|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 2 | Livestock-carrying capacity and overgrazing status of alpine grassland in the Three-River Headwaters region, China显示文摘在中国的三河的 Headwaters 区域是为中流和下游的区域提供环境保护和地区性的持续开发的一个生态的障碍,它也在中国在畜牧起一个重要作用。这研究基于 MODIS NPP 数据在三河的 Headwaters 区域估计了草地收益,并且计算了草地的合适的带家畜的能力。我们通过在实际、合适的带家畜的能力之间的数据比较分析了过度放牧的数字和它的空间分发特征。结果显示出下列:(1 ) 在三河的 Headwaters 区域的全部的草地产量(干草) 与 465.70 kg/hm2 的平均草地收益是在 2010 的 1096 万吨(空间分发接着从东方和东南介绍一个减少的趋势给西方和西北) ;( 2 )在三河的 Headwaters 区域的合适的带家畜的能力是1219万个绵羊单位(此后描述了为苏),并且平均袜子能力是 51.27 苏[合适的带能力在在东方县的 100 SU/km2 上面,在中央县的 60 SU/km2 (除了 Madoi 县),并且在西方的县的 30 SU/km2 ];并且(3 ) 全部的过度放牧数字是在在 2010 的三河的 Headwaters 区域的 652 万苏,与过度放牧的一般水准, 67.88% 的比率和过度放牧的一般水准 27.43 SU/km2 数。更高的过度放牧比率发生在 Tongde, Xinghai, Yushu,河南省和 Z ? 甠据牥慴湩祴漠 ? 桴 ? 慣楬牢瑡潩 ? 敲?瑬 ? 慷 ? 癥污慵整 ? 祢瀠牥潦浲湩 ? 档牡吗?? | ZHANG Jiping | 2014 | Journal of Geographical Sciences2014，24，2： | 25 |
| 3 | Glacial change in the vicinity of Mt. Qomolangma (Everest), central high Himalayas since 1976显示文摘冰河是在高山的区域的最重要的陆地封面之一并且对全球气候特别敏感变化。遥感证明了是在遥远的多山的区域调查冰川的变化的程度的最好的方法。用 Landsat 题目的印射(TM ) 并且从科莫朗马山(珠穆琅玛) 的 multi-spectral-scanner (女士) 图象国家自然保存(QNNP ) ,为 1976, 1988 和 2006 的中央高喜马拉雅山脉,我们为这三个时期导出冰川的程度。面向对象的图象解释方法,专家知识规则和域调查的联合被采用。结果证明(1 ) 在 2006 的冰川的区域是 2710.17 卤 0.011 km2 (大约 7.41% 整个学习区域) ,并且主要定位了到南方并且在 4700 m 之间到上面的 6800 m 海水平;(2 ) 从 1976 ~ 2006, 0.035 km2 和冰川的湖由 36.88 卤扩展了的 501.91 卤减少的冰河 0.035 km2;冰河撤退的率比在北斜坡(14.40%) 上在喜马拉雅山脉的南部的斜坡(16.79%) 上的亚盆是更高的;大多数冰河在 4700 鈥 ? 的举起撤退了,并且主要发生了 400 m,和撤退地区的估计的上面的限制在 6600 m 和 6700 m 之间;(3 ) 温度的增加和在在学习时期上的降水的减少是驾驶撤退的关键因素。 | NIE Yong ZHANG Yili LIU Linshan ZHANG Jiping | 2010 | Journal of Geographical Sciences2010，20，5： | 22 |
| 4 | Impact of livelihood diversification of rural households on their ecological footprint in agro-pastoral areas of northern China显示文摘Human-environment relationship is a focus of academic researches and an understanding of the relationship is important for making effective policies and decisions. In this study, based on rural household survey data of Taibus Banner, Duolun county and Zhengxiangbai Banner in the Inner Mongolia autonomous region of China, we identified the impact of livelihood diversification on ecosystems in these agro-pastoral areas by using the ecological footprint theory and methodology together with the one-way analysis of variance(ANOVA) and correlation analysis methods. In 2011, the total ecological footprint of consumption(EFC) was 0.665 g hm2, and the total ecological footprint of production(EFP) was 2.045 g hm2, which was more than three times the EFC. The ecological footprint of arable land consumption(EFAC) accounted for a large proportion of the EFC, and the ecological footprint of grassland production(EFGP) occupied a large proportion of the EFP. Both the ecological footprint of grassland consumption(EFGC) and EFGP had a significant positive correlation with the income, indicating that income was mainly depended on livestock production and the households with higher incomes consumed more livestock products. The full-time farming households(FTFHs) had the highest EFP, ecological footprint of arable land production(EFAP), EFGP and EFGC, followed by the part-time farming households(PTFHs) and non-farming households(NFHs), which indicated that part-time farming and non-farming employment reduced the occupancy and consumption of rural households on local ecosystems and natural resources to some extent. When farming households engaged in livestock rearing, both the EFAP and EFAC became smaller, while the EFP, EFC, EFGC and EFGP increased significantly. The differences in ecological footprints among different household groups should be taken into account when making ecosystem conservation policies. Encouraging the laborers who have the advantages of participating in non-farming employment to move out of the rural areas and increasing the diversification of livelihoods of rural households are important in reducing the environmental pressures and improving the welfare of households in the study area. Moreover, grassland should be utilized more effectively in the future. | HAO Haiguang ZHANG Jiping LI Xiubin ZHANG Huiyuan ZHANG Qiang | 2015 | Journal of Arid Land2015，7，5： | 19 |
| 5 | Predicting Potential Distribution of Tibetan Spruce (Picea smithiana) in Qomolangma (Mount Everest) National Nature Preserve Using Maximum Entropy Niche-based Model显示文摘Tibetan spruce (Picea smithiana) is an endemic species of the Himalayas,and it distributes only in a re-stricted area with very low number.To address the lack of detailed distributional information,we used maximum en-tropy (Maxent) niche-based model to predict the species' potential distribution from limited occurrence-only records.The location data of P.smithiana,relative bioclimatic variables,vegetation data,digital elevation model (DEM),and the derived data were analyzed in Maxent.The receiver operating characteristic (ROC) curve was applied to assess the prediction accuracy.The Maxent jackknife test was performed to quantify the training gains from data layers and the response of P.smithiana distribution to four typical environmental variables was analyzed.Results show that the model performs well at the regional scale.There is a potential for continued expansion of P.smithiana population numbers and distribution in China.P.smithiana potentially distributes in the lower reaches of Gyirong Zangbo and Poiqu rivers in Gyirong and Nyalam counties in Qomolangma (Mount Everest) National Nature Preserve (QNNP),China.The species prefers warm temperate climate in mountain area and mainly distributes in needle-leaved evergreen closed to open forest and mixed forest along the river valley at relatively low altitudes of about 2000-3000 m.Model simulations suggest that distribution patterns of rare species with few species numbers can be well predicted by Max-ent. | ZHANG Jiping ZHANG Yili LIU Linshan NIE Yong | 2011 | Chinese Geographical Science2011，21，4： | 15 |
| 6 | Shock tube study of kerosene ignition delay at high pressures显示文摘Ignition delay times of China No.3 aviation kerosene were measured behind reflected shock waves using a heated high-pressure shock tube.Experimental conditions covered a wider temperature range of 820-1500 K,at pressures of 5.5,11 and 22 atm,equivalence ratios of 0.5,1.0 and 1.5,and oxygen concentration of 20%.Adsorption of kerosene on the shock tube wall was taken into account.Ignition delay times were determined from the onset of the excited radical OH emission in conjunction with the pressure profiles.The experimental results of ignition delay time were correlated with the equations:11 0.22 1.09 2 3.2 10 [Keros ene ] [O2] exp(69941 RT) and 7 0.88 0.23 4.72 10 P exp(62092 RT).The current measurements provide the ignition delay behavior of China No.3 aviation kerosene at high pressures and air-like O2 concentration. | LIANG JinHu WANG Su HU HongHao ZHANG ShengTao FAN BingCheng CUI JiPing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 13 |
| 7 | Genetic enhancement in cultured human adult stem cells conferred by a single nucleotide recoding显示文摘 | Jiping Yang Jingyi Li Keiichiro Suzuki Xiaomeng Liu Jun Wu Weiqi Zhang Ruotong Ren Weizhou Zhang Piu Chan Juan Carlos Izpisua Belmonte Jing Qu Fuchou Tang Guang-Hui Liu | 2017 | Cell Research2017，27，9： | 12 |
| 8 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 9 | Early filiform needle acupuncture for poststroke depression: a meta-analysis of 17 randomized controlled clinical trials显示文摘OBJECTIVE: To evaluate the effectiveness and safety of filiform needle acupuncture for poststroke depression, and to compare acupuncture with the therapeutic efficacy of antidepressant drugs. DATA RETRIEVAL: We retrieved data from the Chinese National Knowledge Infrastructure(1979–2012), Wanfang(1980–2012), VIP(1989–2012), Chinese Biomedical Literature(1975–2012), PubMed(1966–2012), Ovid Lww(–2012), and Cochrane Library(–2012) Database using the internet. SELECTION CRITERIA: Randomized controlled trials on filiform needle acupuncture versus antidepressant drugs for treatment of poststroke depression were included. Moreover, the included articles scored at least 4 points on the Jadad scale. Exclusion criteria: other acupuncture therapies as treatment group, not stroke-induced depression patients, score < 4 points, non-randomized controlled trials, or animal trials. MAIN OUTCOME MEASURES: These were the Hamilton Depression Scale scores, clinical effective rate, Self-Rating Depression Scale scores, Side Effect Rating Scale scores, and incidence of adverse reaction and events. RESULTS: A total of 17 randomized controlled clinical trials were included. Meta-analysis results displayed that after 4 weeks of treatment, clinical effective rate was better in patients treated with filiform needle acupuncture than those treated with simple antidepressant drugs [relative risk = 1.11, 95% confidence interval(CI): 1.03–1.21, P = 0.01]. At 6 weeks, clinical effective rate was similar between filiform needle acupuncture and antidepressant drug groups. At 2 weeks after filiform needle acupuncture, Hamilton Depression Scale(17 items) scores were lower than in the antidepressant drug group(mean difference =-2.34, 95%CI:-3.46 to-1.22, P < 0.000,1). At 4 weeks, Hamilton Depression Scale(24 items) scores were similar between filiform needle acupuncture and antidepressant drug groups. Self-Rating Depression Scale scores were lower in filiform needle acupuncture group than in the antidepressant drug group. Side Effect Rating Scale was used in only two articles, and no meta-analysis was conducted. Safety evaluation of the 17 articles showed that gastrointestinal tract reactions such as nausea and vomiting were very common in the antidepressant drug group. Incidence of adverse reaction and events was very low in the filiform needle acupuncture group. CONCLUSION: Early filiform needle acupuncture for poststroke depression can perfectly control depression. Filiform needle acupuncture is safe and reliable. Therapeutic effects of filiform needle acupuncture were better than those of antidepressant drugs. | Jiping Zhang Jing Chen Junqi Chen Xiaohui Li Xueyan Lai Shaoqun Zhang Shengxu Wang | 2014 | Neural Regeneration Research2014，9，7： | 11 |
| 10 | Towards reliable Arctic sea ice prediction using multivariate data assimilation显示文摘Rapid declines in Arctic sea ice have captured attention and pose significant challenges to a variety of stakeholders. There is a rising demand for Arctic sea ice prediction at daily to seasonal time scales, which is partly a sea ice initial condition problem. Thus, a multivariate data assimilation that integrates sea ice observations to generate realistic and skillful model initialization is needed to improve predictive skill of Arctic sea ice. Sea ice data assimilation is a relatively new research area. In this review paper, we focus on two challenges for implementing multivariate data assimilation systems for sea ice forecast. First, to address the challenge of limited spatiotemporal coverage and large uncertainties of observations, we discuss sea ice parameters derived from satellite remote sensing that(1) have been utilized for improved model initialization, including concentration, thickness and drift, and(2) are currently under development with the potential for enhancing the predictability of Arctic sea ice, including melt ponds and sea ice leads. Second, to strive to generate the ‘‘best' estimate of sea ice initial conditions by combining model simulations/forecasts and observations, we review capabilities and limitations of different data assimilation techniques that have been developed and used to assimilate observed sea ice parameters in dynamical models. | Jiping Liu Zhiqiang Chen Yongyun Hu Yuanyuan Zhang Yifan Ding Xiao Cheng Qinghua Yang Lars Nerger Gunnar Spreen Radley Horton Jun Inoue Chaoyuan Yang Ming Li Mirong Song | 2019 | Science Bulletin2019，64，1： | 10 |
| 11 | Modified graphene as novel lubricating additive with high dispersion stability in oil显示文摘Graphene is a promising material as a lubricant additive for reducing friction and wear.Here,a dispersing method which combines chemical modification of graphene by octadecylamine and dicyclohexylcarbodiimide with a kind of effective dispersant has been successfully developed to achieve the remarkable dispersion stability of graphene in base oil.The stable dispersion time of modified graphene(0.5 wt%)with dispersant(1 wt%)in PAO-6 could be up to about 120 days,which was the longest time reported so far.At the same time,the lubricant exhibits a significant improvement of tribological performance for a steel ball to plate tribo-system with a normal load of 2 N.The coefficient of friction between sliding surfaces was~0.10 and the depth of wear track on plate was~21 nm,which decreased by about 44%and 90%when compared to pure PAO-6,respectively.Furthermore,the analysis of the lubricating mechanisms in regard to the sliding-induced formation of nanostructured tribo-film has been contacted by using Raman spectra and TEM. | Pu WU Xinchun CHEN Chenhui ZHANG Jiping ZHANG Jianbin LUO Jiyang ZHANG | 2021 | Friction2021，9，1： | 9 |
| 12 | Comparison of clinical effectiveness of acupuncture and a Western drug on allergic rhinitis:study protocol for a randomized controlled trial显示文摘OBJECTIVE: To compare the efficacy of an acupuncture regimen for persistent allergic rhinitis(PER), aimed at improving a patient's mind or Shen in Traditional Chinese Medicine, to that of a second-generation H1-receptor antagonist, cetirizine hydrochloride.METHODS: This multicenter, randomized, controlled clinical trial on PER will be conducted at three institutions in China. The total study period will be 9 weeks. After a 1-week preparatory screening period, 240 eligible participants with PER willbe randomized to receive acupuncture or pharmacotherapy(1∶1) for 4 weeks with a 4-week follow-up. The primary outcome will be changes in7-day average total nasal symptom score. Secondary outcome measures include rhinoconjunctivitis quality of life questionnaire score and total non-nasal symptom score.RESULTS:The presence and seriousness of psychological and emotional impairments should be considered in therapeutic programs for allergic rhinitis.No clinical trial for treating allergic rhinitis via acupuncture regulation of psychological and emotionalactivitieshasbeenreported.CONCLUSION:The findings of the trial will allow us to determine the effects of the mind(Shen)-regulation treatment approach. We will also be able to confirm if the effects of acupuncture are equivalent to those of the conventional drug cetirizine hydrochloride. | Yanping Wang Sheng Chen Peng Wang Cheng Tan Chang Zhang Zhihong Shi Jiping Zhao | 2014 | Journal of Traditional Chinese Medicine2014，34，3： | 9 |
| 13 | Genome-wide identification and analysis of the DREB genes and their expression profiles under abiotic stresses in Chinese jujube(Ziziphus jujuba Mill.)显示文摘CBF/DREB proteins play a critical role in abiotic stress-mediated gene expression and represent attractive regulons for plant breeding programs.However,no study has been conducted for CBF/DREB protein-related genes in jujube(Ziziphus jujuba Mill.).In this study,twenty-five ZjDREB genes were identified and annotated from the jujube(Z.jujuba‘Dongzao’)genome.Detailed analysis,including gene classification,annotation,phylogenetic evaluation,conserved motif determination and expression profiling were performed on all genes.Phylogenetic analysis showed that ZjDREB proteins were divided into five subgroups(A1–A5),but lacking a subgroup A6 corresponding to AtDREBs.The ZjDREB genes were distributed in nine of twelve chromosomes in the genome.Additionally,the expression patterns of the DREB genes under different abiotic stresses were investigated using q RT-PCR.Nineteen ZjDREB genes were down-regulated under low temperature,in contrast six ZjDREB genes(01,03,05,11,23 and 24)were up-regulated.Under drought,salinity and high temperature conditions,expression of ZjDREB03,09,10,14,15,17 and 20 genes were induced and showed similar expression patterns,suggesting that various stress conditions share common elements in the signaling pathway.The results suggest that the family of DREB genes play an important role in abiotic stresses in jujube,and provide a foundation for further functional studies of this important class of transcriptional regulators. | Heying Zhou Jiping Jia Decang Kong Zhendong Zhang Shuang Song Yingyue Li Xiaoming Pang | 2019 | Journal of Forestry Research2019，30，4： | 8 |
| 14 | Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes in urban drinking water system: A review显示文摘Antibiotic resistance in aquatic environment has become an important pollution problem worldwide. In recent years, much attention was paid to antibiotic resistance in urban drinking water systems due to its close relationship with the biosafety of drinking water. This review was focused on the mechanisms of antibiotic resistance, as well as the presence, dissemination and removal of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) in the urban drinking water system. First, the presence of ARB and ARGs in the drinking water source was discussed. The variation of concentration of ARGs and ARB during coagulation, sedimentation and filtration process were provided subsequently, in which filtration was proved to be a promising technology to remove ARGs. However, biological activated carbon (BAC) process and drinking water distribution systems (DWDSs) could be incubators which promote the antibiotic resistance, due to the enrichment of ARGs and ARB in the biofilms attached to the active carbon and pipe wall. Besides, as for disinfection process, mechanisms of the inactivation of ARB and the promotion of conjugative transfer of ARGs under chlorine, ozone and UV disinfection were described in detail. Here we provide some theoretical support for future researches which aim at antibiotic resistance controlling in drinking water. | Qiaowen Tan Weiying Li Junpeng Zhang Wei Zhou Jiping Chen Yue Li Jie Ma | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 8 |
| 15 | Polycyclic aromatic hydrocarbon concentrations, compositions, sources, and associated carcinogenic risks to humans in farmland soils and riverine sediments from Guiyu, China显示文摘The concentrations of 16 priority polycyclic aromatic hydrocarbons(PAHs) were measured in 23 farmland soil samples and 10 riverine sediment samples from Guiyu, China, and the carcinogenic risks associated with PAHs in the samples were evaluated. Guiyu is the largest electronic waste(EW) dismantling area globally, and has been well known for the primitive and crude manner in which EWs are disposed, such as by open burning and roasting. The total PAH concentrations were 56–567 ng/g in the soils and 181–3034 ng/g in the sediments.The Shanglian and Huamei districts were found to be more contaminated with PAHs than the north of Guiyu. The soils were relatively weakly contaminated but the sediments were more contaminated, and sediments in some river sections might cause carcinogenic risks to the groundwater system. The PAHs in the soils were derived from combustion sources,but the PAHs in the sediments were derived from both combustion and petroleum sources. | Pengjun Xu Bu Tao Zhiqiang Ye Hu Zhao Yue Ren Ting Zhang Yeru Huang Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，10： | 8 |
| 16 | Albedo of Coastal Landfast Sea Ice in Prydz Bay,Antarctica:Observations and Parameterization显示文摘The snow/sea-ice albedo was measured over coastal landfast sea ice in Prydz Bay, East Antarctica(off Zhongshan Station)during the austral spring and summer of 2010 and 2011. The variation of the observed albedo was a combination of a gradual seasonal transition from spring to summer and abrupt changes resulting from synoptic events, including snowfall, blowing snow, and overcast skies. The measured albedo ranged from 0.94 over thick fresh snow to 0.36 over melting sea ice. It was found that snow thickness was the most important factor influencing the albedo variation, while synoptic events and overcast skies could increase the albedo by about 0.18 and 0.06, respectively. The in-situ measured albedo and related physical parameters(e.g., snow thickness, ice thickness, surface temperature, and air temperature) were then used to evaluate four different snow/ice albedo parameterizations used in a variety of climate models. The parameterized albedos showed substantial discrepancies compared to the observed albedo, particularly during the summer melt period, even though more complex parameterizations yielded more realistic variations than simple ones. A modified parameterization was developed,which further considered synoptic events, cloud cover, and the local landfast sea-ice surface characteristics. The resulting parameterized albedo showed very good agreement with the observed albedo. | Qinghua YANG Jiping LIU Matti LEPPRANTA Qizhen SUN Rongbin LI Lin ZHANG Thomas JUNG Ruibo LEI Zhanhai ZHANG Ming LI Jiechen ZHAO Jingjing CHENG | 2016 | Advances in Atmospheric Sciences2016，33，5： | 7 |
| 17 | Strengthening shale wellbore with silica nanoparticles drilling fluid显示文摘Nanoparticles have been widely used to reduce wellbore instability problems of shale formation.In this paper,nanoparticle-containing water-based drilling fluids(WBDFs)and oil-based drilling fluids(OBDFs)were evaluated by running three new tests including spontaneous imbibition,swelling rate and acoustic transit time.Results showed that,for the WBDFs,nanoparticles leaded to higher plastic viscosity(PV)and yield point(YP),and lower API-filtration.Moreover,because pore throats of shale can be plugged by nanoparticles,imbibition amount,swelling rate,and Young's-modulus reduction of shale decreased significantly.Higher concentration of nanoparticles can induce better plugging effect.However,for the OBDFs,nanoparticles did not show these positive effects like the nano WBDFs,even leaded to some negative effects such as higher filtration and larger Young'smodulus reduction.The main reasons are that the silica nanoparticles can easily disperse in the WBDFs,and effectively prevent the filtrate invading into shale by plugging pore throats.But the same silica nanoparticles are difficult to disperse in OBDFs,and do not perform the expected functions.This study indicates that nano WBDFs have great potential to reduce the wellbore instability problems of shale formation. | Yili Kang Jiping She Hao Zhang Lijun You Minggu Song | 2016 | Petroleum2016，2，2： | 7 |
| 18 | Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy显示文摘Different types of pores ubiquitously form in cell membranes,leading to various types of cell death that profoundly influence the fate of inflammation and the disease status.However,these pores have never truly been visualized to date.Atomic force microscopy(AFM),which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells,is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic resolution.Here,membrane pore structures were clearly visualized using AFM.This visualization not only describes the aperture and depth of the pore complexes but also highlights differences among the pores formed by perforin and gasdermins in tumor cell membranes and by complement in immune cell membranes.Additionally,this type of visualization also reveals the dynamic process of pore formation,fusion,and repair. | Yuying Liu Tianzhen Zhang Yabo Zhou Jiping Li Xiaoyu Liang Nannan Zhou Jiadi Lv Jing Xie Feiran Cheng Yiliang Fang Yunfeng Gao Ning Wang Bo Huang | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 19 | Occurrence and bioaccumulation of polybrominated diphenyl ethers in sediments and paddy ecosystems of Liaohe River Basin, northeast China显示文摘Concentrations of 16 polybrominated diphenyl ether(PBDE) congeners were measured in river sediments, paddy soils and three species of paddy-field organisms(crab, loach and carp) collected from the Liaohe River Basin, northeastern China. The total contents of PBDEs(∑_(16)PBDEs) in sediments and paddy soils were in the ranges of 273.4–3246.3 pg/g dry weight(dw), and 192.1–1783.8 pg/g dw, respectively. BDE 209 was the dominant congener both in sediments and paddy soils. The concentrations of ∑_(16)PBDEs in sediments were significantly higher than those in the adjacent paddy soils, indicating a potential transport of PBDEs from river to paddy ecosystems via river water irrigation. The biota–soil accumulation factor(BSAF) was calculated as the ratio between the lipid-normalized concentration in paddyfield organisms and the total organic carbon-normalized concentration in paddy soil. The average BSAF values of ∑15PBDEs followed the sequence of crab(3.6) > loach(3.3) > carp(2.1). BDE 154 had the highest BSAF value, and a parabolic trend between BSAF values of individual PBDE congeners and their log KOWvalues was observed. In view of the fact that crab had the larger BSAF value and higher lipid content, the ecological risk and health risk for crab cultivation in paddy fields should be of particular concern. | Xindong Ma Haijun Zhang Wenjun Yao Wen Guo Depeng Li Ziwei Yao Jiping Chen | 2016 | Journal of Environmental Sciences2016，28，5： | 6 |
| 20 | Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity显示文摘血大脑障碍(BBB ) 是在 endothelial 房间和星形细胞之间形成的一条紧密的边界,它在循环把大脑与大多数病原体以及神经毒素分开并且保护。然而,详细说明了涉及 BBB 的形成的分子的播放器完全不被知道。牙质矩阵蛋白质 1 (DMP1 )-proteoglycan (PG ) 被知道涉及骨头和牙质的矿化作用,也与未知功能包括大脑在软纸巾被表示。在现在的学习,我们报导 DMP1-PG 在大脑星形细胞被表示并且在 BBB 充实单位。DMP1 的唯一的 glycosylation 地点在在鼠标的蛋白质的 N 终端域是 serine89 (S89 ) 。有 DMP1 的变异的老鼠削尖把 S89 改变到 glycine (S89G ) 的变化,它蛋白质的完全根除的 glycosylation,表明的严重 BBB 混乱。DMP1 变异的鼠标的另一个品种,缺乏 DMP1 的 C 终端域,表明了正常 BBB 功能。S89G-DMP1 星形细胞的极性被破坏,房间房间粘附被松开。通过一组分析,我们发现 DMP1 glycosylation 极其在 vitro 并且在 vivo 为星形细胞成熟被要求。S89G-DMP1 变异的星形细胞没能表示 aquaporin 4 并且减少了 laminin 和 ZO1 表示,它导致了 BBB 的混乱。有趣地,在 nestin 倡导者驾驶的老鼠大脑的野类型的 DMP1-PG 的 overexpression 在野类型层次以外提高了 laminin 和 ZO1 表示并且能有效地抵抗的静脉内的导致甘露糖醇的 BBB 可逆的洞。一起拿,我们的学习不仅揭示了一个新奇元素,即, DMP1-PG,调整了 BBB 形成,而且把新功能分到 DMP1-PG。 | Bo Jing Chunxue Zhang Xianjun Liu Liqiang Zhou Jiping Liu Yinan Yao Juehua Yu Yuteng Weng Min Pan Jie Liu Zuolin Wang Yao Sun Yi Eve Sun | 2018 | Protein & Cell2018，9，3： | 5 |
您所在的机构暂未开通此部分的功能，请联系管理员