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| 1 | Interleukin-12 Gene Modification Exerts Anti-Tumor Effects on Murine Mammary Sarcoma Cell Line in vivo显示文摘The aim of this project was to investigate the anti-tumor effect of an IL-12 gene modified mammary sarcoma murine cell line, EMT6/IL-12, in mouse model. In this study, we transfected the recombinant eukaryotic plasmid encoding IL-12 gene (pcDNA6-p70) into EMT6 and obtained the IL-12 expressing EMT6/IL-12 cell line. Then EMT6/IL-12 cells were s.c. inoculated into mice. The recombinant vector treatment group was set as control. We then evaluated the inhibition of tumor growth and the anti-tumor immunity function in vivo such as cytotoxicity, proliferation of splenocytes and serial IFN-γ level. And the percentage of IFN-γ producing CD4 or CD8 T cells among splenocytes was also analyzed in tumor bearing mice. Our results showed that the growth of tumors was obviously inhibited in EMT6/IL-12 group. Moreover, the capacities of anti-tumor immunity were all significantly higher in EMT6/IL-12 group compared to the controls. The results of the present investigation support the notion that EMT6/IL-12 could exert gene therapy in tumor model by improving the anti-tumor cellular immunity. | Dan Li Hong Yu Tengfei Xu Jinghua Li Yunfang Sun Wenqing Zhang | 2008 | Cellular & Molecular Immunology2008，5，3： | 9 |
| 2 | Effects of hepatocyte growth factor overexpressed bone marrow‐derived mesenchymal stem cells on prevention from left ventricular remodelling and functional improvement in infarcted rat hearts显示文摘 | Shenxu Wang Xing Qin Dongdong Sun Yunfang Wang Xiaoyan Xie Weiwei Fan Yabin Wang Dong Liang Xuetao Pei Feng Cao | 2012 | Cell Biochem Funct2012，，7： | 2 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Studies on the Levels of Indoor PM10 and PM2.5 in Public Places in Chaoyang District, Beijing显示文摘[Objective]The research aimed to understand the levels of indoor air particles of PM_(10) and PM_(2.5)in public places in Chaoyang District of Beijing City,which will provide scientific basis for making health standards and policies and regulations of indoor air particulate matter in public places.[Method]In order to characterize indoor air quality of public places,shopping mall near the walking street,shopping mall near arterial traffic,barbecue style restaurant and eat hutch unicom Chinese restaurant were selected for this study.LD-3Claser measuring dust detector and Sidepak AM-510 artificial intelligence anti-explosion dust detector were used to test the levels of PM_(10) and PM_(2.5)in the air of the shopping malls and restaurants.The number of smoking customers and if smelling the smoke were recorded simultaneously.[Result]The average densities of PM_(10) and PM_(2.5)in the shopping mall near the walking street were noticeably lower than that near arterial traffic(P< 0.05).The highest level of PM_(2.5)at the barbecue style restaurant and eating hutch unicom Chinese restaurants were 1 090and666g/m^3.The average levels of PM_(10) at the barbecue style restaurant and eating hutch unicom restaurants were 286 and 399g/m3(P<0.05).[Conclusion]The indoor PM_(10) and PM_(2.5)concentrations were high in public places,especially in shopping mall near arterial traffic and restaurant.It should be enhanced to supervise indoor air in public places and establish the risk rating of indoor air quality to protect public health. | Zhang Haixia Zhang Guibin Zhang Meiyun Sun Xiaobing Ai Liyan Zhang Debiao Wei Yunfang | 2016 | Meteorological and Environmental Research2016，7，4： | 0 |
| 5 | Diterpenoids from the aerial parts of Leonurus macranthus显示文摘Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, | Yunfang Zhao Zheng Huang Jing Sun Daoran Pang Xiaonan Chen Huina Yao Zhixiang Zhu Jiao Zheng Pengfei Tu Jun Li | 2019 | Chinese Chemical Letters2019，30，1： | 0 |
| 6 | Structural and Magnetic Properties Studies on Swift Heavy Ion (SHI) Irradiated Fe-based Amorphous Alloys显示文摘 | Sun Jianrong Wang Zhiguang Jin Yunfang Zhu Yabin Shen Tielong Yao Cunfeng Pang Lilong Wei Kongfang Sheng Yanbin Chang Hailong Zhang Hongpeng Wang Ji Zhu Huiping | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 7 | NaHCO_(3)-induced porous PbI_(2) enabling efficient and stable perovskite solar cells显示文摘Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stability and reproducibility compared to the one-step method,which is more suitable for practical application.However,the incomplete conversion of the dense lead iodide(PbI_(2))layer during the sequential spin-coating of formamidinium/methylammonium(FA^(+)/MA^(+))organic amine salts severely affect the performance of PSCs.Herein,sodium bicarbonate(NaHCO_(3))is used to induce the formation of porous PbI_(2),which facilitates the penetration of the FA^(+)/MA^(+)ions and the formation of a perovskite film with high crystallinity and large grain microstructure.Meanwhile,the introduction of Na^(+)not only improves the energetic alignment of the PSC,but also increases the conductivity via p-doping.As a result,the optimized NaHCO_(3)-modified PSC achieves a champion power conversion efficiency of 24.0% with suppressed hysteresis.Moreover,the significant reduction in defect density and ion migration as well as a mild alkaline environment enhance the stability of device.The unencapsulated NaHCO_(3)-modified PSCs maintain over 90% of their original efficiency upon storage in ambient air(30%–40% relative humidity)for 2160 h.We have demonstrated an ingenious strategy for controlling the quality of perovskite and improving the performance of device by low-temperature foaming of simple inorganic molecules of NaHCO_(3). | Yitian Du Ying Wang Jihuai Wu Qi Chen Chunyan Deng Ran Ji Liuxue Sun Lina Tan Xia Chen Yiming Xie Yunfang Huang Yana Vaynzof Peng Gao Weihai Sun Zhang Lan | 2023 | InfoMat2023，5，6： | 0 |
| 8 | Lewis base catalyzed ring-expansion of isatin with 2,2,2-trifluorodiazoethane(CF3CHN2):An efficient route to3-hydroxy-4-(trifluoromethyl)quinolinones显示文摘A Lewis base catalyzed ring expansion of isatin with 2,2,2-trifluorodiazoethane(CF3 CHN2)is developed.It is characterized that the merge of tetramethylethylenediamine and CF3 CHN2 generates reactive triazene intermediates,which construct substituted 3-hydroxy-4-(trifluoromethyl)quinolinones with high efficiency.Synthetic application of the procedure is broadened by 3-trifluormethylpyrazole fused3-hydroxy-4-(trifluoromethyl)quinolinone synthesis. | Shuaipeng Lv Yunfang Sun Yue Xu Shihai Yang Lei Wang | 2020 | Chinese Chemical Letters2020，31，6： | 0 |
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