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| 1 | Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion显示文摘 | Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li | 2018 | Cell Research2018，28，9： | 18 |
| 2 | β-diversity Patterns of Plant Community in Fragmented Habitat in a Degenerated Meadow in Songnen Plain,China显示文摘A number of isolated islands of Leymus chinensis + herbosa community were investigated in fragmented habitat islands,by Braun-Blanquet field survey approach,in a degenerated meadow in the Songnen Plain,China in 2007.These islands were classified as large,medium,and small scales on the basis of the island area(100-1000m2,large island;50-100m2,middle island;10-50m2,small island).Each scale of the investigation involved eight islands.The responses of β-diversity patterns of plant taxon to the habitat fragmentation at local community and metacommunity levels were analyzed on different scales of 24 isolated islands.The results indicated that at the local community level,there were 57 species belonging to 20 families and 49 genera in large islands,49 species belonging to 16 families and 40 genera in middle islands,and 27 species belonging to eight families and 23 genera in small islands.β-diversity indexes for species,genus and family in large,middle,and small islands varied greatly,and the highest value of the indexes was not noted in the largest island.However,the average of the data obtained at the three scales showed that across large islands,Whittaker indexes were low and Bray-Curtis similarity indexes were high,while across small islands,Whittaker indexes were high and Bray-Curtis similarity indexes were low.At the metacommunity level,Whittaker indexes for species and genus showed a great significantly negative double logarithmic correlation(p<0.01) with the island area,whereas the Bray-Curtis indexes for species,genus and family showed a great significantly positive double logarithmic correlation(p<0.01) with the island area.At both local community and metacommunity levels,turnovers of species and genus could respond more sensitively to spatial changes of plant diversity patterns than that of family.Hence,the species and the genus could be used for the analysis of β-diversity patterns of plant community. | HAN Dayong LI Haiyan YANG Yunfei | 2009 | Chinese Geographical Science2009，19，4： | 11 |
| 3 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
| 4 | Extreme Cold Events from East Asia to North America in Winter 2020/21:Comparisons,Causes,and Future Implications显示文摘Three striking and impactful extreme cold weather events successively occurred across East Asia and North America during the mid-winter of 2020/21.These events open a new window to detect possible underlying physical processes.The analysis here indicates that the occurrences of the three events resulted from integrated effects of a concurrence of anomalous thermal conditions in three oceans and interactive Arctic-lower latitude atmospheric circulation processes,which were linked and influenced by one major sudden stratospheric warming(SSW).The North Atlantic warm blob initiated an increased poleward transient eddy heat flux,reducing the Barents-Kara seas sea ice over a warmed ocean and disrupting the stratospheric polar vortex(SPV)to induce the major SSW.The Rossby wave trains excited by the North Atlantic warm blob and the tropical Pacific La Nina interacted with the Arctic tropospheric circulation anomalies or the tropospheric polar vortex to provide dynamic settings,steering cold polar air outbreaks.The long memory of the retreated sea ice with the underlying warm ocean and the amplified tropospheric blocking highs from the midlatitudes to the Arctic intermittently fueled the increased transient eddy heat flux to sustain the SSW over a long time period.The displaced or split SPV centers associated with the SSW played crucial roles in substantially intensifying the tropospheric circulation anomalies and moving the jet stream to the far south to cause cold air outbreaks to a rarely observed extreme state.The results have significant implications for increasing prediction skill and improving policy decision making to enhance resilience in“One Health,One Future”. | Xiangdong ZHANG Yunfei FU Zhe HAN James E.OVERLAND Annette RINKE Han TANG Timo VIHMA Muyin WANG | 2022 | Advances in Atmospheric Sciences2022，39，4： | 7 |
| 5 | Hydrogel-based composites beyond the porous architectures for electromagnetic interference shielding显示文摘With the rapid development of the electronic industry and wireless communication technology,electromagnetic interference(EMI)or pollution has been increasingly serious.This not only severely endangers the normal operation of electronic equipment but also threatens human health.Therefore,it is urgent to develop high-performance EMI shielding materials.The advent of hydrogel-based materials has given EMI shields a novel option.Hydrogels combined with conductive functional materials have good mechanical flexibility,fatigue durability,and even high stretchability,which are beneficial for a wide range of applications,especially in EMI shielding and some flexible functional devices.Herein,the current progress of hydrogel-based EMI shields was reviewed,in the meanwhile,some novel studies about pore structure design that we believe will help advance the development of hydrogel-based EMI shielding materials were also included.In the outlook,we suggested some promising development directions for the hydrogel-based EMI shields,by which we hope to provide a reference for designing hydrogels with excellent EMI shielding performance and multifunctionalities. | Yunfei Yang Mingrui Han Wei Liu Na Wu Jiurong Liu | 2022 | Nano Research2022，15，10： | 5 |
| 6 | Effect of Mo content on microstructure and stress-rupture properties of a Ni-base single crystal superalloy显示文摘The additional 1.5 wt% Mo was added in a Ni-base single crystal(SC) alloy with the composition of Ni–6.5Al–8.0Mo–2.4Cr–6.2Ta–4.9Co–1.5Re–(0.01–0.05)Y(wt%) to study the effect of Mo content on the microstructure and stress-rupture properties. The creep and stress-rupture tests under the conditions of 850 °C/500 MPa and 1100 °C/130 MPa were conducted, and the microstructure of as-cast, heat treated and stress ruptured specimens were analyzed. It was found that the 1.5 wt% Mo addition enhanced the stress-rupture lives at both intermediate(850 °C) and high(1100 °C)temperatures. The microstructure analysis showed that adding 1.5 wt% Mo in the basic alloy affected the microstructure dramatically, i.e., the Mo-rich phases formed in the specimens of as-cast and stress-ruptured specimens. It is considered that the improvement of the stress-rupture lives is duo to the strengthening effect of Mo to both γ and γ'phases and the decrease of stacking fault energy, diffusion constant and dislocation spacing. The Mo-rich phases precipitated under condition of 1100 °C/130 MPa did not affect the creep and stress-rupture properties obviously in the present study. | Yunfei Liang Shusuo Li Cheng Ai Yafang Han Shengkai Gong | 2016 | Progress in Natural Science:Materials International2016，26，1： | 5 |
| 7 | Theory and techniques of data mining in CGF behavior modeling显示文摘For the large quantity of data,rules and models generated in the course of computer generated forces (CGFs) behavior modeling,the common analytical methods are statistical methods based on the tactical rules,tactical doctrine and empirical knowledge.However,from the viewpoint of data mining,we can find many of these analytical methods are also each-and-every different data mining methods.In this paper,we survey the data mining theory and techniques that have appeared in the course of CGF behavior modeling from the viewpoint of data mining.Further,we redefine and reclassify these theories and techniques according to the research requirements of data mining (the knowledge structure of data mining).We aim to help the CGF investigators to learn the key points and the research methods of the data intelligent processing in the CGF behavior modeling,and thus we can provide the references for the colleagues who are engaged in the research and practice of the CGF behavior modeling by this article.We also introduce our ongoing work on the CGF behavior modeling based on data mining. | YIN YunFei GONG GuangHong HAN Liang | 2011 | Science China(Information Sciences)2011，54，4： | 4 |
| 8 | Feedback structure based entropy approach for multiple-model estimation显示文摘The variable-structure multiple-model(VSMM)approach,one of the multiple-model(MM)methods,is a popular and effective approach in handling problems with mode uncertainties.The model sequence set adaptation(MSA)is the key to design a better VSMM.However,MSA methods in the literature have big room to improve both theoretically and practically.To this end,we propose a feedback structure based entropy approach that could fnd the model sequence sets with the smallest size under certain conditions.The fltered data are fed back in real time and can be used by the minimum entropy(ME)based VSMM algorithms,i.e.,MEVSMM.Firstly,the full Markov chains are used to achieve optimal solutions.Secondly,the myopic method together with particle flter(PF)and the challenge match algorithm are also used to achieve sub-optimal solutions,a trade-off between practicability and optimality.The numerical results show that the proposed algorithm provides not only refned model sets but also a good robustness margin and very high accuracy. | Shen-tu Han Xue Anke Guo Yunfei | 2013 | Chinese Journal of Aeronautics2013，26，6： | 3 |
| 9 | Dual-periodic-microstructure-induced color tunable white organic Ught-emitting devices显示文摘 | Yangang BI Jinhai JI Yang CHEN Yushan LIU Xulin ZHANG Yunfei LI Ming XU Yuefeng LIU Xiaochi HAN Qiang GAO Hongbo SUN | 2016 | Frontiers of Optoelectronics2016，9，2： | 2 |
| 10 | LNP-CpG ODN-adjuvanted varicella-zoster virus glycoprotein E induced comparable levels of immunity with Shingrix^(TM) in VZV-primed mice显示文摘Latent varicella-zoster virus(VZV)may be reactivated to cause herpes zoster,which affects one in three people during their lifetime.The currently available subunit vaccine Shingrix^(TM) is superior to the attenuated vaccine Zostavax®in terms of both safety and efficacy,but the supply of its key adjuvant component QS21 is limited.With ionizable lipid nanoparticles(LNPs)that were recently approved by the FDA for COVID-19 mRNA vaccines as carriers,and oligodeoxynucleotides containing CpG motifs(CpG ODNs)approved by the FDA for a subunit hepatitis B vaccine as immunostimulators,we developed a LNP vaccine encapsulating VZV-glycoprotein E(gE)and CpG ODN,and compared its immunogenicity with Shingrix^(TM) in C57BL/6J mice.The results showed that the LNP vaccine induced comparable levels of gE-specific IgG antibodies to Shingrix^(TM) as determined by enzymelinked immunosorbent assay(ELISA).Most importantly,the LNP vaccine induced comparable levels of cellmediated immunity(CMI)that plays decisive roles in the efficacy of zoster vaccines to Shingrix^(TM) in a VZVprimed mouse model that was adopted for preclinical studies of Shingrix^(TM) .Number of IL-2 and IFN-γsecreting splenocytes and proportion of T helper 1(Th1)cytokine-expressing CD4^(+)T cells in LNP-CpG-adjuvanted VZV-gE vaccinated mice were similar to that of Shingrix^(TM) boosted mice.All of the components in this LNP vaccine can be artificially and economically synthesized in large quantities,indicating the potential of LNP-CpGadjuvanted VZV-gE as a more cost-effective zoster vaccine. | Ning Luan Han Cao Yunfei Wang Kangyang Lin Cunbao Liu | 2022 | Virologica Sinica2022，37，5： | 2 |
| 11 | Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus(2022)显示文摘The World Health Organization(WHO)has set the goal of eliminating hepatitis as a threat to public health by 2030.Blocking mother-to-child transmission(MTCT)of hepatitis B virus(HBV)is not only the key to eliminating viral hepatitis,but also a hot issue in the field of hepatitis B prevention and treatment.To standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants,the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines,including 10 steps of pregnancy management and postpartum follow-up,among which screening,antiviral treatment,and infant immunization are its core components. | Zhihua Liu Zhongdan Chen Fuqiang Cui Yang Ding Yunfei Gao Guorong Han Jidong Jia Jie Li Zengde Li Yingxia Liu Qing Mao Ailing Wang Wei Wang Lai Wei Jianhong Xia Qing Xie Xizhong Yang Xueru Yin Hua Zhang Liaoyun Zhang Wenhong Zhang Hui Zhuang Xiaoguang Dou Jinlin Hou | 2022 | Journal of Clinical and Translational Hepatology2022，10，5： | 2 |
| 12 | Intelligent nanotherapeutic strategies for the delivery of CRISPR system显示文摘CRISPR, as an emerging gene editing technology, has been widely used in multiple fields due to its convenient operation, less cost, high efficiency and precision. This robust and effective device has revolutionized the development of biomedical research at an unexpected speed in recent years. The development of intelligent and precise CRISPR delivery strategies in a controllable and safe manner is the prerequisite for translational clinical medicine in gene therapy field. In this review, the therapeutic application of CRISPR delivery and the translational potential of gene editing was firstly discussed. Critical obstacles for the delivery of CRISPR system in vivo and shortcomings of CRISPR system itself were also analyzed. Given that intelligent nanoparticles have demonstrated great potential on the delivery of CRISPR system, here we mainly focused on stimuli-responsive nanocarriers. We also summarized various strategies for CIRSPR-Cas9 system delivered by intelligent nanocarriers which would respond to different endogenous and exogenous signal stimulus. Moreover, new genome editors mediated by nanotherapeutic vectors for gene therapy were also discussed. Finally, we discussed future prospects of genome editing for existing nanocarriers in clinical settings. | Chao Chen Wu Zhong Shiyu Du Yayao Li Yunfei Zeng Kunguo Liu Jingjing Yang Xiaoxiang Guan Xin Han | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 1 |
| 13 | Air-combat behavior data mining based on truncation method显示文摘This paper considers the problem of applying data mining techniques to aeronautical field.The truncation method,which is one of the techniques in the aeronautical data mining,can be used to efficiently handle the air-combat behavior data.The technique of air-combat behavior data mining based on the truncation method is proposed to discover the air-combat rules or patterns.The simulation platform of the air-combat behavior data mining that supports two fighters is implemented.The simulation experimental results show that the proposed air-combat behavior data mining technique based on the truncation method is feasible whether in efficiency or in effectiveness. | Yunfei Yin Guanghong Gong Liang Han | 2010 | Journal of Systems Engineering and Electronics2010，21，5： | 1 |
| 14 | 显示文摘 | Li Yanping Bai Yunfei Han Gaoyi | 2013 | Sensors and Ac- tuators B2013，185，： | 1 |
| 15 | Bortezomib activity and in vitro imeractions with anthracyclines and cytarabine in acute myeloid leukemia ceils are independent of multidrug resistance mechanisms and p53 status 显示文摘 | Hans M Yunfei Z Kieran L | 2007 | Cancer Chemotherapy and Pharmacology2007，60，2： | 1 |
| 16 | Aptamers selected by cell-SELEX for application in cancer studies显示文摘 | Yunfei Zhang Yan Chen Da Han Ismail Ocsoy Weihong Tan | 2010 | Bioanalysis2010，，5： | 1 |
| 17 | Aptamers selected by cell-SELEX for application in cancer studies显示文摘 | Yunfei Zhang Yan Chen Da Han Ismail Ocsoy Weihong Tan | 2010 | Bioanalysis2010，，5： | 1 |
| 18 | Controlapproach to rough set reduction 显示文摘 | Yin Yunfei Gong Guanghong Han Liang | 2009 | Computers &Mathematics with Applications2009，57，1： | 1 |
| 19 | Third-order trajectory planning for high accuracy point-topoint motion显示文摘This article studies a third-order trajectory planning method for point-to-point motion.All available instances for third-order trajectory planning are first analyzed.To distinguish those,three criteria are presented relying on trajectory characteristics.Following that,a fast preprocessing approach considering the trajectory as a whole is given based on the criteria constructed and system constraints.Also,the time-optimality of the trajectory is obtained.The relevant formulas are derived with the combination of geometrical symmetry of trajectory and area method.As a result,an accurate algorithm and its implementation procedure are proposed.The experimental results show the effectiveness and precision of the proposed method.The presented algorithm has been applied in semiconductor manufacturing equipment successfully. | Haihua MU Yunfei ZHOU Sijie YAN Aiguo HAN | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，1： | 1 |
| 20 | Large-Area Gravure-Printed AgNWs Electrode on Water/Oxygen Barrier Substrate for Long-Term Stable Large-Area Flexible Organic Solar Cells显示文摘Large-area AgNWs electrodes(25 cm×10 cm)were fabricated through roll-to-roll printing on the polyvinyl alcohol(PVA)modified water and oxygen barrier substrate.The modification of the barrier film with PVA improved the wettability of silver nanowires on the barrier films and led to the formation of homogenous large-area AgNWs networks.The mechanical flexibility,especially the adhesion force between the silver electrode and the barrier film substrate was dramatically improved through PVA modification.The efficiency of 13.51%for the flexible OSCs with an area of 0.64 cm2 was achieved based on the PET/barrier film/PVA/AgNWs electrode.The long-term stability showed the flexible OSCs based on the PET/barrier film/PVA/AgNWs electrode have a significantly improved stability relative to the device on PET/AgNWs electrode,and comparable air stability as the rigid device with glass/ITO device.The unencapsulated devices maintained nearly 50%of the original efficiency after storage for 600 h in air.After a simple top encapsulation,the flexible devices remained at 60%of the initial efficiency after 2000 h in the air.Therefore,the flexible AgNWs electrode based on the barrier film would have the potential to improve the air storage stability of organic flexible solar cells. | Hao Wang Yaqin Pan Yunfei Han Zhuo Chen Tianyu Liu Lianping Zhang Qun Luo Chang-Qi Ma | 2024 | Chinese Journal of Chemistry2024，42，5： | 0 |
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