zr(the molar ratio of ZrO_(2) is 10%)catalyst reaches the highest value.Correspondingly,the maximum value of space-time yield to methanol with 0.65 gMeOH/(gcat·hr)is obtained on CuZn10Zr at reaction conditions of 220°C and 3 MPa.Detailed characterizations demonstrate that dual active sites are proposed during CO_(2) hydrogenation over CuZn10Zr catalyst.The exposed Cu^(0) takes participate in the activation of H_(2),while on the Cu^(+) species,the intermediate of formate from the co-adsorption of CO_(2) and H_(2) prefers to be further hydrogenated to CH_(3)OH than decomposing into the by-product of CO,yielding a high selectivity of methanol. | Xiucheng Sun Yifei Jin Zaizhe Cheng Guojun Lan Xiaolong Wang Yiyang Qiu Yanjiang Wang Huazhang Liu Ying Li | 2023 | Journal of Environmental Sciences2023，，9： | 1 |
| 14 | 显示文摘 | Lü Changli Guan Cheng Liu Yifei | 2005 | Chemistry of Materials2005，17，9： | 1 |
| 15 | Ultrasensitive Detection of Hepatitis C Virus DNA Subtypes Based on Cucurbituril and Graphene Oxide Nano-composite显示文摘Infectious of hepatitis C viruses(HCVs)lead to hepatic fibrosis,cirrhosis even hepatoma.Developing rapid and sensitive diagnostic method for HCV is of great importance.Based on the host-and-guest interaction between cucurbit[7]uril(CB[7])and methylene blue(MB),a CB[7]-graphene nano-composite(CB[7]-N3-GO)is raised for the electrochemical detection of HCV DNA.The method is able to linearly detect the HCV nucleic acid in the range of 0.2—10 nmol/L with detection limit as low as 160.4 pmol/L.The proposed detection strategy is able to discriminate the lb and 6k subtypes of HCV and has a prospective potential in the blood screen for HCV in clinical diagnosis. | JIANG Ping LI Yifei JU Ting CHENG Wenbo XU Jianhua HAN Kun | 2020 | Chemical Research in Chinese Universities2020，36，2： | 1 |
| 16 | Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial显示文摘Lifestyle interventions,including dietary adjustments and exercise,are important for obesity management.This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet(LCD)or exercise is more effective in metabolism improvement.Forty-five eligible subjects were randomly divided into an LCD group(n=22)and an exercise group(EX,n=23).The subjects either adopted LCD(carbohydrate intake<50 g/day)or performed moderate-to-vigorous exercise(≥30 min/day)for 3 weeks.After the interventions,LCD led to a larger weight loss than EX(−3.56±0.37 kg vs.−1.24±0.39 kg,P<0.001),as well as a larger reduction in fat mass(−2.10±0.18 kg vs.−1.25±0.24 kg,P=0.007)and waist circumference(−5.25±0.52 cm vs.−3.45±0.38 cm,P=0.008).Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance.Triglycerides decreased in both two groups,whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group.Various glycemic parameters,including serum glycated albumin,mean sensor glucose,coefficient of variability(CV),and largest amplitude of glycemic excursions,substantially declined in the LCD group.Only CV slightly decreased after exercise.This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance.Compared with exercise,LCD might be more efficient for weight loss and glucose homeostasis in people with obesity. | Lingli Cai Jun Yin Xiaojing Ma Yifei Mo Cheng Li Wei Lu Yuqian Bao Jian Zhou Weiping Jia | 2021 | Frontiers of Medicine2021，15，3： | 1 |
| 17 | One step hot-pressing method for hybrid Li metal anode of solid-state lithium metal batteries显示文摘Safety issues induced by infinite anode volume change and uncontrolled lithium(Li)dendrite growth have become the biggest obstacle to the practical application of Li metal batteries.In addition,the tra-ditional rolling method makes it difficult to manufacture thin Li foil with high mechanical strength and low Li content.Herein,a three-dimensional(3D)lithophilic carbon paper/copper(Cu)current collector hybrid anode with ultra-low Li metal content is prepared by a hot-pressing method.The highly re-versible and stable lithiophilic layer LiC_(x) formed in situ by heating/pressing treatment provides abun-dant nucleation sites and reduces the Li nucleation overpotential,thereby effectively suppressing Li den-drite growth.Moreover,the volume change and pulverization problems of Li metal anode during depo-sition/stripping also can be accommodated by the 3D skeleton.The optimization effect has been directly confirmed by in-situ optical and ex-situ scanning electron microscope observation.Therefore,highly sta-ble performance(158.4 mA h g^(-1) at 2 C after 200 cycles with a capacity retention of 95.24%)in Li@LCP-Cu||NCM811 coin cell can be achieved.Furthermore,the solid-state battery assembled with the hybrid anode,poly(vinylidene fluoride)(PVDF)-based polymer electrolyte and polyethylene oxide(PEO)interface functional layer also exhibits the best electrochemical and safety performance,which also proves that the Li@LCP-Cu anode has great potential for application in solid-state batteries. | Kaiming Wang Yifei Chen Liang Zhang Qihang Zhang Zhi Cheng Yining Su Fei Shen Xiaogang Han | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 18 | Genetic variant in a BaP-activated super-enhancer increases prostate cancer risk by promoting AhR-mediated FAM227A expression显示文摘Genetic variants in super-enhancers(SEs)are increasingly implicated as a disease risk-driving mechanism.Previous studies have reported an associations between benzo[a]pyrene(BaP)exposure and some malignant tumor risk.Currently,it is unclear whether BaP is involved in the effect of genetic variants in SEs on prostate cancer risk,nor the associated intrinsic molecular mechanisms.In the current study,by using logistic regression analysis,we found that rs5750581T>C in 22q-SE was significantly associated with prostate cancer risk(odds ratio=1.26,P=7.61×10^(-5)).We also have found that the rs6001092T>G,in a high linkage disequilibrium with rs5750581T>C(r^(2)=0.98),is located in a regulatory aryl hydrocarbon receptor(AhR)motif and may interact with the FAM227A promoter in further bioinformatics analysis.We then performed a series of functional and BaP acute exposure experiments to assess biological function of the genetic variant and the target gene.Biologically,the rs6001092-G allele strengthened the transcription factor binding affinity to AhR,thereby upregulating FAM227A,especially upon exposure to BaP,which induced the malignant phenotypes of prostate cancer.The current study highlights that AhR acts as an environmental sensor of BaP and is involved in the SE-mediated prostate cancer risk,which may provide new insights into the etiology of prostate cancer associated with the inherited SE variants under environmental carcinogen stressors. | Lulu Fan Hao Wang Shuai Ben Yifei Cheng Silu Chen Zhutao Ding Lingyan Zhao Shuwei Li Meilin Wang Gong Cheng | 2024 | The Journal of Biomedical Research2024，38，2： | 0 |
| 19 | Metal-organic layers induce in situ nano-structuring of Cu surface in electrocatalytic CO_(2)reduction显示文摘Cu-based catalysts have attracted widespread attention for its capability in electrocatalytically reducing CO_(2)to a variety of products.Surface modification of Cu has become an interesting method for tuning the catalytic performance.Here,we use Zrbased metal-organic layers(MOLs)as the additive of the Cu surface,which enhanced the Faradaic efficiency of CH4 by two times as compared to the untreated polycrystalline Cu foil.Unexpectedly,the MOLs were found to induce in situ nano-structuring of the Cu foil surface within seconds in the electrolysis,as revealed by a combination of scanning electron microscopy(SEM),grazing incidence X-ray diffractometry(GIXRD),and linear sweep voltammetry(LSV)measurements.These surface changes are responsible for the shift of product selectivity.Control experiments suggest that negatively chargedμ3-O−on the Zr-cluster in the MOL might interact with CO-covered Cu surface and induce roughing and nano-structuring.This work reveals a potential role of additive on Cu to induce surface nano-structuring that tunes catalytic activity and selectivity. | Xinru He Jiawei Chen Yifei Xu Yan Shen Yifan Zeng Jieyu Zhu Bingjun Xu Cheng Wang | 2023 | Nano Research2023，16，4： | 0 |
| 20 | Accelerating local SGD for non-IID data using variance reduction显示文摘Distributed stochastic gradient descent and its variants have been widely adopted in the training of machine learning models,which apply multiple workers in parallel.Among them,local-based algorithms,including Local SGD and FedAvg,have gained much attention due to their superior properties,such as low communication cost and privacypreserving.Nevertheless,when the data distribution on workers is non-identical,local-based algorithms would encounter a significant degradation in the convergence rate.In this paper,we propose Variance Reduced Local SGD(VRL-SGD)to deal with the heterogeneous data.Without extra communication cost,VRL-SGD can reduce the gradient variance among workers caused by the heterogeneous data,and thus it prevents local-based algorithms from slow convergence rate.Moreover,we present VRL-SGD-W with an effectivewarm-up mechanism for the scenarios,where the data among workers are quite diverse.Benefiting from eliminating the impact of such heterogeneous data,we theoretically prove that VRL-SGD achieves a linear iteration speedup with lower communication complexity even if workers access non-identical datasets.We conduct experiments on three machine learning tasks.The experimental results demonstrate that VRL-SGD performs impressively better than Local SGD for the heterogeneous data and VRL-SGD-W is much robust under high data variance among workers. | Xianfeng LIANG Shuheng SHEN Enhong CHEN Jinchang LIU Qi LIU Yifei CHENG Zhen PAN | 2023 | Frontiers of Computer Science2023，17，2： | 0 |
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