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| 1 | Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence显示文摘新兴的证据建议 E3 ligases 在多样的生物过程起关键作用,包括在植物的天生的有免疫力的回答。然而,在植物的 E3 ligase 参与的机制天生的免疫是不清楚的。我们报导那米饭基因, OsBBI1,与 E3 ligase 活动编码戒指手指蛋白质,调停用途广泛的疾病抵抗。OsBBI1 的表示被米饭强风真菌 Magnaporthe oryzae,以及化学 inducers 导致, benzothiadiazole 和水杨酸酸。生物化学的分析表明那 OsBBI1 蛋白质在 vitro 拥有 E3 ubiquitin ligase 活动。基因分析表明在一根 Tos17 插入线的 OsBBI1 功能的损失增加了危险性,当在转基因的植物的 OsBBI1 的 overexpression 授与提高的抵抗到 M 的多重赛跑时。oryzae。这显示 OsBBI1 对强风真菌调制用途广泛的抵抗。OsBBI1-overexpressing 植物由 M 在感染地点在房间墙中在酉分的混合物的房间和蛋白质的 cross-linking 显示出 H2O2 累积的高水平。oryzae 与相比野类型(WT ) 植物。房间墙在 OsBBI1-overexpressing 植物是更厚的并且在变异的植物更薄比在 WT 植物。我们的结果建议 OsBBI1 由修改房间墙防卫回答调制用途广泛的抵抗到强风真菌。OsBBI1 的功能的描述为在米饭对最破坏的疾病构造用途广泛的抵抗提供卓见进 E3 调停 ligase 的天生的免疫,和一个实际工具。 | Wei Li Sihui Zhong Guojun Li Qun Li Bizeng Mao Yiwen Deng Huijuan Zhang Longjun Zeng Fengming Song Zuhua He | 2011 | Cell Research2011，21，5： | 30 |
| 2 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 3 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 4 | An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation. | Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He | 2019 | Cell Research2019，29，5： | 10 |
| 5 | Molecular Basis of Disease Resistance and Perspectives on Breeding Strategies for Resistance Improvement in Crops显示文摘Crop diseases are major factors responsible for substantial yield losses worldwide,which affects global food security.The use of resistance(R)genes is an effective and sustainable approach to controlling crop diseases.Here,we review recent advances on R gene studies in the major crops and related wild species.Current understanding of the molecular mechanisms underlying R gene activation and signaling,and susceptibility(S)gene-mediated resistance in crops are summarized and discussed.Furthermore,we propose some new strategies for R gene discovery,how to balance resistance and yield,and how to generate crops with broad-spectrum disease resistance.With the rapid development of new genome-editing technologies and the availability of increasing crop genome sequences,the goal of breeding next-generation crops with durable resistance to pathogens is achievable,and will be a key step toward increasing crop production in a sustainable way. | Yiwen Deng Yuese Ning Dong-Lei Yang Keran Zhai Guo-Liang Wang Zuhua He | 2020 | Molecular Plant2020，13，10： | 6 |
| 6 | Down-regulation of CEACAM1 in breast cancer显示文摘(CEACAM1 ) Carcinoembryonic 抗原相关的粘附分子 1 是一种类型属于 CEA 家庭的 1 transmembrane glycoprotein,它当在身体液体的也可溶的形式或房间上的膜界限形式出现,被发现了存在。异常 CEACAM1 表示与肿瘤前进被联系并且在许多人的恶意被发现了。增加的兴趣在乳癌被奉献给 CEACAM1 的表示,但是大多数这些调查结果是矛盾的。这研究的目的是详细地在乳癌调查 CEACAM1 表示。用染色的 immunohistochemical,我们发现那 CEACAM1 表情与 noncancerous 胸纸巾相比在乳癌纸巾被减少或输。另外,可溶的 CEACAM1 在乳癌房间线的文化媒介铺平是比在一个 nontumorigenic 乳房的那些显著地低的上皮的房间线。Immunofluorescence 分析一致地证明乳癌房间线有膜界限 CEACAM1 的相对低的表示。而且, CEACAM1 mRNA 和蛋白质表示层次在分别地用即时反向的 transcriptase 聚合酶链反应和西方的污点分析测量了的乳癌房间线是下面调整的。一起拿,我们的结果在乳癌表明 CEACAM1 的一条系统的下面规定并且建议恢复 CEACAM1 表示的策略可能对乳癌的治疗有用。 | Changcheng Yang Pingqing He Yiwen Liu Yiqing He Cuixia Yang Yan Du Muqing Zhou Wenjuan Wang Guoliang Zhang Man Wu Feng Gao | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 5 |
| 7 | Changes of microbial composition during wastewater reclamation and distribution systems revealed by high- throughput sequencing analyses显示文摘这研究采用了 454-pyrosequencing 在二废水开垦和分发系统调查微生物引起、病原的社区。11972 个有效 16S rRNA 序列的一个总数从这二个开垦系统被获得,然后由使用 RDP 分类器指明了到相关分类等级。Chao 索引和香农差异索引证明微生物引起的社区的差异沿着废水开垦过程减少了。Proteobacteria 是在消毒以后的回收的水里的最主导的门,它分别地在二个系统占了 83% 和 88% 。包括 Clostridium, Escherichia, Shigella, Pseudomonas 和 Mycobacterium,人的机会主义的病原体被消毒过程选择并且充实。全部的氯和营养素(TOC, NH 3-N 和没有 3-N) 显著地在回收的水期间影响了微生物引起、病原的社区存储和分发过程。我们的结果显示消毒抵抗的病原体应该在回收的水里被控制,自从相对许多的增加在消毒以后的病原的细菌含有与回收的水联系的潜在的公共健康。 | Yiwen LIN Dan LI Siyu ZENG Miao HE | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 5 |
| 8 | Quantification of viable bacteria in wastewater treatment plants by using propidium monoazide combined with quantitative PCR(PMA-qPCR)显示文摘The detection of viable bacteria in wastewater treatment plants(WWTPs) is very important for public health, as WWTPs are a medium with a high potential for waterborne disease transmission. The aim of this study was to use propidium monoazide(PMA) combined with the quantitative polymerase chain reaction(PMA-qPCR) to selectively detect and quantify viable bacteria cells in full-scale WWTPs in China. PMA was added to the concentrated WWTP samples at a final concentration of 100 μmol/L and the samples were incubated in the dark for 5 min, and then lighted for 4 min prior to DNA extraction and qPCR with specific primers for Escherichia coli and Enterococci, respectively. The results showed that PMA treatment removed more than 99% of DNA from non-viable cells in all the WWTP samples, while matrices in sludge samples markedly reduced the effectiveness of PMA treatment. Compared to qPCR, PMA-qPCR results were similar and highly linearly correlated to those obtained by culture assay, indicating that DNA from non-viable cells present in WWTP samples can be eliminated by PMA treatment, and that PMA-qPCR is a reliable method for detection of viable bacteria in environmental samples. This study demonstrated that PMA-qPCR is a rapid and selective detection method for viable bacteria in WWTP samples, and that WWTPs have an obvious function in removing both viable and non-viable bacteria. The results proved that PMA-qPCR is a promising detection method that has a high potential for application as a complementary method to the standard culture-based method in the future. | Dan Li Tiezheng Tong Siyu Zeng Yiwen Lin Shuxu Wu Miao He | 2014 | Journal of Environmental Sciences2014，26，2： | 4 |
| 9 | STRIPE2 Encodes a Putative dCMP Deaminase that Plays an Important Role in Chloroplast Development in Rice显示文摘Mutants with abnormal leaf coloration are good genetic materials for understanding the mechanism of chloroplast development and chlorophyll biosynthesis. In this study, a rice mutant st2(stripe2) with stripe leaves was identified from the g-ray irradiated mutant pool.The st2 mutant exhibited decreased accumulation of chlorophyll and aberrant chloroplasts. Genetic analysis indicated that the st2 mutant was controlled by a single recessive locus. The ST2 gene was finely confined to a 27-kb region on chromosome 1 by the map-based cloning strategy and a 5-bp deletion in Os01g0765000 was identified by sequence analysis. The deletion happened in the joint of exon 3 and intron 3 and led to new spliced products of mRNA. Genetic complementation confirmed that Os01g0765000 is the ST2 gene.We found that the ST2 gene was expressed ubiquitously. Subcellular localization assay showed that the ST2 protein was located in mitochondria. ST2 belongs to the cytidine deaminase-like family and possibly functions as the dCMP deaminase, which catalyzes the formation of dUMP from dCMP by deamination. Additionally, exogenous application of dUMP could partially rescue the st2 phenotype.Therefore, our study identified a putative dCMP deaminase as a novel regulator in chloroplast development for the first time. | Jing Xu Yiwen Deng Qun Li Xudong Zhu Zuhua He | 2014 | Journal of Genetics and Genomics2014，41，10： | 3 |
| 10 | The influence of hyaluronic acid on vascular endothelial cell proliferation and the relationship with ezrin/merlin expression显示文摘它被建立了那玻尿的酸(哈) glycans (nHA ) 和 oligosaccharide (oHA ) 在脉管的 endothelial 房间(EC ) 的生物功能上施加不同效果,导致 angiogenesis 的改变的规定。然而,特定的机制仍然是不清楚的。我们的学习在 EC 在 ezrin 和灰背隼蛋白质上集中了于 nHA 和 oHA 的效果。ezrin 和灰背隼的表示在 EC 生长以及 mRNA 表示上是由 siRNA,和规定的 silenced, ezrin 和灰背隼的激活(phosphorylation ) 由 oHA 刺激了, nHA 被调查。结果表明当与 nHA 对待时,在 ezrin 表示或激活没有重要变化。在与 oHA 被对待以后,而在灰背隼表示没有明显的变化, ezrin 的表示和激活决定性地被增加(包括它的 phosphorylation ) 。与 ezrin 表示 silenced,象它的 phosphorylation 一样的灰背隼的表示在刺激 nHA 的人的脐的静脉 endothelial 房间铺平显著地被提高,当没有重要变化, oHA 导致时。与灰背隼表示 silenced,没有明显的变化在 ezrin 的表示被发现(包括它的 phosphorylation ) 由 nHA 导致了。相反地, ezrin 的表示和它的激活显著地在与 oHA 被对待以后被改进。结果建议为由 oHA 的 EC 增长的提升的机制与 ezrin 的表示和激活有关是可能的,并且由 nHA 的 EC 增长的抑制与灰背隼的表示和激活有关是可能的。 | Wei Mo Cuixia Yang Yiwen Liu Yiqing He Yingzhi Wang Feng Gao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 3 |
| 11 | Improved esophageal squamous cell carcinoma screening effectiveness by risk-stratified endoscopic screening:evidence from high-risk areas in China显示文摘Background:Risk-stratified endoscopic screening(RSES),which offers endoscopy to those with a high risk of esophageal cancer,has the potential to increase effectiveness and reduce endoscopic demands compared with the universal screening strategy(i.e.,endoscopic screening for all targets without risk prediction).Evidence of RSES in high-risk areas of China is limited.This study aimed to estimate whether RSES based on a 22-score esophageal squamous cell carcinoma(ESCC)risk prediction model could optimize the universal endoscopic screening strategy for ESCC screening in high-risk areas of China.Methods:Eight epidemiological variables in the ESCC risk prediction model were collected retrospectively from 26,618 individuals aged 40-69 from three high-risk areas of China who underwent endoscopic screening betweenMay 2015 and July 2017.The model’s performance was estimated using the area under the curve(AUC).Participants were categorized into a high-risk group and a low-risk group with a cutoff score having sensitivities of both ESCC and severe dysplasia and above(SDA)at more than 90.0%.Results:The ESCC risk prediction model had an AUC of 0.80(95% confidence interval:0.75-0.84)in this external population.We found that a score of 8(ranging from 0 to 22)had a sensitivity of 94.2% for ESCC and 92.5% for SDA.The RSES strategy using this threshold score would allow 50.6% of endoscopies to be avoided and save approximately US$0.59 million compared to universal endoscopic screening among 26,618 participants.In addition,a higher prevalence of SDA(1.7%vs.0.9%),a lower number need to screen(60 vs.111),and a lower average cost per detected SDA(US$3.22 thousand vs.US$5.45 thousand)could have been obtained by the RSES strategy.Conclusions:The RSES strategy based on individual risk has the potential to optimize the universal endoscopic screening strategy in ESCC high-risk areas of China. | He Li Chao Ding Hongmei Zeng Rongshou Zheng Maomao Cao Jiansong Ren Jufang Shi Dianqin Sun Siyi He Zhixun Yang Yiwen Yu Zhe Zhang Xibin Sun Guizhou Guo Guohui Song Wenqiang Wei Wanqing Chen Jie He | 2021 | Cancer Communications2021，41，8： | 3 |
| 12 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 13 | CD44 clustering is involved in monocyte differentiation显示文摘进巨噬细胞的单核白血球的区别是在生理、病理学的条件下面的一个重要过程,位于单核白血球区别的机制下面的 butthe 不是完全清楚的。一些粘附分子被报导了 toplay 在房间区别的一个重要角色。CD44 是调停的一个重要粘附分子 cellcell 和 cellmatrixinteraction,并且参予许多细胞的功能。当 CD44 被报导了显示出在单核白血球和巨噬细胞之间的不同 activatedstates,我们建议 CD44 可以涉及单核白血球区别。在这研究,我们在单核白血球区别探索了 CD44 的角色并且进一步学习了被包含在里面的机制。THP-1 房间(人的 monocytic 白血病房间线) 与 phorbol 12 十四酸盐 13 醋酸盐(PMA ) 被导致在 vitro 建立 monocytedifferentiation 的模型。它被发现那个 CD44 表达式,到玻尿的酸的有约束力的能力显著地被增加,并且 distributionof CD44 在区别期间被变换成簇。聚类的导致 PMA 的 CD44 和由堵住 CD44 的 CD44 高表示 weresuppressed,它导致了 CD14 表示的抑制。ERK1/2 signalwas 的导致 PMA 的 phosphorylation 也由堵住 CD44 压制了。我们的结果建议 CD44 涉及单核白血球区别。mechanismsof 单核白血球区别追随者 CD44 激活可以包括 CD44 高表示并且聚类哪个接着带 ERK1/2 的 tophosphorylation。 | Guoliang Zhang Huizhen Zhang Yiwen Liu Yiqing He Wenjuan Wang Yan Du Cuixia Yang Feng Gao | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 2 |
| 14 | State of charge estimation by square root cubature particle filter approach with fractional order model of lithium-ion battery显示文摘In this paper, a square root cubature particle filter approach was designed to estimate the state of charge of lithium-ion battery,which not only enhanced the numerical stability and guaranteed positive definiteness of the state covariance, but also increased accuracy and decreased computation quantity. Due to the fractional characteristics of the battery capacitance, a fractional order model was used to formulate the lithium-ion battery. Considering the high accuracy and easy convergence, a particle swarm optimization algorithm was utilized to identify the model parameters. The above-mentioned approach was modelled and translated into C code, which was downloaded into battery control unit of battery management system for experimental validation. Two kinds of dynamic cycles were utilized to validate the proposed approach at different temperatures, where both unscent Kalman filter and cubature Kalman filter were compared with the proposed approach. Experimental results indicate that the proposed approach has better accuracy and robustness, and fractional order model is more accurate than integer order model.Therefore, the square root cubature particle filter with fractional order model of lithium-ion battery is a good candidate to estimate the state of charge. | LIU YiWen SHI Qin WEI YuJiang HE ZeJia HU XiaoSong HE Lin | 2022 | Science China(Technological Sciences)2022，65，8： | 2 |
| 15 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 16 | Hyaluronan arrests humanbreast cancer cell growth by prolonging the G0/G1 phase of the cell cycle显示文摘In clinical breast cancer patients,quiescent disseminated tumor cells (DTCs)can persist for a long time in the bone marrow (BM)under the influence of microenvironmental cues.As a high molecular weight polysaccharide,hyaluronan (HA)not only has been shown to regulate cancer processes including cell invasion,metastasis,migration,and proliferation,but also is a major component of the BM extracellular matrix.Here,we tested whether HA promotes breast cancer cell quiescence through detecting cell proliferation,cell cycle phase distribution,and the expression of cell cyclerelated regulator proteins.In our results,HA slowed the growth and prolonged the G0/G1 phase of the highly metastatic,bone-seeking human breast cancer MDA-MB-231BO cell line,which is consistent with results that HA activated p38α/β,inhibited phospho-ERK1/2 levels and reduced the ERK/p38 signaling ratio.Additionally,we examined the crucial cell cycle factors p21^cip1 and Cyclin D1,both of which influence the transition from G1 to S phase.The results revealed that p21^cip1 expression was up-regulated by HA,which was consequently accompanied by a decrease in Cyclin D1 level.Further research with a 3D culture model indicated that HA maintained low Ki-67 and high p21^cip1 expression levels in MDA-MB-231BO cells.In summary,our work revealed that HA might contribute to DTC quiescence. | Xiaoyan Chen Yan Du Yiwen Liu Yiqing He Guoliang Zhang Cuixia Yang Feng Gao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 2 |
| 17 | Up-regulation of carcinoembryonic antigen-related cell adhesion molecule 1 in gastrointestinal cancer and its clinical relevance显示文摘 | Muqing Zhou Zhiming Jin Yiwen Liu Yiqing He Yan Du Cuixia Yang Yingzhi Wang Jiajie Hu Lian Cui Feng Gao Manlin Cao | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 2 |
| 18 | Tea stain-inspired solar energy harvesting polyphenolic nanocoatings with tunable absorption spectra显示文摘Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and conversion.One possible solution to this quest is to check nature as a source of matters or inspiration.Inspired by the formation of tea stains,a unique class of dark stain materials generated by the interfacial reaction between tea polyphenols and metal substance,we reported the facile preparation and screening of a series of photothermal nanocoating layers via the metal ion(i.e.C u(ll)>Fe(lll),Ni(ll),Zn(ll))promoted in situ polymerization of typical phenolic moieties of tea polyphenols(i.e.,catechol and pyrogallol).It was found that those resulting metal-polyphenolic nanocoatings showed various promising features,such as high blackness and strong adhesion,excellent and tunable light absorption properties,good hydrophilicity and long-term stability.We further fabricated the photothermal composite devices by/n s/'fty formation of meta卜polyphenolic nanocoatings on pristine silks for solar desalination,which demonstrated promising durable evaporation behaviors with excellent evaporation rates and steam generation efficiencies.We believe that this work could provide more opportunities towards new types of bio-inspired and sustainable photothermal nanomaterials for solar energy harvesting applications such as water desalination. | Lu Yang Yuan Zou Wei Xia Haotian Li Xinyu He Yi Zhou Xianhu Liu Chaoqun Zhang Yiwen Li | 2021 | Nano Research2021，14，4： | 2 |
| 19 | Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains显示文摘The worldwide pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in more than 4.5 million deaths.Although coronaviruses have a proofreading mechanism to maintain the stability of their long genomic RNAs,mutations emerge continuously,and new variants conferring advantages rapidly become the dominant lineages[1].Strategies to fight the COVID-19 pandemic using either vaccines or nonpharmaceutical interventions have specifically been threatened by the emergence of SARS-CoV-2 variants of concern(VOCs)[2]. | Ting Pan Zhongwei Hu Fengyu Hu Yiwen Zhang Bingfeng Liu Changwen Ke Qiumin She Xin He Xiaoping Tang Hui Zhang | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 20 | Identification and fine-mapping of quantitative trait loci(QTL) conferring rice false smut resistance in rice显示文摘Rice false smut(RFS) is a rice fungal disease caused by the biotrophic fungus Ustilaginoidea virens(Cooke) Takahashi. The pathogenic fungus specifically infects rice spikelets at the booting stage and coverts the infected spikelets into false smut balls consisting of hyphae and chlamydospores(Ashizawa et al., 2012);Sun et al. | Yifeng Huang Kaixuan Cui Zhen Zhang Rongyao Chai Hongguang Xie Jianyao Shou Junru Fu Guolin Li Jiyun Liu Shuangqing Wu Guochang Sun Jianfu Zhang Yiwen Deng Zuhua He | 2023 | Journal of Genetics and Genomics2023，50，4： | 1 |
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