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| 1 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic:implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，2： | 69 |
| 2 | A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations显示文摘The Coronavirus Disease 2019(COVID-19)epidemic emerged in Wuhan,China,spread nationwide and then onto half a dozen other countries between December 2019 and early 2020.The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people’s lives.It has also triggered a wide variety of psychological problems,such as panic disorder,anxiety and depression.This study is the first nationwide largescale survey of psychological distress in the general population of China during the COVID-19 epidemic. | Jianyin Qiu Bin Shen Min Zhao Zhen Wang Bin Xie Yifeng Xu | 2020 | General Psychiatry2020，33，1： | 26 |
| 3 | Protective Effect of Magnesium Isoglycyrrhizinate on Ethanol-Induced Testicular Injuries in Mice显示文摘Objective:Ethanol treatment induces an increase in oxidative stress. As licorice compounds are potent antioxidants, our aim was to examine whether magnesium isoglycyrrhizinate attenuated lipid peroxidation, the major end-point of oxidative damage resulting from ethanol administration. Methods: Four groups(18 animals in each group) of male Kunming mice were used. The first group served as control and received 0.4 ml normal saline daily for 18 days orally. The second group of mice was given 56% ethanol at 16 ml/kg body weight per day for 18 days orally. The third group was given the same dose of ethanol and administrated magnesium isoglycyrrhizinate (15 mg/kg.d, i.p.) for 18 days. The fourth group was given the same dose of ethanol and administrated with magnesium isoglycyrrhizinate (45 mg/kg.d, i.p.) for 18 days. Twenty four hours after 9 days or 18 days of treatment the mice were sacrificed using 10% chloral hydrate. Sperm counts and motility in the epididymis were assessed. The lipid peroxidation and antioxidants of testicular mitochondria were also determined. The pathological changes of testicle tissue of the mice were observed by light microscopy. Results: Magnesium isoglycyrrhizinate effectively prevented the ethanol-induced seminiferous epithelium disorganization and degeneration of Sertoli cells and germ cells. Sperm counts and motility of the magnesium isoglycyrrhizinate treated groups were higher than those of the alcohol treated group, but were lower than those of the control group. The drug exhibited an ability to counteract ethanol induced oxidative challenge as it effectively reduced testicular malondialdehyde (MDA) and increased the activities of superoxide dismutase and glutathione peroxidase. Conclusion: Magnesium isoglycyrrhizinate is able to inhibit the ethanol-induced lipid peroxidation and has a protective effect against testicular oxidative injury. | Yuanqiao He Fuqing Zeng Qing Liu Wen Ju Houju Fu Hua Hao Lulu Lia Yifeng Xie | 2010 | The Journal of Biomedical Research2010，24，2： | 9 |
| 4 | Segmentation of Kidney From Ultrasound Images Based on Texture and Shape Priors显示文摘 | Jun Xie Yifeng Jiang Hung-tat Tsui | 2005 | IEEE Transactions on Medical Imaging2005，24，1： | 1 |
| 5 | Clinical features and risk factors for post-partum depression in a large cohort of Chinese women with recurrent major depressive disorder显示文摘 | Tian Tian Yihan Li Dong Xie Yifeng Shen Jianer Ren Wenyuan Wu Chengbin Guan Zhen Zhang Danning Zhang Chengge Gao Xiaoming Zhang Jinbo Wu Hong Deng Gang Wang Yunshu Zhang Yun Shao Han Rong Zhaoyu Gan Yan Sun Bin Hu Jiyang Pan Yi Li Shufan Sun Libo Song Xue | 2011 | Journal of Affective Disorders2011，，3： | 1 |
| 6 | Identification and fine-mapping of quantitative trait loci(QTL) conferring rice false smut resistance in rice显示文摘Rice false smut(RFS) is a rice fungal disease caused by the biotrophic fungus Ustilaginoidea virens(Cooke) Takahashi. The pathogenic fungus specifically infects rice spikelets at the booting stage and coverts the infected spikelets into false smut balls consisting of hyphae and chlamydospores(Ashizawa et al., 2012);Sun et al. | Yifeng Huang Kaixuan Cui Zhen Zhang Rongyao Chai Hongguang Xie Jianyao Shou Junru Fu Guolin Li Jiyun Liu Shuangqing Wu Guochang Sun Jianfu Zhang Yiwen Deng Zuhua He | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
| 7 | Expression of miR-150 and miR-3940-5p is reduced in non-small cell lungcarcinoma and correlates with clinicopathological features显示文摘 | Yifeng Sun Bo Su Peng Zhang Huikang Xie Hui Zheng Yongjie Xu Qiaoling Du Huan Zeng Xiao Zhou Chang Chen Wen Gao | 2013 | Oncology Reports2013，，2： | 1 |
| 8 | Segmentation of kidney from ultrasound images based on texture and shape priors显示文摘 | Jun Xie Yifeng Jiang Hung-tat Tsui | 2005 | IEEE Transactions on Medical Imaging2005，24，1： | 1 |
| 9 | Segmentation of kidney from ultrasound images based on texture and shape priors 显示文摘 | Xie Jun Jiang Yifeng Tsui H | 2005 | IEEE Transactions on Medical Imaging2005，24，1： | 1 |
| 10 | Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis显示文摘The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle strategies to treat various diseases.Numerous synthetic nanoparticles have been developed for pharmaceutical delivery and cancer treatment.However,only a limited number of nanotherapies have enter clinical trials or are clinically approved.Systemically administered nanotherapies are likely to be sequestered by host mononuclear phagocyte system(MPS),resulting in suboptimal pharmacokinetics and insufficient drug concentrations in tumors.Bioinspired drug-delivery formulations have emerged as an alternative approach to evade the MPS and show potential to improve drug therapeutic efficacy.Here we developed a biodegradable polymer-conjugated camptothecin prodrug encapsulated in the plasma membrane of lipopolysaccharide-stimulated macrophages.Polymer conjugation revived the parent camptothecin agent(e.g.,7-ethyl-10-hydroxy-camptothecin),enabling lipid nanoparticle encapsulation.Furthermore,macrophage membrane cloaking transformed the nonadhesive lipid nanoparticles into bioadhesive nanocamptothecin,increasing the cellular uptake and tumor-tropic effects of this biomimetic therapy.When tested in a preclinical murine model of breast cancer,macrophage-camouflaged nanocamptothecin exhibited a higher level of tumor accumulation than uncoated nanoparticles.Furthermore,intravenous administration of the therapy effectively suppressed tumor growth and the metastatic burden without causing systematic toxicity.Our study describes a combinatorial strategy that uses polymeric prodrug design and cell membrane cloaking to achieve therapeutics with high efficacy and low toxicity.This approach might also be generally applicable to formulate other therapeutic candidates that are not compatible or miscible with biomimetic delivery carriers. | Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie Peirong Xu Hongming Pan Hangxiang Wang | 2023 | Bioactive Materials2023，，2： | 1 |
| 11 | The Influence of Meridional Variation in North Pacific Sea Surface Temperature Anomalies on the Arctic Stratospheric Polar Vortex显示文摘This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific SST.The principal component 1(PC1)of the first leading mode is obtained by empirical orthogonal function decomposition.Reanalysis data,numerical experiments,and CMIP5 model outputs all suggest that the PC1 events(positive-minus-negative PC1 events),located relatively northward(i.e.,North PC1 events),more easily weaken the Arctic SPV compared to the PC1 events located relatively southward(i.e.,South PC1 events).The analysis indicates that the North PC1-related Aleutian low anomaly is located over the northern North Pacific and thus enhances the climatological trough,which strengthens the planetary-scale wave 1 at mid-to-high latitudes and thereby weakens the SPV.The weakened stratospheric circulation further extends into the troposphere and favors negative surface temperature anomalies over Eurasia.By contrast,the South PC1-related Aleutian low anomaly is located relatively southward,and its constructive interference with the climatological trough is less efficient at high latitudes.Thus,the South PC1 events could not induce an evident enhancement of the planetary-scale waves at high latitudes and thereby a weakening of the SPV on average.The Eurasian cooling associated with South PC1 events(positive-minus-negative PC1 events)is also not prominent.The results of this study suggest that the meridional positions of the PC1 events may be useful for predicting the Arctic SPV and Eurasian surface temperature variations. | Tao WANG Qiang FU Wenshou TIAN Hongwen LIU Yifeng PENG Fei XIE Hongying TIAN Jiali LUO | 2023 | Advances in Atmospheric Sciences2023，40，12： | 1 |
| 12 | Role of Stratospheric Processes in Climate Change: Advances and Challenges显示文摘In this review,instead of summarizing all the advances and progress achieved in stratospheric research,the main advances and new developments in stratosphere-troposphere coupling and stratospheric chemistry-climate interactions are summarized,and some outstanding issues and grand challenges are discussed.A consensus has been reached that the stratospheric state is an important source of improving the predictability of the troposphere on sub-seasonal to seasonal(S2S)time scales and beyond.However,applying stratospheric signals in operational S2S forecast models remains a challenge because of model deficiencies and the complexities of the underlying mechanisms of stratosphere-troposphere coupling.Stratospheric chemistry,which controls the magnitude and distribution of many important climate-forcing agents,plays a critical role in global climate change.Convincing evidence has been found that stratospheric ozone depletion and recovery have caused significant tropospheric climate changes,and more recent studies have revealed that stratospheric ozone variations can even exert an impact on SSTs and sea ice.The climatic impacts of stratospheric aerosols and water vapor are also important.Although their quantitative contributions to radiative forcing have been reasonably well quantified,there still exist large uncertainties in their long-term impacts on climate.The advances and new levels of understanding presented in this review suggest that whole-atmosphere interactions need to be considered in future for a better and more thorough understanding of stratosphere-troposphere coupling and its role in climate change. | Wenshou TIAN Jinlong HUANG Jiankai ZHANG Fei XIE Wuke WANG Yifeng PENG | 2023 | Advances in Atmospheric Sciences2023，40，8： | 0 |
| 13 | Guided Dropout: Improving Deep Networks Without Increased Computation显示文摘Deep convolution neural networks are going deeper and deeper.How-ever,the complexity of models is prone to overfitting in training.Dropout,one of the crucial tricks,prevents units from co-adapting too much by randomly drop-ping neurons during training.It effectively improves the performance of deep net-works but ignores the importance of the differences between neurons.To optimize this issue,this paper presents a new dropout method called guided dropout,which selects the neurons to switch off according to the differences between the convo-lution kernel and preserves the informative neurons.It uses an unsupervised clus-tering algorithm to cluster similar neurons in each hidden layer,and dropout uses a certain probability within each cluster.Thereby this would preserve the hidden layer neurons with different roles while maintaining the model’s scarcity and gen-eralization,which effectively improves the role of the hidden layer neurons in learning the features.We evaluated our approach compared with two standard dropout networks on three well-established public object detection datasets.Experimental results on multiple datasets show that the method proposed in this paper has been improved on false positives,precision-recall curve and average precision without increasing the amount of computation.It can be seen that the increased performance of guided dropout is thanks to shallow learning in the net-works.The concept of guided dropout would be beneficial to the other vision tasks. | Yifeng Liu Yangyang Li Zhongxiong Xu Xiaohan Liu Haiyong Xie Huacheng Zeng | 2023 | Intelligent Automation & Soft Computing2023，，6： | 0 |
| 14 | Qilan preparation(芪蓝颗粒) inhibits proliferation and induces apoptosis by down-regulating microRNA-21 in humaqin Tca8113 tongue squamous cell carcinoma cells显示文摘OBJECTIVE: The aim of this study was to examine the antitumor effects of Qilan preparation(芪蓝颗粒) on oral squamous cell carcinoma(OSCC) in vitro and to investigate its underlying mechanisms of action. METHODS: Cell proliferation, cell cycle distribution and apoptosis were examined using cell counting kit-8(CCK8) and flow cytometry(FCM). The expression of PTEN and PDCD4 were determined by western blot. Changes in miR-21 levels were quantified using Taq Man stem-loop real-time PCR. After miR-21 was transiently transfected into Tca8113 cells using Lipofectamine?3000, cell proliferation, apoptosis and miR-21 and PDCD4 expression levels were measured. RESULTS: Qilan preparation inhibited Tca8113 cell growth in a dose-and time-dependent manner by inducing apoptosis and cell cycle arrest in S-phase, decreasing miR-21 levels and increasing PTEN and PDCD4 expression. Mi R-21 overexpression reversed the Qilan preparation-induced suppression of cell proliferation and induction of apoptosis while also blocking the increase in PDCD4.CONCLUSIONS: Our study revealed, for the first time, the ability of Qilan preparation to suppress TSCC cell growth and elucidated that Qilan preparation elicits its anti-cancer actions via either the miR-21/PDCD4 or PTEN pathway. | DING Jiamin XING Yifeng CHEN Zuoliang CHEN Wanlu MA Zhongxiong XIE Yunde ZHOU Lin | 2022 | Journal of Traditional Chinese Medicine2022，42，5： | 0 |
| 15 | TAD-Net:An approach for real-time action detection based on temporal convolution network and graph convolution network in digital twin shop-floor[version 1;peer review:2 approved]显示文摘Background:Intelligent monitoring of human action in production is an important step to help standardize production processes and construct a digital twin shop-floor rapidly.Human action has a significant impact on the production safety and efficiency of a shop-floor,however,because of the high individual initiative of humans,it is difficult to realize real-time action detection in a digital twin shop-floor.Methods:We proposed a real-time detection approach for shop-floor production action.This approach used the sequence data of continuous human skeleton joints sequences as the input.We then reconstructed the Joint Classification-Regression Recurrent Neural Networks(JCR-RNN)based on Temporal Convolution Network(TCN)and Graph Convolution Network(GCN).We called this approach the Temporal Action Detection Net(TAD-Net),which realized real-time shop-floor production action detection.Results:The results of the verification experiment showed that our approach has achieved a high temporal positioning score,recognition speed,and accuracy when applied to the existing Online Action Detection(OAD)dataset and the Nanjing University of Science and Technology 3 Dimensions(NJUST3D)dataset.TAD-Net can meet the actual needs of the digital twin shop-floor.Conclusions:Our method has higher recognition accuracy,temporal positioning accuracy,and faster running speed than other mainstream network models,it can better meet actual application requirements,and has important research value and practical significance for standardizing shop-floor production processes,reducing production security risks,and contributing to the understanding of real-time production action. | Qing Hong Yifeng Sun Tingyu Liu Liang Fu Yunfeng Xie | 2021 | Digital Twin2021，1，1： | 0 |
| 16 | Dynamic ageing research of cross‐linked polyethylene cable insulation based on temporal‐spatial dimension under combined electro‐thermal effect显示文摘Dynamic ageing process of cross‐linked polyethylene(XLPE)cable insulation under combined electro‐thermal effect is investigated by the construction of theoretical analysis model and the practice of operation‐simulated ageing test.Firstly,theoretical analysis model is constructed from time and spatial dimensions.From the time dimension,in the light of the impeding trend of internal stress to external stress,the XLPE ageing process of Steady state‐Transition state‐Steady state(STS)is proposed to illustrate the dynamic ageing process of XLPE.From the spatial dimension,the insulation is divided into three scales to quantify the ageing.Secondly,to practice the theoretical analysis model,an operation‐simulated ageing test was conducted on two high voltage alternating current cables with service years of 15 and 30 for 540 days.Subsequently,relevant diagnostic measurements were applied to analyse the influence of physicochemical characteristics on the dielectric and heat transfer performances of the cables.The results show that the degradation of the actual operating cable is an extremely slow process.On the one hand,the response in physical changes of morphology counterbalances the external stress,maintaining the stability.On the other hand,once the chemical changes occur,negative feedback mechanism tends to impede the occurrence of further degradation by regulating fields distribution. | Yifeng Zhao Yue Xie Yu Zhao Jiasheng Huang Xinghui Fan Yangyang Nie Gang Liu | 2023 | High Voltage2023，8，5： | 0 |
| 17 | 罗特希尔德,诺曼· H,皇帝吴昭和她 Devis,神性和皇朝的母亲的众神显示文摘 | Yifeng Xie | 2016 | Frontiers of History in China2016，11，2： | 0 |
| 18 | Countermeasures of the Reform of College Performance-related Salary in the Light of Well-being显示文摘 | Bingshui Li Yifeng Xie | 2014 | International English Education Research2014，，4： | 0 |
| 19 | A novel mutation of glycogen synthase kinase-3β leads to a reduced level of GSK3βprotein in a patient with dilated cardiomyopathy显示文摘Dilated cardiomyopathy(DCM)is a frequently inherited heart condition.A familial transmission rate of 20%-35%has been documented,and most of these cases are autosomal dominant.This condition has a high rate of morbidity and mortality,which can lead to cardiac arrest and persistent heart failure. | Ke Gong Zhiping Tan Haidan Liu Xiaobo Liao Xinmin Zhou Bangliang Yin Shi Zeng Yao Yao Yifeng Yang Li Xie | 2024 | Genes & Diseases2024，11，1： | 0 |
| 20 | Modeling of the whole hydrocarbon-generating process of sapropelic source rock显示文摘Based on experimental data from hydrocarbon generation with a semi-open system, hydrocarbon generation kinetics modeling in gold tube of closed system, high temperature pyrolysis chromatography mass spectrometry experiment with open system and geological data, the characteristics of whole hydrocarbon-generating process, hydrocarbon expulsion efficiency and retained hydrocarbon quantity, origins of natural gas generated in high-over mature stage and cracking temperature of methane homologs were investigated in this study. The sapropelic source rock has a hydrocarbon expulsion efficiency of 30%-60% and 60%-80% in the major oil generation window(with Ro of 0.8%-1.3%) and high maturity stage(with Ro of 1.3%-2.0%) respectively; and the contribution ratio of kerogen degradation gas to oil cracking gas in total generated gas in high maturity stage is about 1:4. The degradation gas of kerogen accounts for 20%, the retained liquid hydrocarbon cracking gas accounts for 13.5%, and the amount of out-reservoir oil cracking gas(including aggregation type and dispersed oil cracking gas) accounts for 66.5%. The lower limit of gas cracking is determined preliminarily. Based on the new understandings, a model of the whole hydrocarbon-generating process of source rock is built. | LI Jian MA Wei WANG Yifeng WANG Dongliang XIE Zengye LI Zhisheng MA Chenghua | 2018 | Petroleum Exploration and Development2018，45，3： | 0 |
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