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| 1 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 2 | Allocation Methodology of Multiple SVCs Considering Operation Scheme Changing显示文摘针对多静止同步补偿器(staticvarcompensator,SVC)对系统共同影响的问题,提出计及运行方式变化的多SVC布点方法。利用规范形分析,基于摄动方程2阶解析解信息建立拓展静态电压稳定边界的多SVC布点分析方法。首先根据静态电压稳定分析方法,确定系统危险运行方式(即距离系统电压崩溃最近的运行方式1;然后在该运行方式下,利用规范形方法对系统进行小扰动电压稳定分析,求出所有负荷节点的电压振荡曲线解析解;最后利用2阶解析解所给出的小扰动1阶振荡幅值和2阶振荡幅值信息,以多SVC布点多种方案对系统降低小扰动幅值的贡献为指标,给出多SVC布点结果。所提方法应用于IEEE30节点系统,试验结果表明,该方法相对于不考虑多点共同影响的多SVC布点方式,其静态电压稳定边界的拓展效果更好。 | XIONG Haoqing TANG Yong ZHANG Xiaohua MENG Yuanjing LIU Yuexin FU Hongjun SUN Huadong YI Jun XIONG Chuanping | 2012 | 中国电机工程学报2012，32，13： | 6 |
| 3 | 1-Naphthol induced PtsAg nanocorals as bifunctional cathode and anode catalysts of direct formic acid fuel cells显示文摘Developing highly efficient bifunctional cathode and anode electrocatalysts is very important for the large-scale application of direct formic acid fuel cells. However, the high-cost and poor CO-tolera nee ability of the most commonly used Pt greatly block this process. To in crease the utilizatio n efficie ncy and exte nd bifunctional properties of precious Pt, herei n, coral-like Pt3Ag nano crystals are developed as an excelle nt bifunctional electrocatalyst through a facile one-pot solvothermal method. The formation mechanism of Ptgg nanocorals has been elaborated well via a series of control experiments. It is proved that 1-naphthol serving as a guiding surfactant plays a key role in the formation of high-quality nano corals. Thanks to the unique coral-like structure and alloy effects, the developed Ptgg nano corals present sign ificantly enhanced electrocatalytic properties (including activity, stability and CO-toleranee ability) towards both the cathodic oxygen reduction and anodic formic acid oxidati on, as compared with those of commercial Pt black and Pt-based nan oparticles. The prese nt synthetic method can also be extended to fabricate other bimetallic electrocatalysts with unique morphology and structure. | Xian Jiang Yang Liu Jiaxin Wang Yufei Wang Yuexin Xiong Qun Liu Naixu Li Jiancheng Zhou Gengtao Fu Dongmei Sun Yawen Tang | 2019 | Nano Research2019，12，2： | 4 |
| 4 | Revisiting the Concentration Observations and Source Apportionment of Atmospheric Ammonia显示文摘While China’s Air Pollution Prevention and Control Action Plan on particulate matter since 2013 has reduced sulfate significantly,aerosol ammonium nitrate remains high in East China.As the high nitrate abundances are strongly linked with ammonia,reducing ammonia emissions is becoming increasingly important to improve the air quality of China.Although satellite data provide evidence of substantial increases in atmospheric ammonia concentrations over major agricultural regions,long-term surface observation of ammonia concentrations are sparse.In addition,there is still no consensus on whether agricultural or non-agricultural emissions dominate the urban ammonia budget.Identifying the ammonia source by nitrogen isotope helps in designing a mitigation strategy for policymakers,but existing methods have not been well validated.Revisiting the concentration measurements and identifying source apportionment of atmospheric ammonia is thus an essential step towards reducing ammonia emissions. | Yuepeng PAN Mengna GU Yuexin HE Dianming WU Chunyan LIU Linlin SONG Shili TIAN Xuemei LÜ Yang SUN Tao SONG Wendell WWALTERS Xuejun LIU Nicholas AMARTIN Qianqian ZHANG Yunting FANG Valerio FERRACCI Yuesi WANG | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 5 | Carrier-free highly drug-loaded biomimetic nanosuspensions encapsulated by cancer cell membrane based on homology and active targeting for the treatment of glioma显示文摘Nanosuspensions,as a new drug delivery system for insoluble drugs,are only composed of a drug and a small amount of stabilizer,which is dispersed in an aqueous solution with high drug-loading,small particle size,high dispersion,and large specific surface area.It can significantly improve the dissolution,bioavailability,and efficacy of insoluble drugs.In this study,paclitaxel nanosuspensions((PTX)NS)were prepared by an ultrasonic precipitation method,with the characteristics of simple preparation and easy repetition.With the help of a homologous targeting mechanism,a kind of glioma C6 cancer cell membrane(CCM)-coated(PTX)NS was developed and modified with DWSW peptide to obtain DWSW-CCM-(PTX)NS with the functions of BBB penetration and tumor targeting.The results showed that the cancer cell membrane could effectively camouflage the nanosuspensions so that it was not cleared by the immune system and could cross the blood-brain-barrier(BBB)and selectively target tumor tissues.Cell uptake experiments and in vivo imaging confirmed that the uptake of DWSW-CCM-(PTX)NS by tumor cells and the distribution in intracranial gliomas increased.Cytotoxicity test and in vivo anti-glioma studies showed that DWSW-CCM-(PTX)NS could significantly inhibit the growth of glioma cells and significantly prolong the survival time of glioma-bearing mice.Finally,the cancer cell membrane coating endowed the nanosuspensions with the biological properties of homologous adhesion and immune escape.This study provides an integrated solution for improving the targeting of nanosuspensions and demonstrates the encouraging potential of biomimetic nanosuspensions applicable to tumor therapy. | Yueyue Fan Yuexin Cui Wenyan Hao Mengyu Chen Qianqian Liu Yuli Wang Meiyan Yang Zhiping Li Wei Gong Shiyong Song Yang Yang Chunsheng Gao | 2021 | Bioactive Materials2021，6，12： | 3 |
| 6 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 7 | Characterization of Bacterial Communities Associating with Larval Development of Yesso Scallop(Patinopecten yessoensisis Jay, 1857) by High-Throughput Sequencing显示文摘Bacterial community presumably plays an essential role in inhibiting pathogen colonization and maintaining the health of scallop larvae, but limiting data are available for Yesso scallop(Patinopecten yessoensisis Jay, 1857) larval development stages. The aim of this study was to characterize and compare the bacterial communities associating with Yesso scallop larval development at fertilized egg S1, trochophora S2, D-shaped larvae S3, umbo larvae S4, and juvenile scallop S5 stages by Illumina high-throughput sequencing. Genomic DNA was extracted from the larvae and their associating bactera, and a gene segment covering V3-V4 region of 16 S r RNA gene was amplified and sequenced using an Illumina Miseq sequencer. Overall, 106760 qualified sequences with an average length of 449 bp were obtained. Sequences were compared with those retrieved from 16 S r RNA gene databases, and 4 phyla, 7 classes, 15 orders, 21 families, 31 genera were identified. Proteobacteria was predominant phylum, accounting for more than 99%, at all 5 larval development stages. At genus level, Pseudomonas was dominant at stages S1(80.60%), S2(87.77%) and S5(68.71%), followed by Photobacterium(17.06%) and Aeromonas(1.64%) at stage S1, Serratia(6.94%), Stenotrophomonas(3.08%) and Acinetobacter(1.2%) at stage S2, Shewanella(25.95%) and Pseudoalteromonas(4.57%) at stage S5. Moreover, genus Pseudoalteromonas became dominant at stages S3(44.85%) and S4(56.02%), followed by Photobacterium(29.82%), Pseudomonas(11.86%), Aliivibrio(8.60%) and Shewanella(3.39%) at stage S3, Pseudomonas(18.16%), Aliivibrio(14.29%), Shewanella(4.11%), Psychromonas(4.04%) and Psychrobacter(1.81%) at stage S4. From the results, we concluded that the bacterial community changed significantly at different development stages of Yesso Scallop larvae. | SUN Xueying LIU Jichen LI Ming ZHAO Xuewei LIANG Jun SUN Pihai MA Yuexin | 2016 | Journal of Ocean University of China2016，15，6： | 3 |
| 8 | Characterization and Expression Analysis of Protein Kinase C Gene from Dunaliella salina显示文摘Protein kinase C (PKC) has a crucial role in signal transduction for a variety of biologically active substances which activate cellular functions and proliferation. We previously isolated the full-length PKC gene from Dunaliella salina (DsPKC) using rapid amplification of cDNA ends (RACE) and RT-PCR methods. And we submitted the mRNA sequence of DsPKC gene to NCBI (Genbank No. JN625213). In the present paper, the DsPKC gene open reading frame obtained by PCR was cloned into pGS-21a vector and transformed into Escherichia coli to generate the fusion protein. Bioinformatics analysis revealed that DsPKC gene was a member of serine/threonine kinase with two conserved domains and highly conserved motifs. The DsPKC was highly expressed upon induction with isopropyl-β-d-thiogalactoside (IPTG) at a final concentration of 0.2 mmol L 1 at 37℃. Under salt stress, the fu- sion protein Green Fluorescent Protein (GFP)-DsPKC was transferred from the cytoplasm to the cell membrane. The expression pat- tern of DsPKC gene was analyzed using real-time quantitative PCR, and indicated that DsPKC gene was up-regulated by 3.0 mol L 1 NaCl at 12 h, which was significantly higher than in control values (P < 0.05). These results suggest that the DsPKC gene plays an important role in response to salt stress in D. salina. | CONG Yuting MA Yuexin WANG Yuan LIU Yiqiong CHAI Xiaojie | 2019 | Journal of Ocean University of China2019，18，4： | 2 |
| 9 | Response of microbial biomass and bacterial community composition to fertilization in a salt marsh in China显示文摘The effects of nitrogen(N) addition on microbial biomass, bacterial abundance, and community composition in sediment colonized by Suaeda heteroptera were examined by chloroform fumigation extraction method, real-time quantitative polymerase chain reaction, and denaturing gradient gel electrophoresis(DGGE) in a salt marsh located in Shuangtai Estuary, China. The sediment samples were collected from plots treated with different amounts of a single N fertilizer(urea supplied at 0.1, 0.2, 0.4 and 0.8 g/kg(nitrogen content in sediment) and different forms of N fertilizers(urea,(NH_4)_2SO_4, and NH_4NO_3, each supplied at 0.2 g/kg(calculated by nitrogen).The fertilizers were applied 1–4 times during the plant-growing season in May, July, August, and September of 2013. Untreated plots were included as a control. The results showed that both the amount and form of N positively influenced microbial biomass carbon, microbial biomass nitrogen, and bacterial abundance. The DGGE profiles revealed that the bacterial community composition was also affected by the amount and form of N.Thus, our findings indicate that short-term N amendment increases microbial biomass and bacterial abundance,and alters the structure of bacterial community. | MA Yuexin TAO Wei LIU Changfa LIU Jiao YANG Zhiping LI Jin LIU Jichen | 2017 | Acta Oceanologica Sinica2017，36，6： | 2 |
| 10 | Resource utilization of slag from desulphurization and slag skimming:A comprehensive recycling process of all components显示文摘In order to make the slag from desulphurization and slag skimming(SDSS)to be comprehensively recycled and utilized,a combined process of beneficiation and building materials preparation was proposed to recover iron from SDSS,meanwhile to apply the remaining slag tailings as cement admixture.From this process,three iron-rich products were recovered in stages by clean gravity-magnetic separation,slag tailings were left.Slag powder was prepared by ultrafine grinding of slag tailings.The stability,setting time and cement mortar strength of the slag tailings cements(STC)which were mixed with Portland cement and slag powder were studied respectively.The results showed that a proper overall performance still could be obtained at the slag powder content of 30%.Chemical composition analysis,X-ray diffraction(XRD)analysis,metallographic microscope and scanning electron microscope(SEM)analysis were employed to assess the characteristics of the SDSS and the products obtained from the whole process.The results indicated that the three iron-rich products could be used as a raw material for steelmaking and ironmaking and the relatively large amount of calcium silicate(C_(2)S)and tricalcium silicate(C_(3)S)in the slag tailings make the addition of slag powder into the Portland cement feasible. | Xiao Liu Peng Gao Yuexin Han | 2022 | International Journal of Mining Science and Technology2022，32，3： | 2 |
| 11 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 12 | Inhibition of spore germination of Ulva pertusa by the marine bacterium Pseudoalteromonas haloplanktis CI4显示文摘The effect of the bacterial strain CI4 on the germination of spores from the green alga Ulva pertusa was assayed and it was found that the bacterial biofilm and cell-free supernatant strongly inhibited spore germination. In attempts to define the chemical nature of the antifouling substance in the supernatant of CI4,the culture supernatants were tested for activity after heat treatment,enzymatic treatments,size fractionation,and separation into aqueous and organic fractions. Results suggest that this bacterium produces an extracellular component with specific activity toward algal spores that was heat-sensitive and between 3 and 10 kDa in molecular size. The exposure of the organic phase fraction to spores showed inhibitive effect on spore germination. Pronase and carboxypeptidase y did not significantly affect the activity of inhibitory component,suggesting that the component was not a protein or a peptide. The bacterium CI4 was identified as Pseudoalteromonas haloplanktis based on the phenotypic characters and 16S rRNA gene analysis. | MA Yuexin LIU Pengliang ZHANG Yongsheng CAO Shanmao LI Dantong CHEN Wei | 2010 | Acta Oceanologica Sinica2010，29，1： | 1 |
| 13 | Comparison of low-grade hematite product characteristics in a high-pressure grinding roller and jaw crusher显示文摘 | Han Yuexin Liu Lei Yuan Zhitao Wang Zehong Zhang Patrick | 2012 | EN2012，，2： | 1 |
| 14 | Formation mechanisms of SrTiO 3 nanoparticles under hydrothermal conditions显示文摘 | Shicheng Zhang Jiaxiang Liu Yuexin Han Bingchen Chen Xingguo Li | 2004 | Materials Science & Engineering B2004，，1： | 1 |
| 15 | An edge detection approach based on directional wavelet transform显示文摘 | Zhen Zhang Siliang Ma Hui Liu Yuexin Gong | 2009 | Computers and Mathematics with Applications2009，，8： | 1 |
| 16 | Comparison of low-grade hematite product characteristics in a high-pressure grinding roller and jaw crusher 显示文摘 | Han Yuexin Liu Lei Yuan Zhitao | 2012 | Minerals and Metallurgical Processing2012，29，2： | 1 |
| 17 | An edge detection approach based on directional wavelet transform显示文摘 | Zhang Zhen Ma Siliang Liu Hui Gong Yuexin | | 0，，08： | 1 |
| 18 | Wet Pre-concentration of Low-grade Hematite in High-pressure Grinding Roller显示文摘 | Zhitao Yuan Lei Liu Yuexin Han | | 0，，： | 1 |
| 19 | Formation mechanisms of SrTiO3 nanoparticles under hydrothermal conditions显示文摘 | Shicheng Zhang Jiaxiang Liu Yuexin Han | 2004 | Materials Science and Engineering B2004，110，1： | 1 |
| 20 | Preparation and characterization of uniform circinate aggregates of sheet ZnO nanoparticles显示文摘Uniform circinate aggregates of sheet ZnO nanoparticles with a specific surface area of 24 m2·g-1 were prepared by the direct precipitation method.The circinate aggregates were hexagonal ZnO,with the wall thickness ranging from 0.5 to 1 μm and the diameter ranging from 5 to 10 μm.The backs of the circinate aggregates were regularly arranged by numerous sheet ZnO nanoparticles with a thickness of 30-80 nm and a diameter of 300-400 nm.The precursors were aggregates of sheet Zn5(CO3)2(OH)6 nanoparticles,which were decomposed into ZnO by calcining in air in the range of 200-285°C,and the ZnO retained the similar special structure.The C2H5OH content had a significant effect on the formation of sheet ZnO.The centripetal force,the Van der Waals force,and the hydrogen bond were deduced as the driving forces of the formation of circinate. | LIU Jiaxiang DING Deling WANG Lisheng and HAN Yuexin | 2008 | Rare Metals2008，27，1： | 1 |
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