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| 1 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 2 | Effect of pulsatile perfusion during cardiopulmonary bypass in terms of radial artery sphygmogram显示文摘OBJECTIVE: To investigate a quantitative method for using radial artery pulse waveforms to assess the effect of pulsatile flow during cardiopulmonary bypass(CPB).METHODS: A total of 34 adults with heart disease who underwent open-heart surgery between April2010 and January 2011 were randomized into a pulsatile perfusion group(n=17) and a non-pulsatile perfusion group(n=17). Radial arterial pulse waveforms of pulsatile and non-pulsatile perfusion patients were observed and compared before and during CPB.RESULTS: No pulse waveform could be detected at patients' radial artery in both groups when the aorta was cross-clamped. Pulse waveforms could be detected at pulsatile perfusion patients' radial artery, but could not be detected at non-pulsatile perfusion patients' radial artery during CPB. Additionally, patients' pulse waveforms during pulsatile perfusion were lower than those before the operation.CONCLUSION: Our findings indicate that radial artery sphygmogram can be used as a valid indicator to evaluate the effectiveness of pulsatile perfusion during CPB. | Zhifeng Zhang Jiatuo Xu Enyuan Zhu Qi Zhang Lu Yu Yongbing Qiu Jianguo Tang Zhaofu Fei Xin Li Liping Tu Chouping Han Ying Liu Zhen Guo Changle Zhou Meiyu Shi Yingxin Qian Yimin Bao Xinming Ji | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 2 |
| 3 | A Preliminary Report of Penile Transplantation显示文摘 | Weilie Hu Jun Lu Lichao Zhang Wen Wu Haibo Nie Yunsong Zhu Zhixiong Deng Yongbing Zhao Wen Sheng Qiyou Chao Xiaofu Qiu Jinghua Yang Ying Bai | 2006 | European Urology2006，，4： | 1 |
| 4 | Exceptionally flame-retardant flexible polyurethane foam composites:synergistic effect of the silicone resin/graphene oxide coating显示文摘A facile strategy was developed to fabricate flexible polyurethane(PU)foam composites with exceptional flame retardancy.The approach involves the incorporation of graphene oxide(GO)into a silicone resin(SiR)solution,which is then deposited onto a PU foam surface via the dip-coating technique and cured.Fourier-transform infrared spectroscopy,scanning electron microscopy,and Raman spectroscopy measurements demonstrated that the SiR and GO were successfully coated onto the PU skeleton and the intrinsic porous structure of the PU foam remained intact.The effects of SiR and GO on the mechanical and thermal stability and flame retardancy of PU composites were evaluated through compression tests,thermogravimetric analysis,vertical combustion tests,and the limiting oxygen index.The measurement results revealed that the composites(PU@SiR-GO)showed superior flame retardancy and thermal and mechanical stability compared to pristine PU or PU coated with SiR alone.The mechanical and thermal stability and the flame-retardant properties of the PU composites were enhanced significantly with increasing GO content.Based on the composition,microstructure,and surface morphology of PU@SiR-GO composites before and after combustion tests,a possible flame-retardance mechanism is proposed.This work provides a simple and effective strategy for fabricating flame retardant composites with improved mechanical performance. | Qian Wu Jincheng Zhang Shengpeng Wang Bajin Chen Yijun Feng Yongbing Pei Yue Yan Longcheng Tang Huayu Qiu Lianbin Wu | 2021 | Frontiers of Chemical Science and Engineering2021，15，4： | 1 |
| 5 | Facile generation of highly durable thiol-functionalized polyhedral oligomeric silsesquioxane based superhydrophobic melamine foam显示文摘In this study,a durable superhydrophobic/superoleophilic melamine foam was fabricated by a facile and rapid one-step thiol-ene click chemistry and Michael addition reaction,which demonstrated excellent robustness in oil/water separation.First,1H,1H,2H-perfluoro-1-hexene reacted with thiol-functionalized polyhedral oligomeric silsesquioxane via the thiol-ene click chemistry to obtain a fluorinated thiol-functionalized polyhedral oligomeric silsesquioxane solution.Subsequently,the melamine foam was immersed to the solution system to form nanoaggregates on the melamine foam surface by the Michael addition reaction in the presence of ultraviolet light.The micro/nano rough structure and low surface energy of the nanoaggregates layer endowed the pristine melamine foam with superhydrophobicity;the water contact angle was greater than 150°.More importantly,the as-prepared melamine foam could withstand harsh conditions,such as a corrosive solution environment,strong ultraviolet light,mechanical compression,high and low temperature exposure,and ultrasonic washing.Driven by gravity,the as-prepared melamine foam could efficiently separate the oil/water mixtures and maintain 98%separation efficiency at high and low temperatures.In addition,it maintained the desirable absorption capability in different oil/organic solvents even after 15 absorption cycles.Accordingly,this facile,low-cost,and robust onestep method provides important support for the superhydrophobic oil/water separation field. | Meng Li Yuanfeng Fang Chun Liu Mengmeng Zhou Xiaomei Miao Yongbing Pei Yue Yan Wenjun Xiao Huayu Qiu Lianbin Wu | 2022 | Frontiers of Chemical Science and Engineering2022，16，8： | 0 |
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