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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 3 | The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells显示文摘Background:Chemotherapy resistance is a primary reason of ovarian cancer therapy failure;hence it is important to investigate the underlying mechanisms of chemotherapy resistance and develop novel potential therapeutic targets.Methods:RNA sequencing of cisplatin-resistant and sensitive(chemoresis-tant and chemosensitive,respectively)ovarian cancer organoids was performed,followed by detection of the expression level of fibrillin-1(FBN1)in organoids and clinical specimens of ovarian cancer.Subsequently,glucose metabolism,angiogenesis,and chemosensitivity were analyzed in structural glycoprotein FBNl-knockout cisplatin-resistant ovarian cancer organoids and cell lines.To gain insights into the specific functions and mechanisms of action of FBN1 in ovarian cancer,immunoprecipitation,silver nitrate staining,mass spectrometry,immunofluorescence,Western blotting,and Forister resonance energy transfer-fluorescence lifetime imaging analyses were performed,followed by in vivo assays using vertebrate model systems of nude mice and zebrafish.Results:FBN1 expression was significantly enhanced in cisplatin-resistant ovar-ian cancer organoids and tissues,indicating that FBNI might be a key factor in chemoresistance of ovarian cancer.We also discovered that FBN1 sustained the energy stress and induced angiogenesis in vitro and in vivo,which promoted the cisplatin-resistance of ovarian cancer.Knockout of FBN1 combined with treat-ment of the antiangiogenic drug apatinib improved the cisplatin-sensitivity of ovarian cancer cells.Mechanistically,FBN1 mediated the phosphorylation of vascular endothelial growth factor receptor 2(VEGFR2)at the Tyrl054 residue,which activated its downstream focal adhesion kinase(FAK)/protein kinase B(PKB or AKT)pathway,induced the phosphorylation of signal transducer and activator of transcription 2(STAT2)at the tyrosine residue 690(Tyr690),pro-moted the nuclear translocation of STAT2,and ultimately altered the expression of genes associated with STAT2-mediated angiogenesis and glycolysis.Conclusions:The FBN1/VEGFR2/STAT2 signaling axis may induce chemore-sistance of ovarian cancer cells by participating in the process of glycolysis and angiogenesis.The present study suggested a novel FBNl-targeted therapy and/or combination of FBN1 inhibition and antiangiogenic drug for treating ovarian cancer. | Ziliang Wang Wei Chen Ling Zuo Midie Xu Yong Wu Jiami Huang Xu Zhang Yongheng Li Jing Wang Jing Chen Husheng Wang Huizhen Sun | 2022 | Cancer Communications2022，42，3： | 3 |
| 4 | A decision tree based decomposition method for oil refinery scheduling显示文摘Refinery scheduling attracts increasing concerns in both academic and industrial communities in recent years.However, due to the complexity of refinery processes, little has been reported for success use in real world refineries. In academic studies, refinery scheduling is usually treated as an integrated, large-scale optimization problem,though such complex optimization problems are extremely difficult to solve. In this paper, we proposed a way to exploit the prior knowledge existing in refineries, and developed a decision making system to guide the scheduling process. For a real world fuel oil oriented refinery, ten adjusting process scales are predetermined. A C4.5 decision tree works based on the finished oil demand plan to classify the corresponding category(i.e. adjusting scale). Then,a specific sub-scheduling problem with respect to the determined adjusting scale is solved. The proposed strategy is demonstrated with a scheduling case originated from a real world refinery. | Xiaoyong Gao Dexian Huang Yongheng Jiang Tao Chen | 2018 | Chinese Journal of Chemical Engineering2018，26，8： | 2 |
| 5 | The chromosome-level Stevia genome provides insights into steviol glycoside biosynthesis显示文摘Stevia(Stevia rebaudiana Bertoni)is well known for its very sweet steviol glycosides(SGs)consisting of a common tetracyclic diterpenoid steviol backbone and a variable glycone.Steviol glycosides are 150–300 times sweeter than sucrose and are used as natural zero-calorie sweeteners.However,the most promising compounds are biosynthesized in small amounts.Based on Illumina,PacBio,and Hi-C sequencing,we constructed a chromosome-level assembly of Stevia covering 1416 Mb with a contig N50 value of 616.85 kb and a scaffold N50 value of 106.55 Mb.More than four-fifths of the Stevia genome consisted of repetitive elements.We annotated 44,143 high-confidence protein-coding genes in the high-quality genome.Genome evolution analysis suggested that Stevia and sunflower diverged~29.4 million years ago(Mya),shortly after the whole-genome duplication(WGD)event(WGD-2,~32.1 Mya)that occurred in their common ancestor.Comparative genomic analysis revealed that the expanded genes in Stevia were mainly enriched for biosynthesis of specialized metabolites,especially biosynthesis of terpenoid backbones,and for further oxidation and glycosylation of these compounds.We further identified all candidate genes involved in SG biosynthesis.Collectively,our current findings on the Stevia reference genome will be very helpful for dissecting the evolutionary history of Stevia and for discovering novel genes contributing to SG biosynthesis and other important agronomic traits in future breeding programs. | Xiaoyang Xu Haiyan Yuan Xiaqing Yu Suzhen Huang Yuming Sun Ting Zhang Qingquan Liu Haiying Tong Yongxia Zhang Yinjie Wang Chunxiao Liu Lei Wu Menglan Hou Yongheng Yang | 2021 | Horticulture Research2021，8，1： | 2 |
| 6 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | Jianlong Wang Yongheng Huang Xuan Zhao | 2003 | Bioresource Technology2003，，2： | 1 |
| 7 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | JIANLONG WANG YONGHENG HUANG XUAN ZHAO | 2004 | Bioresource Technology2004，93，2： | 1 |
| 8 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | Wang Jianglong Huang Yongheng Zhao Xuan | 2004 | Bioresource Technology2004，93，： | 1 |
| 9 | Performance and charac- teristics of anaerobic baffled reactor 显示文摘 | Wang Jian long Huang Yongheng | 2004 | Bioresouree Tech- nology2004，93，3： | 1 |
| 10 | Performance and characteristics of an anaerobic baffled reactor 显示文摘 | Wang Jianlong Huang Yongheng | 2004 | Bioresource Technology2004，93，： | 1 |
| 11 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | Jianlong Wang Yongheng Huang and Xuan Zhao | 2004 | Bioresource Technology2004，，93： | 1 |
| 12 | Trajectory Planning for Automated Driving Based on Ordinal Optimization显示文摘This paper proposes an approach based on Ordinal Optimization(OO) to solve trajectory planning for automated driving. As most planning approaches based on candidate curves optimize the trajectory curve and the velocity profile separately, this paper formulates the problem as an unified Non-Linear Programming(NLP) model,optimizing the trajectory curve and the acceleration profile(acceleration is the derivative of velocity) simultaneously.Then a hybrid optimization algorithm named OODE, developed by combining the idea of OO and Differential Evolution(DE), is proposed to solve the NLP model. With the acceleration profile optimized 'roughly', OODE computes and compares 'rough'(biased but computationally-easier) curve evaluations to select the best curve from candidates, so that a good enough curve can be obtained very efficiently. Then the acceleration profile is optimized again 'accurately' with the selected curve. Simulation results show that good enough solutions are ensured with a high probability and our method is capable of working in real time. | Xiaoxin Fu Yongheng Jiang Dexian Huang Kaisheng Huang Jingchun Wang | 2017 | Tsinghua Science and Technology2017，22，1： | 1 |
| 13 | Performance and Characteristics of an anaerobic baffled reactor (ABR) 显示文摘 | WANG Jianlong HUANG Yongheng | 2004 | Bioresource Tech2004，93，： | 1 |
| 14 | A web-based information system for MCNP simulation of irradiation of complex shaped foods显示文摘 | Huang Yongheng Kim J Moreira RG | 2008 | Applied Engineering in Agriculture2008，24，2： | 1 |
| 15 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | Wang Jianlong Huang Yongheng Zhao Xuan | 2004 | Bioresour Technol2004，93，2： | 1 |
| 16 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | Jianlong Wang Yongheng Huang Xuan Zhao | 2003 | Bioresource Technology2003，，2： | 1 |
| 17 | Performance and characteristics of an anaerobic baffled reactor显示文摘 | WANG Jianlong HUANG Yongheng ZHAO Xuan | 2004 | Bioresource Technology2004，93，： | 1 |
| 18 | Performance and characteristics of an anaerobic baffled reactor 显示文摘 | Wang Jianlong Huang Yongheng | 2004 | Bioresource Technology2004，93，3： | 1 |
| 19 | Performance and characteristics of an anaerobic baffled reactor 显示文摘 | Jianlong Wang Yongheng Huang Xuan Zhao | 2004 | Bioresource Technology2004，93，： | 1 |
| 20 | Performance and Characteristics of an anaerobic baffled reactor显示文摘 | Wang Jianlong Huang Yongheng | 2004 | BioresourceTechnology2004，93，3： | 1 |
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