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| 1 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 2 | GIS-based detection of land use transformation in the Loess Plateau: A case study in Baota District, Shaanxi Province, China显示文摘在过去的十年期间,大努力被作了在黄土高原增加陆地使用转变,特别为减少由植被恢复措施的土壤侵蚀。Grain-for-Green 工程(GFG ) 是在中国的最大的生态的康复程序,它为西方中国的生态地易碎的区域在植被恢复和持续开发上有积极影响。为三个次时期(2000, 2005 和 2010 ) 基于 Landsat TM/ETM 图象,这研究使用了 GIS 技术和一个山斜坡揭示在 Baota 区域把斜坡农田还给草地或树林的时间空间的进化模式的分析模型, Shaanxi 的 Yanan 城市省。结果显示出那:(1 ) 从 2000 ~ 2010,农田的区域在约 35,030 减少了哈,而草地,树林和构造土地增加了,它是在所有陆地使用类型之中的最大的减少,哪个 26,380 很快扩展的草地哈。(2 ) 陆地使用动力学的年度变化率在时期期间是 1.98% 20002010,哪个率为 20002005 时期是 1.05% 并且 2.92% 为 20052010 时期分别地。在过去的十年,把农田还给树林或牧场是增加的草地和树林的主要来源,并且农田的减小分别地在 97.39% 和 85.28% 在草地和树林贡献了增加。(3 ) 当地面斜坡增加,农田减少了,树林和草地显著地增加了。有从 15 潰獳獥楳湯的一个斜坡的区域? | GUO Liying DI Liping LI Gang LUO Qiyou GAO Mingjie | 2015 | Journal of Geographical Sciences2015，25，12： | 11 |
| 3 | The role played by traditional Chinese medicine in preventing and treating COVID-19 in China显示文摘Traditional Chinese medicine(TCM),an ancient system of alternative medicine,played an active role in the prevention and control of COVID-19 in China.It improved the clinical symptoms of patients,reduced the mortality rate,improved the recovery rate,and effectively relieved the operating pressure on the national medical system during critical conditions.In light of the current global pandemic,TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions.Here,we summarize the TCM-related measures that were widely used in China,including TCM guidelines,the Wuchang pattern,mobile cabin hospitals,integrated treatment of TCM and modern medicine for critical patients,and non-medicine therapy for convalescent patients,and describe how TCM effectively treated patients afflicted with the COVID-19.Effective TCM therapies could,therefore,be recommended and practiced based on the existing medical evidence from increased scientific studies. | Qingwei Li Han Wang Xiuyang Li Yujiao Zheng Yu Wei Pei Zhang Qiyou Ding Jiaran Lin Shuang Tang Yikun Zhao Linhua Zhao Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，5： | 10 |
| 4 | Ensemble kernel method:SVM classification based on game theory显示文摘With the development of the support vector machine(SVM),the kernel function has become one of the cores of the research on SVM.To a large extent,the kernel function determines the generalization ability of the classifier,but there is still no general theory to guide the choice and structure of the kernel function.An ensemble kernel function model based on the game theory is proposed,which is used for the SVM classification algorithm.The model can effectively integrate the advantages of the local kernel and the global kernel to get a better classification result,and can provide a feasible way for structuring the kernel function.By making experiments on some standard datasets,it is verified that the new method can significantly improve the accuracy of classification. | Yufei Liu Dechang Pi Qiyou Cheng | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 6 |
| 5 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 6 | Optimization for Microbial Degradation of Dibenzothiophene by Pseudomonas sp. LKY-5 Using Response Surface Methodology显示文摘In this research, the degradation of dibenzothiophene(DBT) was investigated by using Pseudomonas sp. LKY-5 isolated from oil contaminated soil. The response surface methodology(RSM) based on the Box-Behnken design(BBD) was applied for evaluating the interactive effects of four independent variables including substrate concentration, temperature, pH and agitation rate on the DBT removal response. A total of 29 experiments for four factors at three levels were conducted in present study. A second-order regression model was then developed, and the analysis of variance(ANOVA) illustrated that the proposed quadratic model could be utilized to navigate the design space. The value of determination coefficient(R2=0.953 4) indicated a satisfactory agreement between the quadratic model and the experimental data. It was found that DBT removal was more significantly affected(P<0.000 1) by substrate concentration compared with other three parameters. An 100% degradation of DBT could be obtained by Pseudomonas sp. LKY-5 at a substrate concentration of 100 mg/L. | Li Lin Zhao Chaocheng Liu Qiyou Zhang Yunbo Liu Chunshuang Xue Jianliang | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，1： | 5 |
| 7 | Secure multi-party computation solution to Yao's millionaires' problem based on set-inclusion显示文摘Secure multi-party computation is a focus of international cryptography in recent years. Protocols for Yao’s millionaires’ problem have become an important building block of many secure multi-party computation protocols. Their efficiency are crucial to the efficiency of many secure multi-party computation protocols. Unfortunately, known protocols for Yao’s millionaires’ problem have high computational complexity or communication complexity. In this study, based on the 1-out-of-m oblivious transfer and set-inclusion problem, we propose a new protocol to solve this problem. This new protocol is very efficient in terms of both computational and communication complexities. Its privacy-preserving property is also proved by simulation paradigm which is generally accepted in the study of secure multi-party computation. We also compare the information leakage of our new protocol and the known protocols. | LI Shundong DAI Yiqi YOU Qiyou | 2005 | Progress in Natural Science:Materials International2005，15，9： | 4 |
| 8 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 9 | Three-dimensional soil resistivity inversion using patching method显示文摘 | ZHOU Qiyou SHIMADA J SAT() A | 1999 | Jounal of Social Engineering and Geological of Japan1999，39，6： | 1 |
| 10 | Study on Isolation, Identification of A Petroleum Hydrocarbon Degrading Bacterium Bacillus fusiformis sp. and Influence of Environmental Factors on Degradation Efficiency显示文摘A hydrocarbon degrading bacterium KL2-13 was isolated from ten sites of oil contaminated soil in the Karamay oilfield. It was identified as the Bacillus fusiformis sp. bacterium based on its morphological and physiological characteristics and the 16S rDNA sequence analysis. The factors influencing the hydrocarbon degradation by the bacterium KL2-13 were determined. The test results have showed that the hydrocarbon degrading bacterium KL2-13 requires an optimum pH range of 6-8, and the optimum inoculation quantity is 3%. The low-concentration metal ions Fe2+, Mg2+ and Ca2+ can improve the degradation ability of the bacteria KL2-13.Atoo low concentration of Tween-80 does not show obvious promotion to the de- grading bacterium KL2-13, and an excessively high concentration can decrease the degradation ability of the bacterium, the best dosage of which is 2%. The hydrocarbon degrading rate reached 59.07%±0.37% under the optimum culture conditions. | Zhao Dongfeng Wu Weilin Zhang Yunbo Liu Qiyou Yang Haibin Zhao Chaocheng | 2011 | China Petroleum Processing & Petrochemical Technology2011，13，4： | 1 |
| 11 | Comparison of steady state and integral dynamic data reconciliation 显示文摘 | Bagajewicz M J Jiang Qiyou | 2000 | Comp Chem Eng2000，24，： | 1 |
| 12 | Incorporating catechol into electroactive polypyrrole nanowires on titanium to promote hydroxyapatite formation显示文摘To improve the osteointegration property of biomedical titanium,nano-architectured electroactive coating was synthesized through the electrochemical polymerization of dopamine and pyrrole.The highly binding affinity of Ca2t to the catechol moiety of doped dopamine enabled efficient interaction between polypyrrole/polydopamine nanowires and mineral ions.The results indicate that the PPy/PDA nanowires preserved its efficient electro-activity and accelerated the hydroxyapatite deposition in a simulated body fluid.The PPy/PDA nanowires coating could be applied to promote the osteointegration of titanium implant. | Zhengao Wang Jinquan Zeng Guoxin Tan Jingwen Liao Lei Zhou Junqi Chen Peng Yu Qiyou Wang Chengyun Ning | 2018 | Bioactive Materials2018，3，1： | 1 |
| 13 | The Photophysical Properties of Quaternary Lanthanide (Eu3+, Tb3+, Sm3+, Dy3+) Functional Molecular Complexes显示文摘 | Bing Yan Qiyou Xie | 2004 | Monatshefte für Chemie / Chemical Monthly2004，，7： | 1 |
| 14 | Free-standing phosphorous-doped molybdenum nitride in 3D carbon nanosheet towards hydrogen evolution at all pH values显示文摘Highly efficient electrocatalysts towards hydrogen evolution reaction(HER) with large current density at all-pH values are critical for the sustainable hydrogen production. Herein, we report a free-standing HER electrode, phosphorous-doped molybdenum nitride nanoparticles embedded in 3-dimentional carbon nanosheet matrix(P-Mo2N-CNS) fabricated via one-step carbonization and in-situ formation. The asprepared catalyst shows free-standing architecture with interconnected porous microstructure. P-doped Mo2N nanoparticles with an average diameter of 4.4 nm are well embedded in the 3-dimentional vertical carbon nanosheets matrix. Remarkable electrocatalytic HER performance is observed in alkaline, neutral and acidic media at large current densities. The overpotential of P-Mo2N-CNS to drive a current density of 100 mA cm-2 in 0.5 M H2SO4 and 1.0 M PBS is only 181 and 221 mV, respectively. In particular, the current density reaches up to 1000 mA cm-2 at a low overpotential of 256 mV in 1.0 M KOH, much better than that of the commercial Pt/C catalyst. Density functional theory calculations suggest the optimized H sorption kinetics on Mo2N after P doping, elucidating the superior activity. | Qiyou Wang Yan Zhang Wenpeng Ni Yi Zhang Tian Sun Jiaheng Zhang Junfei Duan Yang Gao Shiguo Zhang | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 15 | Characterization and Preparation of Aspergillus niger Naringinase for Debittering Citrus Juice显示文摘 | HuiNi FengChen HuinongCai AnfengXiao QiYou YunzhenLu | 2012 | Journal of Food Science2012，，1： | 1 |
| 16 | Numerical Simulation of Aerodynamic Characteristics of Helicopter Rotor with Tip Slots显示文摘Effects of tip slots on the aerodynamic characteristics of helicopter rotor were investigated numerically by solving three-dimensional Navier-Stokes equations based on unstructured overset grids algorithm.Improved delayed detached eddy simulation (IDDES) based on the Spalart-Allmaras turbulence model and adaptive grid refinement technique were employed.Several slots in the rotor blade tip were designed on the base of Caradonna-Tung rotor to study the effect of tip slots.Numerical results show that tip slots are able to introduce the airflow from the leading edge and turn it in the spanwise direction to be ejected out of the face at the rotor blade tip,which can reduce the strength of the rotor blade tip vortex and accelerate the dissipation process.Although tip slots may lead to the decrease of airfoils' lift coefficient at the root of the rotor blade,it can increase the lift coefficient of airfoils at the rotor blade tip,so the lift of the rotor with tip slots is almost the same as that of the rotor without tip slots.In addition,tip slots can also reduce the intensity of the tip shock wave,which is beneficial to reduce the wave drag of the rotor. | Chen Rongqian Wang Xu Cheng Qiyou Zhu Chengxiang You Yancheng | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，6： | 1 |
| 17 | Integral Approach to Plant Linear Dynamic Reconciliation 显示文摘 | Mignel J Bagajewicz Qiyou Jiang | 1997 | AIChE J1997，43，10： | 1 |
| 18 | Selection of functional consortium for crude oil-contaminated soil remediation显示文摘 | Dongfeng Zhao Chunshuang Liu Lihong Liu Yunbo Zhang Qiyou Liu Wei-Min Wu | 2011 | International Biodeterioration & Biodegradation2011，，8： | 1 |
| 19 | A Preliminary Report of Penile Transplantation显示文摘 | Weilie Hu Jun Lu Lichao Zhang Wen Wu Haibo Nie Yunsong Zhu Zhixiong Deng Yongbing Zhao Wen Sheng Qiyou Chao Xiaofu Qiu Jinghua Yang Ying Bai | 2006 | European Urology2006，，4： | 1 |
| 20 | Studies on dietary phosphorus requirement of juvenile Siberian sturgeon显示文摘 | Xu Qiyou Xu Hong Wang Chang’an | 2011 | Journal of Applied Ichthyology2011，27，： | 1 |
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