|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Factors Affecting Cr(Ⅲ) Oxidation by Manganese Oxides显示文摘The high oxidation ability of manganese oxides or soils was used to study effects of pH and coatingon Cr(Ⅲ) oxidation. The results indicated that Cr(Ⅲ) oxidation peaked in pH 4.0-6.5. The amount andrate of Cr(Ⅲ) being oxidized by uncoated δ-MnO2 were larger than those by Fe oxide- or CaCO3-coatedone. Inorganic Cr(Ⅲ) was more easi1y oxidized by MnO2 than organic complex Cr(Ⅲ) due to differentsurface affinities. Precipitated Cr(Ⅲ) and adsorbed Cr(Ⅲ) might be transferred onto MnO2 surface andthen oxidized to Cr(VI). | CHEN YINGXU CHEN YIYI LIN QI HU ZIQIANG HU HONG and WU JIANYANG(Dept. of Environ. Sci., Zhejiang Agricultural Univereity, Hangzhou, 310029 (China)) | 1997 | Pedosphere1997，7，2： | 5 |
| 3 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 4 | Spatial patterns of urban green space and its actual utilization status in China based on big data analysis显示文摘Urban green space(UGS)is essential for sustainable urbanization and human well-being.The utilization status of UGS is closely related to the provision of ecosystem services for urban residents.Limitations on data availability,however,have led to the absence of a comprehensive approach for evaluating the actual utilization status of UGS at a large scale.Furthermore,differences in actual UGS utilization between intra-urban and peri-urban areas have not received enough attention.This study used big data analysis by combining point of interest(POI)and land use and cover change(LUCC)to quantify the spatial patterns of UGS utilization,and to evaluate the actual utilization status of UGS in 366 cities on the Chinese mainland.We also explored the differences in the actual utilization of UGS in intra-urban and peri-urban areas.The results showed that 94.01%of UGS resources in China had not been utilized.There was a clear pattern of spatial mismatch between the stock and the actual utilization of UGS,especially in the north-western region indicated by the Hu Huanyong Line.The actual utilization rate of UGS was closely related to the regional develop-ment level.There was a certain mismatch between the actual utilization and stock of intraurban green space(IUGS).The hot spots of the actual utilization rate of IUGS were in Yunnan,Guizhou,and Sichuan Provinces in southwestern China.The differ-ences in UGS actual utilization rates between IUGS and peri-urban green space(PUGS)were small in eastern China,but large in south-western and northwestern China.The actual utilization rate of IUGS in most Chinese cities was significantly larger than that of PUGS,indicating that PUGS were not well utilized.Our results provide scientific support for urban and regional planners in targeting specific areas for UGS design and development,and in optimizing future UGS planning in China. | Yiyi Huang Tao Lin Guoqin Zhang Yongguan Zhu Zhiwei Zeng Hong Ye | 2021 | Big Earth Data2021，5，3： | 2 |
| 5 | Tumor-penetrating peptide functionalization enhances the anti-glioblastoma effect of doxorubicin liposomes显示文摘 | Yiyi Yang Zhiqiang Yan Daixu Wei Jian Zhong Lu Liu Lin Zhang Fei Wang Xiaoli Wei Cao Xie Weiyue Lu Dannong He | 2013 | Nanotechnology2013，，40： | 1 |
| 6 | The global registry of COVID-19 clinical trials: indicating the design of traditional Chinese medicine clinical trials显示文摘Objective:To analyze the registration information of Corona Virus Disease 2019(COVID-19)related clinical trials from all the clinical trial registry accepted by the International Committee of Medical Journal Editors(ICMJE).Methods:All the database of ICMJE-accepted clinical trial registry platform were searched for COVID-19 related clinical trials that registered from December 8,2019 to February 19,2020.Results:All the database totally contained data of 209 COVID-19 related clinical trials,including 66(31.6%)traditional Chinese medicine(TCM)related studies and 143(68.4%)non-TCM related studies.176(84.2%)clinical trials were registered in ChiCTR,as 33(15.8%)were registered in ClinicalTrials.gov.There were 152(72.7%)intervention trials,including 9(4.3%in total)preventive trials,136(65.1%in total)therapeutic trials and 7(3.3%in total)convalescent trials.Conclusion:At the present stage,clinical studies are still aiming at exploring the effective treatment of COVID-19,and the existing treatments need more high-quality clinical evidence supporting.Traditional Chinese medicine may have played an important role in all stages of the epidemic preventing and control,and the enthusiasm of carrying out scientific research has also been greatly improved.The relevant policies of clinical trial registration should be popularized among researchers,including traditional Chinese medicine researchers.And the methodological quality of clinical trials’design urges improving. | Xuxu Wei Mengzhu Zhao Chen Zhao Xiaoyu Zhang Ruijin Qiu Yiyi Lin Yang Sun Manke Guan Hongcai Shang | 2020 | TMR Modern Herbal Medicine2020，3，3： | 1 |
| 7 | 美国一般人群尿镉水平与心电图改变的关系显示文摘[目的]观察美国一般人群的尿镉水平与心电图改变的关系,了解镉暴露对心电图的影响。[方法]利用美国第三次国家健康与营养调查(NHANESⅢ)中进行心电图测量,年龄≥40岁的6 889名参与者作为研究对象。采用标准十二导联心电图分析系统记录心电图参数;采用原子吸收光谱法测定尿镉含量。按性别分层,运用多元线性回归分析尿镉水平与心电图改变的关系。[结果]尿镉平均水平为(0.7±0.01)μg/g肌酐,其中男性人群平均(0.6±0.02)μg/g肌酐;女性(0.8±0.02)μg/g肌酐;在男性群体,尿镉水平四分位最高与最低等分相比,多因素调整的心率、PRrr间期、QTrr间期和QRS间期变化及其95%CI分别为1.72(0.05~3.4)次/分,-3.87(-7.3^-0.45)ms,-0.39(-4.09~3.22)ms和-2.64(-4.96^-0.33)ms。在女性群体,尿镉水平最高与最低等分相比,上述相应的心电图参数变化及其95%CI分别为-0.19(-1.72~1.33)次/分,-0.09(-4.13~3.94)ms,1.59(-1.05~4.23)ms和-1.11(-2.68~0.47)ms。[结论]尿镉水平与美国男性一般人群的心电图改变存在一定的关联。 | 黎小飞 Eliseo GUALLAR Ruoxi LIN Yiyi ZHANG 钟秋安 | 2015 | 环境与职业医学2015，32，3： | 1 |
| 8 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 9 | Greenspace’s value orientations of ecosystem service and socioeconomic service in China显示文摘Background:Natural ecosystems provide necessary services for human beings,including ecosystem service values(ESVs)and socioeconomic service values(SSVs).The value orientations of ESVs and SSVs are mainly related to people’s interaction with nature.This study reclassified greenspace from a perspective of exposed and non-exposed greenspace based on the level of interaction by people and greenspace.We applied an expert questionnaire to survey the SSVs value orientations of forestland,grassland,wetland,and water bodies,and quantitatively compared the value orientations between the ESVs and SSVs of greenspace in China.Result:(1)The values of exposed greenspace were relatively far higher than nonexposed greenspace,as it had both ESVs and SSVs.(2)The forestland and grassland had relatively high ESVs and SSVs,and are the priority for both the exposed and non-exposed greenspace.(3)Wetland had relatively high ESVs but low SSVs,which was unpopular for exposed greenspace.(4)The ESVs and SSVs of water body were relatively balanced.Conclusion:Greenspace had both ESVs and SSVs when they are exposed to human.Our study provided an innovative perspective to explore the value orientations of greenspace,which provides an actionable scientific basis for greenspace planning,design and construction in human habitat. | Xia Yao Tao Lin Shoukai Sun Guoqin Zhang Hao Zhou Laurence Jones Wenhui Liu Yiyi Huang Meixia Lin Junmao Zhang Yuan Chena Hong Ye | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 10 | Condensation heat transfer and pressure drop of refrigerant R134a in a small pipe 显示文摘 | Yan Yiyie Lin Tsingfa | 1999 | International Journal of Heat and Mass Transfer1999，，42： | 1 |
| 11 | Condensation heat transfer and pressure drop of refrigerant R-134a in a small pipe显示文摘 | YAN YIYIE LIN TINGFA | 1999 | International Journal of Heat and Mass Transfer1999，42，： | 1 |
| 12 | Ordering effects of cholesterol on sphingomyelin monolayers investigated by high-resolution broadband sum-frequency generation vibrational spectroscopy显示文摘This report investigated the ordering of the alky chain of sphingomyelin(SMs) monolayers induced by cholesterol at the air/water interface using high-resolution broadband sum frequency generation vibrational spectroscopy(HR-BB-SFG-VS). The SFG spectra of the three nature sphingomyelin/cholesterol mixture monolayers with two concentrations of the cholesterol at the air/water interface are performed under different polarization combination. A new resolved CH_2 symmetric stretching(d^+, ~2834 cm^(-1))and the CH3 symmetric stretching(r^+,~2874 cm^(-1)) mode are applied to characterize the conformational order in the sphingomyelin/cholesterol mixture monolayers. It was found that the cholesterol make the sphingosine backbones more conformational order. During this process, the conformational order of the N-linked acyl chain remains unaltered. Moreover, the sphingosine backbones of SMs have much larger contributions to gauche defects of SMs than one in the N-linked acyl chain. These results presented here not only shed lights on understanding of the interactions of sphingomyelin molecules with cholesterol molecules at interface but also demonstrates the ability of HR-BB-SFG to probe such complicated molecular systems. | Yiyi Li Rongjuan Feng Lu Lin Minghua Liu Yuan Guo Zhen Zhang | 2018 | Chinese Chemical Letters2018，29，3： | 1 |
| 13 | Condensation heat transter and pressure drop of refrigerant R - 134a in a small pipe 显示文摘 | Yan Yiyie Lin Tsingfa | 1999 | International Journal of Heat and Mass Transfer1999，42，4： | 1 |
| 14 | Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro显示文摘 | Xi Chen Jianqin Xu Xiang Mu Yiyi Hu Ge Hu Huiqin Duan Tao Zhang Hong Lin Wei Zhang | 2009 | Veterinary Microbiology2009，，2： | 1 |
| 15 | A flexible biometrics remote user authentication scheme显示文摘 | Lin C H Lai Yiyi | 2004 | Computer Standards and In- terfaces2004，27，1： | 1 |
| 16 | A Flexible Biometrics Remote User Authentication Scheme显示文摘 | Lin Chu-Hsing Lai Yiyi | 2004 | Computer Standards and Interfaces2004，27，1： | 1 |
| 17 | Condensation beat transfer and pressure drop of refrigerant R -134a in a small pipe显示文摘 | YAN Yiyie LIN Tingfa | 1999 | International Journal of Heat and Mass Transfer1999，42，4： | 1 |
| 18 | Cyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C–N bonds显示文摘We have developed a practical and mild electrochemical protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C–N bond cleavage without the need for an exter-nal stoichiometric reducing agent or a sacrificial anode.The reaction employs tosyl cyanide(TsCN)or azido allyl alcohol as the cyanation or cyanomethylation reagent,respectively.It shows high functional group compatibility and can be applied for the cyanation of natural product derivatives.Preliminary mechanistic studies indicate the involvement of a radical addition pathway. | Xianqiang Kong Yuchang Wang Yiyi Chen Xiaohui Chen Long Lin Zhong-Yan Cao | 2022 | Organic Chemistry Frontiers2022，9，5： | 1 |
| 19 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://db.cbi.pku.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 20 | Extraordinarily stable and wide-temperature range sodium/potassium-ion batteries based on 1D SnSe2-SePAN composite nanofibers显示文摘Developing electrodes with long lifespan and wide-temperature adaptability is crucial important to achieve high-performance sodium/potassium-ion batteries(SIBs/PIBs).Herein,the SnSe2-SePAN composite was fabricated for extraordinarily stable and wide-temperature range SIBs/PIBs through a coupling strategy between controllable electrospinning and selenylation,in which SnSe2 nanoparticles were uniformly encapsulated in the SePAN matrix.The unique structure of SnSe2-SePAN not only relieves drastic volume variation but also guarantees the structural integrity of the composite,endowing SnSe2-SePAN with excellent sodium/potassium storage properties.Consequently,SnSe2-SePAN displays a high sodium storage capacity and excellent feasibility in a wide working temperature range(-15 to 60℃:300 mAh g^(-1)/700 cycles/-15℃;352 mAh g^(-1)/100 cycles/60℃at 0.5 A g^(-1)).At room temperature,it delivers a record-ultralong cycling life of 192 mAh g^(-1)that exceeds 66000 cycles even at 15 A g^(-1).It exhibits extremely superb electrochemical performance in PIBs(157 mAh g^(-1)exceeding 15000 cycles at 5 A g^(-1)).The ex situ XRD and TEM results attest the conversion-alloy mechanism of SnSe2-SePAN.Also,computational calculations verify that SePAN takes an important role in intensifying the electrochemical performance of SnSe2-SePAN electrode.Therefore,this study breaks new ground on solving the polyselenide dissolution issue and improving the wide temperature workable performance of sodium/potassium storage. | Yiyi Wang Fuyu Xiao Xi Chen Peixun Xiong Chuyuan Lin Hong-En Wang Mingdeng Wei Qingrong Qian Qinghua Chen Lingxing Zeng | 2023 | InfoMat2023，5，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员