|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Salivary exosomal PSMA7: a promising biomarker of inflammatory bowel disease显示文摘煽动性的肠疾病(IBD ) 是包括中国在亚洲增加的流行的世界范围的肠的免疫者不正常的疾病。它是有未知原因的胃肠的道的长期的疾病。Exosomes 是在各种各样的身体液体的小泡。他们有 40-120 的直径 ? nm,并且他们的功能之一是各种各样的物质的长途的转移。在这研究,我们与 IBD 并且在健康控制在病人调查了唾液的 exosomes 的内容与 IBD 在病人探索新 biomarker。在这研究,整个口水与 IBD 从病人被获得(ulcerative 大肠炎(UC ) , n ?=? 37;Crohns 疾病(CD ) , n ?=? 11 ) 并且显然健康的个人(HC, n ?=? 10 ) 。唾液的 exosomes 从样品被提取,并且在 exosomes 以内的蛋白质被液体用色层法分离团分光计(LC-MS/MS ) 识别。结果证明超过 2000 蛋白质与 IBD 从病人在唾液的 exosomes 被检测。通过基因本体论分析,我们发现(PSMA7 ) proteasome 子单元 alpha 类型 7 与 IBD 和健康控制显示出病人之间的特别显著的差别,因为它的表达式水平在 CD 和 UC 组是高得多的。这 exosomal 蛋白质与 proteasome 活动和煽动性的回答有关。我们因此断定在这研究,唾液的 exosomal PSMA7 在在从有 IBD 的题目的唾液的 exosomes 的高水平是在场的。免除病人 colonoscopy 的疼痛能是很有希望的 biomarker。 | Xiaowen Zheng Feng Chen Qian Zhang Yulan Liu Peng You Shan Sun Jiuxiang Lin Ning Chen | 2017 | Protein & Cell2017，8，9： | 19 |
| 2 | Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.)显示文摘Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. | Junjie Cui Yan Yang Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang Chengcheng Feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu | 2020 | Horticulture Research2020，7，1： | 7 |
| 3 | Fine relocation, mechanism, and tectonic indications of middle-small earthquakes in the Central Tibetan Plateau显示文摘The medium-small earthquakes that occurred in the middle part of Tibetan Plateau(32°N–36°N, 90°E–93°E) from August 2016 to June 2017 were relocated using the absolute earthquake location method Hypo2000. Compared to the reports of Chinese Seismological Networks, our relocation results are more clustered on the whole, the horizontal location differences exceed 10 km, and the focal depths are concentrated in 0–8 km, which indicates that the upper crust inside the Tibetan Plateau is tectonically active. In June2017 altogether eight earthquakes above magnitude 3.0 took place; their relocated epicenters are concentrated around Gêladaindong.The relocation results of M<3.0 small earthquakes also showed obvious differences. Therefore, we used the CAP method to invert for the focal mechanisms of the M ≥3.0 earthquakes; results generally tally with the surface geological structures, indicating that the Tibetan Plateau is still under the strong compressional force from the India Plate. Among them the eight earthquakes that occurred near Gêladaindong in June 2017 are all of normal fault type or with some strike-slip at the same time; based on previous research results we conjecture that these events are intense shallow crust responses to deep crust-mantle activities. | YuLan Li BaoShan Wang RiZheng He HongWei Zheng JiangYong Yan Yao Li | 2018 | Earth and Planetary Physics2018，2，5： | 4 |
| 4 | Clinical and pathological features of miR-10b and RHOC gene expression in hepatocellular carcinoma显示文摘Aberrant expression of microRNAs(miRNAs)was reported frequently in different human cancers.The major role of miRNA is targeting 30-UTR of coding gene and causing translational repression or mRNA degradation.miR-10b overexpression was reported to promote breast cancer metastasis by up-regulating RHOC expression.But its expression in hepatocellular carcinoma(HCC)remains unclear.Our study indicated that the expression of miR-10b was different in HCC and adjacent tissue samples,and reduced expression of miR-10b in HCC was related tovein invasion.High-level expression of RHOC was also related to vein invasion in HCC.But no correlation was found between miR-10b and RHOC expression.These results suggest that miR-10b and RHOC are independent predictors of HCC invasion and metastasis. | Jingli Du Yulan Wang Hanjiang Fu Xiaofei Zheng Minggui Lin Mingzhou Guo Lixin Wei | 2014 | Chinese Science Bulletin2014，59，19： | 4 |
| 5 | Prognostic Significance of the Number of Metastatic Lymph Nodes: Is UICC/TNM Node Classification Perfectly Suitable for Early Gastric Cancer?显示文摘 | Baojun Huang Xinyu Zheng Zhenning Wang Meixian Wang Yulan Dong Bo Zhao Huimian Xu | 2009 | Annals of Surgical Oncology2009，，1： | 1 |
| 6 | Determination of Fe, Ca, Mn, Cr, Ni and Cu in Allium macrostemon by AAS显示文摘 | REN YULAN ZHENG WEI YING ZHIWEI | 2012 | Medicinal Plant2012，3，10： | 1 |
| 7 | Determination of Fe,Ca,Mn,Cr,Ni and Cu in allium macrostemon by AAS显示文摘 | Ren Yulan Zheng Wei Ying Zhiwei | 2012 | Medicinal Plant2012，3，10： | 1 |
| 8 | STK 11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in P eutz– J eghers Syndrome显示文摘 | Zhiqing Wang Baoping Wu Rebecca A. Mosig Yulan Chen Fei Ye Yali Zhang Wei Gong Lanbo Gong Fei Huang Xinying Wang Biao Nie Haoxuan Zheng Miao Cui Yadong Wang Juan Wang Chudi Chen Alexandros D. Polydorides David Y. Zhang John A. Martignetti Bo Jiang | 2014 | Human Mutation2014，，7： | 1 |
| 9 | Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation显示文摘 | Jie Chen Hao Yin Yulan Jiang Sarvan Kumar Radhakrishnan Zhan-Peng Huang Jingjing Li Zhan Shi Elisabeth P.C. Kilsdonk Yu Gui Da-Zhi Wang Xi-Long Zheng | 2011 | Arteriosclerosis, Thrombosis, and Vascular Biology2011，，2： | 1 |
| 10 | SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infection显示文摘The long-term immunity and functional recovery after SARS-CoV-2 infection have implications in preventive measures and patient quality of life.Here we analyzed a prospective cohort of 121 recovered COVID-19 patients from Xiangyang,China at 1-year after diagnosis.Among them,chemiluminescence immunoassay-based screening showed 99%(95%CI,98–100%)seroprevalence 10–12 months after infection,comparing to 0.8%(95%CI,0.7–0.9%)in the general population.Total anti-receptor-binding domain(RBD)antibodies remained stable since discharge,while anti-RBD IgG and neutralization levels decreased over time.A predictive model estimates 17%(95%CI,11–24%)and 87%(95%CI,80–92%)participants were still 50%protected against detectable and severe re-infection of WT SARS-CoV-2,respectively,while neutralization levels against B.1.1.7 and B.1.351 variants were significantly reduced.All non-severe patients showed normal chest CT and 21%reported COVID-19-related symptoms.In contrast,53%severe patients had abnormal chest CT,decreased pulmonary function or cardiac involvement and 79%were still symptomatic.Our findings suggest long-lasting immune protection after SARS-CoV-2 infection,while also highlight the risk of immune evasive variants and long-term consequences for COVID-19 survivors. | Yan Zhan Yufang Zhu Shanshan Wang Shijun Jia Yunling Gao Yingying Lu Caili Zhou Ran Liang Dingwen Sun Xiaobo Wang Zhibing Hou Qiaoqiao Hu Peng Du Hao Yu Chang Liu Miao Cui Gangling Tong Zhihua Zheng Yunsheng Xu Linyu Zhu Jin Cheng Feng Wu Yulan Zheng Peijun Liu Peng Hong | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 11 | Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors显示文摘Fibroblast growth factor receptors (FGFRs) have emerged as promising targets for anticancer therapy.In this study,we synthesized and evaluated the biological activity of 66 pyrazolo[3,4-d]pyridazinone derivatives.Kinase inhibition,cell proliferation,and whole blood stability assays were used to evaluate their activity on FGFR,allowing us to explore structureàactivity relationships and thus to gain understanding of the structural requirements to modulate covalent inhibitors’selectivity and reactivity.Among them,compound 10h exhibited potent enzymatic activity against FGFR and remarkably inhibited proliferation of various cancer cells associated with FGFR dysregulation,and suppressed FGFR signaling pathway in cancer cells by the immunoblot analysis.Moreover,10h displayed highly potent antitumor efficacy (TGI Z 91.6%,at a dose of 50 mg/kg) in the FGFR1-amplified NCI-H1581 xenograft model. | Xiaowei Wu Mengdi Dai Rongrong Cui Yulan Wang Chunpu Li Xia Peng Jihui Zhao Bao Wang Yang Dai Dan Feng Tianbiao Yang Hualiang Jiang Meiyu Geng Jing Ai Mingyue Zheng Hong Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 0 |
| 12 | PICOTEES:a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants from Chinese children cohorts显示文摘The growth in biomedical data resources has raised potential privacy concerns and risks of genetic information leakage. For instance, exome sequencing aids clinical decisions by comparing data through web services, but it requires significant trust between users and providers. To alleviate privacy concerns, the most commonly used strategy is to anonymize sensitive data. Unfortunately, studies have shown that anonymization is insufficient to protect against reidentification attacks. Recently, privacy-preserving technologies have been applied to preserve application utility while protecting the privacy of biomedical data. We present the PICOTEES framework, a privacy-preserving online service of phenotype exploration for genetic-diagnostic variants (https://birthdefectlab.cn:3000/). PICOTEES enables privacy-preserving queries of the phenotype spectrum for a single variant by utilizing trusted execution environment technology, which can protect the privacy of the user's query information, backend models, and data, as well as the final results. We demonstrate the utility and performance of PICOTEES by exploring a bioinformatics dataset. The dataset is from a cohort containing 20,909 genetic testing patients with 3,152,508 variants from the Children's Hospital of Fudan University in China, dominated by the Chinese Han population (>99.9%). Our query results yield a large number of unreported diagnostic variants and previously reported pathogenicity. | Xinran Dong Yulan Lu Lanting Guo Chuan Li Qi Ni Bingbing Wu Huijun Wang Lin Yang Songyang Wu Qi Sun Hao Zheng Wenhao Zhou Shuang Wang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 13 | Seasonality modeling of the distribution of Aedes albopictus in China based on climatic and environmental suitability显示文摘Background:Aedes albopictus is a highly invasive mosquito species and a major vector of numerous viral pathogens.Many recent dengue fever outbreaks in China have been caused solely by the vector.Mapping of the potential distribution ranges of Ae.albopictus is crucial for epidemic preparedness and the monitoring of vector populations for disease control.Climate is a key factor influencing the distribution of the species.Despite field studies indicating seasonal population variations,very little modeling work has been done to analyze how environmental conditions influence the seasonality of Ae.albopictus.The aim of the present study was to develop a model based on available observations,climatic and environmental data,and machine learning methods for the prediction of the potential seasonal ranges of Ae.albopictus in China.Methods:We collected comprehensive up-to-date surveillance data in China,particularly records from the northern distribution margin of Ae.albopictus.All records were assigned long-term(1970–2000)climatic data averages based on the WorldClim 2.0 data set.Machine learning regression tree models were developed using a 10-fold crossvalidation method to predict the potential seasonal(or monthly)distribution ranges of Ae.albopictus in China at high resolution based on environmental conditions.The models were assessed based on sensitivity,specificity,and accuracy,using area under curve(AUC).WorldClim 2.0 and climatic and environmental data were used to produce environmental conduciveness(probability)prediction surfaces.Predicted probabilities were generated based on the averages of the 10 models.Results:During 1998–2017,Ae.albopictus was observed at 200 out of the 242 localities surveyed.In addition,at least 15 new Ae.albopictus occurrence sites lay outside the potential ranges that have been predicted using models previously.The average accuracy was 98.4%(97.1–99.5%),and the average AUC was 99.1%(95.6–99.9%).The predicted Ae.albopictus distribution in winter(December–February)was limited to a small subtropical-tropical area of China,and Ae.albopictus was predicted to occur in northern China only during the short summer season(usually June–September).The predicted distribution areas in summer could reach northeastern China bordering Russia and the eastern part of the Qinghai-Tibet Plateau in southwestern China.Ae.albopictus could remain active in expansive areas from central to southern China in October and November.Conclusions:Climate and environmental conditions are key factors influencing the seasonal distribution of Ae.albopictus in China.The areas predicted to potentially host Ae.albopictus seasonally in the present study could reach northeastern China and the eastern slope of the Qinghai-Tibet Plateau.Our results present new evidence and suggest the expansion of systematic vector population monitoring activities and regular re-assessment of epidemic risk potential. | Xueli Zheng Daibin Zhong Yulan He Guofa Zhou | 2020 | Infectious Diseases of Poverty2020，9，1： | 0 |
| 14 | Quantitative analysis of collagen morphology in breast cancer from millimeter scale using multiphoton microscopy显示文摘The tumor microenvironment(TME)is now recognized as an important participant of tumor progression.As the most abundant extracellular matrix component in TME,collagen plays an important role in tumor development.The imaging study of collagen morphological feature in TME is of great significance for understanding the state of tumor.Multiphoton microscopy(MPM),based on second harmonic generation(SHG)and two-photon excitation fluorescence(TPEF),can be used to monitor the morphological changes of biological tissues without labeling.In this study,we used MPM for large-scale imaging of early invasive breast cancer from the tumor center to normal tissues far from the tumor.We found that there were signi¯cant di®erences in collagen morphology between breast cancer tumor boundary,near tumor transition region and normal tissues far from the tumor.Furthermore,the morphological feature of eight collagen¯bers was extracted to quantify the variation trend of collagen in three regions.These results may provide a new perspective for the optimal negative margin width of breast-conserving surgery and the understanding of tumor metastasis. | Yulan Liu Shunwu Xu Deyong Kang Xingxin Huang Shuoyu Xu Lianhuang Li Liqin Zheng Lida Qiu Zhenlin Zhan Xiahui Han Jianxin Chen | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 15 | Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model显示文摘我们评估了 calpain 的角色 integrin 的劈开相关的变化在 integrin IIb3 的 3 细胞质的尾巴用一个 trans 主导的抑制模型的双向发信号。妄想的 Tac-3 蛋白质(即, Tac-3 , Tac-3741 , Tac-3747 , Tac-3754 , Tac-3759 ,并且 Tac-3NITY )由组成细胞外并且人的 IL-2 受体( Tac )和人的 integrin 的 transmembrane 领域 3 细胞质的领域稳定地在怀有人的 glycoprotein Ib-IX 和野类型的 integrin IIb3 的 123 个 CHO 房间被表示。不同房间是为稳定的粘附,并且为在外面在里面代表并且在内外面分别地表明事件的有约束力的可溶的纤维蛋白原的 assayed 并且在使不能调动的纤维蛋白原上传播。禁止的妄想的蛋白质 Tac-3,和 Tac-3NITY 部分稀释了稳定的粘附并且传播。Tac-3, Tac-3759, Tac-3NITY,和 Tac-3754,然而并非 Tac-3747 或 Tac-3741,损害了可溶的纤维蛋白原绑定。结果显示双向发信号被 Tac-3 和 Tac-3NITY 显著地禁止,虽然到更小的程度。而且,仅仅在内外面发信号在 123/Tac-3759 和 123/Tac-3754 房间被损害与相对照一在 123/Tac-3747 和 123/Tac-3741 房间的未经触动的双向发信号。在结论, integrin 的 calpain 劈开 3 在由与细胞质的蛋白质打断它的相互作用而非改变它的符合构造发信号上导致了规章的效果,并且可以因此调整血小板功能。 | Jiansong Huang Yulan Zhou Xiaoyu Su Yuanjing Lyu Lanlan Tao Xiaofeng Shi Ping Liu Zhangbiao Long Zheng Ruan Bing Xiao Wenda Xi Quansheng Zhou Jianhua Mao Xiaodong Xi | 2016 | Frontiers of Medicine2016，10，3： | 0 |
| 16 | Neutron Spectrum Emitted From Cu Target Rod Irradiated With 18 GeV ^(12)C Heavy Ions显示文摘NeutronSpectrumEmittedFromCuTargetRodIrradiatedWith18GeV^(12)CHeavyIonsWangYulan,GuoShilun,TuCaiqing,LiuYonglian,ZhengWenji,H?.. | Wang Yulan,Guo Shilun,Tu Caiqing,Liu Yonglian,Zheng Wenji,Hu Xinhua,R.Brandt,P.Vater,V.Bradnova(Kernchemie, FB14, Universitat Marburg, D-35032 Marburg, Germany Joint Institute for Nuclear Research, Dubna, Russia) | 1996 | 中国原子能科学研究院年报1996，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员