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| 1 | Production of high-quality agarwood in Aquilaria sinensis trees via whole-tree agarwood-induction technology显示文摘我们使用了整个树的 agarwood 感应的技术在 20 个月以内从 Aquilaria sinensis 树生产 agarwood,并且评估了这 agarwood 的质量。结果证明它的特征以质地,化学成分,香精油内容,和乙醇可溶的摘录内容类似于高级野 agarwood 的那些,与远超过繁体中文药 agarwood 的要求的最後的质量,作为在中国药典 2010 显示了。就我们的知识而言,这是第一研究证明高质量的 agarwood 能在整个 A 被生产。经由一种化学上导致的技术的 sinensis 树。 | Xing Li Zhang Yang Yang Liu Jian He Wei Yun Yang Zheng Zhang Jun Qing Huang Huai Qiong Chen Yu Jun Liu | 2012 | Chinese Chemical Letters2012，23，6： | 28 |
| 2 | Microbial flocculant and its application in environmental protection显示文摘1IntroductionAlotofvariedflocculantshavebeenusedinwastewatertreatment,dredgingdownstreamprocessingandsomeindustrialfieldincl... | Zhang Tong, Lin Zhe Department of Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China Zhu Huai lan Department of Environmental Science, East China Normal University, Shanghai 200062, China | 1999 | Journal of Environmental Sciences1999，11，1： | 25 |
| 3 | MATHEMATICAL MODEL FOR THE FLOW WITH SUBMERGED AND EMERGED RIGID VEGETATION显示文摘The article summarizes previous studies on the flow in open channels with rigid vegetation, and constructs a mathematical model for submerged and emerged rigid vegetation. The model involves the forces balance in the control volume in one-dimensional steady uniform flow. For submerged vegetation, the whole flow is divided into four regions: external region, upper vegetated region, transition region and viscous region. According to the Karman similarity theory, the article improves the mixing length expression, and then gives an analytical solution to predict the vertical distribution of stream-wise velocity in the external region. For emerged vegetation, the flow is divided into two region: outer region and viscous region. In the two circumstances, the thicknesses of each region are determined respectively. The comparison between the calculated results and our experimental data and other researchers' data proves that the proposed model is effective. | HUAI Wen-xin CHEN Zheng-bing HAN Jie ZHANG Li-xiang ZENG Yu-hong | 2009 | Journal of Hydrodynamics2009，21，5： | 26 |
| 4 | The structure of turbulent flow through submerged flexible vegetation显示文摘The hydrodynamics of turbulent flow through submerged flexible vegetation is investigated in a flume using acoustic Doppler velocimetery(ADV)measurements.The flow characteristics such as the energetics and momentum transfer derived from convcntional spectral and quadrant analyses are considered as the flow encounters a finite vegetation patch.Consistent with numerous canopy flow experiments,a shear layer and coherent vortex structures near the canopy top emerge caused by Kelvin-Helmholtz instabilities after the flow equilibrates with the vegetated layer.These in stabilities are commonly attributed to velocity differences between non-vegetated and vegetated canopy layers in agreement with numerous experiments and simulations conducted on dense rigid canopies.The power-spectral density function for vertical velocity turbulent fluctuations at different downstream positions starting from the edge of the vegetation layer are also computed.For a preset water depth,the dominant dimensionless frequency is found to be surprisingly invariant around 0.027 despite large differences in vegetation densities.The ejection and sweep events significantly contribute to the Reynolds stresses near the top of the vegetation.The momentum flux carried by ejections is larger than its counterpart carried by the sweeps above the canopy top.However,the momentum flux carried by sweeps is larger below the top of the canopy. | Wen-xin Huai Jiao Zhang Gabriel G.Katul Yong-guang Cheng Xue Tang Wei-jie Wang | 2019 | Journal of Hydrodynamics2019，31，2： | 26 |
| 5 | Numerical simulation of GPS observed clockwise rotation around the eastern Himalayan syntax in the Tibetan Plateau显示文摘From Global Position System(GPS) measurements,there is a clockwise rotation around the eastern Himalayan syntax in the Tibetan Plateau.This phenomenon is difficult to be interpreted by simple two-dimensional modeling from a geodynamic point of view.Because of the extremely thick crust and the lower crust with relatively high temperature in the Tibetan Plateau,the lithospheric rheology in Tibet and surrounding areas present a complex structure.In general,the tectonic structure of the Tibetan Plateau consists of brittle upper crust,ductile lower crust,high viscosity lithospheric upper mantle,and low viscosity asthenosphere,the same as the case in many other continental regions.However,the lower crust in the Tibetan Plateau is much more ductile with a lower viscosity than those of its sur-roundings at the same depth,and the effective viscosity is low along the collision fault zone.In this study,we construct a three-dimensional Maxwell visco-elastic model in spherical coordinate system,and simulate the deformation process of the Tibetan Plateau driven by a continuous push from the Indian plate.The results show that the existence of the soft lower crust under the plateau makes the entire plateau uplift as a whole,and the Himalayas and the eastern Himalayan syntax uplift faster.Since the lower crust of surrounding blocks is harder except in the southeastern corner where the high-temperature material is much softer and forms an exit channel for material transfer,after the whole plateau reaches a certain height,the lower crustal and upper mantle material begins to move eastward or southeastward and drag the upper crust to behave same way.Thus,from the macroscopic point of view,a relative rigid motion of the plateau with a clockwise rotation around the eastern Himalayan syntax is developed. | CAO JianLing SHI YaoLin ZHANG Huai WANG Hui | 2009 | Chinese Science Bulletin2009，54，8： | 23 |
| 6 | A carbon-oxygen-bridged ladder-type building block for efficient donor and acceptor materials used in organic solar cells显示文摘A carbon-oxygen-bridged ladder-type donor unit(CO5) was invented and prepared via an ‘‘intramolecular demethanolization cyclization' approach. Its single crystal structure indicates enhanced planarity compared with the carbon-bridged analogue indacenodithiophene(IDT). Owing to the stronger electron-donating capability of CO5 than IDT, CO5-based donor and acceptor materials show narrower bandgaps. A donor-acceptor(D-A) copolymer donor(PCO5TPD) and an A-D-A nonfullerene acceptor(CO5IC) demonstrated higher performance than IDT-based counterparts, PIDTTPD and IDTIC, respectively. The better performance of CO5-based materials results from their stronger light-harvesting capability and higher charge-carrier mobilities. | Zuo Xiao Fan Liu Xinjian Geng Jianqi Zhang Shizhe Wang Yujun Xie Zhen Li Huai Yang Yongbo Yuan Liming Ding | 2017 | Science Bulletin2017，62，19： | 16 |
| 7 | SEUSS and PIF4 Coordinately Regulate Light and Temperature Signaling Pathways to Control Plant Growth显示文摘 | Junling Huai Xinyu Zhang dialong Li Tingting Ma Ping Zha Yanjun Jing Rongcheng Lin | 2018 | Molecular Plant2018，11，7： | 15 |
| 8 | Study on the anticarcinogenic effect and acutetoxicity of liver-targeting mitoxantrone-nanoparticles显示文摘AIM To study the anticarcinogenic effect and acute toxicity of liver targeting mitoxantrone nanospheres. METHODS The anticarcinogenic effect of mitoxantrone polybutylcyanoacrylate nanoparticles (DHAQ PBCA NP) was investigated by using heterotopic and orthotopic transplantation models of human hepatocellular carcinoma (HCC) in nude mice and was compared with mitoxantrone (DHAQ) and doxorubicin (ADR). The acute toxicity of DHAQ PBCA NP lyophilized injection in mice was also studied. RESULTS The tumor inhibition rates of ADR, DHAQ, DHAQ PBCA NP to orthotopically transplanted HCC were 60 07%, 67 49% and 99 44%, respectively, but regard to heterotopically transplanted HCC, these were 80 03%, 86 18% and 92 90%, which were concordant with the results acquired by mitosis counting and proliferating cell nuclear antigen (PCNA). After iv administration to mice with DHAQ PBCA NP, the LD 50 was 16 9*!mg/*!kg ± 3 9*!mg/*!kg , no obvious local irritation was observed and there was no significant damage to the structure of liver cells, and that of the heart, spleen and kidneys. CONCLUSION The effect of DHAQ PBCA NP was significantly higher than that of DHAQ and ADR in the anti orthotopically transplanted HCC and the acute toxicity was relatively low. | ZHANG Zhi Rong, HE Qin, LIAO Gong Tie and BAI Shao Huai | 1999 | World Journal of Gastroenterology1999，5，6： | 13 |
| 9 | Finite element investigation of the poroelastic effect on the Xinfengjiang Reservoir-triggered earthquake显示文摘Coulomb failure stress changes (ΔCFS) are used in the study of reservoir-induced seismicity (RIS) generation.The threshold value of ΔCFS that can trigger earthquakes is an important issue that deserves thorough research.The M s 6.1 earthquake in the Xinfengjiang Reservoir in 1962 is well acknowledged as the largest reservoir-induced earthquake in China.Therefore, it is a logical site for quantitative calculation of ΔCFS induced by the filling of the reservoir and for investigating the magnitude of CFS that can trigger reservoir seismic activities.To better understand the RIS mechanism, a three-dimensional poroelastic finite element model of the Xinfengjiang Reservoir is proposed here, taking into consideration of the precise topography and dynamic water level.We calculate the instant changes of stress and pore pressure induced by water load, and the time variation of effective stresses due to pore water diffusion.The CFS on the seismogenesis faults and the accumulation of strain energy in the reservoir region are also calculated.Primary results suggest that the reservoir impoundment increases both pore pressure and CFS on the fault at the focal depth.The diffusion of pore pressure was likely the main factor that triggered the main earthquake, whereas the elastic stress owing to water load was relatively small.The magnitude of CFS on seismogenesis fault can reach approximately 10 kPa, and the ΔCFS values at the hypocenter can be about 0.7-3.0 kPa, depending on the fault diffusion coefficient.The calculated maximum vertical subsidence caused by the water load in the Xinfengjiang Reservoir is 17.5 mm, which is in good agreement with the observed value of 15 mm.The accumulated strain energy owing to water load was only about 7.3×10 11 J, even less than 1% of the seismic wave energy released by the earthquake.The reservoir impoundment was the only factor that triggered the earthquake. | CHENG HuiHong ZHANG Huai ZHU BoJing SUN YuJun ZHENG Liang YANG ShaoHua SHI YaoLin | 2012 | Science China Earth Sciences2012，55，12： | 11 |
| 10 | Effect of Host Plants on Development,Fecundity and Enzyme Activity of Spodoptera exigua (Hübner)(Lepidoptera:Noctuidae)显示文摘The beet armyworm,Spodoptera exigua (Lepidoptera:Noctuidae),is an economically important pest of crops worldwide,attacking plants from over 20 families including trans-continental agricultural cotton,corn and citrus crops.In this study,performance and subsequent enzyme activity of beet armyworm reared on host plants from five families were investigated.Significant differences were found in development,fecundity and enzyme activity on different host plants.Survival rate was the highest (42.8%) on asparagus lettuce (Lactuca sativar var.asparagina) and the lowest (17.0%) on sweet pepper (Capsicum annuum).Larval duration was the shortest on asparagus lettuce (12.0 d),and was 43.4% longer on sweet peppers (21.2 d).The activity of acetylcholine esterase (AChE) and carboxylesterase (CarE) in 3rd instar larvae,and soluble carbohydrate and crude protein contents in different host plants were determined.AChE activity was the highest in the larvae feeding on Chinese cabbage (Brassica rapa),but declined by nearly 60% on maize (Zea mays) seedlings.The ratio of soluble carbohydrate content to crude protein content in host plants was found to have a positive effect on oviposition and a negative correlation with larval duration and life time (from larval to adult stages) of the insect. | ZHANG Bin LIU Huai Helen Hull-Sanders WANG Jin-jun | 2011 | Agricultural Sciences in China2011，10，8： | 11 |
| 11 | Preparation of polyclonal antibody specific for NOR1 and detection of its expression pattern in human tissues and nasopharyngeal carcinoma显示文摘包含蛋白质 1 的 Oxidored-nitro 领域(NOR1 ) 基因是首先从鼻咽的癌(NPC ) 孤立的新奇 nitroreductase 基因。它为它的 nitrosation 功能在化学致癌物的形成和 NPC 的 carcinogenesis 起一个重要作用。在鼻咽的癌细胞的野类型的 NOR1 基因的 Overexpression 是有效的禁止细胞生长和增长。在这研究,第一次,我们产生了高度特定的 NOR1 抗体并且在人的纸巾和 NPC 活体检视分析了 NOR1 分发。结果证明那 NOR1 蛋白质主要在人的鼻咽和气管的纸巾被表示。人的心,肝,怒气,胃,冒号,肾,骨胳的肌肉,胸腺,和胰都 NOR1 蛋白质是缺乏的。更重要地,我们在 NPC 纸巾执行了 NOR1 蛋白质表示的 immunohistochemistry 试金,并且结果证明那 NOR1 蛋白质在 NPC 经常是下面表示的。这些数据使 NOR1 的潜在的生理的函数的选择清楚些并且提供不可缺少的引用给 NPC 的 carcinogenesis 进程并且到识别或验证织物特定的药目标。 | Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Ming Zhou Huaying Liu Minghua Wu Rong Wan Xiaoling Li Guiyuan Li | 2009 | Acta Biochimica et Biophysica Sinica2009，41，9： | 10 |
| 12 | Constraint-induced movement therapy in treatment of acute and sub-acute stroke: a meta-analysis of 16 randomized controlled trials显示文摘OBJECTIVE: The aim of this meta-analysis was to evaluate the clinical efficacy of constraint-induced movement therapy in acute and sub-acute stroke.DATA SOURCES: The key words were stroke, cerebrovascular accident, constraint-induced therapy, forced use, and randomized controlled trial. The databases, including China National Knowledge Infrastructure, Wan Fang, Weipu Information Resources System, Chinese Biomedical Literature Database, Pub Med, Medline, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews, were searched for studies on randomized controlled trials for treating acute or sub-acute stroke published before March 2016. DATA SELECTION: We retrieved relevant randomized controlled trials that compared constraint-induced movement therapy in treatment of acute or sub-acute stroke with traditional rehabilitation therapy(traditional occupational therapy). Patients were older than 18 years, had disease courses less than 6 months, and were evaluated with at least one upper extremity function scale. Study quality was evaluated, and data that met the criteria were extracted. Stata 11.0 software was used for the meta-analysis. OUTCOME MEASURES: Fugl-Meyer motor assessment of the arm, the action research-arm test, a motor activity log for amount of use and quality of movement, the Wolf motor function test, and a modified Barthel index.RESULTS: A total of 16 prospective randomized controlled trials(379 patients in the constraint-induced movement-therapy group and 359 in the control group) met inclusion criteria. Analysis showed significant mean differences in favor of constraint-induced movement therapy for the Fugl–Meyer motor assessment of the arm(weighted mean difference(WMD) = 10.822; 95% confidence intervals(95% CI): 7.419–14.226), the action research-arm test(WMD = 10.718; 95% CI: 5.704–15.733), the motor activity log for amount of use and quality of movement(WMD = 0.812; 95% CI: 0.331–1.293) and the modified Barthel index(WMD = 10.706; 95% CI: 4.417–16.966). CONCLUSION: Constraint-induced movement therapy may be more beneficial than traditional rehabilitation therapy for improving upper limb function after acute or sub-acute stroke. | Xi-hua Liu Juan Huai Jie Gao Yang Zhang Shou-wei Yue | 2017 | Neural Regeneration Research2017，12，9： | 9 |
| 13 | Effect of Cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats显示文摘OBJEVTIVE:To investigate the efficacy of Cyclocarya paliurus(C.paliurus)polysaccharides on streptozotocin-induced diabetic nephropathy in rats.METHODS:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of kidney was analyzed using hematoxilin and eosin.Levels of blood glucose,creatinine,urea,uric acid were determined by spectrophotometry.Anti-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ELISA.RESULTS:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal tubule.Compared with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic control.Superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly increased.By contrast,administration of C.paliurus polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of C.paliurus polysaccharides.CONCLUSION:Our findings suggest that C.paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression. | Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 9 |
| 14 | Spectral element analysis on the characteristics of seismic wave propagation triggered by Wenchuan M_s8.0 earthquake显示文摘The 2008 Wenchuan earthquake occurred in an active earthquake zone, i.e., Longmenshan tectonic zone. Seismic waves triggered by this earthquake can be used to explore the characteristics of the fault rupture process and the hierarchical structure of the Earth's interior. We employ spectral element method incorporated with large-scale parallel computing technology, to investigate the characteristics of seismic wave propagation excited by Wenchuan earthquake. We calculate synthetic seismograms with one-point source model and three-point source model respectively. The AK135 model is employed as a prototype of our numerical global Earth model. The Earth's ellipticity, Earth’s medium attenuation, and topography data are taken into consideration. These wave propagation processes are simulated by solving three-dimensional elastic wave governing equations. Three-dimensional visualization of our numerical results displays the profile of the seismic wave propagation. The three-point source, which is proposed from the latest investigations through field observation and reverse estimation, can better demonstrate the spatial and temporal characteristics of the source rupture process than the one-point source. We take comparison of synthetic seismograms with observational data recorded at 16 observatory stations. Primary results show that the synthetic seismograms calculated from three-point source agree well with the observations. This can further reveal that the source rupture process of Wenchuan earthquake is a multi-rupture process, which is composed by at least three or more stages of rupture processes. | YAN ZhenZhen ZHANG Huai YANG ChangChun SHI YaoLin | 2009 | Science China Earth Sciences2009，52，6： | 9 |
| 15 | Effect of TiO_2 on Crystallization of the Glass Ceramics Prepared from Granite Tailings显示文摘The effect of TiO2 on the crystallization behaviors of the glass ceramics prepared from granite tailings was investigated by differential scanning calorimetry(DSC), X-ray diffraction(XRD), and field emission scanning electron microscopy(FESEM). The results showed that the crystallization peak temperature decreased firstly, and then increased with the increase of TiO2 content. The optimum addition amount of TiO2 was 8 wt%. With a single-step heat treatment at 924 ℃ for 1 h, augite precipitated as the only crystalline phase both on the surface and in the interior. The avrami parameter of the sample was 3.25, suggesting a twodimensional crystallization mechanism. The activation energies for phase separation and crystallization of augite were 321.75 and 698.83 k J/mol, respectively. | 程金树 KANG Junfeng LOU Xianchun ZHANG Xiaoman LIU Kai WANG Wentian HUAI Xuguang | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，1： | 9 |
| 16 | Effect of Qilongtoutong granule on calcitonin gene-related peptide,beta-endorphin, serotonin, dopamine, and noradrenalin in migraine model rats and mice显示文摘OBJECTIVE: To study the effect of Qilongtoutong granule(QLTT) on plasma calcitonin gene-related peptide(CGRP), beta-endorphin(β-EP), 5-HT, dopamine(DA), noradrenalin(NE), and blood viscosity in migraine model rats and mice.METHODS: Both the acute blood stasis model group and nitroglycerin-induced migraine model group included 60 Sprague-Dawley rats. The reserpine-reduced model group had 60 Kunming mice.Rats from each test were grouped into normal control group, model group, Zhengtian pill(ZTP)group, and high, moderate, or low-dose QLTT groups. In the acute blood stasis model test, after gavage for 7 days, rats were given 0.8 mL/kg adrenaline hydrochloride subcutaneously twice, and kept in ice water for 5 min. After fasting for 12 h,rats were anesthetized and blood samples were col-lected for detection of blood viscosity. In the nitroglycerin-induced migraine group, after gavage for7 days, rats were intraperitoneally injected nitroglycerin(10 mg/kg), and 4 h later, blood samples were collected from postcava for measuring the plasma CGRP and β-EP levels. In the reserpine-reduced model test, except the normal control group, mice were administered reserpine(0.25 mg/kg, i.h.) for 9 days. Mice received intragastric administration from the third day to the ninth day. One hour after the last gavage, blood and brain tissue samples were obtained. Then, blood clotting time and the contents of neurotransmitters were determined.RESULTS: QLTT-(3.6, 1.8, and 0.9 g/kg) and ZTP-treated rats had lower blood viscosity than that in model rats under different shear rates(P<0.01). QLTT-(3.6, 1.8 g/kg) and ZTP-treated rats had significantly lower plasma CGRP levels and higher plasma β-EP levels than those in model rats(P<0.01). QLTT treatment at dose of 0.9 g/kg had lower plasma CGRP levels as well(P<0.05). QLTT-(5.2,2.6 g/kg) and ZTP-treated mice had longer blood clotting time than that in model mice(P<0.01).QLTT-(2.6 g/kg) and ZTP-treated mice had higher plasma serotonin(5-HT) levels than those in model mice(P<0.05).CONCLUSION: QLTT-treated animals had lower plasma CGRP level, higher plasma β-EP, 5-HT, higher brain tissue 5-HT, NE, DA levels, and lower blood viscosity than those in the migraine model animals. | Xiaofang Wu Meikui Zhang Huai Huang | 2014 | Journal of Traditional Chinese Medicine2014，34，2： | 9 |
| 17 | Adsorption characteristics of a novel ceramsite for heavy metal removal from stormwater runoff显示文摘Urban sediments have rapidly increased in recent years around the world,and their effective management has become an important problem.To remove heavy metals from stormwater runoff and use sediments as a resource,a novel ceramsite was developed using sewer pipe sediments(SPS),river bed sediments(RBS),urban water supply treatment sludge(WSTS),and wastewater treatment plant excess sludge(WWTS).The optimal composition was determined based on the Brunauer–Emmett–Teller specific surface area and an orthogonal test design.The adsorption characteristics of the novel ceramsite for dissolved heavy metals(Cu^(2+)and Cd^(2+)) were investigated through adsorption isotherms and kinetic experiments at(25±1)℃.Both Cu^(2+) and Cd^(2+) were effectively removed by the novel ceramsite,and their equilibrium adsorption was 4.96 mg·g^(-1) and 3.84 mg·g^(-1),respectively.Langmuir isotherms and a pseudo-first-order kinetic equation described the adsorption process better than other techniques.Characterization analysis of the ceramsite composition before and after heavy metal adsorption showed that the Cu^(2+) and Cd^(2+) contents in the ceramsite increased after adsorption.The results revealed that adsorption is both a physical and chemical process,and that ceramsite can be used as a bioretention medium to remove heavy metals from stormwater runoff while simultaneously converting problematic urban sediments into a resource. | Jianlong wang Yuanling Zhao Pingping Zhang Liqiong Yang Huai'ao Xu Guangpeng Xi | 2018 | Chinese Journal of Chemical Engineering2018，26，1： | 9 |
| 18 | Dynamic simulation of interactions between major earthquakes on the Xianshuihe fault zone显示文摘The authors firstly evaluate the strain accumulation rate of the Xianshuihe fault zone based on earth- quake activity. We calculated the stress and seismic moment accumulation rate for each subsection of the Xianshuihe fault zone based on the distribution of geological slip rate and GPS survey results. According to the results, we get the recurrence intervals of characterized earthquakes on each sub- section respectively. A three-dimensional finite element model for western Sichuan is constructed to discuss the earthquakes triggering among major earthquakes (M>6.7) that occurred along the Xianshuihe fault zone since 1893. The calculated Coulomb failure stress changes (ΔCFS) show that 5 of the 6 earthquakes with Ms>6.7 were triggered by positive ΔCFS. The interactions between major earthquakes not only influence recurrence intervals of characterized earthquakes on each subsection, but also change recurrence behavior of major earthquakes along the whole fault zone. | WANG Hui LIU Jie SHI YaoLin ZHANG Huai ZHANG GuoMin | 2008 | Science China Earth Sciences2008，51，10： | 8 |
| 19 | Identification of an Early–Middle Jurassic oxidized magmatic belt,south Gangdese,Tibet,and geological implications显示文摘The south Gangdese region is the site of subduction of the Neo-Tethys and subsequent continental collision. Compared with widespread Cretaceous and Cenozoic magmatism, Early–Middle Jurassic magmatic rocks and related deposits are rarely reported. Our work identified a >200 km long felsic rock belt associated with Cu mineralization in the south Gangdese region. We report here zircon U–Pb ages, zircon Ce^(4+)/Ce^(3+)values, and mineral assemblages of two Cu mineralized intrusions within the belt. A hornblende granite and a diorite porphyry were emplaced at 177.3 Ma and 166.3 Ma, respectively.Geological occurrence and magmatic hematite–magnetite–chalcopyrite intergrowths suggest that Cu mineralization formed coeval with Jurassic intrusions. Mineralized intrusions have high zircon Ce^(4+)/Ce^(3+)and EuN/Eu?N ratios, and hematite–magnetite intergrowths, suggesting their parent magmas were highly oxidized. Hornblende is common and primary fluid inclusions are found in titanite and apatite,indicating their parent magmas were water-saturated and exsolved volatile phases at early stage of magmatic evolution. Those magma characters contribute to the formation of porphyry Cu deposits. Given that majority subduction-related porphyry Cu systems have been eroded following uplift and denudation, the well-preserved Early–Middle Jurassic Cu mineralized igneous rocks in south Gangdese are favorable prospecting targets for subduction-related porphyry Cu deposits. | Yinqiao Zou Xilian Chen Wenting Huang Jian Zhang Huaying Liang Jifeng xu Ling Chen | 2017 | Science Bulletin2017，62，12： | 7 |
| 20 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
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