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| 1 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 2 | 800 Gbit/s transmission over 1 km single-mode fiber using a four-channel silicon photonic transmitter显示文摘We demonstrate the optical transmission of an 800 Gbit/s(4×200 Gbit/s)pulse amplitude modulation-4(PAM-4)signal and a 480 Gbit/s(4×120 Gbit/s)on–off-keying(OOK)signal by using a high-bandwidth(BW)silicon photonic(SiP)transmitter with the aid of digital signal processing(DSP).In this transmitter,a four-channel SiP modulator chip is co-packaged with a four-channel driver chip,with a measured 3 dB BW of 40 GHz.DSP is applied in both the transmitter and receiver sides for pre-/post-compensation and bit error rate(BER)calculation.Back-to-back(B2B)BERs of the PAM-4 signal and OOK signal are first measured for each channel of the transmitter with respect to a variety of data rates.Similar BER performance of four channels shows good uniformity of the transmitter between different channels.The BER penalty of the PAM-4 and OOK signals for 500 m and 1 km standard single-mode fiber(SSMF)transmission is then experimentally tested by using one channel of the transmitter.For a 200 Gbit/s PAM-4 signal,the BER is below the hard-decision forward error correction(HD-FEC)threshold for B2B and below the soft-decision FEC(SD-FEC)threshold after 1 km transmission.For a 120 Gbit/s OOK signal,the BER is below SD-FEC threshold for B2B.After 500 m and 1 km transmission,the data rate of the OOK signal shrinks to 119 Gbit/s and 118 Gbit/s with the SD-FEC threshold,respectively.Finally,the 800 Gbit/s PAM-4 signal with 1 km transmission is achieved with the BER of all four channels below the SD-FEC threshold. | Hongguang Zhang Miaofeng Li Yuguang Zhang Di Zhang Qiwen Liao Jian He Shenglei Hu Bo Zhang Lei Wang Xi Xiao Nan Qi Shaohua Yu | 2020 | Photonics Research2020，8，11： | 5 |
| 3 | Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model显示文摘Chaperone-mediated autophagy(CMA)is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.However,the mechanisms that regulate CMA are not fully understood.Here,using unbiased drug screening approaches,we discover Metformin,a drug that is commonly the first medication prescribed for type 2 diabetes,can induce CMA.We delineate the mechanism of CMA induction by Metformin to be via activation of TAK1-IKKα/β signaling that leads to phosphorylation of Ser85 of the key mediator of CMA,Hsc70,and its activation.Notably,we find that amyloid-beta precursor protein(APP)is a CMA substrate and that it binds to Hsc70 in an IKKα/β-dependent manner.The inhibition of CMA-mediated degradation of APP enhances its cytotoxicity.Importantly,we find that in the APP/PS1 mouse model of Alzheimer's disease(AD),activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Aβplaque levels and reverses the molecular and behavioral AD phenotypes.Our study elucidates a novel mechanism of CMA regulation via Metformin-TAK1-IKKα/β-Hsc70 signaling and suggests Metformin as a new activator of CMA for diseases,such as AD,where such therapeutic intervention could be beneficial. | Xiaoyan Xu Yaqin Sun Xufeng Cen Bing Shan Qingwei Zhao Tingxue Xie Zhe Wang Tingjun Hou Yu Xue Mengmeng Zhang Di Peng Qiming Sun Cong Yi Ayaz Najafov Hongguang Xia | 2021 | Protein & Cell2021，12，10： | 5 |
| 4 | Burden of Mental and Substance Use Disorders-China, 1990−2019显示文摘Summary What is already known about this topic?Mental and substance use disorders have notable contributions to the disease burden in China.What is added by this report?In China,mental disorders and substance use disorders accounted for 20.29 million and 5.76 million disability-adjusted life years(DALYs)in 2019,respectively;depressive disorders were the leading cause of DALYs.For mental disorders,the numbers of DALYs increased 12.06%from 2000 to 2019 while the standardized rates declined 5.24%;for substance use disorders,both the numbers and standardized rates of DALYs decreased 8.52%and 18.52%,respectively. | Chao Ma Shicheng Yu Yueqin Huang Zhaorui Liu Qiqi Wang Hongguang Chen Tingting Zhang Maigeng Zhou | 2020 | China CDC weekly2020，2，41： | 3 |
| 5 | High-speed and high-power germanium photodetector with a lateral silicon nitride waveguide显示文摘Up to now, the light coupling schemes of germanium-on-silicon photodetectors(Ge-on-Si PDs) could be divided into three main categories:(1) vertical(or normal-incidence) illumination, which can be from the top or back of the wafer/chip, and waveguide-integrated coupling including(2) butt coupling and(3) evanescent coupling. In evanescent coupling the input waveguide can be positioned on top, at the bottom, or lateral to the absorber. Here,to the best of our knowledge, we propose the first concept of Ge-on-Si PD with double lateral silicon nitride(Si_(3)N_(4)) waveguides, which can serve as a novel waveguide-integrated coupling configuration: double lateral coupling. The Ge-on-Si PD with double lateral Si_(3)N_(4) waveguides features uniform optical field distribution in the Ge region, which is very beneficial to improving the operation speed for high input power. The proposed Ge-on-Si PD is comprehensively characterized by static and dynamic measurements. The typical internal responsivity is evaluated to be 0.52 A/W at an input power of 25 mW. The equivalent circuit model and theoretical 3 dB optoelectrical(OE) bandwidth investigation of Ge-on-Si PD with lateral coupling are implemented. Based on the small-signal(S21) radio-frequency measurements, under 4 mA photocurrent, a 60 GHz bandwidth operating at-3 V bias voltage is demonstrated. When the photocurrent is up to 12 mA, the 3 dB OE bandwidth still has 36 GHz. With 1 mA photocurrent, the 70, 80, 90, and 100 Gbit/s non-return-to-zero(NRZ) and 100,120, 140, and 150 Gbit/s four-level pulse amplitude modulation clear openings of eye diagrams are experimentally obtained without utilizing any offline digital signal processing at the receiver side. In order to verify the highpower handling performance in high-speed data transmission, we investigate the eye diagram variations with the increase of photocurrents. The clear open electrical eye diagrams of 60 Gbit/s NRZ under 20 mA photocurrent are also obtained. Overall, the proposed lateral Si_(3)N_(4) waveguide structure is flexibly extendable to a light coupling configuration of PDs, which makes it very attractive for developing high-performance silicon photonic integrated circuits in the future. | XIAO HU DINGYI WU HONGGUANG ZHANG WEIZHONG LI DAIGAO CHEN LEI WANG XI XIAO SHAOHUA YU | 2021 | Photonics Research2021，9，5： | 2 |
| 6 | Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice显示文摘 | Fei Xiao Junjie Yu Yajie Guo Jiali Deng Kai Li Ying Du Shanghai Chen Jianmin Zhu Hongguang Sheng Feifan Guo | 2014 | Metabolism2014，，： | 1 |
| 7 | 显示文摘 | Sun Gang Sun Hongguang Liu Yu | 2007 | Polymer2007，48，1： | 1 |
| 8 | Comparative Study on the Curing Kinetics and Mechanism of a Lignin-Based-Epoxy/Anhydride Resin System显示文摘 | SUN Gang SUN Hongguang LIU Yu | 2007 | Polymer2007，28，26： | 1 |
| 9 | A plasma microRNA panel for early detection of colorectal cancer显示文摘 | Shuyang Wang Jianbin Xiang Zhaoyong Li Shaohua Lu Jie Hu Xue Gao Lei Yu Lei Wang Jiping Wang Ying Wu Zongyou Chen Hongguang Zhu | 2015 | Int. J. Cancer2015，，1： | 1 |
| 10 | Modelica-based Object-orient Modeling of Rotor System with Multi-Faults显示文摘Modelica-based object-orient method is proved to be rapid,accurate and easy to modify,which is suitable for prototype modeling and simulation of rotor system,whose parameters need to be modified frequently.Classical non-object-orient method appears to be inefficient because the code is difficult to modify and reuse.An adequate library for object-orient modeling of rotor system with multi-faults is established,a comparison with non-object-orient method on Jeffcott rotor system and a case study on turbo expander with multi-faults are implemented.The relative tolerance between object-orient method and non-object-orient is less than 0.03%,which proves that these two methods are as accurate as each other.Object-orient modeling and simulation is implemented on turbo expander with crack,rub-impact,pedestal looseness and multi-faults simultaneously.It can be conclude from the case study that when acting on compress side of turbo expander separately,expand wheel is not influenced greatly by crack fault,the existence of rub-impact fault forces expand wheel into quasi-periodic motion and the orbit of expand wheel is deformed and enhanced almost 1.5 times due to pedestal looseness.When acting simultaneously,multi-faults cannot be totally decomposed but can be diagnosed from the feature of vibration.Object-orient method can enhance the efficiency of modeling and simulation of rotor system with multi-faults,which provides an efficient method on prototype modeling and simulation. | LI Ming WANG Yu LI Fucai LI Hongguang MENG Guang | 2013 | Chinese Journal of Mechanical Engineering2013，26，6： | 1 |
| 11 | Comparative studyon the curing kinetics and mechanism of a iignin based'epoxy/anhydride resin system 显示文摘 | SUN Gang SUN Hongguang LIU Yu | 2007 | Polymer2007，48，1： | 1 |
| 12 | Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13显示文摘 | Junli Liu Hongguang Xia Minsu Kim Lihua Xu Ying Li Lihong Zhang Yu Cai Helin Vakifahmetoglu Norberg Tao Zhang Tsuyoshi Furuya Minzhi Jin Zhimin Zhu Huanchen Wang Jia Yu Yanxia Li Yan Hao Augustine Choi Hengming Ke Dawei Ma Junying Yuan | 2011 | Cell2011，，1： | 1 |
| 13 | N,N-bis (2-hydroxyethyl) formamide as a new plasticizer for thermoplastic starch 显示文摘 | Dai Hongguang Chang Peter R Yu Jiugao | 2008 | Starch2008，60，12： | 1 |
| 14 | Comparative study on the curing kinetics and mechanism of a lignin- based-epoxy/anhydride resin system显示文摘 | Sun Gang Sun Hongguang Liu Yu | 2007 | Polymer2007，48，1： | 1 |
| 15 | Synthesis of reduced graphene oxide/magnetite composites and investigation of their adsorption performance of fluoroquinolone antibiotics显示文摘 | Yulin Tang Hongguang Guo Lan Xiao Shuili Yu Naiyun Gao Yilong Wang | 2013 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2013，，： | 1 |
| 16 | Fluid flow with compaction and sand production in unconsolidated sandstone reservoir显示文摘The fluid flow of unconsolidated sandstone reservoir can be affected by compaction and sand production which will damage the reservoir and affect oil well productivity.This study aims to measure how the two factors affect the fluid flow.Firstly,single-phase displacement test was applied to investigate how the permeability changed with compaction.Then two-phase displacement test assessed the influence of compaction on oil production.Finally,the characteristics of fluid flow with compaction and sand production were studied under different water content.The results demonstrate that the reduction of permeability with compaction is irreversible,which will result in lower productivity.In contrast,sand production can increase the permeability at mid and high water content,which slows down the decline of oil production.Generally,the oil well productivity is reduced because of compaction even with sand production,especially when the formation pressure drop varies from 2MPa to 4MPa.Consequently,advance water injection is necessary to keep the formation pressure and oil production during oilfield development of unconsolidated sandstone reservoir.Simultaneously,the study can provide theoretical basis and references for the similar reservoirs. | Yu Xiong Hongguang Xu Yongqing Wang Wensheng Zhou Chen Liu Ling Wang | 2018 | Petroleum2018，4，3： | 1 |
| 17 | Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines显示文摘 | Jianjun Li Yushu Dong Hongguang Chen Huanzhi Han Yonghao Yu Guolin Wang Yi Zeng Keliang Xie | 2012 | Brain Research2012，，： | 1 |
| 18 | N-(2-Hydroxyethyl)formamide as a new plasticizer for thermoplastic starch显示文摘 | Hongguang Dai Peter R. Chang Fei Peng Jiugao Yu Xiaofei Ma | 2009 | Journal of Polymer Research2009，，5： | 1 |
| 19 | SH3P2,an SH3 domain-containing protein that interacts with both Pib and AvrPib,suppresses effector-triggered,Pib-mediated immunity in rice显示文摘Plants usually keep resistance(R)proteins in a static state under normal conditions to avoid autoimmunity and save energy for growth,but R proteins can be rapidly activated upon perceiving pathogen invasion.Pib,the first cloned blast disease R gene in rice,encoding a nucleotide-binding leucine-rich repeat(NLR)protein,mediates resistance to the blast fungal(Magnaporthe oryzae)isolates carrying the avirulence gene AvrPib.However,the molecular mechanisms about how Pib recognizes AvrPib and how it is inactivated and activated remain largely unclear.In this study,through map-based cloning and CRISPR-Cas9 gene editing,we proved that Pib contributes to the blast disease resistance of rice cultivar Yunyin(YY).Furthermore,an SH3 domain-containing protein,SH3P2,was found to associate with Pib mainly at clathrin-coated vesicles in rice cells,via direct binding with the coiled-coil(CC)domain of Pib.Interestingly,overexpression of SH3P2 in YY compromised Pib-mediated resistance to M.oryzae isolates carrying AvrPib and Pib-AvrPib recognition-induced cell death.SH3P2 competitively inhibits the self-association of the Pib CC domain in vitro,suggesting that binding of SH3P2 with Pib undermines its homodimerization.Moreover,SH3P2 can also interact with AvrPib and displays higher affinity to AvrPib than to Pib,which leads to dissociation of SH3P2 from Pib in the presence of AvrPib.Taken together,our results suggest that SH3P2 functions as a“protector”to keep Pib in a static state by direct interaction during normal growth but could be triggered off by the invasion of AvrPib-carrying M.oryzae isolates.Our study reveals a new mechanism about how an NLR protein is inactivated under normal conditions but is activated upon pathogen infection. | Yunjie Xie Yupeng Wang Xiangzhen Yu Yuelong Lin Yongsheng Zhu Jinwen Chen Hongguang Xie Qingqing Zhang Lanning Wang Yidong Wei Yanjia Xiao Qiuhua Cai Yanmei Zheng Mo Wang Huaan Xie Jianfu Zhang | 2022 | Molecular Plant2022，15，12： | 1 |
| 20 | Disintegration and acidification of MBR sludge under alkaline conditions 显示文摘 | Yu Hongguang Wang Zhiwei Wang Qiaoying | 2013 | Chemical Engineering Journal2013，231，9： | 1 |
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