|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxygen and Hydrogen Isotopes of Waters in the Ordos Basin,China:Implications for Recharge of Groundwater in the North of Cretaceous Groundwater Basin显示文摘从 1988 年 1 月在 Ordos 盆从气象学的车站收集到 2005 年 12 月的几百件降水样品被用来建立一根本地大气的水线并且计算现代降水的加权的平均同位素的作文。氧和氢同位素,与为 δ
18 分别地, O 和 δD 在春天在冬季和富人被弄空,并且逐渐地在夏天和秋天减少,说明季节的效果是可观的。他们也证明南方部分和 Ordos 盆的北方部分之间的同位素的差别不是明显的,并且在中间的部分的同位素通常被弄空。32 件样品的同位素作文从浅地下水收集了(不到 150 m 的深度) 在到有为 δ
18 O 并且从 85 ‰到有为 δD 的 63 ‰的一般水准的 46 ‰。他们中的大多数与现代降水是相同的。22 中间、深的地下水的同位素作文(比 275 m 的深度大) 为 δ
18 O 并且从 89 ‰到有为 δD 的 76 ‰的一般水准的 63 ‰。一般水准珍视,说明是显著地不到那些现代降水中间、深的地下水在比较地更低的空气温度被再装。14 C 证明中间、深的地下水的 recharge 在迟了的更新世开始了。从八个湖收集的 13 件湖水样品的同位素定义一个本地蒸发趋势,与 3.77 的一个相对扁平的斜坡,并且证明湖水被现代降水和浅地下水主要喂。 | YANG Yuncheng SHEN Zhaoli WENG Dongguang HOU Guangcai ZHAO Zhenhong WANG Dong PANG Zhonghe | 2009 | Acta Geologica Sinica(English Edition)2009，83，1： | 10 |
| 2 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 3 | Groundwater Systems and Resources in the Ordos Basin,China显示文摘Ordos 盆是在西北的中国的大规模沉积的盆。到顶的从底部的 hydrostratigraphic 单位是 pre 寒武纪的变形岩石,更低的古生代的碳酸盐岩石,上面对中生代碎屑状的岩石和新生代存款古生代。全部的厚度直到 6000 m。三个地下水系统在 Ordos 盆是在场的,基于地质的设置,即石灰岩地区常见的地形地下水系统,白垩纪碎屑状的地下水系统和第四级的地下水系统。这份报纸系统地描述每个系统的地下水流动模式和对地下水资源的全面评价。 | HOU Guangcai LIANG Yongping SU Xiaosi ZHAO Zhenghong TAO Zhengping YIN Lihe YANG Yuncheng WANG Xiaoyong | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 5 |
| 4 | Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein显示文摘Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis(AS).The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood.In this study,we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1(ABCA1)expression,ABCA1-mediated cholesterol efflux,and aortic AS.Macrophage sortilin expression was upregulated by oxidized low-density lipoproteins(ox-LDLs)in both concentration-and time-dependent manners.Its expression reached the peak level when cells were incubated with 50μg/ml ox-LDL for 24 h.Overexpression of sortilin in macrophage reduced cholesterol efflux,leading to an increase in intracellular total cholesterol,free cholesterol,and cholesterol ester.Sortilin was found to bind with ABCA1 protein and suppress macrophage ABCA1 expression,resulting in a decrease in cholesterol efflux from macrophages.The inhibitory effect of sortilin in cholesterol efflux was partially reversed by treatment with chloroquine,a lysosomal inhibitor.On the contrary,the ABCA1 protein level and ABCA1-mediated cholesterol efflux is increased by sortilin short hairpin RNA transfection.The fecal and biliary cholesterol 3H-sterol from cholesterol-laden mouse peritoneal macrophage was reduced by sortilin overexpression through lentivirus vector(LV)-sortilin in low-density lipoprotein receptor knockout mice,which was prevented by co-treatment with chloroquine.Treatment with LV-sortilin reduced plasma high-density lipoprotein and increased plasma ox-LDL levels.Accordingly,aortic lipid deposition and plaque area were exacerbated,and ABCA1 expression was reduced in mice in response to infection with LV-sortilin alone.These effects of LV-sortilin were partially reversed by chloroquine.Sortilin enhances lysosomal degradation of ABCA1 protein and suppresses ABCA1-mediated cholesterol efflux from macrophages,leading to foam cell formation and AS development. | Yuncheng Lv Jing Yang Anbo Gao Sha Sun Xilong Zheng Xi Chen Wei Wan Chaoke Tang Wei Xie Suyun Li Dongming Guo Tianhong Peng Guojun Zhao Liyuan Zhong | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 4 |
| 5 | Distribution of δ^(34)S and δ^(18)O in SO_4^(2-) in Groundwater from the Ordos Cretaceous Groundwater Basin and Geological Implications显示文摘The Ordos Cretaceous Groundwater Basin,located in an arid-semiarid area in northwestern China,is a large-style groundwater basin.SO_4^(2-) is one of the major harmful components in groundwater.Dissolved SO_4^(2-) concentrations,andδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater from 14 boreholes and in gypsum from aquifer were analyzed.Results show that SO_4^(2-) in shallow groundwaters originates from precipitation,sulfide oxidation,and dissolution of stratum sulphate,with a big range ofδ^(34)S values,from-10.7‰to 9.2‰,and addition of SO_4^(2-) in deep groundwater results from dissolution of stratum sulphate,with biggerδ^(34)S values,from 7.8‰to 18.5‰,compared with those in shallow groundwater.This research also indicates that three types of sulphate are present in the strata,and characterized by highδ^(34)S values and highδ^(18)O values-style,highδ^(34)S values and middleδ^(18)O valuesstyle, middleδ^(34)S values and lowδ^(18)O values-style,respectively.Theδ^(34)S-SO_4^(2-) andδ^(18)O-SO_4^(2-) in groundwater have a good perspective for application in distinguishing different groundwater systems and determining groundwater circulation and evolution in this area. | YANG Yuncheng SHEN Zhaoli WEN Dongguang HOU Guangcai SHE Hongquan ZHAO Zhenhong WANG Dong LI Jingwen | 2010 | Acta Geologica Sinica(English Edition)2010，84，2： | 3 |
| 6 | A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis显示文摘Excessive accumulation of cholesterol inβcells initiates endoplasmic reticulum(ER)stress and associated apoptosis.We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin(SCGN)and then attenuates insulin secretion.Here,we aimed to determine whether cholesterol-induced SCGN decrease is involved in the modulation of ER stress and apoptosis in pancreaticβcells.In this study,MIN6 cells were treated with oxidized low-density lipoprotein(ox-LDL)for 24 h,and then intracellular lipid droplets and cell apoptosis were quantified,and SCGN and ER stress markers were identified by western blot analysis.Furthermore,small interfer RNA(siRNA)-mediated SCGN knockdown and recombinant plasmid-mediated SCGN restoration experiments were performed to confirm the role of SCGN in ER stress and associated cell apoptosis.Finally,the interaction of SCGN with ATF4 was computationally predicted and then validated by a co-immunoprecipitation assay.We found that ox-LDL treatment increased the levels of ER stress markers,such as phosphorylated protein kinase-like endoplasmic reticulum kinase,phosphorylated eukaryotic initiation factor 2 alpha,activating transcription factor 4(ATF4),and transcription factor CCAAT-enhancer-binding protein homologous protein,and promoted MIN6 cell apoptosis;in addition,the expression of SCGN was downregulated.siRNA-mediated SCGN knockdown exacerbatedβ-cell ER stress by increasing ATF4 expression.Pretreatment of MIN6 cells with the recombinant SCGN partly antagonized ox-LDL-induced ER stress and apoptosis.Furthermore,a co-immunoprecipitation assay revealed an interaction between SCGN and ATF4 in MIN6 cells.Taken together,these results demonstrated that pancreaticβ-cell apoptosis induced by ox-LDL treatment can be attributed,in part,to an SCGN/ATF4-dependent ER stress response. | Li Wu Yuncheng Lv Ying Lv Sunmin Xiang Zhibo Zhao Ziqing Tang Linling Ou Bin Yan Xinhua Xiao Gebo Wen Renxian Cao Jing Yang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 2 |
| 7 | Temporal-spatial distributions of road silt loadings and fugitive road dust emissions in Beijing from 2019 to 2020显示文摘Road silt loading(sL)is an important parameter in the fugitive road dust(FRD)emissions.In this study,the improved Testing Re-entrained Aerosol Kinetic Emissions from Roads(TRAKER)combined with the AP-42 method was firstly developed to quickly measure and estimate the sLs of paved roads in Beijing,China.The annual average sLs in Beijing was 0.59±0.31 g/m^(2)in 2020,and decreased by 22.4%compared with that in 2019.The seasonal variations of sLs followed the order of spring>winter>summer>autumn in the two years.The seasonal mean road sLs on the same type road in the four seasons presented a decline trend from^(2)019 to 2020,especially on the Expressway,decreasing 47.4%-72.7%.The road sLs on the different type roads in the same season followed the order of Major arterial∼Minor arterial∼Branch road>Express road,and Township road∼Country highway>Provincial highway∼National highway.The emission intensities of PM10 and PM_(2.5)from FRD in Beijing in 2020 were lower than those in 2019.The PM10 and PM_(2.5)emission intensities at the four planning areas in the two years all presented the order of the capital functional core area>the urban functional expansion area>the urban development new area>the ecological conservation and development area.The annual emissions of PM10 and PM_(2.5)from FRD in Beijing in 2020 were 74,886 ton and 18,118 ton,respectively,decreasing by∼33.3%compared with those in 2019. | Haibin Wang Lihui Han Tingting Li Song Qu Yuncheng Zhao Shoubin Fan Tong Chen Haoran Cui Junfang Liu | 2023 | Journal of Environmental Sciences2023，，10： | 1 |
| 8 | Effect of commercialprocessing on pesticide residues in orange products显示文摘 | LI Yuncheng JIAO Bining ZHAO Qiyang | 2012 | European FoodResearch and Technology2012，234，3： | 1 |
| 9 | Derivation and Characterization of Ovine Embryonic Stem-Like Cell Lines in Semi-defined Medium Without Feeder Cells显示文摘 | Yuncheng Zhao Jiapeng Lin Liqin Wang | 2011 | J Exp Zool2011，315，： | 1 |
| 10 | Air pollutant emissions from the asphalt industry in Beijing,China显示文摘Improving our understanding of air pollutant emissions fromthe asphalt industry is critical for the development and implementation of pollution control policies.In this study,the spatial distribution of potential maximum emissions of volatile organic compounds(VOCs)in the complete life cycle of asphaltmixtures,as well as the particulate matter(PM),asphalt fume,nonmethane hydrocarbons(NMHCs),VOCs,and benzoapyrene(BaP)emissions from typical processes(e.g.,asphalt and concrete mixing stations,asphalt heating boilers,and asphalt storage tanks)in asphalt mixing plants,were determined in Beijing in 2017.The results indicated that the potential maximum emissions of VOCs in the complete life cycle of asphalt mixtures were 18,001 ton,with a large contribution from the districts of Daxing,Changping,and Tongzhou.The total emissions of PM,asphalt fume,NMHC,VOCs,and BaP from asphalt mixing plants were 3.1,12.6,3.1,23.5,and 1.9×10^(−3)ton,respectively.The emissions of PMfromasphalt and concretemixing stations contributed themost to the total emissions.The asphalt storage tankwas the dominant emission source of VOCs,accounting for 96.1%of the total VOCs emissions in asphalt mixing plants,followed by asphalt heating boilers.The districts of Daxing,Changping,and Shunyi were the dominant regions for the emissions of PM,asphalt fume,NMHC,and BaP,while the districts of Shunyi,Tongzhou,and Changping contributed the most emissions of VOCs. | Song Qu Shoubin Fan Gang Wang Wanqing He Kangli Xu Lei Nie Yuncheng Zhao Qingchun Zhu Tingting Li Guohao Li | 2021 | Journal of Environmental Sciences2021，33，11： | 1 |
| 11 | PAID study design on the role of PKC activation in immune/inflammation-related depression:a randomised placebo-controlled trial protocol显示文摘Background Inflammation that is mediated by microglia activation plays an important role in the pathogenesis of depression.Microglia activation can lead to an increase in the levels of proinflammatory cytokines,including TNF-α,which leads to neuronal apoptosis in the specific neural circuits of some brain regions,abnormal cognition and treatment-resistant depression(TRD).Protein kinase C(PKC)is a key regulator of the microglia activation process.We assume that the abnormality in PKC might result in abnormal microglia activation,neuronal apoptosis,significant changes in emotional and cognitive neural circuits,and TRD.In the current study,we plan to target at the PKC signal pathway to improve the TRD treatment outcome.Methods and analysis This is a 12-week,ongoing,randomised,placebo-controlled trial.Patients with TRD(N=180)were recruited from Shanghai Mental Health Center,Shanghai Jiao Tong University.Healthy control volunteers(N=60)were recruited by advertisement.Patients with TRD were randomly assigned to‘escitalopram+golimumab(TNF-αinhibitor)’,‘escitalopram+calcium tablet+vitamin D(PKC activator)’or‘escitalopram+placebo’groups.We define the primary outcome as changes in the 17-item Hamilton Depression Rating Scale(HAMD-17).The secondary outcome is defined as changes in anti-inflammatory effects,cognitive function and quality of life.Discussion This study might be the first randomised,placebo-controlled trial to target at the PKC signal pathway in patients with TRD.Our study might help to propose individualised treatment strategies for depression.Trial registration number The trial protocol is registered with ClinicalTrials.gov under protocol ID 81930033 and ClinicalTrials.gov ID NCT04156425. | Xiaoyun Guo Ruizhi Mao Lvchun Cui Fan Wang Rubai Zhou Yun Wang Jia Huang Yuncheng Zhu Yamin Yao Guoqing Zhao Zezhi Li Jun Chen Jinhui Wang Yiru Fang | 2021 | General Psychiatry2021，34，2： | 0 |
| 12 | Perspective of World Economy and China's External Economic Environment显示文摘Owing to a series of impacts of the '9·11 terrorist attack,' the accounting scandals of big companies, Iraq War and the SARS crisis in the past two years, the world economy that might have rebounded forcefully has been on a wavering process of slow recovery. | Tao Jian Chen Fengying Zhao Hongtu Zhang Yuncheng Jiang Yong Liang Jianwu Ni Jianjun Li Hongyan | 2003 | Contemporary International Relations2003，13，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员