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| 1 | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer显示文摘Long non-coding RNAs(lnc RNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lnc RNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lnc RNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lnc RNAs, and discusses future opportunities for lnc RNA-based therapies using antisense oligonucleotides. | Yiwen Fang Melissa J. Fullwood | 2016 | Genomics, Proteomics & Bioinformatics2016，14，1： | 63 |
| 2 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 3 | Experimental demonstrations of high-Q superconducting coplanar waveguide resonators显示文摘We successfully designed and fabricated an absorption-type of superconducting coplanar waveguide (CPW) resonators. The resonators are made from a niobium film (about 160 nm thick) on a high-resistance Si substrate, and each resonator is fabricated as a meandered quarter-wavelength transmission line (one end is short to the ground and another end is capacitively coupled to a through feedline). With a vector network analyzer we measured the transmissions of the applied microwave through the resonators at ultra-low temperature. The obtained loaded quality factors are significantly high, i.e. up to ~10 6 . When the temperature increases slowly from the base temperature (20 mK), the resonance frequencies of the resonators are blue shifted and the quality factors are lowered slightly. In principle, this type of device can integrate a series of CPW resonators with a common feedline, making it a promising candidate as the data bus for coupling distant solid-state qubits and the sensitive detector of single photons. | LI HaiJie WANG YiWen WEI LianFu ZHOU PinJia WEI Qiang CAO ChunHai FANG YuRong YU Yang WU PeiHeng | 2013 | Chinese Science Bulletin2013，58，20： | 8 |
| 4 | Structural and Functional Tailoring of Melanin-Like Polydopamine Radical Scavengers显示文摘Melanin is a ubiquitous but poorly understood polymeric,dark brown to black pigment biomaterial found both in nature and by organic synthesis.Its structural heterogeneity and disordered covalent/noncovalent interactions make it a grand challenge to tune and improve the physical and biological properties of both melanin sources.Herein,we report a facile one-pot fabrication approach for synthetic melanins with controlled size and composition via copolymerization of dopamine and basic amino acid such as arginine in an aqueous solution.The resulting arginine-doped polydopamine melanin-like nanoparticles possess less ordered nonplanar microstructures within the particles,whereas the conventional polydopamine-based melanins contain a variety of compactπ-stacked microstructures.The assembly of these distinct polymeric microstructures could lead the preceding ones for greater accessibility to free radicals,with resultant stronger free-radical scavenging effect,and thus,exhibit superior antioxidant performance toward cellular oxidative stress.This work has inspired us to continue to fabricate new synthetic melanin pigments with tunable and improved functions by rational structural tailoring. | Peng Yang Zhipeng Gu Fang Zhu Yiwen Li | 2020 | CCS Chemistry2020，2，2： | 4 |
| 5 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 6 | Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide unit in alkyl side chain显示文摘Blue light-emitting polyfluorenes containing dibenzothiophene-S,S-dioxide(SO) unit in alkyl side chain(PF-FSOs and PF-CzSOs) were synthesized. All the polymers show high thermal stability with the decomposition temperatures over400 °C. The highest occupied molecular orbital(HOMO) and the lowest unoccupied molecular orbital(LUMO) energy levels of the copolymer slightly decrease with the increase of SO content in side chain. PL spectra of the polymers show slightly red shift and broadening with the increase of solvent polarities, indicating unremarkable intramolecular charge transfer(ICT) effect in the polymers containing SO unit in alkyl side chain. EL spectra of the polymers are almost unchanged in the current densities from 100 to 400 mA cm.2, indicating the superb EL stability of the resulted polymers. The EL spectra of the copolymers exhibit obvious blue-shift and narrowing with the CIE of(0.18, 0.11) for PF-FSO10 and(0.17, 0.11) for PF-CzSO10, respectively,compared with PF-SO10 containing SO unit in main chain with the CIE of(0.16, 0.17) and PFO with the CIE of(0.18, 0.18).The superior device performances were obtained with the luminous efficiency(LEmax) of 1.17 and 0.68 cd A.1 for PF-FSO15 and PF-CzSO20, respectively, compared with the LEmax of 0.37 cd A.1 for PFO. The results indicate that linking SO unit to alkyl side chain of the polyfluorene is a promising strategy for efficient blue light-emitting polymers. | Yiwen Fang Jie Liu Yuhao Zhang Ting Guo Fei Huang Wei Yang Yong Cao | 2017 | Science China Chemistry2017，60，10： | 2 |
| 7 | Motor assessment of developing common marmosets显示文摘Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. The common marmoset(Callithrix jacchus), a small New World monkey, has recently attracted much attention as a potential nonhuman primate model for understanding human physiology and diseases. However, little is known about its gross motor development. In the present study, we found that marmosets have a critical period for motor development in postnatal weeks 2 to 5, and acquire most of their motor skills by 8 weeks of age. We also developed methods to assess their motor functions, which will be useful for the evaluation of motor performance in marmoset models of human diseases. In addition, we found that marmosets exhibit a 'head-to-tail' sequence of motor development similar to that found in humans, further supporting the notion that they provide a good animal model for studying the neuronal mechanisms underlying human motor development. | Yiwen Wang Qin Fang Neng Gong | 2014 | Neuroscience Bulletin2014，30，3： | 1 |
| 8 | A modified light-dark box test for the common marmoset显示文摘The common marmoset(Callithrix jacchus) has attracted extensive attention for use as a non-human primate model in biomedical research, especially in the study of neuropsychiatric disorders. However, behavioral test methods are still limited in the field of marmoset research. The light-dark box is widely used for the evaluation of anxiety in rodents, but little is known about light-dark preference in marmosets. Here, we modified the light-dark test to study this behavior. The modified apparatus consisted of three compartments: one transparent open area and two closed opaque compartments. The closed compartments could be dark or light. We found that both adult and young marmosets liked to explore the open area, but the young animals showed more interest than adults. Furthermore, when one of the closed compartments was light and the other dark, the adult marmosets showed a preference for the dark compartment, but the young animals had no preference. These results suggest that the exploratory behavior and the light-dark preference in marmosets are age-dependent. Our study provides a new method to study exploration, anxiety, and fear in marmosets. | Yiwen Wang Qin Fang Neng Gong | 2014 | Neuroscience Bulletin2014，30，3： | 1 |
| 9 | Establishing the adoption of electronic word-of-Mouth through consumers' perceived credibility 显示文摘 | Fan Yiwen Miao Yifeng Fang Yuhsien | 2013 | International Business Research2013，6，3： | 1 |
| 10 | The Indicator System Based on BP Neural Network Model for Net - mediated Public Opinion on Unexpected Emergency 显示文摘 | Zhang Yiwen Qi Jiayin Fang Binxing Li Yuxiao | 2011 | China Communications2011，，3： | 1 |
| 11 | A Review on the Protection Mechanism of Trehalose on Plant Tissues and Animal Cells显示文摘Trehalose is a non-reducing disaccharide composed of glucose molecules connected byα-glycosidic bond.This soluble substance plays an important role of protecting green algae and other lower plants from stress.It can help plants cope with extreme environments such as severe cold,drought and high salinity,regulate the stomatal conductance and water utilization rate of plants,and participate in the growth and metabolism regulation of plants as a signal molecule.As an impermeable cryoprotectant,trehalose is widely used in the refrigeration protection of various animal cells and tissues due to its non-toxicity and high efficiency.According to the research results at home and abroad in recent years,the protection,regulation and mechanism of trehalose on plant tissues and animal cells were summarized,so as to provide a theoretical basis for the further development and utilization of trehalose. | Yiwen WANG Shujing QUAN Huan MA Dehai LIU Fuhong XIE Guocan CHEN Baitao WANG Mingli AN Fang DING | 2019 | Agricultural Biotechnology2019，8，4： | 1 |
| 12 | Comprehensive gene expression analysis by transcript profiling显示文摘 | Jonathan Donson Yiwen Fang Gregg Espiritu-Santo Weimei Xing Andres Salazar Susie Miyamoto Veronica Armendarez Wayne Volkmuth | 2002 | Plant Molecular Biology (-)2002，，1： | 1 |
| 13 | Comprehensive gene expression analysis by transcript profiling显示文摘 | Jonathan Donson Yiwen Fang Gregg Espiritu-Santo Weimei Xing Andres Salazar Susie Miyamoto Veronica Armendarez Wayne Volkmuth | 2002 | Plant Molecular Biology2002，，1： | 1 |
| 14 | Bioinspired fluorescent dihydroxyindoles oligomers显示文摘In this paper we report the desgin and synthesis of dihydroxyindoles oligomers based reversible fluorescence sensor.We find dihydroxyindoles-2-carboxylic acid derived oligmer(P-DHICA)has the highest selectivity and sensitivity for Cu^2+detection.This work provide a highly efficient,environmentally friendly biosensor for potential use in medical testing. | Zhan Li Tianyou Wang Fang Zhu Zhao Wang Yiwen Li | 2020 | Chinese Chemical Letters2020，31，3： | 1 |
| 15 | Design and in-situ construct BiOI/Bi/TiO_(2)photocatalysts with metal-mediated heterostructures employing oxygen vacancies in TiO_(2)nanosheets显示文摘The conventional p-n heterojunction photocatalysts suffer from the incompatibility between the interfacial charge transfer efficiency and the redox ability of charge carriers.To optimize the interfacial charge transfer of the conventional BiOI/TiO_(2) p-n photocatalyst,we synthesized the BiOI/Bi/TiO_(2) ternary photocatalyst with sandwiched metallic bismuth(Bi~0)by the oxygen-vacancy assisted method.The DFT calculation and structural characterizations confirmed the reaction of the electron-rich oxygen vacancies in the 2D-TiO_(2) nanosheets(TiO_(2)-NS)with the adsorbed BiO~+species.This reaction broke the Bi-O bonds to form Bi^(0) nanoparticles in-situ at the interface but still maintained the p-n heterojunction well.The NO-TPD and XRD analyses for samples correlated the Bi~0 formation with the oxygen vacancy concentrations well.The sandwiched Bi~0 functioned as an electronic transfer mediator like that in the Z-scheme heterostructure.Comparing with 0.20 BiOI/TiO_(2)-NP(NP,Nanoparticles),0.20 BiOI/Bi/TiO_(2)-NS-a(NS,Nanosheet)showed a much improved catalytic performance,i.e.,duplicated apparent quantum yield(AQY)and triplicated reaction rate constant(k).Also,the formation mechanism and the reaction mechanism were investigated in detail.This work provides a new strategy for the improving of the conventional p-n photocatalysts and new insights into the nature of the photocatalysis. | Chenchen Zhang Wenbin Chen Dairong Hu Hanjie Xie Yibing Song Binbin Luo Yiwen Fang Wenhua Gao Ziyi Zhong | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 16 | Carrier-Free Deferoxamine Nanoparticles against Iron Overload in Brain显示文摘Although considerable progress has been achieved in treating iron-overload diseases with deferoxamine(DFO)-based biomaterials,high DFO loading and multifunctional integration in one system are still grand challenges.Herein,a series of carrier-free,high DFO-loading(∼80%),uniform spherical nanoparticles(NPs)assisted by polyphenols have been facilely developed with both efficient iron and reactive oxygen species-scavenging properties.Interestingly,those DFO-based NPs have demonstrated excellent scavenging performance in iron-overloaded cell model and energetically exhibited brain cell protection in vivo in intracerebral hemorrhage animal models.This study could provide a promising strategy to significantly improve the curative effect of DFO delivery systems for iron-overload diseases. | Fang Zhu Jian Zhong Junfei Hu Peng Yang Jianhua Zhang Minghua Zhang Yiwen Li Zhipeng Gu | 2023 | CCS Chemistry2023，5，1： | 0 |
| 17 | A high strength, wear and corrosion-resistant, antibacterial and biocompatible Nb-5 at.% Ag alloy for dental and orthopedic implants显示文摘Refractory metal niobium(Nb) incorporated with a small amount of silver(Ag),the resulting Nb-Ag twophase alloys,were fabricated by mechanical alloying and spark plasma sintering.The microstructure,mechanical properties,wear resistance,corrosion behavior,in vitro and in vivo antibacterial properties and biocompatibility of the Nb-Ag alloys were systematically investigated.The results show that the mechanical properties,wear resistance,corrosion resistance and antibacterial ability were significantly enhanced after addition of 5 at.% Ag.The fabricated Nb-5 at.% Ag alloy demonstrates high yield strength of up to ~1486 MPa and fracture strain of ~35 %.The precipitated Ag particles could reduce friction and wear.The enhanced corrosion resistance was attributed to the higher relative density of the sintered alloys and the formation of a stable and dense passive film of niobium and silver oxides.In vitro and in vivo evaluations show that the Nb-5 at.% Ag alloy also has strong antibacterial activity and good biocompatibility and osteointegration ability.These results demonstrate great potential of the nanostructured Nb-Ag alloys for dental and orthopedic implants. | Tian Wan Kangjie Chu Ju Fang Chuanxin Zhong Yiwen Zhang Xiang Ge Yonghui Ding Fuzeng Ren | 2021 | Journal of Materials Science & Technology2021，，21： | 0 |
| 18 | Germplasm resources and secondary metabolism regulation in Reishi mushroom(Ganoderma lucidum)显示文摘Ganoderma lucidum is a valuable medical macrofungus with a myriad of diverse secondary metabolites,in which triterpenoids are the major constituents.This paper introduced the germplasm resources of genus Ganoderma from textual research,its distribution and identification at the molecular level.Also we overviewed G.lucidum in the components,the biological activities and biosynthetic pathways of ganoderic acid,aiming to provide scientific evidence for the development and utilization of G.lucidum germplasm resources and the biosynthesis of ganoderic acid. | Xinyu He Yiwen Chen Zhenhao Li Ling Fang Haimin Chen Zongsuo Liang Ann Abozeid Zongqi Yang Dongfeng Yang | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 19 | Metabolic profile analysis based on GC-TOF/MS and HPLC reveals the negative correlation between catechins and fatty acids in the cottonseed of Gossypium hirsutum显示文摘Background: The diversified and high value-added utilization of cotton by products can promote the sustainable development of modern agriculture. Di erences in potential nutrients among varieties can be explained by variations in the composition and abundance of fatty acids, polyphenols, carbohydrates, amino acids, and organic acids. Therefore, the analysis of metabolite species and relationships in cottonseed is meaningful for the development of cotton byproducts.Results: In this study, the metabolomes of three representative cotton cultivars of di erent species were compared using untargeted GC-TOF/MS analysis. A total of 263 metabolites were identified from 705 peaks, and their levels were compared across cultivars. Principal component analysis and OPLS-DA clearly distinguish these samples based on metabolites. There were significant di erences in the contents of amino acids, carbohydrates, organic acids, flavonoids, and lipids in G. hirsutum TM-1 compared with G. arboreum Shixiya1 and G. barbadense Hai7124. Notably, the bioactive nutrient compound catechin obtained from the di erential metabolites significantly accumulated in TM-1. Furthermore, a comprehensive analysis using catechin and oil-related traits was conducted in core collections of Gossypium hirsutum. The results revealed the reliability of the GC-TOF/MS analysis, as well as that catechin content has a negative association with myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, arachidic acid, and total fatty acids.Conclusion: These findings suggest that untargeted GC-TOF/MS analysis could provide a new method for investigating the underlying plant biochemistry of nutrient variation in cottonseed, and that catechin content has a negative association with oil-related traits in cottonseed. This study may pave the way to exploit the value of cotton byproducts. | MA Lei CHEN Yabing XU Shuangjiao DONG Ruidan WANG Yiwen FANG Dan PENG Jun TIAN Xinquan | 2022 | Journal of Cotton Research2022，5，2： | 0 |
| 20 | 3D-printed strontium-incorporatedβ-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity,enhanced strength,and excellent bioactivity显示文摘In bone tissue engineering,scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining and bone regeneration,attracting increasingly interests in clinical practice.In this study,strontium-incorporatedβ-tricalcium phosphate(β-TCP),named Sr-TCP,bioceramic triply periodic minimal surface(TPMS)structured scaffolds were successfully fabricated by digital light processing(DLP)-based 3D printing technique,achieving high porosity,enhanced strength,and excellent bioactivity.The Sr-TCP scaffolds were first characterized by element distribution,macrostructure and microstructure,and mechanical properties.Notably,the compressive strength of the scaffolds reached 1.44 MPa with porosity of 80%,bringing a great mechanical breakthrough to porous scaffolds.Furthermore,the Sr-TCP scaffolds also facilitated osteogenic differentiation of mouse osteoblastic cell line(MC3T3-E1)cells in both gene and protein aspects,verified by alkaline phosphatase(ALP)activity and polymerase chain reaction(PCR)assays.Overall,the 3D-printed Sr-TCP bioceramic TPMS structured scaffolds obtained high porosity,boosted strength,and superior bioactivity at the same time,serving as a promising approach for bone regeneration. | Yanbo Shan Yang Bai Shuo Yang Qing Zhou Gang Wang Biao Zhu Yiwen Zhou Wencan Fang Ning Wen Rujie He Lisheng Zhao | 2023 | Journal of Advanced Ceramics2023，12，9： | 0 |
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