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| 1 | Hierarchical construction of CNT networks in aramid papers for high-efficiency microwave absorption显示文摘Carbon nanotubes(CNTs)incorporated polymeric composites have been extensively investigated for microwave absorption at target frequencies to meet the requirement of radar cross-section reduction.In this work,a strategy of efficient utilization of CNT in producing CNT incorporated aramid papers is demonstrated.The layer-by-layer self-assembly technique is used to coat the surfaces of meta-aramid fibers and fibrils with CNT,providing novel raw materials available for the large-scale papermaking.The hierarchical construction of CNT networks resolves the dilemma of increasing CNT content and avoiding the agglomeration of CNT,which is a frequent challenge for CNT incorporated polymeric composites.The composite paper,which contains abundant heterogeneous interfaces and long-range conductive networks,is capable of reaching a high permittivity and dielectric loss tangent at a low CNT loading,its complex permittivity is,so far,adjustable in the range of(1.20−j0.05)to(25.17−j18.89)at 10 GHz.Some papers with optimal matching thicknesses achieve a high-efficiency microwave absorption with a reflection loss lower than−10 dB in the entire X-band. | You Wu Li Chen Yixuan Han Panbo Liu Haihong Xu Guanze Yu Yingying Wang Tao Wen Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，5： | 9 |
| 2 | High-performance Li-S battery cathode with catalyst-like carbon nanotube-MoP promoting polysulfide redox显示文摘 | Yingying Mi Wen Liu Xiaolin Li Julia Zhuang Henghui Zhou Hailiang Wang | 2017 | Nano Research2017，10，11： | 6 |
| 3 | Leachate treatment using a demonstration aged refuse biofilter显示文摘Approximately 7000 m3 of aged refuse(AR) with a placement of over eight years was excavated from Shanghai Refuse Landfill,the largest landfill in China,and used for the construction of a two-stage bioreactor(AR biofilter) media for the biological treatment of 100 m3 of refuse landfill leachate.It was found that over 64% of COD,96.9%-99.8% of NH4+-N,and 95.8%-99.8% of BOD5 could be removed by the AR biofilter,when the leachate with initial COD,BOD5,and NH4+-N concentrations were 986-4128 mg/L,264-959 mg/L,and 538-1583 mg/L,respectively.The corresponding concentrations in the effluent were reduced to below 300-400 mg/L,2-12 mg/L,and 10-20 mg/L,respectively.The effluent was clear and pale yellow with suspended solid below 150 mg/L and color below 150 Pt/Co degree.Meanwhile,the total nitrogen removal was only 49%-63%,indicating a relative poor denitrification capacity of AR biofilter.The effluent pH was neutral and the population of Escherichia coli was less than 10-1 CFU/mL.Hence,it was considered that the demonstration project can work well for the effective treatment of leachate. | Hongjiang Li Yingying Gu Youcai Zhao Zhiping Wen | 2010 | Journal of Environmental Sciences2010，22，7： | 6 |
| 4 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 5 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 6 | The behavior of 3d electrons and defects in TiAl-based alloys containing V and Cu studied by positron annihilation显示文摘Information of defects and 3d electrons in transition metals (Ti,V,Cu) and TiAl-based alloys (Ti50Al50,Ti50Al48V2,Ti50Al48Cu2) can be extracted from the positron lifetime and coincidence Doppler broadening spectra. The results show that the 3d electron signals for the transition metals Ti,V and Cu increase with the number of 3d electrons. The 3d electron signal and the electron density for binary TiAl alloy are relatively low due to the (Ti)3d-(Al)3p interactions. The addition of V and Cu atoms to TiAl alloy leads to the increase in the electron densities in bulk and the defects on grain boundaries simultaneously,as well as the enhancement of the 3d electron signal. The 3d electron signal in the spectrum of Ti50Al48Cu2 alloy is higher than that of Ti50Al48V2 alloy. | DENG Wen CHEN ZhenYing JIANG HaiFeng SUN ShunPing ZHU YingYing HUANG YuYang | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，9： | 2 |
| 7 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 8 | Recent developments in regenerative ophthalmology显示文摘Regenerative medicine(RM)is one of the most promising disciplines for advancements in modern medicine,and regenerative ophthalmology(RO)is one of the most active fields of regenerative medicine.This review aims to provide an overview of regenerative ophthalmology,including the range of tools and materials being used,and to describe its application in ophthalmologic subspecialties,with the exception of surgical implantation of artificial tissues or organs(e.g.,contact lens,artificial cornea,intraocular lens,artificial retina,and bionic eyes)due to space limitations.In addition,current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted. | Ye Shen He Shen Dongyu Guo Xinghuai Sun Yuan Sun Nan Hong Xiawei Wang Chen Xie Yuan Zhao Qin He Le Jin Yingying Wen Bo Jiang Chenying Yu Miaomiao Zhu Feng Cai Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，10： | 2 |
| 9 | Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing显示文摘Bone is known to have a natural function to heal itself.However,if the bone damage is beyond a critical degree,intervention such as bone grafting may be imperative.In this work,the fabrication of a novel bone scaffold composed of natural bone components and polycaprolactone(PCL)using 3D printing is put forward.α1,3-galactosyltransferase deficient pigs were used as the donor source of a xenograft.Decellularized porcine bone(DCB)with attenuated immunogenicity was used as the natural component of the scaffold with the aim to promote bone regeneration.The 3D printed DCB-PCL scaffolds combined essential advantages such as uniformity of the interconnected macropores and high porosity and enhanced compressive strength.The biological properties of the DCB-PCL scaffolds were evaluated by studying cell adhesion,viability,alkaline phosphatase activity and osteogenic gene expression of human bone marrow-derived mesenchymal stem cells.The in vitro results demonstrated that the DCB-PCL scaffolds exhibit an enhanced performance in promoting bone differentiation,which is correlated to the DCB content.Furthermore,critical-sized cranial rat defects were used to assess the effect of DCB-PCL scaffolds on bone regeneration in vivo.The results confirm that in comparison with PCL scaffolds,the DCB-PCL scaffolds can significantly improve new bone formation in cranial defects.Thus,the proposed 3D printed DCB-PCL scaffolds emerge as a promising regeneration alternative in the clinical treatment of large bone defects. | Qiongxi Pan Chenyuan Gao Yingying Wang Yili Wang Cong Mao Quan Wang Sophia N.Economidou Dennis Douroumis Feng Wen Lay Poh Tan Huaqiong Li | 2020 | Bio-Design and Manufacturing2020，3，4： | 1 |
| 10 | Molecularly im-printed matrix solid-phase dispersion coupled to micellar electrok-inetic chromatography for simultaneous determination of triazinesin soil, fruit, and vegetable samples显示文摘 | Yingying Wen Lingxin Chen Jinhua Li | 2012 | Electrophoresis2012，，33： | 1 |
| 11 | A compression-based algorithm for Chinese word segmentation computational linguistics显示文摘 | Teahan W J Wen Yingying McNab R | 2000 | Computational Linguistlcs2000，26，3： | 1 |
| 12 | Biodegradation of p -nitrophenol by Rhodococcus sp. CN6 with high cell surface hydrophobicity显示文摘 | Jingshun Zhang Zhongtao Sun Yingying Li Xiang Peng Wen Li Yanchun Yan | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 13 | Molecularly imprinted matrix solid-phase dispersion coupled to micellar electrokinetic chromatography for simultaneous determina- tion of triazines in soil, fruit, and vegetable samples显示文摘 | Wen Yingying Chen Lingxin Li Jinhua | 2012 | E- lectrophoresis2012，33，15： | 1 |
| 14 | Quantitative structure-property relationship study for the prediction of characteristic infrared absorption of carbonyl group of commonly used carbonyl compounds 显示文摘 | Mu Guangfen Liu Huitao Wen Yingying Luan Feng | 2011 | l/ibrational Spectroscopy2011，55，： | 1 |
| 15 | miR-96-5p regulates myocardial infarction-induced cardiac fibrosis via Smad7/Smad3 pathway显示文摘Fibrotic remodelling contributes to heart failure in myocardial infarction.MicroRNAs(miRNAs)play a crucial role in myocardial fibrosis.However,current antifibrotic therapeutic strategies using miRNAs are far from effective.In this study,we aim to investigate the effect of miR-96-5p on cardiac fibrosis.Our work reveals a significant upregulation of miR-96-5p level in the ventricular tissues of myocardial infarction mice,as well as in neonatal rat cardiac fibroblasts stimulated with TGF-βor Ang II as shown by qPCR assay.In myocardial infarction mice,miR-96-5p knockdown using antagomir alleviates the aggravated cardiac fibrosis and exacerbated myocardial function caused by myocardial infarction surgery as shown by the echocardiography and Masson’s staining analysis.In contrast,immunofluorescence staining results reveal that miR-96-5p overexpression in neonatal rat cardiac fibroblasts contributes to an increase in the expressions of fibrosis-associated genes and promotes the proliferation and differentiation of cardiac fibroblasts.Conversely,miR-96-5p downregulation using inhibitor presents adverse consequences.Furthermore,Smad7 expression is downregulated in fibrotic cardiac tissues,and the Smad7 gene is identified as a direct target of miR-96-5p by dual luciferase assay.Indeed,Smad7 knockdown weakens the antifibrotic effect of the miR-96-5p inhibitor on cardiac fibroblasts.Moreover,Smad3 phosphorylation is elevated in fibrotic cardiac tissues,and interestingly,the Smad3 inhibitor suppresses the profibrotic effect of the miR-96-5p mimic.Taken together,our findings demonstrate that the Smad7/Smad3 signaling pathway mediates the profibrotic effect of miR-96-5p in cardiac fibrosis. | Huanyu Gu Yi Duan Shanshan Li Qin Wang Wen Zhen Wei Zhang Yingying Zhang Min Jiang Chun Wang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 1 |
| 16 | Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis显示文摘Metastasis is the leading cause of cancer-related death.The interactions between circulating tumor cells and endothelial adhesion molecules in distant organs is a key step during extravasation in hematogenous metastasis.Surgery is a common intervention for most primary solid tumors.However,surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells(ECs).Currently,there are no effective interventions to prevent distant metastasis.Here,we show that HECTD3 deficiency in ECs significantly reduces tumor metastasis in multiple mouse models.HECTD3 depletion downregulates expression of adhesion molecules,such as VCAM-1,ICAM-1 and E-selectin,in mouse primary ECs and HUVECs stimulated by inflammatory factors and inhibits adhesion of tumor cells to ECs both in vitro and in vivo.We demonstrate that HECTD3 promotes stabilization,nuclear localization and kinase activity of IKKa by ubiquitinating IKKa with K27-and K63-linked polyubiquitin chains at K296,increasing phosphorylation of histone H3 to promote NF-kB target gene transcription.Knockout of HECTD3 in endothelium significantly inhibits tumor cells lung colonization,while conditional knockin promotes that.IKKa kinase inhibitors prevented LPS-induced pulmonary metastasis.These findings reveal the promotional role of the HECTD3-IKKa axis in tumor hematogenous metastasis and providea potential strategy for tumormetastasis prevention. | Fubing Li Huichun Liang Hua You Ji Xiao Houjun Xia Xi Chen Maobo Huang Zhuo Cheng Chuanyu Yang Wenjing Liu Hailin Zhang Li Zeng Yingying Wu Fei Ge Zhen Li Wenhui Zhou Yi Wen Zhongmei Zhou Rong Liu Dewei Jiang Ni Xie Bin Liang Zhenzhen Liu Yanjie Kong Ceshi Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 17 | Astrocytic endothelin-1 overexpression impairs learning and memory ability in ischemic stroke via altered hippocampal neurogenesis and lipid metabolism显示文摘Vascular etiology is the second most prevalent cause of cognitive impairment globally.Endothelin-1,which is produced and secreted by endothelial cells and astrocytes,is implicated in the pathogenesis of stroke.However,the way in which changes in astrocytic endothelin-1 lead to poststroke cognitive deficits following transient middle cerebral artery occlusion is not well understood.Here,using mice in which astrocytic endothelin-1 was overexpressed,we found that the selective overexpression of endothelin-1 by astrocytic cells led to ischemic stroke-related dementia(1 hour of ischemia;7 days,28 days,or 3 months of reperfusion).We also revealed that astrocytic endothelin-1 overexpression contributed to the role of neural stem cell proliferation but impaired neurogenesis in the dentate gyrus of the hippocampus after middle cerebral artery occlusion.Comprehensive proteome profiles and western blot analysis confirmed that levels of glial fibrillary acidic protein and peroxiredoxin 6,which were differentially expressed in the brain,were significantly increased in mice with astrocytic endothelin-1 overexpression in comparison with wild-type mice 28 days after ischemic stroke.Moreover,the levels of the enriched differentially expressed proteins were closely related to lipid metabolism,as indicated by Kyoto Encyclopedia of Genes and Genomes pathway analysis.Liquid chromatography-mass spectrometry nontargeted metabolite profiling of brain tissues showed that astrocytic endothelin-1 overexpression altered lipid metabolism products such as glycerol phosphatidylcholine,sphingomyelin,and phosphatidic acid.Overall,this study demonstrates that astrocytic endothelin-1 overexpression can impair hippocampal neurogenesis and that it is correlated with lipid metabolism in poststroke cognitive dysfunction. | Jie Li Wen Jiang Yuefang Cai Zhenqiu Ning Yingying Zhou Chengyi Wang Sookja Ki Chung Yan Huang Jingbo Sun Minzhen Deng Lihua Zhou Xiao Cheng | 2024 | Neural Regeneration Research2024，19，3： | 1 |
| 18 | Ulinastatin- and thymosin α1-based immunomodulatory strategy for sepsis: A meta-analysis显示文摘 | Dong Han Wenli Shang Guizuo Wang Li Sun Yingying Zhang Hongxia Wen Lingbin Xu | 2015 | International Immunopharmacology2015，，2： | 1 |
| 19 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://db.cbi.pku.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 20 | Expert consensus on prevention and control of COVID-19 in the neurological intensive care unit(first edition)显示文摘During the COVID-19 epidemic,the treatment of critically ill patients has been increasingly difficult and challenging.During the epidemic,some patients with neurological diseases also have COVID-19,which could be misdiagnosed and cause silent transmission and nosocomial infection.Such risk is high in a neurological intensive care unit(NCU).Therefore,prevention and control of epidemic in critically ill patients is of utmost importance.The principle of NCU care should include comprehensive screening and risk assessment,weighing risk against benefits and reducing the risk of COVID-19 transmission while treating patients as promptly as possible. | Furong Wang Jingyi Liu Ping Zhang Wen Jiang Le Zhang Meng Zhang Junfang Teng Jinquan Wang Xiaoqi Xie Jie Cao Wei Li Yongming Wu Hao Zhou Yingying Su Suyue Pan Liping Liu | 2020 | Stroke & Vascular Neurology2020，5，3： | 1 |
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