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| 1 | Regional Disparity and Convergence of China's Inbound Tourism Economy显示文摘Comprehending regional characteristics and influencing factors of China's inbound tourism economy is im-portant to make effective policies that will help inbound tourism develop harmoniously and shrink regional disparity.This paper studied the regional disparity and convergence of China's inbound tourism economy during 1996-2008 with the methods of σ-convergence,club convergence and β-convergence.The results indicate that 1) inbound tourism receipts per capita(ITRPC) of the whole country,the eastern,central and western regions presented the rapid increas-ing trend;2) ITRPC of the whole country was characterized by convergence;3) the eastern region presented club con-vergence,but the central and western regions did not show this trend;4) the star-hotel levels and investment in fixed assets for the tourism industry per capita had a same trend to growth rates of ITRPC,promoting inbound tourism de-velopment,and there was no difference among the 31 provinces(municipalities) in the mainland of China;5) but the proportion of employed persons in the tourism industry accounting for total population and the proportion of the terti-ary industry accounting for GDP had a reversal trend to growth rates of ITRPC,shrinking the provincial disparity in inbound tourism economy,and there were differences between the developed provinces and the developing provinces.Based on these analyses,we put forward some suggestions for the developing provinces to speed up inbound tourism economy. | WANG Shuxin HE Yuanqing WANG Xueding ZHU Guofeng CAO Weihong | 2011 | Chinese Geographical Science2011，21，6： | 40 |
| 2 | Pattern of stress change and its effect on seismicity rate caused by M_s8.0 Wenchuan earthquake显示文摘We use five published source models to calculate the Coulomb failure stress changes induced by the Ms8.0 Wenchuan earthquake, and analyze the association between stress changes and the subsequent earthquakes. Based on the analysis of uncertainties resulting from source models, we determine the stress changes on nearby faults caused by the Wenchuan earthquake. Moreover, we focus on the seismicity rate change as a function of time on every fault under the influence of stress changes. The results indicate that the spatial distributions of aftershocks correlate well with the regions where stress is calculated to increase using the related models. The largest lobes of dropped stress lie in the west and east sides of source fault. The largest lobes of increased failure stress close to southern and northern ends of the source fault extend into the whole source failure plane. In addition, another region of increased stress lies in the Wenchuan-Yingxiu zone close to the southern segment of source fault, where a large number of aftershocks have occurred. And subsequent earthquakes seem to extend to even more remote distances; therefore, this area also has a high risk of seismic hazard. We find that the positive stress changes on nearby faults imposed by the Wenchuan earthquake produce an encouraging effect on seismicity rate. The effect is most significant on the Pengxian-Guanxian fault and Qingchuan fault, the value of seismicity rate maintains two times greater than the value before the mainshock for the next hundred years on these faults, and the time needed for the aftershock rate to recover to the pre-mainshock seismicity rate can reach up to 800-900 yr. The influence is not significant on the western Qinling fault, the Longquanshan fault, the Xianshuihe fault, the Yulongxi fault, the Anninghe fault, the Minjiang fault, and the Aba fault. Compared with the seismicity rate on these faults before the mainshock, the aftershock rate is raised by less than two times, and the time of perturbation duration is not long. The stress changes on the Fubianhe fault and Huya fault are negative, which reduce the seismicity for the next thousand years. Under the influence of stress changes caused by the Wenchuan earthquake, both Pengxian-Guanxian fault and Qingchuan fault have a high risk of earthquake occurrence. | XIE ChaoDi ZHU YuanQing LEI XingLin YU HaiYing HU XiongLin | 2010 | Science China Earth Sciences2010，53，9： | 17 |
| 3 | Spatial distribution and temporal trends in potential evapotranspiration over Hengduan Mountains region from 1960 to 2009显示文摘在 19612009 期间在 Hengduan 山区域基于 20 个车站的气象学的数据,潜在的土壤水分蒸发蒸腾损失总量的年度、季节的变化与 Penman-Monteith 模型一起在联合被分析。与在 ArcGIS 下面的花键插值的方法,潜在的土壤水分蒸发蒸腾损失总量的空间分发被介绍研究地区性的差别,并且关联分析被用来讨论影响潜在的土壤水分蒸发蒸腾损失总量的主导的因素。结果显示自从 1960 年代,年度潜在的土壤水分蒸发蒸腾损失总量显示出一个减少的趋势,特别从 1980 年代到 1990 年代,当自从 2000,它显示出一个增加的趋势时。地区性的潜在的土壤水分蒸发蒸腾损失总量显示出 0.17 公里 a1 的率。在 Hengduan 山的北方,中间和南方的潜在的土壤水分蒸发蒸腾损失总量在学习时期上展出了减少的趋势,并且它的地区性的趋势在从西南的衰落上到东北。 | ZHU Guofeng HE Yuanqing PU Tao WANG Xufeng JIA Wenxiong LI Zongxing XIN Huijuan | 2012 | Journal of Geographical Sciences2012，22，1： | 16 |
| 4 | Branched tetraether lipids in Chinese soils:Evaluating the fidelity of MBT/CBT proxies as paleoenvironmental proxies显示文摘The ubiquitous occurrence of branched glycerol dialkyl glycerol tetraethers(br GDGTs) in soils has allowed development of new proxies for reconstruction of past climate and environment. The methylation and cyclization degrees of br GDGTs, expressed as MBT and CBT, respectively, are reported to be mainly controlled by mean annual air temperature(MAAT) and soil p H. However, the br GDGT-derived temperatures and soil p H scatter widely when data from different environmental conditions are considered. In this study, we collected over 300 soil samples from China, which are representative of humid(Xishuangbanna, Guangzhou, and Shanghai), semi-arid(Dongying) and semi-arid/arid(Lanzhou, Tibetan Plateau) regions. Collectively we have the most extensive dataset that broadly characterizes the distribution of br GDGTs according to climate zones in China. The overall data demonstrate that the MBT/CBT derived temperatures better match the measured MAATs in humid and non-alkaline regions than those from regions of low MAP(<400 mm/yr) and above neutral soil p H(>7.0–7.5). Similarly, CBT describes soil p H much better in humid and non-alkaline soils than in semi-arid/arid and alkaline soils; the semi-arid/arid and alkaline soils tend to show a positive correlation between soil p H and CBT, which contradicts that in the humid and non-alkaline soils. While soil p H, MAAT and mean annual precipitation(MAP) are dominating factors controlling the br GDGT distribution across all climate zones, conductivity, total organic carbon and total nitrogen, as well as soil water content can also play an important role locally. Removing br GDGT-II resulted in a revised CBT index that provides more accurate estimation of p H, especially in semi-arid/arid and alkaline soils. The overall Chinese dataset demonstrates that continental air temperature derived from br GDGT-proxies can vastly deviate from real measurements and should be used with extreme caution in paleo-climate or-environment studies. | ZHENG FengFeng ZHANG ChuanLun CHEN YuFei LI FuYan MA CenLing PU Yang ZHU YuanQing WANG YongLi LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，7： | 10 |
| 5 | Isolation of Growth Hormone-Releasing Hormone and Its Receptor Genes from Scatophagus argus and Their Expression Analyses显示文摘The teleost Scatophagus argus is a species whose females grows faster than males.Growth hormone(gh)mRNA abundance in females pituitary is higher than that in males;however the mechanism underlining such differential is still unknown.Growth hormone(GH)is tightly associated with GH-releasing hormone(Ghrh)in vertebrates.In this study,Ghrh gene(ghrh)and its receptor gene,ghrhr,were isolated from S.argus.Tissue expression analysis showed that ghrh and ghrhr were mainly expressed in hypothalamus while ghrhr was expressed in pituitary and gh was predominantly expressed in pituitary.Twenty cultured S.argus individuals were used to compare ghrh,ghrhr and gh mRNA abundances,120 g and 181 g average weight for male(n=11)and female(n=9),respectively.Real-time PCR indicated that the ghrh and ghrhr mRNA abundances in male hypothalamus were significantly higher than those in female hypothalamus while that of gh mRNA abundance was significantly higher in female pituitary than in male pituitary.The ghrh and ghrhr mRNA abundances were significantly up-regulated in female hypothalamus 3 h after injection of 0.1 mg kg^-1 body weight Ghrh while pituitary ghrhr and gh mRNA abundances were not affected.In female hypothalamus,ghrh and ghrhr m RNA abundances were not affected at 6 h post-injection of 4 mg kg^-1 body weight 17α-methyltes-tosterone(17α-MT)or 17β-Estradiol(E2).In female pituitary,ghrhr m RNA abundance was down-regulated by 17α-MT while that of gh m RNA abundance was up-regulated by E2.Our findings indicated that E2,rather than Ghrh,plays an important role in up-regulating the expression of gh in female S.argus,which should aid to understand the sexual dimorphism of teleost growth. | JIANG Dongneng SHI Hongjuan LIU Qianqing WANG Tuo HUANG Yuanqing HUANG Yang DENG Siping CHEN Huapu TIAN Changxu ZHU Chunhua LI Guangli | 2019 | Journal of Ocean University of China2019，18，6： | 6 |
| 6 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 7 | Mathematical modeling of fluid flow, heat transfer and inclusion transport in a four strand tundish显示文摘Mathematical simulation was used for trouble-shooting and optimization. By the mathematical simulation, fluid flow and heat transfer of molten-steel in a four-strand tundish of a billet caster under different conditions (bare tundish and tundish with flow control device) were analyzed. The results showed that (1) the tundish with flow control device (FCD) has an important effect on the fluid pattern and temperature distribution; (2) the unsteady solving method was used to model the inclusion motions at different time periods, and it showed that the FCD is advantageous to separate the nonmetallic inclusions. According to the simulation results, the main problem existing in the industry production was found, and some helpful measurements were executed. Consequently, the large nonmetallic inclusions were separated, and the content of total oxygen was reduced. The quality of steel was greatly improved. | Yufeng Wang Guanghua Wen Ping Tang Mingmei Zhu Yuanqing Chen Weizhao Song | 2007 | Journal of University of Science and Technology Beijing2007，14，1： | 4 |
| 8 | Cross-calibration on the electromagnetic field detection payloads of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite(CSES)deploys three payloads to detect the electromagnetic environment in the ionosphere.The tri-axial fluxgate magnetometers(FGM),as part of the high precision magnetometer(HPM),measures the Earth magnetic vector field in a frequency range from direct current(DC)to 15 Hz.The tri-axial search coil magnetometer(SCM)detects the alternating current(AC)related magnetic field in a frequency range from several Hz to 20 k Hz,and the electric field detector(EFD)measures the spatial electric field in a broad frequency band from DC to 3.5 MHz.This work mainly crosscalibrates the consistency of these three payloads in their overlapped detection frequency range and firstly evaluates CSES’s timing system and the sampling time differences between EFD and SCM.A sampling time synchronization method for EFD and SCM waveform data is put forward.The consistency between FGM and SCM in the ultra-low-frequency(ULF)range is validated by using the magnetic torque(MT)signal as a reference.A natural quasiperiodic electromagnetic wave event verifies SCM and EFD’s consistency in extremely low-frequency and very low-frequency(ELF/VLF)bands.This cross-calibration work is helpful to upgrade the data quality of CSES and brings valuable insights to similar electromagnetic detection solutions by low earth orbit satellites. | ZHIMA Zeren ZHOU Bin ZHAO ShuFan WANG Qiao HUANG JianPing ZENG Li LEI JunGang CHEN Yu LI Cheng YANG DeHe SUN XiaoYing MIAO YuanQing ZHU XingHong SHEN XuHui | 2022 | Science China(Technological Sciences)2022，65，6： | 3 |
| 9 | Geographic modeling and simulation systems for geographic research in the new era: Some thoughts on their development and construction显示文摘Regionality,comprehensiveness,and complexity are regarded as the basic characteristics of geography.The exploration of their core connotations is an essential way to achieve breakthroughs in geography in the new era.This paper focuses on the important method in geographic research:Geographic modeling and simulation.First,we clarify the research requirements of the said three characteristics of geography and its potential to address geo-problems in the new era.Then,the supporting capabilities of the existing geographic modeling and simulation systems for geographic research are summarized from three perspectives:Model resources,modeling processes,and operational architecture.Finally,we discern avenues for future research of geographic modeling and simulation systems for the study of regional,comprehensive and complex characteristics of geography.Based on these analyses,we propose implementation architecture of geographic modeling and simulation systems and discuss the module composition and functional realization,which could provide theoretical and technical support for geographic modeling and simulation systems to better serve the development of geography in the new era. | Min CHEN Guonian LV Chenghu ZHOU Hui LIN Zaiyang MA Songshan YUE Yongning WEN Fengyuan ZHANG Jin WANG Zhiyi ZHU Kai XU Yuanqing HE | 2021 | Science China Earth Sciences2021，64，8： | 3 |
| 10 | Hydrochemical char- acteristics of typical rivers in a temperate glacier basin, China 显示文摘 | Pu Tao He Yuanqing Zhu Guofeng | 2013 | Environmental Earth Sciences2013，68，3： | 1 |
| 11 | Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response显示文摘Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains elusive.Here,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic arteries.Typically,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and infammation.In contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process.Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation.Mechanistically,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation.Especially,compared to macrophages,endothelial STING activation plays a more pronounced role in atherosclerosis.We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction. | Xuesong Li Xiang Chen Longbin Zheng Minghong Chen Yunjia Zhang Ruigong Zhu Jiajing Chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao Hongshan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 12 | Analysis and elimination of tri-band beacon interference with the fluxgate sensors onboard CSES显示文摘High precision magnetometer(HPM)is a magnetic field detection payload onboard China Seismo-Electromagnetic Satellite(CSES),including two fluxgate magnetometers(FGM)and a coupled dark state magnetometer(CDSM).Observations show that FGM appears to be influenced when tri-band beacon(TBB)is powered on and emits electromagnetic waves.The interference phenomenon is further validated based on both in-orbit observation analysis and electromagnetic compatibility(EMC)tests on the ground.A joint correction algorithm based on the least square fitting and first-order difference method according to scalar magnetometer data is proposed to eliminate the interference.The algorithm significantly improves the consistency of HPM data.After correction,the average scalar deviation error could be reduced from 9.0 nT to around 0.7 nT. | TONG YuQi CHENG BingJun MIAO YuanQing ZHOU Bin ZHU XingHong YANG YanYan LIU Ji GOU XiaoChen ZHANG YiTeng WANG JinDong LI Lei MAGNES Werner LAMMEGGER Roland POLLINGER Andreas ZEREN Zhima SHEN XuHui | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 13 | Regulations in the United States for cell transplantation clinical trials in neurological diseases显示文摘Objective: This study aimed to use a systematic approach to evaluate the current utilization, safety, and effectiveness of cell therapies for neurological diseases in human. And review the present regulations, considering United States(US) as a representative country, for cell transplantation in neurological disease and discuss the challenges facing the field of neurology in the coming decades. Methods: A detailed search was performed in systematic literature reviews of cellular‐based therapies in neurological diseases, using Pub Med, web of science, and clinical trials. Regulations of cell therapy products used for clinical trials were searched from the Food and Drug Administration(FDA) and the National Institutes of Health(NIH).Results: Seven most common types of cell therapies for neurological diseases have been reported to be relatively safe with varying degrees of neurological recovery.And a series of regulations in US for cellular therapy was summarized including preclinical evaluations, sourcing material, stem cell manufacturing and characterization,cell therapy product, and clinical trials. Conclusions: Stem cell‐based therapy holds great promise for a cure of such diseases and will value a growing population of patients. However, regulatory permitting activity of the US in the sphere of stem cells, technologies of regenerative medicine and substitutive cell therapy are selective, theoretical and does not fit the existing norm and rules. Compiled well‐defined regulations to guide the application of stem cell products for clinical trials should be formulated. | He Zhu Yuanqing Tan Qi Gu Weifang Han Zhongwen Li Jason S. Meyer Baoyang Hu | 2015 | Translational Neuroscience and Clinics2015，1，2： | 1 |
| 14 | Attitude Track- ing of Rigid Spacecraft with Bounded Disturbances 显示文摘 | XIA Yuanqing ZHU Zheng FU Mengyin | 2011 | IEEE Transactions on Automatic Control2011，58，2： | 1 |
| 15 | Sliding- mode Attitude Tracking of Rigid Spacecraft with Disturbances 显示文摘 | LU Kunfen XIA Yuanqing ZHU Zheng | 2012 | Jour- nal of The Franklin Institute2012，349，2012： | 1 |
| 16 | Back-stepping Sliding Mode Control for Missile Systems Based on Extended State Ob- server 显示文摘 | Xia Yuanqing Zhu Zheng Fu Mengyin | 2011 | lET Control Theory Applications2011，5，1： | 1 |
| 17 | Gut microbiota,inflammation,and molecular signatures of host response to infection显示文摘Gut microbial dysbiosis has been linked to many noncommunicable diseases.However,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to infection.Here,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the COVID-19.We demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,individuals.We further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 individuals.Fecal metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and inflammation.Overall,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy individuals.These results may provide novel insights into the cross-talk between gut microbiota and host immune system. | Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang Zelei Miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng | 2021 | Journal of Genetics and Genomics2021，48，9： | 1 |
| 18 | Attitude tracking of rigid spacecraft with bounded disturbances显示文摘 | Xia Yuanqing Zhu Zheng Fu Mengyin | 2011 | IEEE Transactions on Industrial Electronics2011，58，2： | 1 |
| 19 | Sliding mode attitude tracking of rigid spacecraft with disturbances显示文摘 | Kunfeng Lu Yuanqing Xia Zheng Zhu Michael V. Basin | 2011 | Journal of the Franklin Institute2011，，： | 1 |
| 20 | Attitude tracking of rigid spacecraft with bounded disturbances显示文摘 | Xia Yuanqing Zhu Zheng Fu Mengyin | 2011 | IEEE Trans- actions on Industrial Electronics2011，58，2： | 1 |
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