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| 1 | Dynamic response analysis under atmospheric disturbances for helicopters based on elastic blades显示文摘A flight dynamics model based on elastic blades for helicopters is developed.Modal shape analysis is used to describe the rotating elastic blades for the purpose of reducing the elastic degrees of freedom for blades.The analytical result is employed to predict the rotor forces and moments.The equilibrium equation of the flight dynamics model is then constructed for the elastic motion for blades and the rigid motion for other parts.The nonlinear equation is further simplified,and the gradient descent algorithm is adopted to implement the trim simulation.The trim analysis shows that the effect of blade elasticity on the accuracy of rotor forces and moments is apparent at high speed,and the proposed method presents good accuracy for trim performance.The timedomain response is realized by a combination of the Newmark method and the adaptive RungeKutta method.The helicopter control responses of collective pitch show that the response accuracy of the model at a yaw-and-pitch attitude is improved.Finally,the influence of blade elasticity on the helicopter dynamic response in low-altitude wind shear is investigated.An increase in blade elasticity reduces the oscillation amplitude of the yaw angle and the vertical speed by more than 70%.Compared with a rigid blade,an elastic blade reduces the vibration frequency of the angular velocity and results in a fast return of the helicopter to its stable flight. | Tong Liu Yuting Dai Guanxin Hong Linpeng Wang | 2017 | Chinese Journal of Aeronautics2017，30，2： | 4 |
| 2 | Sandwiching Sulfur into the Dents Between N,O Co-Doped Graphene Layered Blocks with Strong Physicochemical Confinements for Stable and High-Rate Li-S Batteries显示文摘The development of lithium-sulfur batteries(LSBs)is restricted by their poor cycle stability and rate performance due to the low conductivity of sulfur and severe shuttle effect.Herein,an N,O co-doped graphene layered block(NOGB)with many dents on the graphene sheets is designed as effective sulfur host for high-performance LSB s.The sulfur platelets are physically confined into the dents and closely contacted with the graphene scaffold,ensuring structural stability and high conductivity.The highly doped N and O atoms can prevent the shuttle effect of sulfur species by strong chemical adsorption.Moreover,the micropores on the graphene sheets enable fast Li^+transport through the blocks.As a result,the obtained NOGB/S composite with 76 wt%sulfur content shows a high capacity of 1413 mAh g^-1 at 0.1 C,good rate performance of 433 mAh g^-1 at 10 C,and remarkable stability with 526 mAh g^-1 at after 1000 cycles at 1 C(average decay rate:0.038%per cycle).Our design provides a comprehensive route for simultaneously improving the conductivity,ion transport kinetics,and preventing the shuttle effect in LSBs. | Mengjiao Shi Su Zhang Yuting Jiang Zimu Jiang Longhai Zhang Jin Chang Tong Wei Zhuangjun Fan | 2020 | Nano-Micro Letters2020，12，11： | 3 |
| 3 | SERS study on the synergistic effects of electric field enhancement and charge transfer in an Ag2S quantum dots/plasmonic bowtie nanoantenna composite system显示文摘Localized surface plasmon resonance(LSPR)of nanostructures and the interfacial charge transfer(CT)of semiconductor materials play essential roles in the study of optical and photoelectronic properties.In this paper,a composite substrate of Ag2S quantum dots(QDs)coated plasmonic Au bowtie nanoantenna(BNA)arrays with a metalinsulator-metal(MIM)configuration was built to study the synergistic effect of LSPR and interfacial CT using surface-enhanced Raman scattering(SERS)in the near-infrared(NIR)region.The Au BNA array structure with a large enhancement of the localized electric field(E-field)strongly enhanced the Raman signal of adsorbed p-aminothiophenol(PATP)probe molecules.Meanwhile,the broad enhanced spectral region was achieved owing to the coupling of LSPR The as-prepared Au BNA array structure facilitated enhancements of the excitation as well as the emission of Raman signal simultaneously,which was established by finite-difference time-domain simulation.Moreover,Ag2S semiconductor QDs were introduced into the BNA/PATP system to further enhance Raman signals,which benefited from the interfacial CT resonance in the BNA/Ag2S-QDs/PATP system.As a result,the Raman signals of PATP in the BNA/Ag2S-QDs/PATP system were strongly enhanced under 785 nm laser excitation due to the synergistic effect of E-field enhancement and interfacial CT.Furthermore,the SERS polarization dependence effeas of the BNA/Ag2S-QDs/PATP system were also investigated.The SERS spectra indicated that the polarization dependence of the substrate increased with decreasing polarization angles(θpola)of excitation from p-polarized(θpola=90°)excitation to s-polarized(θpola=0°)excitation.This study provides a strategy using the synergistic effect of interfacial CT and E-field enhancement for SERS applications and provides a guidance for the development of SERS study on semiconductor QD-based plasmonic substrates,and can be farther extended to other material-nanostructure systems for various optoelectronic and sensing applications. | BIN WANG CHEN ZHAO HUANYU LU TINGTING ZOU SUBHASH C.SINGH ZHI YU CHAONAN YAO XIN ZHENG JUN XING YUTING ZOU CUNZHU TONG WEILI YU BO ZHAO CHUNLEI GUO | 2020 | Photonics Research2020，8，4： | 1 |
| 4 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 5 | Effect of ultramicropores and inner space of carbon materials on the capacitive sodium storage performance显示文摘1.Introduction Carbon materials have been widely investigated as the anode materials for Na+storage due to their moderate capacity,good stability,and low cost.The Na+storage mechanisms of carbon are generally classified into diffusion-controlled interlayer insertion/desertion and capacitive-controlled surface adsorption/desorption[1]. | Zimu Jiang Su Zhang Jing Feng Yuting Jiang Shichuan Liang Qiqi Li Mengjiao Shi Meng Cao Mingyi Zhang Tong Wei Zhuangjun Fan | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 6 | USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia显示文摘T-cell acute lymphoblastic leukemia(T-ALL)is a highly aggressive leukemia that is primarily caused by aberrant activation of the NOTCH1 signaling pathway.Recent studies have revealed that posttranslational modifications,such as ubiquitination,regulate NOTCH1 stability,activity,and localization.However,the specific deubiquitinase that affects NOTCH1 protein stability remains unestablished.Here,we report that ubiquitin-specific protease 7(USP7)can stabilize NOTCH1.USP7 deubiquitinated NOTCH1 in vivo and in vitro,whereas knockdown of USP7 increased the ubiquitination of NOTCH1.USP7 interacted with NOTCH1 protein in T-ALL cells,and the MATH and UBL domains of USP7 were responsible for this interaction.Depletion of USP7 significantly suppressed the proliferation of T-ALL cells in vitro and in vivo,accompanied by downregulation of the NOTCH1 protein level.Similarly,pharmacologic inhibition of USP7 led to apoptosis of T-ALL cells.More importantly,we found that USP7 was significantly upregulated in human T-ALL cell lines and patient samples,and a USP7 inhibitor exhibited cell cytotoxicity toward primary T-ALL cells,indicating the clinical relevance of these findings.Overall,our results demonstrate that USP7 is a novel deubiquitinase that stabilizes NOTCH1.Therefore,USP7 may be a promising therapeutic target in the currently incurable T-ALL. | Huizhuang Shan Xiangyun Li Xinhua Xiao Yuting Dai Jinyan Huang Junjun Song Meng Liu Li Yang Hu Lei Yin Tong Li Zhou Hanzhang Xu Yingli Wu | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 0 |
| 7 | Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment显示文摘Human lung adenosquamous cell carcinoma(LUAS),containing both adenomatous and squamous pathologies,harbors strong plasticity and is significantly associated with poor prognosis.We established an up-to-date comprehensive genomic and transcriptomic landscape of LUAS in 109 Chinese specimens and demonstrated LUAS development via adeno-to-squamous transdifferentiation.Unsupervised transcriptomic clustering and dynamic network biomarker analysis identified an inflammatory subtype as the critical transition stage during LUAS development.Dynamic dysregulation of the counteracting lineage-specific transcription factors(TFs),containing adenomatous TFs NKX2-1 and FOXA2,and squamous TFs TP63 and SOX2,finely tuned the lineage transition via promoting CXCL3/5-mediated neutrophil infiltration.Genomic clustering identified the most malignant subtype featured with STK11-inactivation,and targeting LSD1 through genetic deletion or pharmacological inhibition almost eradicated STK11-deficient lung tumors.These data collectively uncover the comprehensive molecular landscape,oncogenic driver spectrum and therapeutic vulnerability of Chinese LUAS. | Shijie Tang Yun Xue Zhen Qin Zhaoyuan Fang Yihua Sun Chongzhe Yuan Yunjian Pan Yue Zhao Xinyuan Tong Jian Zhang Hsinyi Huang Yuting Chen Liang Hu Dasong Huang Ruiqi Wang Weiguo Zou Yuan Li Roman KThomas Andrea Ventura Kwok-Kin Wong Haiquan Chen Luonan Chen Hongbin Ji | 2023 | National Science Review2023，10，4： | 0 |
| 8 | Characteristics of premanufacture CD8^(+) T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma显示文摘Although chimeric antigen receptor(CAR)T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies,more than 60%of patients with diffuse large B-cell lymphoma(DLBCL)treated with CAR-T cell therapies fail to achieve a durable response.To reveal changes in CAR-T cell therapy and identify response biomarkers,we conducted a retrospective analysis of pre-manufacture source T cells and CAR-T cell products and their association with outcome in 58 patients with r/rDLBCL who received tandem CD19/CD20 CAR-T cell therapy.We performed bulk RNA-Seq,single-cell RNA-Seq,and paired T cell receptor sequencing on CAR-T cell products and pre-manufacture T cells from DLBCL patients.We note that a CD8+stem cell-like memory T cell population with a higher proportion and enhanced activating capacity of the CAR-T cell products was key to achieving durable clinical response.By analysing autologously-derived,pre-manufacture T cells,our data suggest that heterogeneity in the cellular and molecular features of pre-manufacture T cells contribute to the variation in efficacy after CAR-T cell therapy in DLBCL.The differences in anti-tumour efficacy of CAR-T cells among patients with different clinical outcomes appear to be due to the loss of CCR7 gene expression,coupled with increased expression of activation-and inhibitor-related genes in the CD8+naïve-T cell populations among the apheresis T cells from patients with a poor molecular response.These findings significantly advance our understanding of the underlying molecular determinants of pre-manufacture T cell function. | Yao Wang Chuan Tong Yuting Lu Zhiqiang Wu Yelei Guo Yang Liu Jianshu Wei Chunmeng Wang Qingming Yang Weidong Han | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 9 | Sputtered Stainless Steel on Silicon Photoanode for Stable Seawater Splitting in Photoelectrochemical Flow Cell显示文摘Photoelectrochemical(PEC)seawater splitting is a promising method for the direct utilization of solar energy and abundant seawater resources for hydrogen production.Photoelectrodes are susceptible to various ions in seawater and complicated competitive reactions,resulting in the failure of photoelectrodes.This paper proposes the design and fabrication of diff erent sputtered stainless steel(SS)fi lms deposited on silicon photoanodes,completely isolating the electrolytes and semiconductor substrate.Upon coupling with the PEC flow cell,the back-illuminated photoanode coated with 316 SS cocatalyst achieves stable operation for 70 h in natural seawater with a highly alkaline KOH(30 wt.%,7.64 mol/L)electrolyte due to the remarkable protection eff ect of the substrate from stainless steel,while the PEC seawater splitting system achieves a record hydrogen production rate of 600μmol/(h·cm^(2)).An appropriate Ni/Fe ratio in the SS ensures remarkable oxygen evolution activity,while chromic oxide ensures the effective anticorrosion effect by adjusting the microenvironment of the photoanodes.Moreover,fabricating PEC flow cells with photoanodes coated with SS cocatalysts are a viable strategy for PEC seawater splitting. | Shixuan Zhao Bin Liu Gong Zhang Qingzhen Wang Yuan Cai Yuting Tong Shujie Wang Peng Zhang Tuo Wang Jinlong Gong | 2023 | Transactions of Tianjin University2023，29，6： | 0 |
| 10 | A new method for quantitative analysis of M13 bacteriophage by atomic force microscopy显示文摘Quantitative analysis is essential for virus research,especially in determining the virus titer.The classical method plaque assay is time-consuming,complex,and difficult for the phages that cannot form apparent plaque on the solid medium.In order to realize rapid and effective detection,a new method combining atomic force microscopy(AFM)observation and mathematical calculation is established.In this research,M13 phages with an appropriate dilution ratio were observed and counted by AFM.Based on the counting results,the titer of M13 phages can be calculated simply through mathematical substitution.Instead of cultivating overnight in plaque assay,this new method can be implemented within a few hours.Moreover,it is a method that can achieve visualization for titer determination and have the potential to determine the phages that fail to form apparent plaque,which is significant in virus quantitative assessment. | Yuting Wu Shuai Liu Zhiwei Liu Bing Liu Bin Du Zhaoyang Tong Jianjie Xu | 2022 | Synthetic and Systems Biotechnology2022，7，4： | 0 |
| 11 | Reciprocal activation of antigen-presenting cells and CAR T cells triggers a widespread endogenous anti-tumor immune response through sustained high-level IFNγproduction显示文摘Adoptive cell transfer(ACT)using chimeric antigen receptor(CAR)modified T cells and T cell receptor(TCR)engineered T cells has shown therapeutic efficacy in cancer treatment1,2.CAR T cells are widely applicable to tumor patients because of their ability to directly identify tumor cells in an MHCindependent manner. | Yelei Guo Chuan Tong Zhiqiang Wu Yuting Lu Yao Wang Weidong Han | 2023 | Cancer Biology & Medicine2023，20，11： | 0 |
| 12 | Identification and characterization of mammaglobin-A epitope in heterogenous breast cancers for enhancing tumor-targeting therapy显示文摘Although targeted therapy has been extensively investigated for breast cancers,a molecular target with broad application is currently unavailable due to the high heterogeneity of these cancers.Mammaglobin-A(Mam-A),which is overexpressed in most breast carcinomas,has been proposed as a promising target.However,the lack of specific targeting moieties due to uncertain binding epitopes hampers further translational study.Here,seven potential epitopes of Mam-A were disclosed,and a unique epitope was then identified in most types of breast cancers,despite the genotypic heterogeneity.With phage display technology,the epitope was determined to be N-terminal amino acids 42–51 of Mam-A(N42–51).Then,the N42–51 epitope-specific monoclonal antibody,mAb785,was conjugated to poly lactic-co-glycolic acid(PLGA)nanoparticles loaded with therapeutic agents,thereby enhancing the drug uptake and therapeutic efficacy in different genotypes of breast cancers.The computer simulation of the N42–51 epitope and the mAb785 structures,as well as their interactions,further revealed the specific targeting mechanism of the mAb785-conjugated nanoparticles to breast cancers. | Zhiqiang Liu Xiqin Yang Cuimi Duan Jiangxue Li Rongsheng Tong Yuting Fan Jiannan Feng Ruiyuan Cao Wu Zhong Xiaoyan Feng Heqiu Zhang Lulu Cai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 13 | Polarizable Additive with Intermediate Chelation Strength for Stable Aqueous Zinc‑Ion Batteries显示文摘Aqueous zinc-ion batteries are promising due to inherent safety,low cost,low toxicity,and high volumetric capacity.However,issues of dendrites and side reactions between zinc metal anode and the electrolyte need to be solved for extended storage and cycle life.Here,we proposed that an electrolyte additive with an intermediate chelation strength of zinc ion—strong enough to exclude water molecules from the zinc metal-electrolyte interface and not too strong to cause a significant energy barrier for zinc ion dissociation—can benefit the electrochemical stability by suppressing hydrogen evolution reaction,overpotential growth,and den-drite formation.Penta-sodium diethylene-triaminepentaacetic acid salt was selected for such a purpose.It has a suitable chelating ability in aqueous solutions to adjust solvation sheath and can be readily polarized under electrical loading conditions to further improve the passivation.Zn||Zn symmetric cells can be stably operated over 3500 h at 1 mA cm^(-2).Zn||NH4V4O10 full cells with the additive show great cycling stability with 84.6%capacity retention after 500 cycles at 1 A g^(-1).Since the additive not only reduces H2 evolution and corrosion but also modifies Zn2+diffusion and deposition,highlyreversible Zn electrodes can be achieved as verified by the experimental results.Our work offers a practical approach to the logical design of reliable electrolytes for high-performance aqueous batteries. | Yuting Xia Rongao Tong Jingxi Zhang Mingjie Xu Gang Shao Hailong Wang Yanhao Dong Chang‑An Wang | 2024 | Nano-Micro Letters2024，16，5： | 0 |
| 14 | The metabolic switch of cancer From the 2016 Sino-US Symposium on Cancer Metabolism, Chongqing, P.R. China, October 10e11, 2016显示文摘Although remarkable progress has been made in oncology research,cancer is still a leading cause of death worldwide.It is well recognized that cancer is a genetic disease,yet metabolic alterations or reprogramming are the major phenotypes associated with the(epi-)genetic modifications of cancer cells.Thus,understanding the metabolic changes of tumor cells will facilitate the diagnosis of cancer,alleviate drug resistance and provide novel druggable targets that can lead to cures for cancer.The first Sino-US Symposium on Cancer Metabolism was held in Chongqing on October 10th and 11th,with the theme of“cancer metabolism and precision cancer therapy”.The symposium brought about a dozen keynote speakers each from the US and China's Mainland,as well as one hundred delegates with an interest in cancer metabolism.This short article will briefly summarize the advances reported during this meeting. | Yuting Ma Xuemei Tong Yong Liao | 2017 | Genes & Diseases2017，4，1： | 0 |
| 15 | Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids显示文摘Vitamin A (VA) plays an essential role in modulating both the gut microbiota and gut barrier function.Short-chain fatty acids (SCFAs),as metabolites of the gut microbiota,protect the physiological intestinal barrier;however,they are compromised when VA is deficient.Thus,there is an urgent need to understand how and which SCFAs modulate colonic epithelial barrier integrity in VA deficiency (VAD).Herein,compared with normal VA rats (VAN),at the beginning of pregnancy,we confirmed that the colonic desmosome junction was impaired in the VAD group,and the amounts of acetate,propionate,and butyrate declined because of the decreased abundance of SCFA-producing bacteria (Romboutsia ,Collinsella ,and Allobaculum ).The differentially expressed genes correlated with the gut barrier and the histone deacetylase complex between the VAD and VAN groups were enriched by RNA sequencing.In the VAD group,the expression levels of colonic CEA cell adhesion molecule 1 (CEACAM1) were down-regulated,and the levels of histone deacetylase 1 (HDAC1) and HDAC3 were up-regulated.Intriguingly,the above changes in the VAD groups were rescued by VA supplementation in the early postnatal period.Further study indicated that in Caco-2 cells,butyrate treatment significantly repressed the enrichment of HDAC3 on the promoter of the CEACAM1 gene to induce its expression.Our findings support that butyrate intervention can alleviate the impairment of colonic barrier function caused by VAD,and timely postnatal VA intervention may reverse the damage caused by VAD on gut barrier integrity during pregnancy. | Junyan Yan Lu Xiao Di Feng Baolin Chen Ting Yang Bei Tong Ruifang Luo Yuting Wang Jie Chen | 2024 | Genes & Diseases2024，11，2： | 0 |
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