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| 1 | ECharts: A declarative framework for rapid construction of web-based visualization显示文摘While there have been a dozen of authoring systems and programming toolkits for visual design and development,users who do not have programming skills,such as data analysts or interface designers,still may feel cumbersome to efficiently implement a web-based visualization.In this paper,we present ECharts,an open-sourced,web-based,cross-platform framework that supports the rapid construction of interactive visualization.The motivation is driven by three goals:easy-touse,rich built-in interactions,and high performance.The kernel of ECharts is a suite of declarative visual design language that customizes built-in chart types.The underlying streaming architecture,together with a high-performance graphics renderer based on HTML5 canvas,enables the high expandability and performance of ECharts.We report the design,implementation,and applications of ECharts with a diverse variety of examples.We compare the utility and performance of ECharts with C3.js,HighCharts,and Chart.js.Results of the experiments demonstrate the efficiency and scalability of our framework.Since the first release in June 2013,ECharts has iterated 63 versions,and attracted over 22,000 star counts and over 1700 related projects in the GitHub.ECharts is regarded as a leading visualization development tool in the world,and ranks the third in the GitHub visualization tab. | Deqing Li Honghui Mei Yi Shen Shuang Su Wenli Zhang Junting Wang Ming Zu Wei Chen | 2018 | Visual Informatics2018，2，2： | 69 |
| 2 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 3 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 4 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 5 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 6 | T cell–associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model显示文摘Although oxymatrine(OMT) has been shown to directly inhibit the replication of hepatitis B virus(HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection.The infection was achieved by tail vein injection of a large volume of DNA solution. OMT(2.2, 6.7 and20 mg/kg) was administered by daily intraperitoneal injection for 6 weeks. The efficacy of OMT was evaluated by the levels of HBV DNA, hepatitis B surface antigen(HBs Ag), hepatitis B e antigen(HBe Ag)and hepatitis B core antigen(HBc Ag). The immunoregulatory activity of OMT was evaluated by serum ELISA and flow cytometry. Results shows that OMT at 20 mg/kg inhibited HBV replication, and it was more efficient than entecavir(ETV) in the elimination of serum HBs Ag and intrahepatic HBc Ag. Inaddition, OMT accelerated the production of interferon-γ(IFN-γ) in a dose-dependent manner in CD4^+T cells. Our findings demonstrate the beneficial effects of OMT on the enhancement of immunological function and in the control of HBV antigens. The findings suggest this drug to be a good antiviral therapeutic candidate for the treatment of HBV infection. | Xiuxiu Sang Ruilin Wang Yanzhong Han Cong’en Zhang Honghui Shen Zhirui Yang Yin Xiong Huimin Liu Shijing Liu Ruisheng Li Ruichuang Yang Jiabo Wang Xuejun Wang Zhaofang Bai Xiaohe Xiao | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 20 |
| 7 | Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants. | Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2019 | Molecular Plant2019，12，7： | 18 |
| 8 | Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants显示文摘 | Lei Yang Xiaohui Zhang Liren Wang Shuming Yin Biyun Zhu Ling Xie Qiuhui Duan Huiqiong Hu Rui Zheng Yu Wei Liangyue Peng Honghui Han Jiqin Zhang Wenjuan Qiu Hongquan Geng Stefan Siwko Xueli Zhang Mingyao Liu Dali Li | 2018 | Protein & Cell2018，9，9： | 13 |
| 9 | Thermal entanglement in a mixed-spin Heisenberg XXZ model under a nonuniform external magnetic field显示文摘The thermal entanglement in (1/2,1) mixed-spin Heisenberg XXZ model is investigated under an external nonuniform magnetic field. In the uniform magnetic field system,the critical magnetic field Bc and critical temperature Tc are increased by increasing the anisotropic parameter k. The degree of magnetic field b plays an important role in improving the critical temperature and enlarging the region of entan-glement in the nonuniform magnetic field system. | WANG Fei JIA HongHui ZHANG HaiLiang ZHANG XueAo CHANG ShengLi | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，12： | 13 |
| 10 | Modelling urban expansion using a multi agentbased model in the city of Changsha显示文摘Although traditional urban expansion simulation models can simulate dynamic features, these models fail to address complex changes produced by different agents' behaviors. The paper has built up a set of spatial-temporal land resource allocation rules and developed a dynamic urban expansion model based on a multi-agent system, which can simulate the interaction among different agents, such as residents, peasants, and governments. This model is applied to simulate urban expansion process taking Changsha City, in China as a study area. The results show that this model can not only reflect basic characteristics of urban expansion, but also help explain the reasons for urban expansion process and understand the effect of agents' behavior on the expansion process, and provide insights into the causing factors behind the expansion. In addition, in contrast to simulation results with land use classification map from remote sensing images, the precision of the simulation reached over 68% with higher precision than cellular automata model according to the cell-by-cell comparison. The results suggest that the model can help to provide land use decision making support to government and urban planners. | ZHANG Honghui ZENG Yongnian BIAN Ling YU Xijun | 2010 | Journal of Geographical Sciences2010，20，4： | 11 |
| 11 | Short-range ordering and its effects on mechanical properties of high-entropy alloys显示文摘In this letter,we briefly summarize experimental and theoretical findings of fo rmation and characterization of short-range orderings(SROs)as well as their effects on the defo rmation behavior of high-entropy alloys(HEAs).We show that existence of SROs is a common yet key structural feature of HEAs,and tuning the degree of SROs is an effective way for optimizing mechanical properties of HEAs.In additional,the challenges concerning about formation mechanism and characterization of SROs in HEAs are discussed,and future research activities in this regard are also proposed. | Yuan Wu Fei Zhang Xiaoyuan Yuan Hailong Huang Xiaocan Wen Yihan Wang Mengyuan Zhang Honghui Wu Xiongjun Liu Hui Wang Suihe Jiang Zhaoping Lu | 2021 | Journal of Materials Science & Technology2021，，3： | 8 |
| 12 | Investigation on the fabrication of lightweight aggregate with acid-leaching tailings of vanadium-bearing stone coal minerals and red mud显示文摘Proper treatment of acidleaching tailings(ALTs)of vanadiumbearing stone coal minerals is of great urgency.One approach is adding it into the raw materials during the preparation of lightweight aggregate(LWA).But clay is always needed.In this paper,another solid waste,red mud,was mixed with ALTs as a source of flux components instead of clay.Evaluation of the physical characteristics,morphological structures,as well as crystal phases during the sintering process were investigated.When their mixtures with a proper ratio were sintered at 1080℃,a glassy phase with certain viscosity was formed,and the gases generated simultaneously were encapsulated by the melt.Finally,LWA with a onehour water absorption as low as 1.46%,a bulk density as low as 728.76 kgm 3 and a compressive strength as high as 10.77 MPa was fabricated. | Chunguang Song Hongling Zhang Yuming Dong Lili Pei Honghui Liu Junsheng Jiang Hongbin Xu | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 6 |
| 13 | DESIGN METHOD OF MAGNETORHEOLOGICAL FLUID SHOCK ABSORBER FOR CAR SUSPENSION显示文摘The Bingham constitutive model,which is previously used in depiction of magnetorheological(MR)fluids rheological behaviors for design devices,exhibits discontinuous characteristics in representation of pre-yield behaviors and post-yield behaviors.A Biviscous constitutive model is presented to depict theological behaviors of MR fluids and design automotive shock absorber.Quasi-static flow equations of MR fluids in annular channels are set theoretically up based on Navier-Stokes equations and several rational simplifications are made.And both flow boundary conditions and flow compatibilities conditions are established.Meantime,analytical velocity profiles of MR fluids though annular channels are obtained via solution of the quasi-static flow equations using Biviscous constitutive model.The prediction methodology of damping force offered by MR fluid shock absorber is formulated and damping performances are predicated in order to determine design parameters.MR fluid shock absorber for Mazda 323 car suspension is designed and fabricated in Chongqing University,China.Measurements from sinusoidal displacement cycle by Shanchuan Shock Absorber Ltd.of China North Industry Corporation reveal that the analytical methodology and design theory are reasonable. | LIAO Changrong ZHANG Honghui YU Miao CHEN Weimin | 2008 | Chinese Journal of Mechanical Engineering2008，21，5： | 5 |
| 14 | An approach to measuring business-IT alignment maturity via DoDAF2.0显示文摘Measuring the business-IT alignment(BITA)of an organization determines its alignment level,provides directions for further improvements,and consequently promotes the organizational performances.Due to the capabilities of enterprise architecture(EA)in interrelating different business/IT viewpoints and elements,the development of EA is superior to support BITA measurement.Extant BITA measurement literature is sparse when it concerns EA.The literature tends to explain how EA viewpoints or models correlate with BITA,without discussing where to collect and integrate EA data.To address this gap,this paper attempts to propose a specific BITA measurement process through associating a BITA maturity model with a famous EA framework:DoD Architectural Framework 2.0(DoDAF2.0).The BITA metrics in the maturity model are connected to the meta-models and models of DoDAF2.0.An illustrative ArchiSurance case is conducted to explain the measurement process.Systematically,this paper explores the process of BITA measurement from the viewpoint of EA,which helps to collect the measurement data in an organized way and analyzes the BITA level in the phase of architecture development. | ZHANG Mengmeng CHEN Honghui MAO Yi LUO Aimin | 2020 | Journal of Systems Engineering and Electronics2020，31，1： | 5 |
| 15 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 16 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 17 | SHY2 as a node in the regulation of root meristem development by auxin, brassinosteroids, and cytokinin显示文摘In multicellular organisms,the balance be-tween cell division and differentiation determines organ size,and represents a central unknown in devel-opmental biology.In Arabidopsis roots,this balance is mediated between cytokinin and auxin through a reg-ulatory circuit converging on the IAA3/SHORT HYPO-COTYL 2(SHY2)gene.Here,we show that crosstalk between brassinosteroids(BRs)and auxin occurs in the vascular transition zone to promote root meristem de-velopment.We found that BR increases root meristem size by up-regulating expression of the PINFORMED 7(PIN7)gene and down-regulating expression of the SHY2 gene.In addition,BES1 could directly bind to the pro-moter regions of both PIN7 and SHY2,indicating that PIN7 and SHY2 mediate the BR-induced growth of the root meristem by serving as direct targets of BES1.Moreover,the PIN7 overexpression and loss-of-function SHY2 mutant were sensitive to the effects of BR and could partially suppress the short-root phenotypes associated with deficient BR signaling.Interestingly,BRs could inhibit the accumulation of SHY2 protein in response to cytokinin.Taken together,these findings suggest that a complex equilibrium model exists in which regulatory interactions among BRs,auxin,and cytokinin regulate optimal root growth. | Taotao Li Xinke Kang Wei Lei Xiuhong Yao Lijuan Zou Dawei Zhang Honghui Lin | 2020 | Journal of Integrative Plant Biology2020，62，10： | 5 |
| 18 | Dominant mutations in CHK1 cause pronuclear fusion failure and zygote arrest that can be rescued by CHK1 inhibitor显示文摘Dear Editor,Infertility poses a major challenge to human reproductive health,affecting approximately 48 million women worldwide.1 Assisted reproductive techniques(ART),including in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI),enable infertile women to have their biological embryos in vitro and further give birth to babies after embryo transfer.However,about 10%of all human embryos produced by ART are blocked in the early embryonic stage2 and approximately 2%fertilized oocytes derived from ART could not accomplish the first cell division.3 About one half of human infertility cases involve an underlying genetic factor,although the majority of genetic causes have remained elusive.4 In this study,we report that dominant mutations in CHK1 are responsible for pronuclear fusion failure and zygote arrest(PFF-ZA)in 7 out of 29 cases,likely through increasing the CHK1 activity.Importantly,PFF-ZA caused by these mutations could be effectively rescued by using the CHK1 inhibitor,PF477736. | Honghui Zhang Tailai Chen Keliang Wu Zhenzhen Hou Shigang Zhao Chuanxin Zhang Yuan Gao Ming Gao Zi-Jiang Chen Han Zhao | 2021 | Cell Research2021，31，7： | 4 |
| 19 | Superior electrochemical performance of La-Mg-Ni-based alloys with novel A_(2)B_(7)-A_(7)B_(23) biphase superlattice structure显示文摘Nickel metal hydride(Ni-MH) rechargeable batteries hold an important position in the new-energy vehicle market owing to their key technology advantages. Their negative electrode materials—hydrogen storage alloys(HSAs) are always on the spotlight and are the key to compete with the burgeoning Li-ion batteries. Here, for the first time we report a series of biphase supperlattice HSAs with a(La,Mg)_(2)Ni_7 matrix phase and a novel(La,Mg)_(7)Ni_(23) secondary phase. The biphase alloys show discharge capacities of402–413 m Ahg^(-1) compared with 376–397 mAhg^(-1) of the other multi-or single-phase alloys. These values are among the highest for superlattice HSAs. In addition, the alloy with 15.4 wt.%(La,Mg)_(7)Ni_(23) phase exhibits good high rate dischargeability due to the proper compromise between the amount of crystal boundaries and equilibrium plateau voltage. The cycling stability of the biphase alloys is lower than that of the single-phase alloy but is till higher than the multiphase alloy. The novel superlattice biphase alloys with superior overall electrochemical properties are expected to inspire further design and development of HSAs as advanced electrode materials for power batteries. | Jingjing Liu Shuai Zhu Xiangyu Chen Jie Xu Lu Zhang Kai Yan Wei Chen Honghui Cheng Shumin Han | 2021 | Journal of Materials Science & Technology2021，，21： | 4 |
| 20 | Main controlling factors for hydrocarbon reservoir formation and petroleum distribution in Cratonic Area of Tarim Basin显示文摘The Cratonic Area of the Tarim Basin is lo-cated in the central part of the basin, developing primarilywith Cambrian marine source rocks and secondly Middle toUpper Ordovician marine and Carboniferous-Permiantransitional facies source rocks. The source rocks werematured in the changeable period and space, formingmultiple hydrocarbon generating centers during the periods.The Cratonic Area experienced multiple tectonic orogenies,forming several palaeouplifts. The matching conditionbetween effective hydrocarbon generating centers and thepalaeouplifts in various periods is the main control factor forthe formation and distribution of hydrocarbon reservoirs.The palaeouplifts have experienced multiple hydrocar-bon-filling phases, several periods of modifications and evenbreakdown. The palaeouplifts and the adjacent slopesaround the effective hydrocarbon generating center composethe most favorable places for hydrocarbon accumulation.The hydrocarbon phase is related with the evolution of thehydrocarbon generating center. In the Tarim Basin’sCratonic Area, reservoirs were mostly formed during lateHercynian. The originally formed hydrocarbon reservoirswhich are adjacent to source kitchens and in the goodpreservation condition are the most favorable prospectingtargets. Hydrocarbon is richly accumulated under theregional caprock, surrounding the faulted trends, and overand below the unconformity surfaces. Reservoirs in theCarboniferous sandstone, Ordovician karstic weatheredcrust and carbonate rock inside the buried hill compose themain intervals for hydrocarbon accumulation. Carboni-ferous and Silurian sandstone pinchout reservoirs andcarbonate lithologic reservoirs with rich fractures and poresare the main targets for further prospecting. | ZHANG Guangya WANG Hongjun LI Honghui | 2002 | Chinese Science Bulletin2002，47，S1： | 3 |
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