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| 1 | A multicenter hospital-based diagnosis study of automated breast ultrasound system in detecting breast cancer among Chinese women显示文摘Objective: The automated breast ultrasound system(ABUS) is a potential method for breast cancer detection;however, its diagnostic performance remains unclear. We conducted a hospital-based multicenter diagnostic study to evaluate the clinical performance of the ABUS for breast cancer detection by comparing it to handheld ultrasound(HHUS) and mammography(MG).Methods: Eligible participants underwent HHUS and ABUS testing; women aged 40–69 years additionally underwent MG. Images were interpreted using the Breast Imaging Reporting and Data System(BI-RADS).Women in the BI-RADS categories 1–2 were considered negative. Women classified as BI-RADS 3 underwent magnetic resonance imaging to distinguish true-and false-negative results. Core aspiration or surgical biopsy was performed in women classified as BI-RADS 4–5, followed by a pathological diagnosis. Kappa values and agreement rates were calculated between ABUS, HHUS and MG.Results: A total of 1,973 women were included in the final analysis. Of these, 1,353(68.6%) and 620(31.4%)were classified as BI-RADS categories 1–3 and 4–5, respectively. In the older age group, the agreement rate and Kappa value between the ABUS and HHUS were 94.0% and 0.860(P<0.001), respectively; they were 89.2% and0.735(P<0.001) between the ABUS and MG, respectively. Regarding consistency between imaging and pathology results, 78.6% of women classified as BI-RADS 4–5 based on the ABUS were diagnosed with precancerous lesions or cancer; which was 7.2% higher than that of women based on HHUS. For BI-RADS 1–2, the false-negative rates of the ABUS and HHUS were almost identical and were much lower than those of MG.Conclusions: We observed a good diagnostic reliability for the ABUS. Considering its performance for breast cancer detection in women with high-density breasts and its lower operator dependence, the ABUS is a promising option for breast cancer detection in China. | Xi Zhang Xi Lin Yanjuan Tan Ying Zhu Hui Wang Ruimei Feng Guoxue Tang Xiang Zhou Anhua Li Youlin Qiao | 2018 | Chinese Journal of Cancer Research2018，30，2： | 13 |
| 2 | Calibration of microwave network analyzer显示文摘This paper presents a systematic description of the methods for calibrating microwave network analyzer and test fixtures, and discusses the problems arising in the calibration. The general criteria for choosing calibration standards and corresponding algorithms are discussed and suggestions to overcome these problems and improve the calibration accuracy are also given. It has been found that for reciprocal test fixtures, the four equations obtained with the thru standard can be used at the same time. Meanwhile,the calibration accuracy can be improved. It has been shown that using the same calibration procedures but different algorithms may lead to the occurrence of frequency limitation. | ZHU Ninghua WANG Youlin CHEN Zhenyu | 2004 | Science China(Technological Sciences)2004，47，2： | 4 |
| 3 | The Zα domain of fish PKZ facilitates the B-Z conformational transition of oligonucleotide DNAs with d(GC), inserts显示文摘PKZ (象 PKR 一样) 在鱼作为 elF2 kinase 家庭的一个成员被发现,它在 C 终端并且也拥有 eIF2 kinase 的一个保存催化领域在 N 终端的二个 Z-DNA-binding 领域(Z1 和 Z2 ) 。PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能仍然保持不清楚。调查 PKZ Z 怎么与 Z-DNA 交往的分子的机制,我们在 Escherichia coli 罗塞达碑紧张表示了 Z 多肽 Z12 并且在 Ni-NTA 上由亲密关系层析净化了树脂。oligonucleotide DNA 与的不同长度各种各样插入,也就是 d (GC ) n (n = 6, 8, 10, 13 ) , d (TA ) n (n = 6, 10 ) , non-d (GC ) ,和 non-d (TA ) ,被设计并且综合。圆形的二色性光谱和胶化活动性移动试金被用来在不同 oligonucleotide DNA 的 conformational 转变上调查 Z12 的效果。结果证明 oligonucleotide DNA 当 Z12 不在时保留了常规 B-DNA 符合构造。与 Z12 滴定的增加的数量, d (GC ) n 被认出并且在某种程度上把符合构造变换成 Z-DNA。与增加重复数字(从 n = 6 到 n = 13 ) , conformational 转变的趋势变得更明显。然而,有 n 插入的 d (TA ) 的 oligonucleotides 的符合构造面对 Z12 有点变化了,并且 Z12 没在有 non-d (GC ) 或 non-d (TA ) 的 oligonucleotides 的转变插入的 conformational 上有效果。胶化活动性移动试金进一步证明 Z12 能与 d (GC ) 绑在 oligonucleotide 10。换句话说, Z12 能与 n 插入到 Z-DNA 符合构造的 d (GC ) 转 oligonucleotides 并且与高亲密关系绑在它。 | Puzhong Lu Shoulong Deng Youlin Zhu Yongbin Yan Yong Liu Chengyu Hu | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 3 |
| 4 | The Zα domain of fish PKZ converts DNA hairpin with d(GC)n inserts to Z-conformation显示文摘PKZ,蛋白质 kinase 包含 Z-DNA 领域,是脊椎动物 eIF2 kinase 家庭的一个新奇成员。在 N 终点在 C 终点和二个 Z-DNA 有约束力的领域(Z1 和 Z2 ) 包含一个催化领域, PKZ 能通过 Z 的绑定被激活到 Z-DNA。然而, PKZ Z 的规章的功能尚待被证实。这里,蛋白质被表示在 DNA conformational 转变,野类型的 Z1Z2 和 11 异种上理解 PKZ Z 的影响并且净化。同时, DNA hairpinsd (GC ) 的几不同长度 nT4 (GC ) n (n = 26 ) 并且 RNA hairpinr (GC ) 6T4 (GC ) 6 被综合。这些合成 DNA 或 RNA 发卡的符合构造上的 Z1Z2 和变异的蛋白质的效果被使用圆形的二色性光谱和胶化活动性移动试金调查。结果证明 DNA 发卡当 Z1Z2 不在时保留了常规 B-DNA 符合构造,当一些 DNA 发卡(n3 ) 在 Z1Z2 正式就职下面被变换成 Z 符合构造时。趋势按比例与 GC 重复的增加的数量被联系。与 Z1Z2 比较, Z1Z1 而非 Z2Z2 在变换 d (GC ) 显示了一个更高的能力 6T4 (GC ) 6 从 B- 到 Z-DNA。这些结果证明那 Z1 子域比 Z2 子域在 BZ conformational 转变的过程起了一个更必要的作用。变异的蛋白质(K34A, N38A, R39A, Y42A, P57A, P58A,和 W60A ) 不能变换 d (GC ) 6T4 (GC ) 6 进 Z-DNA,而 S35A 或 K56A 保留了一些部分活动。有趣地, Z1Z2 也能导致 r (GC ) 6T4 (GC ) 从 A 符合构造的 6 RNA 到在适当条件下面的 Z 符合构造。 | Puzhong Lu Shoulong Deng Chuxin Wu Youlin Zhu Yong Liu Gang Lin Yongbin Yan Chengyu Hu | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 2 |
| 5 | Dynamic Connection-Level Call Admission Control in Multi-Services Cellular Networks显示文摘 | LIU Gan XU Changchun ZHU Guangxi RUAN Youlin WU Weimin | 2005 | Chinese Journal of Electronics2005，14，4： | 1 |
| 6 | Tsing Ma Bridge Deck under Skew Winds-Part I : Aerodynamic Coefficients 显示文摘 | ZHU Luodong XU Youlin XIANG Haifan | 2002 | Journal of Wind Engineering and Industrial Aerodynamics2002，90，7： | 1 |
| 7 | Tsing Ma Bridge Deck under Skew Winds-Part Ⅱ : Flutter Derivatives 显示文摘 | ZHU Luodong XU Youlin XIANG Haifan | 2002 | Journal of Wind Engineering and Industrial Aerodynamics2002，90，7： | 1 |
| 8 | A Multicenter Retrospective Analysis of Survival Outcome Following Postoperative Chemoradiotherapy in Non–Small-Cell Lung Cancer Patients With N2 Nodal Disease显示文摘 | Bingwen Zou Yong Xu Tao Li Wenhui Li Bangxian Tang Lin Zhou Lu Li Yongmei Liu Jiang Zhu Meijuan Huang Jin Wang Li Ren Youlin Gong Guowei Che Lunxu Liu Mei Hou You Lu | 2010 | International Journal of Radiation Oncology Biology Physics2010，，2： | 1 |
| 9 | Tsing Ma bridge deck under skew winds-part II: flutter derivatives 显示文摘 | ZHU Ledong XU Youlin XIANG Haifan | 2002 | Journal of Wind Engineering and Industrial Aerodynamics2002，90，7： | 1 |
| 10 | Buffeting response of longspan cable-supposed bridges under skew winds, part 1: theory显示文摘 | ZHU Ledong XU Youlin | 2005 | Journal of Sound and Vibration2005，281，345： | 1 |
| 11 | Buffeting response of longspan cable-supported bridges under skew winds, part 2: case study 显示文摘 | XU Youlin ZHU Ledong | 2005 | Journal of Sound and Vibration2005，281，345： | 1 |
| 12 | Linear electromagnetic devices for vibration damping and energy harvesting:modeling and testing显示文摘 | ZHU Songye SHEN Wenai XU Youlin | 2012 | Engineering Structures2012，34，34： | 1 |
| 13 | Tsing Ma bridge deck under skew winds-Part 1 : aerodynamic coefficients 显示文摘 | ZHU Ledong XU Youlin ZHANG Feng | 2002 | Journal of Wind Engineering and In- dustrial Aerodynamics2002，90，7： | 1 |
| 14 | Tsing Ma bridge deck under skew winds-Part Ⅱ: flutter derivatives 显示文摘 | ZHU Ledong XU Youlin XIANG Haifan | 2002 | Journal of Wind Engineering and Industrial Aero- dynamics2002，90，7： | 1 |
| 15 | Ctenopharyngodon idella IKKβ interacts with PKR and IκBα显示文摘原子因素 kappa-B kinase (IKK ) 的禁止者是 IKK 建筑群的一个子单元。它能响应大量刺激通过 phosphorylating IB 激活 NF-B 小径。在现在的学习,从草鲤鱼的 IKK 基因(Ctenopharyngodon idella;KT282114 ) 被相应克隆克隆并且识别并且 cDNA 结束(种族) 快速扩大技术。完全的 CiIKK cDNA 是在长度的 3428 bp,与编码 778 氨基酸的多肽的 2337 bp 的最长开的读物框架(ORF ) 。CiIKK 的推出的氨基酸顺序有类似的领域分发到那些哺乳动物。例如, CiIKK 在 N 终端由一个 serine/threonine kinase 领域组成,在中间的一个基本区域 leucin 拉链(BRLZ ) 领域, homeobox 联系了 leucin 拉链(HALZ ) 领域和 IKK NEMO (NF-B 必要调节的人) 在 C 终端的有约束力的领域。种系发生的树分析也证明 CiIKK 对 zebrafish IKK (DrIKK ) 并且清楚地高度相应从不同哺乳动物并且两栖动物对应物。CiIKK 的表示无所不在地在草鲤鱼并且显著地的肝,肠,肾,鳃,怒气,心,和大脑纸巾被发现在在刺激与下面的 CIK 房间起来调整 Poly 我: C 和使紫外失去活性草鲤鱼出血性的病毒。在小径在鱼和 CiIKK 的角色调查 NF-B 小径的激活机制,我们在试金下面由 co-immunoprecipitation 和 GST 拉与 IB 与 IKK 和 IKK 探索了蛋白质 kinase R (PKR ) 的蛋白质相互作用。在每对之间的相互作用被证实。结果建议 CiIKK 可以是在在鱼的 NF-B 小径的激活的一个主要成员。 | Haizhou Wang Qun Xu Xiaowen Xu Yousheng Hu Qunhao Hou Youlin Zhu Chengyu Hu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 1 |
| 16 | Optimum parameters of Maxwell model-defined dampers used to link adjacent structures显示文摘 | Zhu Hongping Xu Youlin | 2005 | Journal of Sound and Vibration2005，279，2： | 1 |
| 17 | The long non-coding RNA DANA2 positively regulates drought tolerance by recruitingERF84 to promote JMJ29-mediated histone demethylation显示文摘Tens of thousands of long non-coding RNAs have been uncovered in plants,but few of them have been comprehensively studied for their biological function and molecular mechanism of their mode of action.Here,we show that the Arabidopsis long non-coding RNA DANA2 interacts with an AP2/ERF transcription factor ERF84 in the cell nucleus and then affects the transcription of JMJ29 that encodes a Jumonji C domain-containing histone H3K9 demethylase.Both RNA sequencing(RNA-seq)and genetic analyses demonstrate that DANA2 positively regulates drought stress responses through JMJ29.JMJ29 positively regulates the expression of ERF15 and GOLS2 by modulation of H3K9me2 demethylation.Accordingly,mutation of JMJ29 causes decreased ERF15 and GOLS2 expression,resulting in impaired drought tolerance,in agreement with drought-sensitive phenotypes of dana2 and erf84 mutants.Taken together,these results demonstrate that DANA2 is a positive regulator of drought response and works jointly with the transcriptional activator ERF84 to modulate JMJ29 expression in plant response to drought. | Pengxiang Zhang Reqing He Jun Yang Jingjing Cai Zhipeng Qu Rongxin Yang Jinbao Gu Zhen-Yu Wang David LAdelson Youlin Zhu Xiaofeng Cao Dong Wang | 2023 | Molecular Plant2023，16，8： | 0 |
| 18 | Changes of the Proteomic Profiles in Human High-metastatic Large Cell Lung Cancer Cell Line L9981 by Transfecting with nm23-H1 Gene显示文摘Background and Objective Cancer metastasis is not only the malignant characteristics of lung cancer, but also the key cause of failure to cure and high mortality. It has been proved | Youlin DENG Wen ZHU Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyy LIU Zhihao WU Ke XU Ojnghua ZHOU | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 19 | Expanding the range of CRISPR/Cas9-directed genome editing in soybean显示文摘The CRISPR/Cas9 system has been widely applied for plant genome editing.The commonly used SpCas9 has been shown to rely on the protospacer adjacent motif(PAM)sequences in the canonical form NGG and non-canonical NAG.Although these PAM sequences are extensively distributed across plant genomes,a broader scope of PAM sequence is required to expand the range of genome editing.Here we report the adoption of three variant enzymes,xCas9,SpCas9-NG and XNG-Cas9,to produce targeted mutation in soybean.Sequencing results determined that xCas9 with the NGG and KGA(contains TGA and GGA)PAMs successfully induces genome editing in soybean genome.SpCas9-NG could recognize NGD(contains NGG,NGA and NGT),RGC(contains AGC and GGC),GAA and GAT PAM sites.In addition,XNG-Cas9 was observed to cleave soybean genomic regions with NGG,GAA and AGY(contains AGC and AGT)PAM.Moreover,off-target analyses on soybean editing events induced by SpCas9 and xCas9 indicated that two high-fidelity Cas9 variants including eSpCas9(enhanced specificity SpCas9)and exCas9(enhanced specificity xCas9)could improve the specificity of the GGA PAM sequence without reducing on-target editing ficiency.These findings significantly expand the scope of Cas9-mediated genome editing in soybean. | Reqing He Pengxiang Zhang Yuchuan Yan Chen Yu Liyun Jiang Youlin Zhu Dong Wang | 2022 | aBIOTECH2022，3，2： | 0 |
| 20 | Manipulation of plant height in garden asparagus (Asparagus officinalis L.) through CRISPR/Cas9-mediated aspSPL14 allele editing显示文摘Dear Editor,Reduction in plant height has been associated with yield increases and yield stability in a number of important crop species,such as wheat and rice[1].In these plants,dwarfing is mainly attributed to the inability to synthesize or respond to certain phytohormones,predominantly gibberellin(GA)[2].Ideal Plant Architecture 1(IPA1),an miR156 target gene,encodes SPL14 and it is able to bind directly to the promoters of multiple GA biosynthetic,signal,and deactivating genes in rice[3].Moreover,IPA1 loss-of-function mutants exhibit dwarf phenotypes[4]. | Jingsong Zhou Reqing He Xiaojing Liu Bingbing Zhang Guangyu Chen Dong Wang Youlin Zhu | 2023 | Horticulture Research2023，10，7： | 0 |
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