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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | An alternative therapy for drug-resistant epilepsy: transcutaneous auricular vagus nerve stimulation显示文摘 | Rong Peijing Liu Aihua Zhang Jianguo Wang Yuping Yang Anchao Li Liang Ben Hui Li Liping Liu Rupeng He Wei Liu Huanguang Huang Feng Li Xia Wu Peng Zhu Bing | 2014 | Chinese Medical Journal2014，，2： | 20 |
| 3 | Climate change in Mt. Qomolangma region since 1971显示文摘Using monthly average, maximum, minimum air temperature and monthly precipitation data from 5 weather stations in Mt. Qomolangma region in China from 1971 to 2004, climatic linear trend, moving average, low-pass filter and accumulated variance analysis methods, the spatial and temporal patterns of the climatic change in this region were analyzed. The main findings can be summarized as follows: (1) There is obvious ascending tendency for the interannual change of air temperature in Mt. Qomolangma region and the ascending tendency of Tingri, the highest station, is the most significant. The rate of increasing air temperature is 0.234 oC/decade in Mt. Qomolangma region, 0.302 oC/decade in Tingri. The air temperature increases more strongly in non-growing season. (2) Compared with China and the global average, the warming of Mt. Qomolangma region occurred early. The linear rates of temperature increase in Mt. Qomolangma region exceed those for China and the global average in the same period. This is attributed to the sensitivity of mountainous regions to climate change. (3) The southern and northern parts of Mt. Qomolangma region are quite different in precipitation changes. Stations in the northern part show increasing trends but are not statistically significant. Nyalam in the southern part shows a decreasing trend and the sudden decreasing of precipitation occurred in the early 1990s. (4) Compared with the previous studies, we find that the warming of Mt. Qomolangma high-elevation region is most significant in China in the same period. The highest automatic meteorological comprehensive observation station in the world set up at the base camp of Mt. Qomolangma with a height of 5032 m a.s.l will play an important role in monitoring the global climate change. | YANG Xuchao ZHANG Yili ZHANG Wei YAN Yuping WANG Zhaofeng DING Mingjun CHU Duo | 2006 | Journal of Geographical Sciences2006，16，3： | 12 |
| 4 | Applications of gold nanorods in biomedical imaging and related fields显示文摘Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered. | MA ZhiYa XIA HongXing LIU YuPing LIU Bo CHEN Wei ZHAO YuanDi | 2013 | Chinese Science Bulletin2013，58，21： | 6 |
| 5 | Solid Acid Used as Highly Efficient Catalyst for Esterification of Free Fatty Acids with Alcohols显示文摘Anovel solid acid catalyst, which was prepared from sodium alginate (SA) and metal chlorides and characterized with XRD and FT-IR spectrometry, was used for the preparation of biodiesel via esterification reaction. The study results showed that the aluminum-alginate complex prepared in a cheap and easy way exhibited high catalytic activity, and a 92.6% conversion of methyl oleate was obtained in the presence of 4m% of catalyst dosage upon refluxing for 3h of methanol and acid mixed in a molar ratio of 10:1. It should be noted that the catalyst can be applied to the esterification reaction of fatty acids with various carbon chain length on methanol or different short chain alcohols, indicating that the catalyst is suitable for the preparation of biodiesel from waste oils with a high acid value. | Zhang Qiuyun Li Hu Qin Wenting Liu Xiaofang Zhang Yuping Xue Wei Yang Song | 2013 | China Petroleum Processing & Petrochemical Technology2013，15，1： | 6 |
| 6 | Preparation of an anti-diethylstilbestrol monoclonal antibody and development of an indirect competitive ELISA to detect diethylstilbestrol in biological samples显示文摘Based on the preparation of an anti-diethylstilbestrol(DES) monoclonal antibody,a simple and convenient indirect competitive enzyme-linked immunosorbent assay(ELISA) method for DES detection has been developed.The monoclonal antibody demonstrated high sensitivity to DES with an IC50 value of 275 pg mL-1 and detection limit(LOD) of 90 pg mL-1.The specificity of the assay was studied by measuring cross-reactivity of the antibody with structurally related compounds of ethinyl estradiol(<7%),estrone(<0.1%),estriol(<0.1%),and diethylstilbestrol benzoate(<0.1%).Chicken,fish,shrimp,urine and bile spiked with different concentration of DES were detected by the developed method,and the recovery rates were greater than 79.5%.Intra-and inter-assay variations were about 6%.This method exhibited high stability with a coefficient of variation less than 10% in buffer and in real samples.The LODs in fish/shrimp,liver,feed and urine spiked with DES were 600,600,4800 and 600 pg mL-1,respectively.These results confirmed that the antibody to DES was successfully produced and could be used to establish ELISA methods for DES detection in food producing animals. | LI WeiHua MENG Meng HE FangYang WAN YuPing XUE HuYin LIU Wei YIN WeiWei XU Jing FENG CaiWei WANG ShanLiang LU Xiao LIU JinTing XI RiMo | 2011 | Chinese Science Bulletin2011，56，8： | 4 |
| 7 | Female Plant Types of Ginkgo biloba L. in China显示文摘Ginkgo biloba is a dioecious and unique species within Ginkgo family and Ginkgo genus, but it shows a big variability. From 1950s, resources of female plants in China were investigated and collected, and the seed anatomical structure and morphological characters at different development stages were observed. According to the shape, length, width and thickness of ovule bracket and seed stone, as well as the characteristics of both sides and top of the stone, the female plants of Ginkgo biloba have been divided into five types, long-stone, Buddha-finger, horse-bell, mume-stone and round-stone. In addition, the important cultivars belonging to different types were also determined. The stone weight, index of stone shape, and contents of dry matter, amylose, amylopectin, starch, rough protein, soluble sugar and hydrocyanic acid in seed kernel of each type were measured, and the qualities of seed stone were appraised, which lays a foundation for the improvement and utilization of female plant resources in Ginkgo biloba. | Chen Peng He Fengren Tao Jun Qian Bolin Wei Jun Ling Yuping Wang Li Department of Horticulture, Agricultural College Yangzhou University, Yangzhou 225009, P.R.China | 2003 | Forestry Studies in China2003，5，2： | 4 |
| 8 | Research on DC Protection Strategy in Multi-Terminal Hybrid HVDC System显示文摘Multi-terminal hybrid high-voltage direct current(HVDC)systems have been developed quickly in recent years in power transmission area.However,for voltage-source converter(VSC)stations in hybrid HVDC systems,no direct current(DC)filters are required.In addition,the DC reactor is also not installed at the line end because the DC fault can be limited by the converter itself.This means that the boundary element at the line end is absent,and the single-ended protections used in line commutated converter(LCC)based HVDC(LCC-HVDC)systems or VSC-HVDC systems cannot distinguish the fault line in multi-terminal hybrid HVDC systems.This paper proposes a novel singleended DC protection strategy suitable for the multi-terminal hybrid HVDC system,which mainly applies the transient information and active injection concept to detect and distinguish the fault line.Compared with the single-ended protections used in LCC-HVDC and VSC-HVDC systems,the proposed protection strategy is not dependent on the line boundary element and is thus suitable for the multiterminal hybrid HVDC system.The corresponding simulation cases based on power systems computer aided design(PSCAD)/electromagnetic transients including DC(EMTDC)are carried out to verify the superiority of the proposed protection. | Yuping Zheng Jiawei He Bin Li Tonghua Wua Wei Dai Ye Li | 2021 | Engineering2021，7，8： | 4 |
| 9 | A Potential Global Standard Stratotype-Section and Point of the Moscovian Stage(Carboniferous)显示文摘Conodonts 和 fusulinids 是为细分和相关 Bashkirian 和 Moscovian 阶层的二个最广泛地使用的关於生命的组。因为在存在边界定义建议,其各个有劣势之中有许多争论,全球 Moscovian 阶段的底的定义是未定的。Declinognathodus donetzianus 容易在它的 paleogeographic 分发被认出,但是有点限制了。Idiognathoides postsulcatus 是稍微更普遍的,但是它不太容易被识别,它的出现可以是从区域的 diachronous 到区域。Diplognathodus ellesmerensis 容易被认出并且甚至更普遍,但是它通常是稀罕的,它的祖先足够地不被知道。南方贵州的 Naqing 节,华南包含多样的 conodont 在不同 taxa,包括的 Idiognathoides, Idiognathodus, Diplognathodus, Neognathodus, Gondolella 和 Mesogondolella 之中的进化的系。在有众多的过渡形式几乎 Naqing 节的每个系,哪个为华南的前景上演在决定基础 Moscovian 起一个关键作用的表演定义好。 | WANG Xiangdong QI Yuping Lance LAMBERT WANG Zhihao WANG Yue HU Keyi LIN Wei CHEN Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 3 |
| 10 | Three-dimensional properties of mesoscale cyclonic warm-core and anticyclonic cold-core eddies in the South China Sea显示文摘In general,a mesoscale cyclonic(anticyclonic)eddy has a colder(warmer)core,and it is considered as a cold(warm)eddy.However,recently research found that there are a number of'abnormal'mesoscale cyclonic(anticyclonic)eddies associated with warm(cold)cores in the South China Sea(SCS).These'abnormal'eddies pose a challenge to previous works on eddy detection,characteristic analysis,eddy-induced heat and salt transports,and even on mesoscale eddy dynamics.Based on a 9-year(2000–2008)numerical modelling data,the cyclonic warm-core eddies(CWEs)and anticyclonic cold-core eddies(ACEs)in the SCS are analyzed.This study found that the highest incidence area of the'abnormal'eddies is the northwest of Luzon Strait.In terms of the eddy snapshot counting method,8620 CWEs and 9879 ACEs are detected,accounting for 14.6%and 15.8%of the total eddy number,respectively.The size of the'abnormal'eddies is usually smaller than that of the'normal'eddies,with the radius only around 50 km.In the generation time aspect,they usually appear within the 0.1–0.3 interval in the normalized eddy lifespan.The survival time of CWEs(ACEs)occupies 16.3%(17.1%)of the total eddy lifespan.Based on two case studies,the intrusion of Kuroshio warm water is considered as a key mechanism for the generation of these'abnormal'eddies near the northeastern SCS. | Wenjin Sun Yu Liu Gengxin Chen Wei Tan Xiayan Lin Yuping Guan Changming Dong | 2021 | Acta Oceanologica Sinica2021，40，10： | 3 |
| 11 | Polarization-enhanced AlGaN solar-blind ultraviolet detectors显示文摘AlGaN solar-blind ultraviolet detectors have great potential in many fields,although their performance has not fully meet the requirements until now.Here,we proposed an approach to utilize the inherent polarization effect of AlGaN to improve the detector performance.AlGaN heterostructures were designed to enhance the polarization field in the absorption layer,and a high built-in field and a high electron mobility conduction channel were formed.As a result,a high-performance solar-blind ultraviolet detector with a peak responsivity of 1.42 A/W at 10 V was achieved,being 50 times higher than that of the nonpolarization-enhanced one.Moreover,an electron reservoir structure was proposed to further improve the performance.A higher peak responsivity of 3.1 A/W at30 V was achieved because the electron reservoir structure could modulate the electron concentration in the conduction channel.The investigation presented here provided feasible approaches to improve the performance of the AlGaN detector by taking advantage of its inherent property. | Ke Jiang Xiaojuan Sun Zi-Hui Zhang Jianwei Ben Jiamang Che Zhiming Shi Yuping Jia Yang Chen Shanli Zhang Wei Lv Dabing Li | 2020 | Photonics Research2020，8，7： | 3 |
| 12 | A LOSSLESS COMPRESSION ALGORITHM OF REMOTE SENSING IMAGE FOR SPACE APPLICATIONS显示文摘A simple and adaptive lossless compression algorithm is proposed for remote sensing image compression,which includes integer wavelet transform and the Rice entropy coder.By analyzing the probability distribution of integer wavelet transform coefficients and the characteristics of Rice entropy coder,the divide and rule method is used for high-frequency sub-bands and low-frequency one.High-frequency sub-bands are coded by the Rice entropy coder,and low-frequency coefficients are predicted before coding.The role of predictor is to map the low-frequency coefficients into symbols suitable for the entropy coding.Experimental results show that the average Compression Ratio(CR) of our approach is about two,which is close to that of JPEG 2000.The algorithm is simple and easy to be implemented in hardware.Moreover,it has the merits of adaptability,and independent data packet.So the algorithm can adapt to space lossless compression applications. | Sui Yuping Yang Chengyu Liu Yanjun Wang Jun Wei Zhonghui He Xin | 2008 | Journal of Electronics(China)2008，25，5： | 3 |
| 13 | A single nucleotide substitution at 5'-UTR of GSN1 represses its translation and leads to an increase of grain length in rice显示文摘Rice grain size is an important trait that affects rice yield and quality, and thus the identification of genes related to grain size is of great significance for improving rice yield and quality. Many genes related to grain size, such as DEP1(Huang et al., 2009),GW5(Liu et al., 2017). | Xia Zhang Peng Qin Youlin Peng Bo Ma Jiangbo Hu Shijun Fan Binhua Hu Guohua Zhang Hua Yuan Wei Yan Weilan Chen Bin Tu Hang He Bingtian Ma Yuping Wang Shigui Li | 2019 | Journal of Genetics and Genomics2019，46，2： | 2 |
| 14 | Interbasin exchanges and their roles in global ocean circulation:A study based on 1 400 years' spin up of MOM4p1显示文摘A global prognostic model based on MOM4p1,which is a primitive equation nonBoussinesq numerical model,has been integrated with 1 400 years from the state of rest based on the realistic topography to study the long-term pattern of combined wind-driven and thermodynamically-driven general circulation.The model is driven by monthly climatological mean forces and includes 192×189 horizontal grids and31 pressure-based vertical levels.The main objective is to investigate the mass and heat transports at interbasin passages and their compensations and roles in the global ocean circulation under equilibrium state of long-term spin up.The kinetic energy analysis divides the spin up process into three stages:the quasi-stable state of wind driven current,the growing phase of thermodynamical circulation and the equilibrium state of thermohaline circulation.It is essential to spin up over a thousand years in order to reach the thermohaline equilibrium state from a state of rest.The Arctic Throughflow from the Bering Strait to the Greenland Sea and the Indonesian Throughflow(ITF)are captured and examined with their compensations and existing data.Analysis reveals that the slope structures of sea surface height are the dynamical driving mechanism of the Pacific-Arctic-Atlantic throughflow and ITF.The analysis denotes,in spite of O(1.4×106m3/s)of the southward volume transport in the northern Atlantic,that there is still O(1 PW)of heat transported northward since the northward currents in the upper layer carry much higher temperature water than the southward flowing northern Atlantic deep water(NADW).Meridional volume and heat transports are focused on the contributions to NADW renewals and Atlantic meridional overturning circulation(AMOC).Quantitative descriptions of the interbasin exchanges are explained by meridional compensations and supported by previous observations and numerical modeling results.Analysis indicates that the volume and heat exchanges on the interbasin passages proposed in this article manifest their hub roles in the Great Ocean Conveyor System. | ZHU Yaohua WEI Zexun FANG Guohong WANG Yonggang GUAN Yuping | 2014 | Acta Oceanologica Sinica2014，33，1： | 2 |
| 15 | Fast Distance Protection Scheme for Wind Farm Transmission Lines Considering R-L and Bergeron Models显示文摘The distributed capacitance of the line becomes larger as the scale of wind farms,the transmission voltage level,and the transmission distance increase.Hence,the error of the traditional time-domain distance protection scheme based on the R-L model,which ignores the distributed capacitance of the line,becomes unacceptable.Therefore,the error of the time-domain fault location method based on the R-L model,especially the maximum error range,is theoretically analyzed in this paper.On this basis,a novel fault location method based on the RL and Bergeron models is proposed.Then,a fast time-domain distance protection scheme is designed.In the proposed scheme,the error in the fitting calculation is used to construct a weight matrix,and an algorithm for solving the time-domain differential equations is designed to improve the calculation speed and stability.Compared with the traditional frequency-domain distance protection scheme,the proposed scheme is independent of the power supply characteristics;thus,it is suitable for wind farm transmission lines.In addition,compared with the traditional method based on the R-L model,the proposed scheme effectively avoids the negative influence of the distributed capacitance of the line,which significantly improves the operating speed.Different types of faults are simulated by PSCAD/EMTDC to verify the effectiveness and superiority of the proposed scheme. | Zepeng Hu Bin Li Yuping Zheng Tonghua Wu Jiawei He Bin Yao Yaru Sheng Wei Dai Xindong Li | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，3： | 2 |
| 16 | Cooling effect of ballast revetment on the roadbed of Qinghai-Tibetan Railway显示文摘The data obtained through the roadbed surface thermal regime experiment (ROBSTREX), which was carried out at Beiluhe test section of Qinghai-Tibetan Railway from October to December in 2002, were used to estimate the cooling effect of ballast revetment on the roadbed. The results show that both riprap rock ballast revetment and crushed stone ballast revetment can reduce the temperature of the roadbed. But the cooling effect of riprap rock ballast revetment is better than that of crushed stone ballast revetment when the temperature of roadbed is higher. The cooling effect of crushed stone ballast revetment is better than that of riprap rock ballast revetment when the temperature of the roadbed is lower, especially at deeper roadbed layers. In the frozen season, the heat release from the roadbed also shows that the cooling effect of ballast revetment on the roadbed is obvious, and the cooling effect of crushed stone-ballast revetment on the roadbed is much evident than that of riprap rock ballast revetment. | HU Zeyong CHENG Guodong QIAN Zeyu WANG Jiemin WEI Guoan HOU Xuhong GU Lianglei YAN Yuping | 2004 | Science China Earth Sciences2004，47，z1： | 2 |
| 17 | Carboniferous integrative stratigraphy and timescale of China显示文摘The Carboniferous period lasted about 60 Myr, from ~358.9 Ma to ~298.9 Ma. According to the International Commission on Stratigraphy, the Carboniferous System is subdivided into two subsystems, i.e., Mississippian and Pennsylvanian, including 6 series and 7 stages. The Global Stratotype Sections and Points(GSSPs) of three stages have been ratified, the Tournaisian, Visean, and Bashkirian stages. The GSSPs of the remaining four stages(i.e., the Serpukhovian, Moscovian,Kasimovian, and Gzhelian) have not been ratified so far. This paper outlines Carboniferous stratigraphic subdivision and correlation on the basis of detailed biostratigraphy mainly from South China, and summarizes the Carboniferous chronostratigraphic framework of China. High-resolution biostratigraphic study reveals 37 conodont zones, 24 foraminiferal(including fusulinid) zones, 13 ammonoid zones, 10 brachiopod zones, and 10 rugose coral zones in the Carboniferous of China. The biostratigraphic framework based on these biozones warrants the precise correlation of regional stratigraphy of China(including2 subsystems, 4 series, and 8 stages) to that of the other regions globally. Meanwhile, the Carboniferous chemo-, sequence-,cyclo-, and event-stratigraphy of China have been intensively studied and can also be correlated worldwide. Future studies on the Carboniferous in China should focus on(1) the correlation between shallow-and deep-water facies and between marine and continental facies,(2) high-resolution astronomical cyclostratigraphy, and(3) paleoenvironment and paleoclimate analysis based on geochemical proxies such as strontium and oxygen isotopes, as well as stomatal indices of fossil plants. | Xiangdong WANG Keyi HU Wenkun QIE Qingyi SHENG Bo CHEN Wei LIN Le YAO Qiulai WANG Yuping QI Jitao CHEN Zhuoting LIAO Junjun SONG | 2019 | Science China Earth Sciences2019，62，1： | 2 |
| 18 | Preparation and mineralization of PLGA/Gt electrospun fiber mats显示文摘Poly(lactic-co-glycolic acid)(PLGA)/gelatin(Gt) ultrafine composite fibers were fabricated via electro-spinning.The effect of gelatin on the morphology and tensile property of the electrospun fiber mats was investigated.Mineralization was carried out in 10×simulated body fluid(10SBF).The deposited calcium phosphate(CaP) was identified by scanning electron microscopy(SEM),energy dispersive spectroscopy(EDS),X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FTIR).Results indicated that the average diameter of PLGA/Gt electrospun fibers was much smaller than that of PLGA fibers and the addition of gelatin increased the tenacity of wet mats.Two types of calcium phosphate deposits with different molar ratios of Ca/P were obtained when the electrospun PLGA/Gt mat was incubated in 10SBF.CaP crystals nucleated and grew faster on PLGA/Gt fiber mats rather than on PLGA membranes.'Honeycomb-like' crystals grew on the surface of PLGA/Gt electrospun fibers.After 4 h,the surface of the fibers was entirely coated with these crystals. | ZHAO Jin ZHAO YuPing ZHANG Wei YUAN XiaoYan YAO KangDe | 2009 | Chinese Science Bulletin2009，54，8： | 2 |
| 19 | Hierarchically mesoporous carbon spheres coated with a single atomic Fe-N-C layer for balancing activity and mass transfer in fuel cells显示文摘Novel cost-effective fuel cells have become more attractive due to the demands for rare and expensive platinum-group metal(PGM)catalysts for mitigating the sluggish kinetics of the oxygen reduction reaction(ORR).The high-cost PGM catalyst in fuel cells can be replaced by earth-abundant transition-metalbased catalysts,that is,an Fe-N-C catalyst,which is considered one of the most promising alternatives.However,the performance of the Fe-N-C catalyst is hindered by the low catalytic activity and poor stability,which is caused by insufficient active sites and the lack of optimization of the triple-phase interface for mass transportation.Herein,a novel Fe–N–C catalyst consisting of mono-dispersed hierarchically mesoporous carbon sphere cores and single Fe atom-dispersed functional shells are presented.The synergistic effect between highly dispersed Fe-active sites and well-organized porous structures yields the combination of high ORR activity and high mass transfer performance.The half-wave potential of the catalyst in 0.1M H_(2)SO_(4) is 0.82 V versus reversible hydrogen electrode,and the peak power density is 812 mW·cm^(−2) in H_(2)–O_(2) fuel cells.Furthermore,it shows superior methanol tolerance,which is almost immune to methanol poisoning and generates up to 162 mW·cm^(−2) power density in direct methanol fuel cells. | Chengyong Shu Qiang Tan Chengwei Deng Wei Du Zhuofan Gan Yan Liu Chao Fan Hui Jin Wei Tang Xiao-dong Yang Xiaohua Yang Yuping Wu | 2022 | Carbon Energy2022，4，1： | 2 |
| 20 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
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