|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Study on the antiulcer effects of Veronicastrum axillare on gastric ulcer in rats induced by ethanol based on tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)显示文摘Objective:To assess whether Veronicastrum axillare(V.axillare)can ameliorate ethanol-induced gastric mucosal lesions in rats,reduce the production of pro-inflammatory cytokines,suppress apoptosis and improve local microcirculation disturbances.Methods:Totally 48 male Sprague-Dawley rats were randomly divided into six groups,eight rats in each group.Rats in the normal group and the model group were administered with 0.9%normal saline respectively.Rats in the positive group and ranitidine group were administered with 0.18%ranitidine suspension by intragastric administration respectively.Those in the high dose V.axillare group,the medium dose V.axillare group and the low dose V.axillare group were administrated with V.axillare at the daily dose of 2.8 g/kg,1.4 g/kg and 0.7 g/kg by intragastric administration.Gastric mucosal lesions were produced by intragastric administration of absolute ethanol.Water extract of V.axillare was successively injected for 14 d and last day was injected 1 h before ethanol administration.Gastric mucosal ulcer index and ulcer inhibitory rate were counted by improved Guth methods.The tissue sections were made for pathological histology analysis.Also,we measured the concentrations of tumor necrosis factor-α(TNF-α)and endothelin-1(ET-1)in gastric mucosal,as an index of the pro-inflammatory cytokines,apoptosis and local microcirculation.Besides,the mRNA contents of TNF-αand ET-1 were measured to verify effects on gene expression by real-time fluorescent quantitative PCR.Results:Water extract of V.axillare significantly ameliorated the gastric mucosal lesions induced by ethanol administration(P<0.01).Pro-inflammatory cytokines,TNF-a and ET-1 were increased after ethanol administration and significantly reduced by water extract of V.axillare.The expressions of TNF-αand ET-1 mRNA were also be inhibited by water extract of V.axillare.Conclusion:Current evidences show water extract of V.axillare is effective for defending against ethanol-induced gastric mucosal lesions,significantly inhibiting the production of proinflammatory cytokines and the expressions of TNF-αand ET-1 mRNA,which may be useful for inhibiting apoptosis and improving local microcirculation. | Yong Du Weichun Zhao Leilei Lu Jiayan Zheng Xishi Hu Zhehan Yu Lixin Zhu | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，12： | 13 |
| 2 | Downwash distribution of single-rotor unmanned agricultural helicopter on hovering state显示文摘The effective coverage and velocity of downwash are directly related to the assemblage of spraying system and spraying effect.The downwash of the unmanned agricultural helicopter(UAH)N-3 was discussed in the paper.The computational fluid dynamics(CFD)methods were used to simulate and analyze the distribution of the downwash,and a wind field measurement device had been designed to test the downwash of UAH N-3.In the tests,the UAH N-3 was raised up to 5.0 m,6.0 m and 7.0 m from the ground,“annular-radial-distribution-point”method was introduced,8 directions separated by an angle of 45°(the radial direction)with the intersection point of the main rotor shaft and the ground plane as the center,0.5 m as the step length for the longitudinal(to 2.5 m)and radial(to 4.0 m)direction to set the sample points,considering the range of the rotor rotating circular area mainly.The 5 m height results of N-3 were fully discussed to describe the downwash distribution with the longitudinal altitude increased and the radial distance increased.The standard deviations of five test altitudes for eight directions were comparatively analyzed,the results showed that the total standard deviation was not greater than 0.6 m/s.The overall relative maximum margin of error calculated from the simulation and measurement data was between 0.6 and 0.7,which verified the credibility of the simulation data.High-order polynomials were used to fitting the simulation and measurement data,the fitting results showed that the polynomial coefficient of determination R^(2) met or exceeded 0.75 when the altitudes were more than 1 m,indicating the fit equation having the reference values.When the altitudes equal or less than 0.5 m,the polynomial coefficient of determination R^(2) was smaller,ranging during 0.3 to 0.7.The study would provide some foundations for the optimization of the assemblage of spraying system on the single-rotor UAH,which would promote China aviation plant protection. | Zhang Songchao Xue Xinyu Sun Zhu Zhou Lixin Jin Yongkui | 2017 | International Journal of Agricultural and Biological Engineering2017，10，5： | 13 |
| 3 | 肠道菌群在功能性便秘中的作用显示文摘功能性便秘非常常见,但其发病机制尚不明了。越来越多的证据显示,功能性便秘与肠道微生态失调有关,而肠道微生态与肠道转运之间很可能存在相互影响。本文对功能性便秘发生过程中肠道微生态所发挥作用的证据进行了总结。肠道微生态通过胆酸、短链脂肪酸、5-羟色胺和甲烷等相关微生物代谢活动调控结肠动力、结肠黏膜分泌和吸收,进而促使功能性便秘的发生。作为肠道微生态影响功能性便秘的证据支持,用益生菌、益生元、合生元和中药治疗功能性便秘时,常可观察到患者肠道微生态在菌种组成和功能上的改变。深入研究功能性便秘的病理发生,阐明微生态制剂治疗功能性便秘的药理机制,将为功能性便秘的新型治疗方法提供理论基础。 | Shengsheng Zhang Ruixin Wang Danyan Li Luqing Zhao Lixin Zhu | 2021 | Gastroenterology Report2021，9，5： | 13 |
| 4 | CIC-3 chloride channels are essential for cell proliferation and cell cycle progression in nasopharyngeal carcinoma cells显示文摘ClC-3,为激活卷的氯化物编码候选人蛋白质的基因(Cl ?) 隧道,可以涉及肿瘤开发。此处,我们用 antisense 报导研究调查 ClC-3 在鼻咽的癌 CNE-2Z 房间由影响房间增长的机制的击倒的策略。与 immunoblots 和 MTT 试金,我们证明 ClC-3 的表示是房间周期依赖者并且以一种类似的集中依赖者方式,为 ClC-3 特定的 antisense oligonucleotide 禁止了 ClC-3 蛋白质表示和房间增长。ClC-3 的表示水平与房间增长相关。而且在暴露于 ClC-3 antisense oligonucleotide 的房间,克隆的效率被禁止,并且房间在 S 阶段被逮捕。ClC-3 antisense oligonucleotide 禁止了激活卷的 Cl 吗?当前(ICl,体积) 并且以一种集中依赖者方式的规章的体积减少(RVD ) 。另外, ICl,体积或 RVD 断然在对待的房间与房间增长被相关。在结论, ClC-3 通过包含 ICl,体积和 RVD 的调整的机制涉及房间增长和房间周期前进。CIC-3 可以在人的癌症代表一个治疗学的目标。 | Bin Xu Jianwen Mao Liwei Wang Linyan Zhu Hongzhi Li Weizhang Wang Xiaobao Jin Jiayong Zhu Lixin Chen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，6： | 12 |
| 5 | Estimation and prediction of plastic waste annual input into the sea from China显示文摘Marine plastic debris has been a pervasive issue since the last century, and research on its sources and fates plays a vital role in the establishment of mitigation measures. However, data on the quantity of plastic waste that enters the sea on a certain timescale remain largely unavailable in China. Here, we established a model using material flow analysis method based on life cycle assessment to follow plastic product from primary plastic to plastic waste with statistical data and monitoring data from accurate sources. This model can be used to estimate and forecast the annual input of plastic waste into the sea from China until 2020. In 2011, 0.547 3–0.751 5 million tons of plastic waste entered the seas in China, with a growth rate of 4.55% per year until 2017. And the amount will decrease to0.257 1 to 0.353 1 million tons in 2020 under the influence of governmental management. The amount of plastic waste discharged from coastal areas calculated in this study was much larger than that from river, thus it is suggested to strengthen the governance and control of plastic waste in coastal fishery activities in China in order to reduce the amount of marine plastic waste input. | BAI Mengyu ZHU Lixin AN Lihui PENG Guyu LI Daoji | 2018 | Acta Oceanologica Sinica2018，37，11： | 11 |
| 6 | Discovery of carbonaceous compressions and their multicellular tissues from the Changzhougou Formation (1 800 Ma) in the Yanshan range, North China显示文摘In 1997 and 1998, hundreds of specimens of megascopic carbonaceous compressions or algal fossils were found from - 1800-million-year old Changzhougou Formation, which is the lowermost unit of the latest Palaeoproterozoic Changcheng Group (~1 600-1 800 Ma) in the Xinglong-Kuancheng areas at the middle Yanshan Range, North China. They are discoid, ellipsoid and sausage-like, namely shaped like Chuaria Shouhsiennia (Ellipsophyta) and Tawuia. By adopting HF acid-resistant maceration coupled with scanning electron microscope and petrologic section, the authors made a preliminary research on the histology for some circular and ellipsoid carbonaceous compressions, namely Chuaria- and Shouhsienia-llke forms, in addition to their morphology. The following three types of multicellular tissues have been found in the fragments of them: colony-like, pseudoparenchyma-like and parenchyma-like. All of the new data about multicelluar tissues not only supply a very important basis in histology to determine the | ZHU Shixing SUN Shufen HUANG Xueguang HE Yuzhen ZHU Gengxin SUN Lixin ZHANG Kuan | 2000 | Chinese Science Bulletin2000，45，9： | 10 |
| 7 | Anomaly Models of Spatial Structures for Copper-Molybdenum Ore Deposits and their Application显示文摘This paper discusses the enrichment and depletion regularities for porphyry copper-molybdenum ore deposits in different regions and varied deposit genetic types in the same area, taking three porphyry copper-molybdenum ore deposits (i.e., the Chengmenshan in Jiangxi, Wunugetushan in Inner Mongolia, Baishantang in Gansu) and two copper deposits in Gansu Province (the Huitongshan skarn deposit and Gongpoquan composite deposit) as case studies. The results show that porphyry Cu-Mo deposits or skarn copper deposits include both enrichment of the ore-forming elements and associated elements, and depletion of some lithophile dispersed elements, rare earth elements (REE) and some major elements. And the depleted elements vary with deposits, having generality and their own features. On a deposit scale, the positive anomalies of enriched elements and negative anomalies of depleted elements follow in a sequence to comprise regular anomaly models of spatial structures. The exploration in the Tongchang deposit in Jiangxi and Huitongshan deposit in Gansu suggests that anomaly models play a key role in the identification of mineral occurrences and deposits compared to one single enriched element anomaly. And the anomaly models exert a critical effect on the optimization of prospecting targets and their potential evaluation. | MA Shengming ZHU Lixin LIU Chongmin XI Mingjie TANG Shixin | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 8 | Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea显示文摘Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of S.erythraea.Herein,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in S.erythraea A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin biosynthesis.EMSA and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their transcription.Furthermore,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin production.Given demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial S.erythraea WB.Compared with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and ermE.When cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to WB.The strategy reported here will be useful to improve antibiotics production in other industrial actinomycete. | Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 7 |
| 9 | Complete three-dimensional coseismic displacements due to the 2021 Maduo earthquake in Qinghai Province,China from Sentinel-1 and ALOS-2 SAR images显示文摘On 22 nd May 2021(local time),an earthquake of M_(s)7.4 struck Maduo county in Qinghai Province,China.This was the largest earthquake in China since the 2008 Wenchuan earthquake.In this study,ascending/descending Sentinel-1 and advanced land observation satellite-2(ALOS-2)synthetic aperture radar(SAR)images were used to derive the three-dimensional(3-D)coseismic displacements of this earthquake.We used the differential interferometric SAR(In SAR,DIn SAR),pixel offset-tracking(POT),multiple aperture In SAR(MAI),and burst overlap interferometry(BOI)methods to derive the displacement observations along the line-of-sight(LOS)and azimuth directions.To accurately mitigate the effect of ionospheric delay on the ALOS-2 DIn SAR observations,a polynomial fitting method was proposed to optimize range-spectrum-split-derived ionospheric phases.In addition,the 3-D displacement field was obtained by a strain model and variance component estimation(SM-VCE)method based on the high-quality SAR displacement observations.Results indicated that a left-lateral fault slip with the largest horizontal displacement of up to 2.4 m dominated this earthquake,and the small-magnitude vertical displacement with an alternating uplift/subsidence pattern along the fault trace was more concentrated in the near-fault regions.Comparison with the global navigation satellite system data indicated that the SM-VCE method can significantly improve the accuracy of the displacements compared to the classical weighted least squares method,and the incorporation of the BOI displacements can substantially benefit the accuracy of north-south displacement.In addition to the displacements,three coseismic strain invariants calculated based on the strain model parameters were also investigated.It was found that the eastern and western parts of the faults suffered more significant strains compared with the epicenter region. | Jihong LIU Jun HU Zhiwei LI Zhangfeng MA Lixin WU Weiping JIANG Guangcai FENG Jianjun ZHU | 2022 | Science China Earth Sciences2022，65，4： | 6 |
| 10 | Water takeoff performance calculation method for amphibious aircraft based on digital virtual flight显示文摘Owing to the strong coupling among the hydrodynamic forces,aerodynamic forces and motion of amphibious aircraft during the water takeoff process,the water takeoff performance is difficult to calculate accurately and quickly.Based on an analysis of the dynamics and kinematics characteristics of amphibious aircraft and the hydrodynamic theory of high-speed planing hulls,a suitable mathematical model is established for calculating the hydrodynamics of aircraft during water takeoff.A pilot model is designed to illustrate how pilots are affected by the lack of visual reference and the necessity to simultaneously control the pitch angle,flight velocity and other parameters during water takeoff.Combined with the aerodynamic model,engine thrust model and aircraft motion model,a digital virtual flight simulation model is developed for amphibious aircraft during water takeoff,and a calculation method for the water takeoff performance of amphibious aircraft is proposed based on digital virtual flight.Typical performance indicators,such as the liftoff time and liftoff distance,can be obtained via digital virtual flight calculations.A comparison of the measured flight test data and the calculation results shows that the calculation error is less than 10%,which verifies the correctness and accuracy of the proposed method.This method can be used for the preliminary evaluation of airworthiness compliance of amphibious aircraft design schemes,and the relevant calculation results can also provide a theoretical reference for the formulation of flight test plans for airworthiness certification. | Lixin WANG Haipeng YIN Kun YANG Hailiang LIU Jianghui ZHU | 2020 | Chinese Journal of Aeronautics2020，33，12： | 5 |
| 11 | High He-ion irradiation resistance of CrMnFeCoNi high-entropy alloy revealed by comparison study with Ni and 304SS显示文摘High entropy alloys(HEAs) have presented potential applications in nuclear power plants owing to their novel atomic structure based high irradiation resistance. However, understanding of He-ion irradiation of HEAs is still lacking. In this work, we reveal He-ion irradiation resistance of HEA CrMnFeCoNi by comparison study with a pure Ni and a 304 stainless steel(304SS). It is found that the damage structure in the three materials can be characterized with He bubbles and stacking faults/stacking fault tetrahedrons((SFs/SFTs), which show a similar depth distribution after He-ion irradiation at both RT and 450℃.Although the He bubbles have a similar size about 2nm after irradiation at RT, the He bubble sizes of the HEA, 304SS, and Ni increase to 4.0±0.9,5.3±1.0 and 6.7 ±1.0 nm after irradiation at 450℃, respectively. Moreover, the density of SFs/SFTs displays in an order of Ni < 304 SS < HEA at both RT and 450℃.The He-ion irradiation at RT causes significant hardness enhancement for the three materials, however,compared to RT, after irradiation at 450℃, the Ni presents softening, while the 304SS, especially the HEA,shows further hardening. Thus, the HEA CrMnFeCoNi possesses the smallest He bubble size, the densest SFs/SFTs, and the highest hardening, indicating the best structural stability, as well as the best He-ion irradiation resistance, which can be attributed to its low mobility of He atoms and point defects. | Lixin Yang Hualong Ge Jian Zhang Ting Xiong Qianqian Jin Yangtao Zhou Xiaohong Shao Bo Zhang Zhengwang Zhu Shijian Zheng Xiuliang Ma | 2019 | Journal of Materials Science & Technology2019，35，3： | 5 |
| 12 | Joint horizontal and vertical deep learning feature for vehicle re-identification显示文摘Dear editor,Vehicle re-identification is a procedure in which a query image of a vehicle can be matched to vehicle images captured by different cameras in a data gallery.This procedure is extremely important for the improvement of public safety;however,accurately re-identifying vehicles is a very challenging computer vision task because vehicle images are captured from different camera view-points and they usually contain large variations in appearances.Therefore,the development of an effective vehicle re-identification method is both challenging and socially meaningful. | Jianqing ZHU Huanqiang ZENG Xin JIN Yongzhao DU Lixin ZHENG Canhui CAI | 2019 | Science China(Information Sciences)2019，62，9： | 4 |
| 13 | Characterization and of Ralstonia TAL-Like DNA-Binding Specificities Effectors显示文摘从 Xanthomonas sp 的抄写像使活跃之物的受动器(故事) 。为染色体工程应用被用作可定制的 DNA 有约束力的模块。Ralstonia solanacearum 像故事的蛋白质(RTL ) 展出类似的结构的特征到故事,包括一个中央 DNA 有约束力的领域填写了 of35 氨基的酸长的重复。这里,我们描绘他们作为 transcriptional 使活跃之物在植物房间原子核, mediateDNA 绑定,和力量功能本地化的 RTL 和表演。RTL 有唯一的 DNA 有约束力的体系结构并且是 enrichedin 重复变量 di 残余(RVD ) ,它决定重复 DNA 有约束力的特性。我们决定了 DNA 有约束力的 specificitiesfor RVD 序列 ND, HN, NP,和 NT。RVD ND 调停和 C 核苷酸的高度特定的相互作用, HN interactsspecifically 与 A 和 G 核苷酸,和 NP 绑在 C, A,和 G 核苷酸。而且,我们发展了一高度为设计 RTL 受动器的 efficientrepeat 集会途径。一起拿,我们的数据证明 RTL 是是要定制为指向的 genomic 和 epigenomicmodifications 绑在选择用户的 DNA 序列的优秀选择的唯一的 DNA-targetingmodules。这些调查结果将在 pathogenicityof Ralstonia spp.Key 词有关 RTL 分子的生物学和 RTL 角色便于研究: | Lixin Li Ahmed Atef Agnieszka Piatek Zahir Ali Marek Piatek Mustapha Aouida Altanbadralt Sharakuu Ali Mahjoub Guangchao Wang Suhail Khan Nina V. Fedoroff Jian-Kang Zhu Magdy M. Mahfouz | 2013 | Molecular Plant2013，6，4： | 3 |
| 14 | PRMT5 in gene regulation and hematologic malignancies显示文摘Arginine methylation is a common posttranslational modification that governs important cellular processes and impacts development,cell growth,proliferation,and differentiation.Arginine methylation is catalyzed by protein arginine methyltransferases(PRMTs),which are classified as type I and type II enzymes responsible for the formation of asymmetric and symmetric dimethylarginine,respectively.PRMT5 is the main type II enzyme that catalyzes symmetric dimethylarginine of histone proteins to induce gene silencing by generating repressive histone marks,including H2AR3me2s,H3R8me2s,and H4R3me2s.PRMT5 can also methylate nonhistone proteins such as the transcription factors p53,E2F1 and p65.Modifications of these proteins by PRMT5 are involved in diverse cellular processes,including transcription,translation,DNA repair,RNA processing,and metabolism.A growing literature demonstrates that PRMT5 expression is upregulated in hematologic malignancies,including leukemia and lymphoma,where PRMT5 regulates gene expression to promote cancer cell proliferation.Targeting PRMT5 by specific inhibitors has emerged as a potential therapeutic strategy to treat these diseases. | Fen Zhu Lixin Rui | 2019 | Genes & Diseases2019，6，3： | 3 |
| 15 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 16 | Geochemical Features and Metallogenic Prediction of the Caixiashan-Weiquan Area in the East Tianshan Region显示文摘Caixiashan-Weiquan 区域是在东方 Tianshan metallogenic 带的一个重要矿石集中区域。第一,这份报纸学习 Matoutan mapsheet 的 1:200000 溪流沉积的 1564 件样品的 geochemical 特征,在 Caixiashan 和 Weiquan 存款被定位的地方。处理,探索 geochemical 数据的分析和解释在发现矿石的过程起一个重要作用,它与 geochemical 样品的测量元素内容是否能有效地指导矿物质探索的工作有关。作为一个高度非线性的动态系统,神经网络与常规 geochemical 途径相比以原则和特征更类似于人的大脑。它能使自己适应环境,总结法律,完全的模式识别。第二,作者使用了分类所有的神经网络基于溪流沉积样品的 10 个矿化作用元素取样以便决定可能的矿物质矿石,减少矿石目标的范围并且学习第九组样品的指示物元素的 Kohonen ,它是主要,最近到沉积物,结果证明神经网络能描出 metallogenic 未来的区域并且在深 geochemical 信息的发现是有效的。 | LU Lu ZHU Lixin XIAO Keyan MA Shengming YIN Jiangning XU Mingzuan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 3 |
| 17 | Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community- dwelling populations显示文摘Background and purpose This study aimed to investigate the association of metabolic syndrome(MetS)with both intracranial atherosclerotic stenosis(ICAS)and imaging markers of cerebral small vessel disease(CSVD)in a community-based sample.Methods This study included 943 participants(aged 55.6±9.2 years,36.1%male)from the community-based Shunyi cohort study.MetS was defined according to the joint interim criteria and quantified by the MetS severity Z-score.ICAS was evaluated by brain magnetic resonance angiography.The MRI markers of CSVD,including white matter hyperintensities(WMHs),lacunes,cerebral microbleeds(CMBs)and enlarged perivascular spaces(EPVS),were assessed.Multiple regression models were used to investigate the association of MetS severity Z-score with ICAS and these CSVD markers.Results We found that risk of ICAS(OR=1.75,95%CI 1.39 to 2.21,p<0.001)increased consistently with MetS severity.MetS severity was significantly associated with higher risks of WMH volume(β=0.11,95%CI 0.01 to 0.20,p=0.02)and lacunes(OR=1.28,95%CI 1.03 to 1.59,p=0.03)but not the presence of CMBs(OR=0.93,95%CI 0.74 to 1.16,p=0.51)and PVS severity(EPVS in basal ganglia:OR=0.96,95%CI 0.84 to 1.09,p=0.51 and EPVS in white matter:OR=1.09,95%CI 0.96 to 1.23,p=0.21).Conclusions Our findings suggest that WMH and lacunes share risk factors with atherosclerosis of the cerebral artery,whereas the impact of glucose and lipid metabolic disorder to CMB or EPVS might be weak. | Mei-Jun Shu Fei-Fei Zhai Ding-Ding Zhang Fei Han Lixin Zhou Jun Ni Ming Yao Shu-Yang Zhang Li-Ying Cui Zheng-Yu Jin Hui-Juan Zhu Yi-Cheng Zhu | 2021 | Stroke & Vascular Neurology2021，6，4： | 3 |
| 18 | Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH显示文摘 | Lixin Zhu Susan S. Baker Chelsea Gill Wensheng Liu Razan Alkhouri Robert D. Baker Steven R. Gill | 2013 | Hepatology2013，，2： | 3 |
| 19 | Astragaloside Ⅳ suppresses post-ischemic natural killer cell infiltration and activation in the brain:involvement of histone deacetylase inhibition显示文摘Natural killer(NK)cells,a type of cytotoxic lymphocytes,can infiltrate into ischemic brain and exacerbate neuronal cell death.Astragaloside Ⅳ(ASIV)is the major bioactive ingredient of Astragalus membranaceus,a Chinese herbal medicine,and possesses potent immunomodulatory and neuroprotective properties.This study investigated the effects of ASIV on post-ischemic brain infiltration and activation of NK cells.ASIV reduced brain infarction and alleviated functional deficits in MCAO rats,and these beneficial effects persisted for at least 7 days.Abundant NK cells infiltrated into the ischemic hemisphere on day 1 after brain ischemia,and this infiltration was suppressed by ASIV.Strikingly,ASIV reversed NK cell deficiency in the spleen and blood after brain ischemia.ASIV inhibited astrocyte-derived CCL2 upregulation and reduced CCR2+NK cell levels in the ischemic brain.Meanwhile,ASIV attenuated NK cell activating receptor NKG2D levels and reduced interferon-γproduction.ASIV restored acetylation of histone H3 and the p65 subunit of nuclear factor-κB in the ischemic brain,suggesting inhibition of histone deacetylase(HDAC).Simultaneously,ASIV prevented p65 nuclear translocation.The effects of ASIV on reducing CCL2 production,restoring acetylated p65 levels and preventing p65 nuclear translocation were mimicked by valproate,an HDAC inhibitor,in astrocytes subjected to oxygen-glucose deprivation.Our findings suggest that ASIV inhibits post-ischemic NK cell brain infiltration and activation and reverses NK cell deficiency in the periphery,which together contribute to the beneficial effects of ASIV against brain ischemia.Furthermore,ASIV’s effects on suppressing NK cell brain infiltration and activation may involve HDAC inhibition. | Baokai Dou Shichun Li Luyao Wei Lixin Wang Shiguo Zhu Zhengtao Wang Zunji Ke Kaixian Chen Zhifei Wang | 2021 | Frontiers of Medicine2021，15，1： | 3 |
| 20 | Effect of Adsorption of ZrO2 in Catalysts on the Efficiency of Hydrolysis of Cellulose to Sugar in Aqueous System under Microwave Radiation显示文摘Summary of main observation and conclusion Five types of ZrO2 are used to simply establish an effective aqueous catalytic system with sulfuric acid for the hydrolysis of cellulose to sugar,respectively.By adjusting surface roughness and particle size of ZrO2 dfferent adsorption is produced.Accordingy,following the thought to inhibit the self-aggregation nature of cellulose,after the introduction of ZrO2 with adsorption in catalysts,the efficiency of the hydrolysis of cellulose to sugar is improved.The results show different ZrO2 can produce different effects during the hydrolysis of the cellulose with rela-tively low crystallinity.Under the optimal conditions,the conversion of cellulose and TRS yield reaches 95.5%and 93.6%,respectively.Through this re-search,it reveals the critical point to organize a feasible and useful way for the hydrolysis of cellulose to sugar with high efficiency in an aqueous system.An important theoretical and technical support is also provided for the conversion and utiliation of cellulose in the future. | Ying Qiao Lixin Feng Zhongqiu Li Zhenyu Zhang Jing Chen Haining Na Jin Zhu Lai Chen | 2020 | Chinese Journal of Chemistry2020，38，4： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员