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| 1 | Sentinel Node Mapping for Gastric Cancer: A Prospective Multicenter Trial in Japan显示文摘 | Yuko Kitagawa Hiroya Takeuchi Yu Takagi Shoji Natsugoe Masanori Terashima Nozomu Murakami Takashi Fujimura Hironori Tsujimoto Hideki Hayashi Nobunari Yoshimizu Akinori Takagane Yasuhiko Mohri Kazuhito Nabeshima Yoshikazu Uenosono Shinichi Kinami Junichi S | 2013 | Journal of Clinical Oncology2013，，29： | 11 |
| 2 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 3 | Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma—a comparison between L-TAE with Farmorubicin and L-TAE with Adriamycin: preliminary results (second cooperative study)显示文摘 | Saburo Kawai Masayoshi Tani Jun Okamura Makoto Ogawa Yasuo Ohashi Morito Monden Shigeki Hayashi Jushiro Inoue Yoshifumi Kawarada Mitsuo Kusano Yasuhiko Kubo Chikazumi Kuroda Yu Sakata Yoshiyuki Shimamura Kenji Jinno Akira Takahashi Kenichi Takayasu Kazuo | 1994 | Cancer Chemotherapy and Pharmacology1994，，1： | 1 |
| 4 | A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity显示文摘 | Hiroshi Yoshida Yu Katayose Michiaki Unno Masanori Suzuki Hideaki Kodama Shin-ichi Takemura Ryutaro Asano Hiroki Hayashi Kuniharu Yamamoto Seiki Matsuno Toshio Kudo | 2003 | Cancer Immunology Immunotherapy2003，，2： | 1 |
| 5 | Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis显示文摘 | Jiu-Hong Wu Fang-Rong Chang Ken-ichiro Hayashi Hiroaki Shiraki Chih-Chuang Liaw Yuka Nakanishi Kenneth F. Bastow Donglei Yu Ih-Sheng Chen Kuo-Hsiung Lee | 2003 | Bioorganic & Medicinal Chemistry Letters2003，，13： | 1 |
| 6 | Neurovascularized flee short head of the biceps femods muscle transfer for one-stage reanimation of facial paralysis 显示文摘 | Aldteru Hayashi Yu Maruyama | 2006 | Plast Reconstr Surg2006，117，6： | 1 |
| 7 | Usefulness of Transcription–Reverse Transcription Concerted Reaction Method for Detecting Circulating Tumor Cells in Patients With Colorectal Cancer显示文摘 | Nobutaka Sato Naoko Hayashi Yu Imamura Yohei Tanaka Koichi Kinoshita Jyunji Kurashige Seiya Saito Ryuichi Karashima Kotaro Hirashima Yohei Nagai Yuji Miyamoto Masaaki Iwatsuki Yoshifumi Baba Masayuki Watanabe Hideo Baba | 2012 | Annals of Surgical Oncology2012，，6： | 1 |
| 8 | Preparation of narrow size distribution CdS quantum dots in sodium borosilicate glass by the sol-gel process显示文摘 | AO H K Y Hayashi K Yu L | 1994 | SPIE1994，4748，： | 1 |
| 9 | Phosphorylated mTOR Expression is Associated with Poor Prognosis for Patients with Esophageal Squamous Cell Carcinoma显示文摘 | Kotaro Hirashima MD Yoshifumi Baba MD PhD Masayuki Watanabe MD PhD Ryu-ichi Karashima MD Nobutaka Sato MD Yu Imamura MD PhD Yukiharu Hiyoshi MD PhD Yohei Nagai MD Naoko Hayashi MD PhD Ken-ichi Iyama MD PhD Hideo Baba MD PhD | 2010 | Annals of Surgical Oncology2010，，9： | 1 |
| 10 | Adenoviral Oncolytic Suicide Gene Therapy for a Peritoneal Dissemination Model of Gastric Cancer in Mice显示文摘 | Yu Imamura Shinji Ishikawa Nobutaka Sato Ryuichi Karashima Kotaro Hirashima Yukiharu Hiyoshi Youhei Nagai Yoshikatsu Koga Naoko Hayashi Masayuki Watanabe Gen Yamada Hideo Baba | 2010 | Annals of Surgical Oncology2010，，2： | 1 |
| 11 | Quantitative analyses of matrixmetalloproteinase activity after traumatic brain injury in adult rats显示文摘 | Hayashi T Kaneko Y Yu S | 2009 | Brain Res2009，1280，： | 1 |
| 12 | Major hepatectomy for perihilar cholangiocarcinoma显示文摘 | Michiaki Unno Yu Katayose Toshiki Rikiyama Hiroshi Yoshida Kuniharu Yamamoto Takanori Morikawa Hiroki Hayashi Fuyuhiko Motoi Shinichi Egawa | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，4： | 1 |
| 13 | Evaluation of C02 Reduction and Primary Energy Savings for Collective Housing with Fuel Cells Considering Variability in Demand显示文摘 | Manato Kameda Yu Fuj imoto Yasuhiro Hayashi | 2014 | Journal of Energy and Power Engineering2014，8，2： | 0 |
| 14 | γ-Butyrolactone Synthesis from Allylic Alcohols Using the CO_(2)Radical Anion显示文摘γ-Butyrolactone structures are commonly found in various natural products and serve as crucial building blocks in organic synthesis.Consequently,the development of methods for synthesizingγ-butyrolactones has garnered significant interest within the organic synthesis community.In this study,we present a direct and highly efficient approach for the synthesis ofγ-butyrolactones from allylic alcohols.Notably,this study represents the first instance ofγ-butyrolactone synthesis initiated by radical hydrocarboxylation using CO_(2)^(•–),generated from metal formates,followed by cyclization.This two-step process is achieved through the synergistic interaction of photoredox and hydrogen atom transfer(HAT)catalysis,resulting in the production ofγ-butyrolactones with exceptional efficiency.Additionally,when employingα,α-diaryl allylic alcohol derivatives as substrates,the reaction involves 1,2-aryl migration,which occurs concomitantly with CO_(2)^(•–)addition,leading to the formation of 4,5-substituted lactones in a good yield.The artificial force induced reaction(AFIR)method identified the preferred 1,2-aryl migration pathway along with potential byproduct pathways,in which the targeted 1,2-migration was found to be the most plausible pathway. | Saeesh R.Mangaonkar Hiroki Hayashi Wataru Kanna Suvankar Debbarma Yu Harabuchi Satoshi Maeda Tsuyoshi Mita | 2024 | Precision Chemistry2024，2，3： | 0 |
| 15 | Nature:科学家鉴别出调节机体睡眠的两个关键基因显示文摘近日,刊登在国际杂志Nature上的一项研究报告中,来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因,这两个基因能够帮助调节机体深度睡眠和做梦的水平,相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。此前研究者通过对小鼠进行研究发现了能够控制机体快速眼动睡眠的基因,同时该基因还能够诱导深度睡眠。而第二个基因能够控制机体对快速眼动睡眠的需求量,相关研究为科学家们提供了一个关键的切入点来帮助解释睡眠工作的机制,同时研究者还鉴别出了治疗睡眠障碍的潜在靶点。 | Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Shinichi Miyazaki, Linzi Connor, Yu Hayashi, Qinghua Liu, Joseph S. Takahashi Masashi Yanagisawa Hiromasa Funato Makito Sato Masashi Yanagisawa Shin Nakane, Jun Tomita Kazuhiko Kume Seiya Mizuno, Fumihiro Sugiyama Satoru Takahashi Vivek Kumar Joseph S. Takahashi Vivek Kumar Ikuo Miura, Tomohiro Suzuki Shigeharu Wakana Atsushi Watanabe Manabu Abe Kenji Sakimura Yu Hayashi Qinghua Liu Joseph S. Takahashi Masashi Yanagisawa Masashi Yanagisawa | 2017 | 现代生物医学进展2017，17，6： | 0 |
| 16 | Microevolution of Mitochondrial Cytochrome oxidase subunit I in Drosophila melanogaster at "Evolution Canyon", Israel显示文摘 | Nobuhiko Asada Hui Sun Kaori Hayashi Kohta Inomata Yu Harada Erika Sugino Shintaro Takasaki Eviatar Nevo | 2015 | Journal of Life Sciences2015，9，10： | 0 |
| 17 | A fully inkjet-printed disposable gas sensor matrix with molecularly imprinted gas-selective materials显示文摘A method was used to fabricate a fully inkjet-printed gas sensor matrix on photographic paper.An electrode matrix comprising 36 interdigital electrodes in a high-density layout that is easy to integrate has been fabricated using a combination of insulating ink and commercial silver ink.Molecular-imprinted polymer(MIP)inks were then made using a simple solution mixing method,and these inks were printed together with carbon black ink on the electrode matrix to complete production of the sensor.Finally,experimental dynamic sensing of volatile organic compounds verifies that for detection of gases corresponding to the MIP template molecules,the MIP layer offers improvements in both sensitivity and selectivity when compared with non-imprinted polymer layers.The matrix can produce a response of more than 20%to 3 ppm propenoic acid gas through adjustment of the printing times for the carbon black layer and the MIP layer. | Lingpu Ge Xiao Ye Zeping Yu Bin Chen Chuanjun Liu Hao Guo Shiyi Zhang Fumihiro Sassa Kenshi Hayashi | 2022 | npj Flexible Electronics2022，6，1： | 0 |
| 18 | Laparoscopic retroperitoneal lymph node dissection versus open retroperitoneal lymph node dissection for testicular cancer:A comparison of clinical and perioperative outcomes显示文摘Objective:This study was performed to evaluate the clinical and perioperative outcomes of laparoscopic retroperitoneal lymph node dissection(L-RPLND)and open retroperitoneal lymph node dissection(O-RPLND)performed by one surgeon at a single center.Methods:We evaluated 30 patients with stage IIA germ cell tumors who underwent retroperitoneal lymph node dissection(15 underwent L-RPLND and 15 underwent O-RPLND)at our institution between April 1,2010 and March 31,2018.The clinical parameters were compared between patients who underwent L-RPLND using the retroperitoneal approach and those who underwent O-RPLND using the transperitoneal approach.There were no significant differences in the background characteristics of the two groups except for the median follow-up duration(46 months for L-RPLND and 71 months for O-RPLND,p=0.02).Results:L-RPLND was associated with a shorter mean operative time(mean 222 min for L-RPLND vs.453 min for O-RPLND,p<0.001).There was significantly less blood loss during surgery in the L-RPLND group compared to the O-RPLND group(mean 165 mL for L-RPLND vs.403 mL for O-RPLND,p<0.001).Parameters related to postoperative recovery were significantly better for the L-RPLND group than for the O-RPLND group.There were no differences in the histopathological characteristics between the two groups.No patients in either group exhibited disease recurrence.Conclusion:Patients who underwent L-RPLND had more rapid recovery,and shorter hospital stay compared to those who underwent O-RPLND;complications were comparable between the two groups.L-RPLND is an efficient procedure with the benefits of minimally invasive surgery. | Toshihide Shishido Takatsugu Okegawa Kenjiro Hayashi Kazuki Masuda Satoru Taguchi Yu Nakamura Mitsuhiro Tambo Hiroshi Fukuhara | 2022 | Asian Journal of Urology2022，9，2： | 0 |
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