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| 1 | Designing N-doped graphene/ReSe_(2)/Ti_(3)C_(2) MXene heterostructure frameworks as promising anodes for high-rate potassium-ion batteries显示文摘Developing high-performance anodes for potassium ion batteries(KIBs) is of paramount significance but remains challenging.In the normal sense,electrode materials are prepared by ubiquitous wet chemical routes,which otherwise might not be versatile enough to create desired heterostructures and/or form clean interfacial areas for fast transport of K-ions and electrons.Along this line,rate capability/cycling stability of resulting KIBs are greatly handicapped.Herein we present an all-chemical vapor deposition approach to harness the direct synthesis of nitrogen-doped graphene(NG)/rhenium diselenide(ReSe_2)hybrids over three-dimensional MXene supports as superior heterostructure anode material for KIBs.In such an innovative design,1 T'-ReSe2 nanoparticles are sandwiched in between the NG coatings and MXene frameworks via strong interfacial interactions,thereby affording facile K~+ diffusion,enhancing overall conductivity,boosting high-power performance and reinforcing structural stability of electrodes.Thus-constructed anode delivers an excellent rate performance of 138 mAh g^(-1) at 10.0 A g^(-1) and a high reversible capacity of 90 mAh g^(-1) at 5 A g^(-1) after 300 cycles.Furthermore,the potassium storage mechanism has been systematically probed by advanced in situlex situ characterization techniques in combination with first principles computations. | Zhou Xia Xiwen Chen Haina Cia Zhaodi Fan Yuyang Yi Wanjian Yin Nan Wei Jingsheng Cai Yanfeng Zhang Jingyu Sun | 2021 | Journal of Energy Chemistry2021，30，2： | 9 |
| 2 | MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma显示文摘MicroRNAs (miRNAs ) 是经常是玩的小非编码的 RNA 的一种类型在 carcinogenesis 的重要角色,而是 miRNAs 的 carcinogenic 机制仍然是不清楚的。这研究将在癌(GC ) 调查功能和 miR-638 的机制。在 GC 和 miR-638 的 DNA 拷贝数字的 miR-638 的表示被即时 PCR 检测。房间增长上的 miR-638 的效果被数 kit-8 试金测量。不同试金,包括生物信息学算法(TargetScan 并且人权保护) ,酶报告试金并且西方的弄污,被用来在 GC 识别 miR-638 的目标基因。在临床的 CRC 纸巾的 miR-638 目标基因的表示被 immunohistochemical 试金也验证。从这研究,我们发现 miR-638 与相应 noncancerous 纸巾(NCT ) 相比是在 GC 纸巾的 downregulated,并且 miR-638 的 DNA 拷贝数字比 NCT 在 GC 是更低的,它可以在 GC 导致 miR-638 的相应 downregulation。miR-638 的宫外的表示在 vitro 禁止了 GC 细胞生长。随后,我们鉴别 PLD1 是在 GC,和 silencing PLD1 表示 phenocopied 的 miR-638 的目标基因 GC 房间增长上的 miR-638 的禁止的效果。而且,我们观察到 PLD1 是在在预言的 GC 的 PLD1 的 GC 纸巾,和高表示的 overexpressed 差的全面幸存。在摘要,我们表明 miR-638 通过禁止 PLD1 在 GC 作为肿瘤 suppressor 工作。 | Jiwei Zhang Zehua Bian Jialiang Zhou Mingxu Song Zhihui Liu Yuyang Feng Li Zhe Binbin Zhang Yuan Yin Zhaohui Huang | 2015 | Protein & Cell2015，6，9： | 8 |
| 3 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 4 | LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency显示文摘Super-enhancers(SEs)comprise large clusters of enhancers,which are co-occupied by multiple lineage-specific and master tran-scription factors,and play pivotal roles in regulating gene expression and cell fate determination.However,it is still largely un-known whether and how SEs are regulated by the noncoding portion of the genome.Here,through genome-wide analysis,wefound that tpng noncoding RNA(IncRNA)genes preferentially lie next to SEs.In mouse embryonic stem cells(mESCs),depletionof$E-associated IlncRNA transcripts dysregulated the activity of their nearby SEs.Specifically,we revealed a critical regulatoryrole of the IncRNA gene Platr22 in modulating the activity of a nearby SE and the expression of the nearby pluripotency regulatorZFP281.Through these regulatory events,Platr22 contributes to pluripotency maintenance and proper differentiation of mESCs.Mechanistically,Platr22 transcripts coat chromatin near the SE region and interact with DDX5 and hnRNP-L.DDX5 further recruitsp300 and other factors related to active transcription.We propose that these factors assemble into a transcription hub,thus pro-moting an open and active epigenetic chromatin state.0ur study highlights an unanticipated role for a class of lncRNAs in epige-netically controlling the activity and vulnerability to perturbation of nearby SEs for cell fate determination. | Pixi Yan Yuyang Lu Jing Niu Juntao Gao Michael Q.Zhang Yafei Yin Xiaohua Shen | 2021 | Journal of Molecular Cell Biology2021，13，4： | 2 |
| 5 | Transcriptomic analysis reveals the molecular mechanisms of rumen wall morphological and functional development induced by different solid diet introduction in a lamb model显示文摘Background:This study aimed to elucidate the molecular mechanisms of solid diet introduction initiating the cellular growth and maturation of rumen tissues and characterize the shared and unique biological processes upon different solid diet regimes.Methods:Twenty-four Hu lambs were randomly allocated to three groups fed following diets:goat milk powder only(M,n=8),goat milk powder+alfalfa hay(MH,n=8),and goat milk powder+concentrate starter(MC,n=8).At 42 days of age,the lambs were slaughtered.Ruminal fluid sample was collected for analysis of concentration of volatile fatty acid(VFA)and microbial crude protein(MCP).The sample of the rumen wall from the ventral sac was collected for analysis of rumen papilla morphology and transcriptomics.Results:Compared with the M group,MH and MC group had a higher concentration of VFA,MCP,rumen weight,and rumen papilla area.The transcriptomic results of rumen wall showed that there were 312 shared differentially expressed genes(DEGs)between in“MH vs.M”and“MC vs.M”,and 232 or 796 unique DEGs observed in“MH vs.M”or“MC vs.M”,respectively.The shared DEGs were most enriched in VFA absorption and metabolism,such as peroxisome proliferator-activated receptor(PPAR)signaling pathway,butanoate metabolism,and synthesis and degradation of ketone bodies.Additionally,a weighted gene co-expression network analysis identified M16(2,052 genes)and M18(579 genes)modules were positively correlated with VFA and rumen wall morphology.The M16 module was mainly related to metabolism pathway,while the M18 module was mainly associated with signaling transport.Moreover,hay specifically depressed expression of genes involved in cytokine production,immune response,and immunocyte activation,and concentrate starter mainly altered nutrient transport and metabolism,especially ion transport,amino acid,and fatty acid metabolism.Conclusions:The energy production during VFA metabolism may drive the rumen wall development directly.The hay introduction facilitated establishment of immune function,while the concentrate starter enhanced nutrient transport and metabolism,which are important biological processes required for rumen development. | Daming Sun Yuyang Yin Changzheng Guo Lixiang Liu Shengyong Mao Weiyun Zhu Junhua Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 2 |
| 6 | Spectral and biodistributional engineering of deep near-infrared chromophore显示文摘Fluorescence-guided surgery calls for development of near-infrared fluorophores.Despite the wide-spread application and a safe clinical record of Indocyanine Green(ICG),its maximal absorption wavelength at780 nm is rather short and longer-wavelength dyes are desired to exploit such benefits as low phototoxicity and deep penetration depth.Here,we report ECY,a stable deep near-infrared(NIR)fluorochromic scaffold absorbing/emitting at 836/871 nm with a fluorescence quantum yield of 16%in CH_(2)Cl_(2).ECY was further rationally engineered for biological distribution specificity.Analogous bearing different numbers of sulfonate group or a polyethylene glycol chain were synthesized.By screening this focused library upon intravenous injection to BALB/c mice,ECYS2 was identified to be a suitable candidate for bioimaging of organs involved in hepatobiliary excretion,and ECYPEG was found to be a superior candidate for vasculature imaging.They have potentials in intraoperative imaging. | Yan Dong Xicun Lu Yi Li Weichao Chen Lei Yin Jie Zhao Xinru Hu Xinran Li Zuhai Lei Yuyang Wu Hao Chen Xiao Luo Xuhong Qian Youjun Yang | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 7 | Constructing CdSe QDs modified porous g-C_(3)N_(4)heterostructures for visible light photocatalytic hydrogen production显示文摘Constructing heterostructures with narrow-band-gap semiconductors is a promising strategy to extend light absorption range of graphitic carbon nitride(g-C_(3)N_(4))and simultaneously promote charge separation for its photocatalytic activity improvement.However,its highly localized electronic states of g-C_(3)N_(4)hinder photo-carrier migration through bulk towards heterostructure interfaces,resulting in low charge carrier separation efficiency of solid bulk g-C_(3)N_(4)-based heterostructures.Herein,porous g-C_(3)N_(4)(PCN)material with greatly shortened migration distance of photo-carriers from bulk to surface was used as an effective substrate to host Cd Se quantum dots to construct type II heterostructure of Cd Se/PCN for photocatalytic hydrogen production.The homogeneous modification of the Cd Se quantum dots throughout the whole bulk of PCN together with proper band alignments between Cd Se and PCN enables the effective separation of photo-generated charge carriers in the heterostructure.Consequently,the Cd Se/PCN heterostructure photocatalyst gives the greatly enhanced photocatalytic hydrogen production activity of192.3μmol h^(-1),which is 4.4 and 8.1 times that of Cd Se and PCN,respectively.This work provides a feasible strategy to construct carbon nitride-based heterostructure photocatalysts for boosting visible light driven water splitting performance. | Zheng Zhang Yuyang Kang Li-Chang Yin Ping Niu Chao Zhen Runze Chen Xiangdong Kang Fayu Wu Gang Liu | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 8 | Full moment tensor inversion constrained by doublecouple focal mechanism for induced seismicity显示文摘In this study,we propose a new method to determine full moment tensor solution for induced seismicity.This method generalizes the full waveform matching algorithm we have developed to determine the double-couple(DC)focal mechanism based on the neighbourhood algorithm.One major difference between the new method and the former one is that we adopt a new misfit function to constrain the candidate moment tensor solutions with respect to a reference DC solution in addition to other misfit terms characterizing the waveform matching.Through synthetic tests using a real passive seismic survey geometry,the results show the new constraint can help better recover the DC components of inverted moment tensors.We further investigate how errors in the velocity model and source location affect the moment tensor solution.The synthetic test results indicate that the constrained inversion is robust in recovering both the DC and non-DC components.We also test the proposed method on several real induced events in an oil/gas field in Oman using the same observation system as synthetic tests.While it is found that the full moment tensor solutions without using the DC constraints have much larger non-DC components than solutions with the DC constraints,both solutions are able to fit the observed waveforms at similar levels.The synthetic and real test results suggest the proposed DC constrained inversion method can reliably retrieve full moment tensor solutions for the induced seismicity. | Yuyang Tan Haijiang Zhang Junlun Li Chen Yin Furong Wu | 2020 | Earthquake Science2020，33，4： | 0 |
| 9 | enOsCas12f1-mediated exon skipping for Duchenne muscular dystrophy therapy in humanized mouse model显示文摘Duchenne muscular dystrophy(DMD)is a severe neuromuscular disorder caused by mutations in the dystrophin gene,which encodes the essential protein dystrophin.This genetic condition,affecting approximately 1 in 5000 male births worldwide(Birnkrant et al.,2018),is characterized by progressive muscle weakness and wasting,leading to premature death in the second or third decade of life(Farini et al.,2016).The absence of dystrophin protein causes instability in the sarcolemma,which predisposes individuals to myonecrosis and activation of inflammatory signaling cascades.Unfortunately,there is currently no effective cure for DMD,and glucocorticoid steroids are commonly used in clinical settings to delay symptom development(Merlini et al.,2003). | Ming Jin Jiajia Lin Yu Zhang Qingquan Xiao Xiangfeng Kong Xiumei Zhang Zhurui Shao Yin Wang Yuyang Yu Jinjing Li Wan-Jin Chen Guoling Li Hui Yang Ning Wang | 2024 | Journal of Genetics and Genomics2024，51，2： | 0 |
| 10 | Alterations in nutrient digestion and utilization associated with different residual feed intake in Hu sheep显示文摘Improving feed efficiency is crucial to the animal industry.Residual feed intake(RFI)is now regarded as an index of feed efficiency evaluation and is independent of growth characteristics.Our study aims to explore the alterations in growth performance and nutrient digestion in Hu sheep with different RFI phenotypes.Sixty-four male Hu sheep(body weight=24.39±1.12 kg;postnatal days=90±7.9)were selected for the study.After an evaluation period of 56 days and power analysis,samples were collected from 14 low RFI(L-RFI group,power=0.95)and 14 high RFI sheep(H-RFI group,power=0.95).The L-RFI sheep yielded a lower(P<0.05)feed conversion ratio and dry matter intake;however,both groups exhibited similar average daily gain(P>0.05).The acid detergent fiber,neutral detergent fiber,organic matter,and crude protein apparent digestibility were higher(P<0.05)in L-RFI sheep.N intake and fecal N output(%of N intake)were lower(P<0.05)and N retention(%of N intake)was higher(P<0.05)in L-RFI sheep,whereas no difference(P>0.05)was found in urine N output(%of N intake)between the 2 groups.Furthermore,L-RFI sheep gave lower(P<0.05)serum glucose concentrations and higher(P<0.05)non-esterified fatty acid concentrations.Meanwhile,a lower ruminal acetate molar proportion(P<0.05)and higher propionate molar proportion(P<0.05)were observed in L-RFI sheep.In summary,these results revealed that despite having lower dry matter intake,L-RFI sheep possess higher nutrient digestibility,N retention,ruminal propionate production and serum glucose utilization,in order to meet energy demands.Selection for low RFI sheep could reduce feed costs,which in turn provides economic benefits to the sheep industry. | Hongbo Zeng Yuyang Yin Lingxi Chen Zhuoxin Xu Yang Luo Qian Wang Bin Yang Jiakun Wang | 2023 | Animal Nutrition2023，，2： | 0 |
| 11 | Optimizing segmented trajectory data storage with HBase for improved spatio-temporal query efficiency显示文摘The surging accumulation of trajectory data has yielded invaluable insights into urban systems,but it has also presented challenges for data storage and management systems.In response,specialized storage systems based on non-relational databases have been developed to support large data quantities in distributed approaches.However,these systems often utilize storage by point or storage by trajectory methods,both of which have drawbacks.In this study,we evaluate the effectiveness of segmented trajectory data storage with HBase optimizations for spatio-temporal queries.We develop a prototype system that includes trajectory segmentation,serialization,and spatio-temporal indexing and apply it to taxi trajectory data in Beijing.Ourfindings indicate that the segmented system provides enhanced query speed and reduced memory usage compared to the Geomesa system. | Yi Bao Zhou Huang Xuri Gong Yuyang Zhang Ganmin Yin Han Wang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 12 | Relative Varying Dynamics Based Whole Cutting Process Optimization for Thin‑walled Parts显示文摘Thin-walled parts are typically difficult-to-cut components due to the complex dynamics in cutting process.The dynamics is variant for part during machining,but invariant for machine tool.The variation of the relative dynamics results in the difference of cutting stage division and cutting parameter selection.This paper develops a novel method for whole cutting process optimization based on the relative varying dynamic characteristic of machining system.A new strategy to distinguish cutting stages depending on the dominated dynamics during machining process is proposed,and a thickness-dependent model to predict the dynamics of part is developed.Optimal cutting parameters change with stages,which can be divided by the critical thickness of part.Based on the dynamics comparison between machine tool and thickness-varying part,the critical thicknesses are predicted by an iterative algorithm.The proposed method is validated by the machining of three benchmarks.Good agreements have been obtained between prediction and experimental results in terms of stages identification,meanwhile,the optimized parameters perform well during the whole cutting process. | Yuyang Tang Jun Zhang Jia Yin Lele Bai Huijie Zhang Wanhua Zhao | 2022 | Chinese Journal of Mechanical Engineering2022，35，6： | 0 |
| 13 | Highly efficient electrocatalytic nitrogen fixation enabled by the bridging effect of Ru in plasmonic nanoparticles显示文摘Plasmon-generated hot electrons show great potential for driving chemical reactions.The utilization efficiency of hot electrons is highly dependent on the interaction of the electronic states at the interfaces between plasmonic nanoparticles and other materials/molecules.Strong interaction can produce new hybridized electron states,which permit direct hot-electron transfer,a more efficient transfer mechanism.However,Au usually has very weak interaction with most molecules because of its inertness,which makes direct hot-electron transfer impossible.Herein,the improvement of the hot-electron transfer efficiency from Au to N_(2)is demonstrated by introducing a Ru bridging layer.Both the N_(2)fixation rate and Faradic efficiency(FE)are enhanced by the excitation of plasmons.The enhancement of the N_(2)fixation rate is found to arise from plasmon-generated hot electrons.Theoretical calculations show that the strong interaction of the Ru electronic states with the N_(2)molecular orbitals produces new hybridized electronic states,and the Ru d electrons also strongly couple with the Au sp electrons.Such a bridging role of Ru makes direct hot-electron transfer from Au to N_(2)possible,improving the FE of nitrogen fixation.Our findings demonstrate a new approach to increasing the utilization efficiency of plasmonic hot electrons for chemical reactions and will be helpful to the design of plasmonic catalysts in the future. | Hang Yin Jinwu Hu Caihong Fang Yuyang Wang Lixia Ma Nan Zhang Shouren Zhang Ruibin Jiang Jianfang Wang | 2023 | Nano Research2023，16，1： | 0 |
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