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| 1 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 2 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 3 | Protective effect of Danhong injection in patients with acute myocardial infarction at a high risk of no-reflow during primary percutaneous coronary intervention显示文摘Objective To observe the effect of Danhong injection(DI)in patients with acute ST-segment elevation myocardial infarction(STEMI)at a high risk of no-reflow(NR)during primary percutaneous coronary intervention(PCI).Methods Patients were placed in a DI group and control group.The DI group was given DI and the control group was given physiologic saline.The administration lasted 4 to 6 days in both groups after PCI.Cardiac magnetic resonance(CMR)was carried out during the perioperative period(7±2 days).The primary endpoint of the study was myocardial infarct size(IS)imaged on delayed-enhancement CMR.The secondary endpoint was major adverse cardiac events observed 6 months after PCI.Results In total,160 high-risk NR patients were enrolled,and 110 patients completed the CMR examination.According to postoperative CMR,the Myocardial Salvage Index and left ventricular ejection fraction were higher in the DI group(0.57±0.13 vs.0.48±0.17,P<0.01;49.3%±6.9%vs.46.2%±7.7%,P=0.03,respectively),whereas the IS was lower(19.7%±5.6%vs.22.2%±6.5%,P=0.04),compared with that in the control group.These differences were observed to be significant.After 6 months,the prevalence of major adverse cardiac events in the DI group decreased compared with that in the control group,but the differences were not observed to be significant(P>0.05).Conclusion The application of DI can reduce the myocardial infarct size in STEMI patients at a high risk of NR during primary PCI. | Qi YOU Jing WANG Wei DONG Feng TIAN Hong-Xu LIU Jing JING Yun-Dai CHEN | 2019 | Journal of Geriatric Cardiology2019，16，5： | 15 |
| 4 | A new type of leak-floor flip bucket显示文摘Flip buckets are commonly used to discharge flow away from a hydraulic structure into the downstream to dissipate energy.A new leak-floor flip bucket is presented,making the ski-jump water jet a typical long-narrow nappe.Based on the model experiments and numerical simulation,the flow pattern,formation process and mechanism of the leak-floor flip bucket are studied.The results show that cross section flow shape develops from the'Y-type'to'|-type',and this is because the natural pressure difference is generated when water flows through the leak-floor area and moves transversely from both sides to the center.Different from the slit-type flip bucket with sidewall contraction,the leak-floor flit bucket makes the water jet narrow and long without high pressure on the side walls of the flip bucket.Under the same jet length condition,the maximum sidewall pressure of the slit-type is 4.67 times that of the leak-floor flip bucket.The effects of flow discharge on the jet length are less significant for the leak-floor bucket than for the slit-type bucket. | DENG Jun YANG ZhengLi TIAN Zhong ZHANG FaXing WEI WangRu YOU Xiang XU WeiLin | 2016 | Science China(Technological Sciences)2016，59，4： | 15 |
| 5 | Effects of warming and clipping on plant and soil properties of an alpine meadow in the Qinghai-Tibetan Plateau, China显示文摘Climate warming and livestock grazing are known to have great influences on alpine ecosystems like those of the Qinghai-Tibetan Plateau(QTP) in China. However, it is lacking of studies on the effects of warming and grazing on plant and soil properties in these alpine ecosystems. In this study, we reported the related research from manipulative experiment in 2010–2012 in the QTP. The aim of this study was to investigate the individual and combined effects of warming and clipping on plant and soil properties in the alpine meadow ecosystem. Infrared radiators were used to simulate climate warming starting in July 2010, while clipping was performed once in October 2011 to simulate the local livestock grazing. The experiment was designed as a randomized block consisting of five replications and four treatments: control(CK), warming(W), clipping(C) and warming+clipping combination(WC). The plant and soil properties were investigated in the growing season of the alpine meadow in 2012. The results showed that W and WC treatments significantly decreased relative humidity at 20-cm height above ground as well as significantly increases air temperature at the same height, surface temperature, and soil temperature at the depth of 0–30 cm. However, the C treatment did not significantly decrease soil moisture and soil temperature at the depth of 0–60 cm. Relative to CK, vegetation height and species number increased significantly in W and WC treatment, respectively, while vegetation aboveground biomass decreased significantly in C treatment in the early growing season. However, vegetation cover, species diversity, belowground biomass and soil properties at the depth of 0–30 cm did not differ significantly in W, C and WC treatments. Soil moisture increased at the depth of 40–100 cm in W and WC treatments, while belowground biomass, soil activated carbon, organic carbon and total nitrogen increased in the 30–50 cm soil layer in W, C and WC treatments. Although the initial responses of plant and soil properties to experimental warming and clipping were slow and weak, the drought induced by the downward shift of soil moisture in the upper soil layers may induce plant belowground biomass to transfer to the deeper soil layers. This movement would modify the distributions of soil activated carbon, organic carbon and total nitrogen. However, long-term data collection is needed to further explain this interesting phenomenon. | Man Hou XU Fei PENG Quan Gang YOU Jian GUO Xia Fei TIAN Min LIU Xian XUE | 2015 | Journal of Arid Land2015，7，2： | 14 |
| 6 | Application of next-generation sequencing technology to precision medicine in cancer: joint consensus of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology显示文摘Next-generation sequencing(NGS) technology is capable of sequencing millions or billions of DNA molecules simultaneously.Therefore, it represents a promising tool for the analysis of molecular targets for the initial diagnosis of disease, monitoring of disease progression, and identifying the mechanism of drug resistance. On behalf of the Tumor Biomarker Committee of the Chinese Society of Clinical Oncology(CSCO) and the China Actionable Genome Consortium(CAGC), the present expert group hereby proposes advisory guidelines on clinical applications of NGS technology for the analysis of cancer driver genes for precision cancer therapy. This group comprises an assembly of laboratory cancer geneticists, clinical oncologists, bioinformaticians,pathologists, and other professionals. After multiple rounds of discussions and revisions, the expert group has reached a preliminary consensus on the need of NGS in clinical diagnosis, its regulation, and compliance standards in clinical sample collection. Moreover, it has prepared NGS criteria, the sequencing standard operation procedure(SOP), data analysis, report, and NGS platform certification and validation. | Xuchao Zhang Zhiyong Liang Shengyue Wang Shun Lu Yong Song Ying Cheng Jianming Ying Weiping Liu Yingyong Hou Yangqiu Li Yi Liu Jun Hou Xiufeng Liu Jianyong Shao Yanhong Tai Zheng Wang Li Fu Hui Li Xiaojun Zhou Hua Bai Mengzhao Wang You Lu Jinji Yang Wenzhao Zhong Qing Zhou Xuening Yang Jie Wang Cheng Huang Xiaoqing Liu Xiaoyan Zhou Shirong Zhang Hongxia Tian Yu Chen Ruibao Ren Ning Liao Chunyan Wu Zhongzheng Zhu Hongming Pan Yanhong Gu Liwei Wang Yunpeng Liu Suzhan Zhang Tianshu Liu Gong Chen Zhimin Shao Binghe Xu Qingyuan Zhang Ruihua Xu Lin Shen Yilong Wu | 2019 | Cancer Biology & Medicine2019，16，1： | 14 |
| 7 | Estimates of genetic and phenotypic parameters for weight and length in Paralichthys olivaceus(Temminck et Schlegel)显示文摘The complete diallel cross design was employed to estimate the genetic parameters of the growth of Japanese flounder (Paralichthys olivaceus). A total of 60 full-sib families were cultivated and two growth-related traits, body weight (BW) and body length (BL), were examined at average 2, 3 and 8 months of age respectively, with 1 800 individuals measured in each age group (30 per family). Based on the additive-dominance-maternal-effect genetic analysis model, the restricted maximum likelihood approach was used to estimate various (co)variance components. The results showed that narrow-sense heritability estimates of BW and BL were respectively: 0.29 ± 0.01 and 0.22 ± 0.02 at 2 months of age, 0.32 ± 0.02 and 0.30 ± 0.04 at 3 months of age, 0.48 ± 0.04 and 0.40 ± 0.05 at 8 months of age; broad-sense heritability estimates were respectively: 0.44 ± 0.02 and 0.54 ± 0.04 at 2 months of age, 0.35 ± 0.01 and 0.36 ± 0.03 at 3 months of age, 0.49 ± 0.03 and 0.45 ± 0.04. All heritabilities were statistically significant (P <0.05). Additive genetic correlations between BW and BL at 2, 3 and 8 months of age were consistently positive and highly significant (P <0.01): 0.93 ± 0.02, 0.95 ± 0.03 and 0.92 ± 0.03 respectively. Maternal effect was significant (P <0.05) only at 2 months of age, and was not detected at 3 and 8 months of age. According to the heritability estimates, the mass selection strategy should be efficient for the breeding of Japanese flounder. | TIAN Yongsheng XU Tianjun LIANG You CHEN Songlin | 2011 | Acta Oceanologica Sinica2011，30，6： | 13 |
| 8 | Inflammatory cytokine gene polymorphisms increase the risk of atrophic gastritis and intestinal metaplasia显示文摘AIM: To investigate the effects of interleukin-8 (IL-8 ), macrophage migration inhibitory factor (MIF ) gene polymorphisms, Helicobacter pylori (H. pylori ) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM). METHODS: A total of 372 cases were selected from a cohort study in Linqu County, a high risk area for gastric cancer (GC) in northern China. To obtain a sufficient group size, patients with normal or superficial gastritis were included. Based on an average follow-up period of 56 mo, the 372 cases were divided into no progres-sion group (no histological progression from normal or superficial gastritis, n = 137), group Ⅰ (progressed from normal or superficial gastritis to SCAG, n = 134) and group Ⅱ (progressed from normal or superficial gastritis to IM, n = 101). IL-8 , MIF gene polymorphisms were detected by polymerase chain reaction-based denaturing high-performance liquid chromatography analysis and DNA sequencing. RESULTS: An increased risk of SCAG was found in subjects with IL-8-251 AA genotype [odds ratio (OR) = 2.62, 95% CI: 1.23-5.72] or IL-8-251 A allele carriers (AA + AT) (OR = 1.81, 95% CI: 1.06-3.09). An elevated risk of IM was found in subjects with IL-8-251 AT genotype (OR = 2.27, 95% CI: 1.25-4.14) or IL-8-251 A allele carriers (OR = 2.07, 95% CI: 1.16-3.69). An increased risk of SCAG was found in subjects with MIF-173 GC genotype (OR = 2.36, 95% CI: 1.38-4.02) or MIF-173 C allele carriers (GC + CC) (OR = 2.07, 95% CI: 1.21-3.55). An elevated risk of IM was found in subjects with MIF-173 CC genotype (OR = 2.27, 95% CI: 1.16-4.46) or MIF-173 C allele carriers (OR = 3.84, 95% CI: 1.58-9.34). The risk of SCAG and IM was more evident in subjects carrying IL-8-251 A allele (OR = 6.70, 95% CI: 1.29-9.78) or MIF-173 C allele (OR = 6.54, 95% CI: 2.97-14.20) and positive for H. pylori infection. CONCLUSION: IL-8-251 and MIF-173 gene polymorphisms are significantly associated with the risk of SCAG and IM in a population with a high risk of GC in Linqu County, Shandong Province, China. | Li, Zhong-Wu Wu, Ying Sun, Yu Liu, Lu-Ying Tian, Meng-Meng Feng, Guo-Shuang You, Wei-Cheng Li, Ji-You | 2010 | World Journal of Gastroenterology2010，16，14： | 11 |
| 9 | Ultrafast fiber lasers mode-locked by two-dimensional materials:review and prospect显示文摘The year 2019 marks the 10th anniversary of the first report of ultrafast fiber laser mode-locked by graphene.This result has had an important impact on ultrafast laser optics and continues to offer new horizons.Herein,we mainly review the linear and nonlinear photonic properties of two-dimensional(2D)materials,as well as their nonlinear applications in efficient passive mode-locking devices and ultrafast fiber lasers.Initial works and significant progress in this field,as well as new insights and challenges of 2D materials for ultrafast fiber lasers,are reviewed and analyzed. | TIAN JIANG KE YIN CONG WANG JIE YOU HAO OUYANG RUNLIN MIAO CHENXI ZHANG KE WEI HAN LI HAITAO CHEN RENYAN ZHANG XIN ZHENG ZHONGJIE XU XIANGAI CHENG HAN ZHANG | 2020 | Photonics Research2020，8，1： | 11 |
| 10 | Hemodynamic changes of fractional flow reserve after double kissing crush and provisional stenting technique for true bifurcation lesions显示文摘 | YE Fei CHEN Shao-liang ZHANG Jun-jie ZHU Zhong-sheng KAN Jing TIAN Nai-liang LIN Song LIU Zhi-zhong YOU Wei XU Hai-mei XU Jing | 2012 | Chinese Medical Journal2012，，15： | 10 |
| 11 | Adsorption behavior of carbon dioxide and methane in bituminous coal:A molecular simulation study显示文摘The adsorption behavior of CO_2, CH_4 and their mixtures in bituminous coal was investigated in this study. First, a bituminous coal model was built through molecular dynamic(MD) simulations, and it was confirmed to be reasonable by comparing the simulated results with the experimental data. Grand Canonical Monte Carlo(GCMC)simulations were then carried out to investigate the single and binary component adsorption of CO_2 and CH_4with the built bituminous coal model. For the single component adsorption, the isosteric heat of CO_2 adsorption is greater than that of CH_4 adsorption. CO_2 also exhibits stronger electrostatic interactions with the heteroatom groups in the bituminous coal model compared with CH_4, which can account for the larger adsorption capacity of CO_2 in the bituminous coal model. In the case of binary adsorption of CO_2 and CH_4mixtures, CO_2 exhibits the preferential adsorption compared with CH_4 under the studied conditions. The adsorption selectivity of CO_2 exhibited obvious change with increasing pressure. At lower pressure, the adsorption selectivity of CO_2 shows a rapid decrease with increasing the temperature, whereas it becomes insensitive to temperature at higher pressure. Additionally, the adsorption selectivity of CO_2 decreases gradually with the increase of the bulk CO_2 mole fraction and the depth of CO_2 injection site. | Jing You Li Tian Chao Zhang Hongxing Yao Wu Dou Bin Fan Songqing Hu | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 10 |
| 12 | Interpretation of Climate Change and Agricultural Adaptations by Local Household Farmers: a Case Study at Bin County, Northeast China显示文摘Although climate change impacts and agricultural adaptations have been studied extensively,how smallholder farmers perceive climate change and adapt their agricultural activities is poorly understood.Survey-based data(presents farmers’personal perceptions and adaptations to climate change)associated with external biophysical-socioeconomic data(presents real-world climate change)were used to develop a farmer-centered framework to explore climate change impacts and agricultural adaptations at a local level.A case study at Bin County(1980s-2010s),Northeast China,suggested that increased annual average temperature(0.6°C per decade)and decreased annual precipitation(46 mm per decade,both from meteorological datasets)were correctly perceived by 76 and 66.9%,respectively,of farmers from the survey,and that a longer growing season was confirmed by 70%of them.These reasonably correct perceptions enabled local farmers to make appropriate adaptations to cope with climate change:Longer season alternative varieties were found for maize and rice,which led to a significant yield increase for both crops.The longer season also affected crop choice:More farmers selected maize instead of soybean,as implicated from survey results by a large increase in the maize growing area.Comparing warming-related factors,we found that precipitation and agricultural disasters were the least likely causes for farmers’agricultural decisions.As a result,crop and variety selection,rather than disaster prevention and infrastructure improvement,was the most common ways for farmers to adapt to the notable warming trend in the study region. | YU Qiang-yi WU Wen-bin LIU Zhen-huan Peter H Verburg XIA Tian YANG Peng LU Zhong-jun YOU Liang-zhi TANG Hua-jun | 2014 | Journal of Integrative Agriculture2014，13，7： | 8 |
| 13 | Dasycarine, a New Quinoline Alkaloid from Dictamnus dasycarpus显示文摘Dasycarine, a new quinoline alkaloid along with five known compounds, dictamine, dihydroobacunone, obacunone, fraxinellone and β-sitosterol, were isolated from Dictamnus dasycarpus. The structure of dasycarine was identified as 4, 5, 8- trimethoxyl -3- (3- methyl -2- butenyl)- 2- quinone by 1D and 2D NMR techniques. | Jin CHEN Jing Sheng TANG Jun TIAN You Ping WANG Feng E WU | 2000 | Chinese Chemical Letters2000，11，8： | 7 |
| 14 | Protective effect of Yiguanjian decoction against DNA damage on concanavalin A-induced liver injury mice model显示文摘OBJECTIVE:To investigate the inhibitory effect of Yiguanjian decoction(YD) on DNA damage in Concanavalin A(Con A)-induced liver injury mice model and to explain the possible mechanism.METHODS:Totally 120 male BALB/c mice were randomly divided into 6 groups,20 mice each:normal group,model group,Bifendate group,YD low dose group,YD middle dose group and YD high dose group.Except normal group,liver injury model induced by Con A was established.While modeling,each mouse in YD group was given YD(0.4 m L/20 g per day) by intragastric administration(0.13 g YD for YD low dose group;0.26 g for YD middle dose group;0.52 g for YD high dose group).Bifendate group was given Bifendate(0.2 gnd model·kg-1 grou·d-1) by gavage.Normal group ap were fed with same volume of physiological saline daily.After 8 weeks,the serum alanine transaminase(ALT)and aspartate transaminase(AST) were tested.The hematoxylin-eosin staining was used to evaluate the grade of liver inflammation and liver fibrosis stage.Hepatocellular DNA damage was detected by single cell gel electrophoresis technology.The protein expression of tumor necrosis factor-α(TNF-α),Bax and Mut T Homolog 1(MTH1) was detected by western blotting and enzyme linked immunosorbent assay.Bax m RNA and MTH1 m RNA were detected by Real-time Polymerase Chain Reaction(PCR).RESULTS:YD can improve the degree of liver inflammation and fibrosis in the liver of chronic hepatitis mice,the dose effect relationship is remarkable(P < 0.05).YD can reduce liver cell DNA damage.The difference between YD middle dose group and model group was statistically significant(P < 0.05).YD middle dose group had decreased the protein expression of TNF-α in the mice liver of immunological liver injury(P < 0.05).YD can increase the protein expression of Bax(P < 0.05).Compared with normal group,the protein expression of MTH1 was decreased(P < 0.05),but there was no statistical significance between YD group and model group(P >0.05).YD can increase the m RNA expression of Bax and MTH1(both P < 0.05).CONCLUSION:YD can effectively inhibit the DNA damage in immunological liver injury mice,the mechanism may be that it can decrease the TNF-αand increase the Bax and MTH1 expression. | Tian Mengxi Liu Wenlan You Hongjie Zhao Qingzhou Ouyang Luodan Gao Biane Zhang Xin Che Niancong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 7 |
| 15 | Chemotherapy in conjunction with traditional Chinese medicine for survival of elderly patients with advanced non-small-cell lung cancer:protocol for a randomized double-blind controlled trial显示文摘BACKG ROUND: Traditional Chinese medicine(TCM) is considered an important complementary therapy with beneficial effects for cancer patients.Elderly patients with non-small-cell lung cancer(NSCLC) are a complex patient group with increasing co-morbidity and shrinking physiological reserve, and may derive substantial benefit from the supportive aspects of TCM.Researchers from Shanghai Longhua Hospital found that qi and yin deficiency is a common syndrome in patients with stage III or IV lung cancer.This project was designed to study the combination of single-agent chemotherapy with TCM methods of benefiting qi and yin in elderly patients with advanced NSCLC.METHODS AND DESIGN: This is a double-blind controlled, multi-center, and prospective study with randomly selected participants from elderly NSCLC patients in China.Seventy-six patients who meet the inclusion criteria will be allocated into two groups, which will receive treatments of 3-week single-agent chemotherapy with TCM or placebo for four cycles.Progression-free survival(PFS) is the primary end point, and the secondary end points are overall survival, objective response rate, time-to-progression, and quality of life(EORTC QLQ-LC43, and TCM syndrome score).Mean while, other end points such as toxicity, side effects and safety of the treatments will be assessed.DISCUSSION: Results from this study may provide evidence on the effectiveness, and parameters for the usage of single-agent chemotherapy combined with or without TCM on PFS of elderly patients with NSCLC.TRIAL REGISTRATION: ClinicalTrials.gov.(Identifier: NCT01780181). | Zhi-yi Zhou Ling Xu He-gen Li Jian-hui Tian Li-jing Jiao Sheng-fu You Zhi-fen Han Yi Jiang Hui-ru Guo Hui Liu | 2014 | Journal of Integrative Medicine2014，12，3： | 6 |
| 16 | Value of c-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Population显示文摘Objective:To investigate the value of c-Met in predicting progression of precancerous gastric lesions.Methods:A population-based study was conducted to detect the overexpression of c-Met by immunohisto-chemical analysis in 124 subjects with precancerous gastric lesions.Odds ratio(OR) and 95% confidence interval(95% CI) were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions.Results:The positive rates of c-Met were 55.7% in intestinal metaplasia(IM) and 64.8% in dysplasia(DYS),respectively.Stratified analysis indicated that the proportion of c-Met overexpression was 71.4% for IM progressive group,significantly higher than that for IM persistent group(40.0%,P<0.05).Compared to the IM persistent group,unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.416(95% CI:2.084-26.398).Conclusion: c‐Met plays an important role in gastric carcinogenesis. Detection of c‐Met is of value in predicting progression of precancerous gastric lesions from IM to DYS. | YU Sun Meng-meng Tian Li-xin Zhou Wei-cheng You Ji-you Li | 2012 | Chinese Journal of Cancer Research2012，24，1： | 6 |
| 17 | A survey of next generation mobile communications researchin China显示文摘With the rapid development of wireless communication networks, the fourth generation (4G) has emerged to move beyond the limitations of the third generation (3G), with increased bandwidth, enhanced quality of services, and reduced costs of resources. In this paper, we discuss the key technologies of 4G and focus on surveying the ongoing research in 4G communications in China. The 4G technologies under investigation include multicarrier transmission, multiple antenna techniques, carrier aggregation, relays, cognitive radio, distributed antenna systems, network convergence, and network self-optimization. These technologies are the building blocks of 4G and contribute largely to the requirements of International Mobile Telecommunications Advanced (IMT-Advanced). For each technology, its benefits, research topics, and some existing approaches are examined. Finally, we briefly discuss the challenges and future research issues in 4G systems. | TIAN JinFeng 1,2 , ZHENG XiaoYing 2,3 , HU HongLin 1,2 YOU XiaoHu 1,3 1 Shanghai Research Center for Wireless Communications (WiCO), Shanghai 200335, China 2 Shanghai Institute of Microsystem and Information Technology (SIMIT), Chinese Academy of Sciences (CAS), Shanghai 200050, China 3 National Mobile Communications Research Laboratory, Southeast University (SEU), Nanjing 210096, China | 2011 | Chinese Science Bulletin2011，56，27： | 6 |
| 18 | Advances of surface-enhanced Raman and IR spectroscopies: from nano/microstructures to macro-optical design显示文摘Raman and infrared(IR)spectroscopy are powerful analytical techniques,but have intrinsically low detection sensitivity.There have been three major steps(i)to advance the optical system of the light excitation,collection,and detection since 1920s,(ii)to utilize nanostructure-based surface-enhanced Raman scattering(SERS)and surface-enhanced infrared absorption(SEIRA)since 1990s,and(iii)to rationally couple(i)and(ii)for maximizing the total detection sensitivity since 2010s.After surveying the history of SERS and SEIRA,we outline the principle of plasmonics and the different mechanisms of SERS and SEIRA.We describe various interactions of light with nano/microstructures,localized surface plasmon,surface plasmon polariton,and lightning-rod effect.Their coupling effects can significantly increase the surface sensitivity by designing nanoparticle–nanoparticle and nanoparticle–substrate configuration.As the nano/microstructures have specific optical near-field and far-field behaviors,we focus on how to systematically design the macro-optical systems to maximize the excitation efficiency and detection sensitivity.We enumerate the key optical designs in particular ATR-based operation modes of directional excitation and emission from visible to IR spectral region.We also present some latest advancements on scanning-probe microscopy-based nanoscale spectroscopy.Finally,prospects and further developments of this field are given with emphasis on emerging techniques and methodologies. | Hai-Long Wang En-Ming You Rajapandiyan Panneerselvam Song-Yuan Ding Zhong-Qun Tian | 2021 | Light(Science & Applications)2021，10，9： | 5 |
| 19 | Thermal sprayed WC-Co coatings and their mechanical properties显示文摘HVOF thermal spraying tests were carried out for thermal spraying the coatings with two kinds of cermet powders,which are microstructured Sulzer Metco Diamalloy 2004 WC-12%Co powders and nanostructured WC-12%Co powders.The microstructures of the as-prepared WC-12%Co coatings were then characterized by using XRD analyzer and SEM.The mechanical properties of the two coatings were evaluated by microhardness test,bend test,cup test,tensile test and abrasive wear test.The results showed that the mechanical properties of WC-12%Co coatings sprayed with nanostructured WC-12%Co powder is higher than that of coatings sprayed with microstructured WC-12%Co powders,and the reasons were discussed. | WANG You,YANG Yong,TIAN Wei,and LI Chonggui Department of Materials Science,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 5 |
| 20 | Tea Consumption is Associated with Increased Risk of Kidney Stones in Northern Chinese: A Cross-sectional Study显示文摘Kidney stones are a common urinary system condition that can progress to kidney disease.Previous studies on the association between tea consumption and kidney stones are inconsistent.A cross‐sectional study to investigate the association between tea consumption and kidney stones was conducted from 2013 to 2014 and recruited 9,078northern Chinese adults.A total of 8,807participants were included in the final analysis. | WU Zhong Biao JIANG Tian LIN Guo Bing WANG You Xin ZHOU Yong CHEN Zhen Qian XU Yong Ming YE Hai Bo CHEN Bo Jun BAO Xiao Zhao ZHANG Cun Ming | 2017 | Biomedical and Environmental Sciences2017，30，12： | 5 |
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