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| 1 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 2 | Particle-bound PCDD/Fs in the Atmosphere of an Electronic Waste Dismantling Area in China显示文摘Objective Particulate samples from the atmosphere in an electronic waste dismantling area were collected to investigate the levels and sources of polychlorinated dibenzo‐p‐dioxins and dibenzofurans (PCDD/Fs). Methods Particulate samples including total suspended particulates (TSP) and particulate matter <2.5 μm diameter (PM2.5) were collected on selected non‐rainy days in summer (Jul 10-12, 2006) and winter (Jan 11-13, 2007) from Fengjiang (FJ), an electronic waste (e‐waste) dismantling area in eastern China, and an adjacent area Luqiao (LQ). The samples were analyzed by isotope dilution ‐ high resolution gas chromatography / high resolution mass spectrometry (HRGC/HRMS). Results In FJ, the mean PCDD/F concentrations (mean TEQ values) were 280.6 pg Nm‐3 (3.432 pg WHO‐TEQ Nm‐3) for the TSP samples and 223.3 pg Nm‐3 (3.180 pg WHO‐TEQ Nm‐3) for the PM2.5 samples. The total PCDD/F concentrations and TEQs in the PM2.5 samples were about 66.8%‐108.0% of the TSP samples, indicating that the fine particles contained higher levels of PCDD/Fs than coarse particles. The PCDD/F levels in FJ were much higher than those detected in common urban areas around the world, suggesting that the study area was heavily polluted by PCDD/Fs. Furthermore, the total average daily PCDD/F intake in FJ was estimated at 62.11 pg WHO‐TEQ kg‐1·day‐1 for adults and 110.11 pg WHO‐TEQ kg‐1·day‐1 for children, which greatly exceeds the WHO (1998) tolerable daily intake of 1-4 pg of WHO‐TEQ kg‐1·day‐1. Conclusion The PCDD/F homologues and congener profiles confirmed that the PCDD/Fs in FJ originated from crude e‐waste recycling activities. The severe dioxin pollution present in FJ has also substantially influenced the adjacent area of LQ through atmospheric transport. Open burning of medical waste was another source of PCDD/Fs identified in LQ. | WEN Sheng GONG Yan LI JingGuang SHI TingMing ZHAO YunFeng WU YongNing | 2011 | Biomedical and Environmental Sciences2011，24，2： | 6 |
| 3 | Geographic scenario:a possible foundation for further development of virtual geographic environments显示文摘It has been two decades since virtual geographic environments(VGEs)were initially proposed.While relevant theories and technologies are evolving,data organization models have always been the foundation of VGE development,and they require further exploration.Based on the comprehensive consideration of the characteristics of VGEs,geographic scene is proposed to organize geographic information and data.We empirically find that geographic scene provides a suitable organization schema to support geo-visualization,geo-simulation,and geo-collaboration.To systematically investigate the concept and method of geographic scene,Geographic Scenario is proposed as the theory on developing geographic scene,and corresponding key issues of the Geographic Scenario are illustrated in this article.Prospects of the proposed method are discussed with the hope of informing future studies of VGEs. | Guonian Lü Min Chen Linwang Yuan Liangchen Zhou Yongning Wen Mingguan Wu Bin Hu Zhaoyuan Yu Songshan Yue Yehua Sheng | 2018 | International Journal of Digital Earth2018，11，4： | 4 |
| 4 | Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction显示文摘Regionality,comprehensiveness,and complexity are regarded as the basic characteristics of geography.The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era.This paper focuses on the important method in geographic research:Geographic modeling and simulation.First,we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era.Then,the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives:Model resources,modeling processes,and operational architecture.Finally,we discern avenues for future research of geographic modeling and simulation systems for the study of regional,comprehensive and complex characteristics of geography.Based on these analyses,we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization,which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era. | Min CHEN Guonian LV Chenghu ZHOU Hui LIN Zaiyang MA Songshan YUE Yongning WEN Fengyuan ZHANG Jin WANG Zhiyi ZHU Kai XU Yuanqing HE | 2021 | Science China Earth Sciences2021，64，8： | 3 |
| 5 | Epidemiology of foodborne disease outbreaks caused by Vibrio parahaemolyticus , China, 2003–2008显示文摘 | Yongning Wu Jian Wen Yi Ma Xiaochen Ma Yan Chen | 2014 | Food Control2014，，： | 2 |
| 6 | Prototyping an open environment for sharing geographical analysis models on cloud computing platform显示文摘The sharing of geographical analysis models is of crucial importance for simulating geographic processes and phenomena in the current geographical information systems(e.g.Digital Earth),but there remain some issues that have not been completely resolved.The challenges include,eliminating model heterogeneity and searching for suitable infrastructures to support the open sharing and effective execution of models.Taking advantage of cloud computing,this article aims to address the above issues and develop an open environment for geographical analysis model sharing.On the basis of the analysis of the applicability of cloud computing,the architecture of the open environment is proposed.More importantly,key strategies designed for heterogeneous model description,model encapsulating as well as model deploying and transparent accessing in the cloud are discussed in detail to establish such an environment.Finally,the prototype environment is implemented,and experiments were conducted to verify the environment’s feasibility to support the sharing of geographical analysis models. | Yongning Wen Min Chen Guonian Lu Hui Lin Li He Songshan Yue | 2013 | International Journal of Digital Earth2013，6，4： | 1 |
| 7 | Construction of a virtual lunar environment platform显示文摘Many of the world’s powerful and wealthy nations,including China,have devoted both large amounts of funding and considerable promotion to lunar research and exploration.The launch of Chinese Chang’e-1 satellite and the construction of the scientific observation data platform created a favourable opportunity for research into the lunar geometrical,physical and chemical environment.Based on this background,a Wide Area Network(WAN)based virtual lunar environment was constructed for observation data sharing and further exploration.The systematic architecture and framework were introduced and then strategies of mass data(e.g.lunar digital elevation model,lunar digital orthophoto map and typical thematic lunar data)organisation,integration,management and scheduling were then set up to achieve the 3D visualisation of typical lunar geomorphic features.Furthermore,the integration method of 3D lunar data and the process model of impact craters were studied;thus,the whole lunar and celestial collision process could be dynamically simulated.The results indicate that the WAN-based virtual lunar platform can be used effectively for public information sharing,scientific exploration and further to promote the development of deep space exploration in China. | Min Chen Hui Lin Yongning Wen Li He Mingyuan Hu | 2013 | International Journal of Digital Earth2013，6，5： | 1 |
| 8 | Self-Reported Food Allergy Prevalence Among Elementary School Children—Nanchang City, Jiangxi Province, China, 2021显示文摘What is already known about this topic?The prevalence of food allergy(FA)among the general population has been increasing in recent decades,and seriously affects the physical and mental health and the quality of life of many people—especially children.What is added by this report?The survey estimated self-reported FA prevalence using a standardized FA questionnaire among school children in Nanchang City,Jiangxi Province,China in 2021.What are the implications for public health practice?Based on the local,epidemiological characteristics of food allergy,public policies on the prevention and management of FA should be developed and preventive practices should be promoted to decrease the overall prevalence of FA. | Hua Feng Nan Luo Fang Chen Xinyu Li Yu Wen Chengwei Liu Yan Chen Yongning Wu | 2022 | China CDC weekly2022，4，34： | 1 |
| 9 | A framework on task configuration and execution for distributed geographical simulation显示文摘Geographical simulation is a popular method in geographical and environmental research.Many models developed to address geographic and environmental issues are distributed worldwide.However,due to the lack of portals,these models are still difficult to invoke for geographical simulations in open web environments.This study designs and develops a framework to assemble service-oriented models from volunteers distributed worldwide for geographical simulations on the web.The framework consists of three layers(task layer,data exchange layer,and model execution layer)that establish a network of serviceoriented locally shared models and simulation tasks for user configurations.With the help of such a framework,users can configure simulation tasks and invoke suitable models shared worldwide for geographical simulations.This article provides an application of the distributed simulation of gross primary production(GPP)by the Biome-BioGeochemical Cycles(BGC)model in China.This application shows that the framework can be beneficial for model assembly from volunteers’computers and distributed simulation tasks that are run for geographical and environmental issues,which can be applied to Digital Earth initiatives. | Fengyuan Zhang Min Chen Ming Wang Zihuan Wang Shuo Zhang Songshan Yue Yongning Wen Guonian Lü | 2021 | International Journal of Digital Earth2021，14，9： | 1 |
| 10 | Virtual Geographic Environments (VGEs): A New Generation of Geographic Analysis Tool显示文摘 | Hui Lin Min Chen Guonian Lu Qing Zhu Jiahua Gong Xiong You Yongning Wen Bingli Xu Mingyuan Hu | 2013 | Earth-Science Reviews2013，，： | 1 |
| 11 | The human body burden of polybrominated diphenyl ethers and their relationships with thyroid hormones in the general population in Northern China显示文摘 | Feifei Huang Sheng Wen Jingguang Li Yuxin Zhong Yunfeng Zhao Yongning Wu | 2014 | Science of the Total Environment2014，，： | 1 |
| 12 | A model-service deployment strategy for collaboratively sharing geo-analysis models in an open web environment显示文摘Geo-analysis models can be shared and reused via model-services to support more effective responses to risks and help to build a sustainable world.The deployment of model-services typically requires significant effort,primarily because of the complexity and disciplinary specifics of geo-analysis models.Various modelling participants engage in the collaborative modelling process:geo-analysis model resources are provided by model providers,computational resources are provided by computational resource providers,and the published model-services are accessed by model users.This paper primarily focuses on model-service deployment,with the basic goal of providing a collaboration-oriented method for modelling participants to conveniently work together and make full use of modelling and computational resources across an open web environment.For model resource providers,a model-deployment description method is studied to help build model-deployment packages;for computational resource providers,a computational resource description method is studied to help build model-service containers and connectors.An experimental system for sharing and reusing geo-analysis models is built to verify the capability and feasibility of the proposed methods.Through this strategy,modellers from dispersed regions can work together more easily,thus providing dynamic and reliable geospatial information for Future Earth studies. | Yongning Wen Min Chen Songshan Yue Peibei Zheng Guoqiang Peng Guonian Lu | 2017 | International Journal of Digital Earth2017，10，4： | 0 |
| 13 | A new academic impact metric for evaluating geographic simulation models显示文摘Geographic simulation models can be used to explore and better understand the geographical environment. Recent advances in geographic and socio-environmental research have led to a dramatic increase in the number of models used for this purpose. Some model repositories provide opportunities for users to explore and apply models,but few provide a general evaluation method for assessing the applicability and recognition of models. In this study,an academic impact evaluation method for models is proposed. Five indices are designed based on their pertinence. The analytical hierarchy process is used to calculate the index weights,and the academic impacts of models are quantified with the weighted sum method. The time range is controlled to evaluate the life-term and annual academic impacts of the models. Some models that met the evaluation criteria from different domains are then evaluated. The results show that the academic impact of a model can be quantified with the proposed method,and the major research areas that models impact are identified. | Kai Xu Min Chen Albert J.Kettner C.Michael Barton Barry F.W.Croke Anthony J.Jakeman Daniel P.Ames Hsiao-Hsuan Wang Susan M.Cuddy Songshan Yue Yongning Wen Fengyuan Zhang Yixuan Zhang Guonian Lü | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
| 14 | A new three-dimensional terrain-following tidal model of free-surface flows显示文摘一个三维的水动力学模型被介绍它联合一个地面追随者有一个水平地直角的曲线的坐标系统的垂直坐标接近河口,大陆人架,和港口适合复杂底部地形学和海岸线。更高效地解决管理方程,我们改进含蓄的方法,它是广泛地在水平二维的浅水方程的数字建模使用了的轮流出现的方向,并且把它递有相对小的计算努力的一个三维的潮汐的模型。通过几个测试用例和现实主义的应用在纸介绍了模型能够在近岸的区域模仿周期的往来活动的水流,风驱动的流动, Ekman 螺线,和潮汐的水流,这能被表明。 | Fuqiang LU | 2015 | Frontiers of Earth Science2015，9，4： | 0 |
| 15 | A topological framework for real-time 3D weather radar data processing显示文摘Real-time 3D weather radar data processing makes it possible to efficiently simulate meteorological processes in digital Earth and support the assessment of meteorological disasters.The current real-time meteorological operation system can only deal with radar data within 2D space as a flat map and lacks supporting 3D characteristics.Thus,valuable 3D information imbedded in radar data cannot be completely presented to meteorological experts.Due to the large amount of data and high complexity of radar data 3D operation,regular methods are not competent for supporting real-time 3D radar data processing and representation.This study aims to perform radar data 3D operations with high efficiency and instant speed to provide real-time 3D support for the meteorological field.In this paper,a topological framework composed of basic inner topological objects is proposed along with the quadtree structure and LOD architecture,based on which 3D operations on radar data can be conducted in a split second and 3D information can be presented in real time.As the applications of the proposed topological framework,two widely used 3D algorithms in the meteorological field are also implemented in this paper.Finally,a case study verifies the applicability and validity of the proposed topological framework. | Mingyue Lu Zhangjian Chen Jin Wang Qian Zhang Zaiyang Ma Min Chen Yongning Wen | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
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